Amino acid dipepetide frequency for Mycoplasma hyorhinis SK76

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.539AlaAla: 2.539 ± 0.121
0.228AlaCys: 0.228 ± 0.035
2.335AlaAsp: 2.335 ± 0.113
2.459AlaGlu: 2.459 ± 0.124
2.894AlaPhe: 2.894 ± 0.123
2.355AlaGly: 2.355 ± 0.119
0.711AlaHis: 0.711 ± 0.062
4.91AlaIle: 4.91 ± 0.172
5.948AlaLys: 5.948 ± 0.167
4.85AlaLeu: 4.85 ± 0.139
0.846AlaMet: 0.846 ± 0.066
3.876AlaAsn: 3.876 ± 0.134
1.166AlaPro: 1.166 ± 0.072
2.243AlaGln: 2.243 ± 0.086
1.685AlaArg: 1.685 ± 0.087
3.661AlaSer: 3.661 ± 0.133
3.186AlaThr: 3.186 ± 0.154
2.295AlaVal: 2.295 ± 0.096
0.531AlaTrp: 0.531 ± 0.05
1.653AlaTyr: 1.653 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.176CysAla: 0.176 ± 0.03
0.036CysCys: 0.036 ± 0.014
0.192CysAsp: 0.192 ± 0.037
0.216CysGlu: 0.216 ± 0.06
0.415CysPhe: 0.415 ± 0.044
0.291CysGly: 0.291 ± 0.046
0.092CysHis: 0.092 ± 0.017
0.343CysIle: 0.343 ± 0.038
0.271CysLys: 0.271 ± 0.043
0.407CysLeu: 0.407 ± 0.042
0.072CysMet: 0.072 ± 0.016
0.156CysAsn: 0.156 ± 0.028
0.14CysPro: 0.14 ± 0.028
0.204CysGln: 0.204 ± 0.036
0.08CysArg: 0.08 ± 0.02
0.303CysSer: 0.303 ± 0.041
0.136CysThr: 0.136 ± 0.03
0.224CysVal: 0.224 ± 0.034
0.028CysTrp: 0.028 ± 0.011
0.132CysTyr: 0.132 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
2.375AspAla: 2.375 ± 0.118
0.116AspCys: 0.116 ± 0.027
2.259AspAsp: 2.259 ± 0.109
3.182AspGlu: 3.182 ± 0.114
4.152AspPhe: 4.152 ± 0.152
1.872AspGly: 1.872 ± 0.108
0.703AspHis: 0.703 ± 0.052
4.275AspIle: 4.275 ± 0.123
5.581AspLys: 5.581 ± 0.148
5.289AspLeu: 5.289 ± 0.158
0.615AspMet: 0.615 ± 0.053
3.74AspAsn: 3.74 ± 0.158
1.385AspPro: 1.385 ± 0.098
2.192AspGln: 2.192 ± 0.099
1.074AspArg: 1.074 ± 0.063
3.784AspSer: 3.784 ± 0.171
2.299AspThr: 2.299 ± 0.114
2.818AspVal: 2.818 ± 0.11
0.479AspTrp: 0.479 ± 0.046
2.323AspTyr: 2.323 ± 0.084
0.0AspXaa: 0.0 ± 0.0
Glu
3.233GluAla: 3.233 ± 0.138
0.319GluCys: 0.319 ± 0.062
3.15GluAsp: 3.15 ± 0.129
5.221GluGlu: 5.221 ± 0.228
4.108GluPhe: 4.108 ± 0.147
2.239GluGly: 2.239 ± 0.104
0.906GluHis: 0.906 ± 0.071
6.539GluIle: 6.539 ± 0.17
7.832GluLys: 7.832 ± 0.226
6.403GluLeu: 6.403 ± 0.201
0.87GluMet: 0.87 ± 0.068
5.88GluAsn: 5.88 ± 0.156
1.19GluPro: 1.19 ± 0.074
3.297GluGln: 3.297 ± 0.131
1.541GluArg: 1.541 ± 0.096
3.158GluSer: 3.158 ± 0.14
2.766GluThr: 2.766 ± 0.13
3.709GluVal: 3.709 ± 0.143
0.407GluTrp: 0.407 ± 0.042
2.327GluTyr: 2.327 ± 0.11
0.0GluXaa: 0.0 ± 0.0
Phe
3.453PheAla: 3.453 ± 0.131
0.295PheCys: 0.295 ± 0.038
3.748PheAsp: 3.748 ± 0.129
3.936PheGlu: 3.936 ± 0.135
4.048PhePhe: 4.048 ± 0.171
2.611PheGly: 2.611 ± 0.11
0.83PheHis: 0.83 ± 0.059
5.333PheIle: 5.333 ± 0.2
5.709PheLys: 5.709 ± 0.139
7.221PheLeu: 7.221 ± 0.241
0.647PheMet: 0.647 ± 0.058
4.172PheAsn: 4.172 ± 0.145
1.437PhePro: 1.437 ± 0.079
1.844PheGln: 1.844 ± 0.084
1.517PheArg: 1.517 ± 0.078
5.533PheSer: 5.533 ± 0.19
2.699PheThr: 2.699 ± 0.104
4.216PheVal: 4.216 ± 0.153
0.938PheTrp: 0.938 ± 0.064
2.782PheTyr: 2.782 ± 0.127
0.0PheXaa: 0.0 ± 0.0
Gly
2.247GlyAla: 2.247 ± 0.116
0.184GlyCys: 0.184 ± 0.035
1.744GlyAsp: 1.744 ± 0.102
2.084GlyGlu: 2.084 ± 0.106
2.806GlyPhe: 2.806 ± 0.109
2.335GlyGly: 2.335 ± 0.143
0.754GlyHis: 0.754 ± 0.054
4.18GlyIle: 4.18 ± 0.169
3.856GlyLys: 3.856 ± 0.171
3.752GlyLeu: 3.752 ± 0.134
0.655GlyMet: 0.655 ± 0.052
2.128GlyAsn: 2.128 ± 0.091
0.978GlyPro: 0.978 ± 0.066
1.948GlyGln: 1.948 ± 0.105
1.405GlyArg: 1.405 ± 0.09
3.182GlySer: 3.182 ± 0.21
2.786GlyThr: 2.786 ± 0.16
2.615GlyVal: 2.615 ± 0.115
0.467GlyTrp: 0.467 ± 0.046
1.629GlyTyr: 1.629 ± 0.084
0.0GlyXaa: 0.0 ± 0.0
His
0.603HisAla: 0.603 ± 0.045
0.076HisCys: 0.076 ± 0.023
0.495HisAsp: 0.495 ± 0.042
0.587HisGlu: 0.587 ± 0.048
1.142HisPhe: 1.142 ± 0.089
0.619HisGly: 0.619 ± 0.055
0.311HisHis: 0.311 ± 0.036
1.421HisIle: 1.421 ± 0.078
1.589HisLys: 1.589 ± 0.089
1.525HisLeu: 1.525 ± 0.083
0.168HisMet: 0.168 ± 0.024
1.114HisAsn: 1.114 ± 0.061
0.567HisPro: 0.567 ± 0.053
0.583HisGln: 0.583 ± 0.048
0.463HisArg: 0.463 ± 0.04
1.11HisSer: 1.11 ± 0.07
0.774HisThr: 0.774 ± 0.054
0.495HisVal: 0.495 ± 0.046
0.124HisTrp: 0.124 ± 0.021
0.559HisTyr: 0.559 ± 0.056
0.0HisXaa: 0.0 ± 0.0
Ile
4.998IleAla: 4.998 ± 0.155
0.535IleCys: 0.535 ± 0.051
4.83IleAsp: 4.83 ± 0.126
5.76IleGlu: 5.76 ± 0.178
6.235IlePhe: 6.235 ± 0.238
3.693IleGly: 3.693 ± 0.148
1.178IleHis: 1.178 ± 0.068
8.343IleIle: 8.343 ± 0.296
9.828IleLys: 9.828 ± 0.231
9.257IleLeu: 9.257 ± 0.266
1.186IleMet: 1.186 ± 0.073
6.822IleAsn: 6.822 ± 0.173
2.687IlePro: 2.687 ± 0.103
3.158IleGln: 3.158 ± 0.137
2.232IleArg: 2.232 ± 0.118
7.836IleSer: 7.836 ± 0.178
4.259IleThr: 4.259 ± 0.147
5.034IleVal: 5.034 ± 0.172
0.89IleTrp: 0.89 ± 0.076
3.597IleTyr: 3.597 ± 0.134
0.0IleXaa: 0.0 ± 0.0
Lys
5.126LysAla: 5.126 ± 0.168
0.204LysCys: 0.204 ± 0.025
5.613LysAsp: 5.613 ± 0.175
8.607LysGlu: 8.607 ± 0.222
5.393LysPhe: 5.393 ± 0.139
3.425LysGly: 3.425 ± 0.136
1.681LysHis: 1.681 ± 0.081
10.746LysIle: 10.746 ± 0.238
11.593LysLys: 11.593 ± 0.301
9.88LysLeu: 9.88 ± 0.249
1.988LysMet: 1.988 ± 0.095
9.533LysAsn: 9.533 ± 0.228
2.483LysPro: 2.483 ± 0.102
4.986LysGln: 4.986 ± 0.149
2.814LysArg: 2.814 ± 0.121
6.044LysSer: 6.044 ± 0.154
6.188LysThr: 6.188 ± 0.169
5.317LysVal: 5.317 ± 0.149
1.158LysTrp: 1.158 ± 0.076
4.515LysTyr: 4.515 ± 0.118
0.0LysXaa: 0.0 ± 0.0
Leu
5.776LeuAla: 5.776 ± 0.191
0.279LeuCys: 0.279 ± 0.036
5.98LeuAsp: 5.98 ± 0.187
7.645LeuGlu: 7.645 ± 0.22
5.477LeuPhe: 5.477 ± 0.2
4.124LeuGly: 4.124 ± 0.151
1.249LeuHis: 1.249 ± 0.082
9.118LeuIle: 9.118 ± 0.274
10.99LeuLys: 10.99 ± 0.243
8.559LeuLeu: 8.559 ± 0.26
1.293LeuMet: 1.293 ± 0.072
7.836LeuAsn: 7.836 ± 0.216
2.351LeuPro: 2.351 ± 0.096
3.337LeuGln: 3.337 ± 0.104
2.471LeuArg: 2.471 ± 0.1
6.93LeuSer: 6.93 ± 0.151
4.902LeuThr: 4.902 ± 0.147
5.693LeuVal: 5.693 ± 0.159
0.83LeuTrp: 0.83 ± 0.055
2.898LeuTyr: 2.898 ± 0.116
0.0LeuXaa: 0.0 ± 0.0
Met
0.711MetAla: 0.711 ± 0.056
0.064MetCys: 0.064 ± 0.016
0.523MetAsp: 0.523 ± 0.05
0.715MetGlu: 0.715 ± 0.056
0.89MetPhe: 0.89 ± 0.06
0.527MetGly: 0.527 ± 0.045
0.204MetHis: 0.204 ± 0.031
1.138MetIle: 1.138 ± 0.066
1.88MetLys: 1.88 ± 0.103
1.441MetLeu: 1.441 ± 0.075
0.251MetMet: 0.251 ± 0.033
0.998MetAsn: 0.998 ± 0.068
0.399MetPro: 0.399 ± 0.039
0.635MetGln: 0.635 ± 0.05
0.307MetArg: 0.307 ± 0.031
1.277MetSer: 1.277 ± 0.086
0.643MetThr: 0.643 ± 0.055
0.627MetVal: 0.627 ± 0.043
0.1MetTrp: 0.1 ± 0.022
0.411MetTyr: 0.411 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.206AsnAla: 3.206 ± 0.109
0.255AsnCys: 0.255 ± 0.033
3.114AsnAsp: 3.114 ± 0.124
4.467AsnGlu: 4.467 ± 0.148
5.014AsnPhe: 5.014 ± 0.179
2.511AsnGly: 2.511 ± 0.117
1.11AsnHis: 1.11 ± 0.067
6.726AsnIle: 6.726 ± 0.187
9.03AsnLys: 9.03 ± 0.215
8.096AsnLeu: 8.096 ± 0.212
0.93AsnMet: 0.93 ± 0.061
6.539AsnAsn: 6.539 ± 0.234
2.862AsnPro: 2.862 ± 0.142
3.916AsnGln: 3.916 ± 0.159
1.836AsnArg: 1.836 ± 0.086
5.856AsnSer: 5.856 ± 0.211
3.553AsnThr: 3.553 ± 0.198
3.437AsnVal: 3.437 ± 0.135
0.886AsnTrp: 0.886 ± 0.069
3.429AsnTyr: 3.429 ± 0.121
0.0AsnXaa: 0.0 ± 0.0
Pro
1.273ProAla: 1.273 ± 0.082
0.104ProCys: 0.104 ± 0.02
1.397ProAsp: 1.397 ± 0.078
1.832ProGlu: 1.832 ± 0.115
1.465ProPhe: 1.465 ± 0.068
1.222ProGly: 1.222 ± 0.088
0.475ProHis: 0.475 ± 0.045
2.563ProIle: 2.563 ± 0.118
2.359ProLys: 2.359 ± 0.112
2.192ProLeu: 2.192 ± 0.099
0.267ProMet: 0.267 ± 0.034
1.944ProAsn: 1.944 ± 0.095
0.483ProPro: 0.483 ± 0.057
1.006ProGln: 1.006 ± 0.077
0.75ProArg: 0.75 ± 0.065
1.952ProSer: 1.952 ± 0.116
1.948ProThr: 1.948 ± 0.114
1.501ProVal: 1.501 ± 0.082
0.307ProTrp: 0.307 ± 0.033
0.966ProTyr: 0.966 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
2.375GlnAla: 2.375 ± 0.111
0.084GlnCys: 0.084 ± 0.02
2.22GlnAsp: 2.22 ± 0.099
3.241GlnGlu: 3.241 ± 0.132
1.888GlnPhe: 1.888 ± 0.089
1.784GlnGly: 1.784 ± 0.12
0.559GlnHis: 0.559 ± 0.051
4.355GlnIle: 4.355 ± 0.142
4.802GlnLys: 4.802 ± 0.149
3.409GlnLeu: 3.409 ± 0.113
0.691GlnMet: 0.691 ± 0.054
3.792GlnAsn: 3.792 ± 0.163
1.142GlnPro: 1.142 ± 0.081
2.319GlnGln: 2.319 ± 0.121
1.481GlnArg: 1.481 ± 0.077
2.387GlnSer: 2.387 ± 0.111
2.355GlnThr: 2.355 ± 0.124
2.216GlnVal: 2.216 ± 0.108
0.403GlnTrp: 0.403 ± 0.042
1.433GlnTyr: 1.433 ± 0.084
0.0GlnXaa: 0.0 ± 0.0
Arg
1.373ArgAla: 1.373 ± 0.079
0.084ArgCys: 0.084 ± 0.021
1.249ArgAsp: 1.249 ± 0.067
1.932ArgGlu: 1.932 ± 0.107
1.641ArgPhe: 1.641 ± 0.065
1.198ArgGly: 1.198 ± 0.08
0.407ArgHis: 0.407 ± 0.048
2.539ArgIle: 2.539 ± 0.117
3.018ArgLys: 3.018 ± 0.131
2.527ArgLeu: 2.527 ± 0.104
0.475ArgMet: 0.475 ± 0.048
1.824ArgAsn: 1.824 ± 0.094
0.834ArgPro: 0.834 ± 0.061
1.194ArgGln: 1.194 ± 0.074
1.102ArgArg: 1.102 ± 0.076
1.493ArgSer: 1.493 ± 0.086
1.234ArgThr: 1.234 ± 0.067
1.541ArgVal: 1.541 ± 0.089
0.271ArgTrp: 0.271 ± 0.036
1.122ArgTyr: 1.122 ± 0.073
0.0ArgXaa: 0.0 ± 0.0
Ser
3.253SerAla: 3.253 ± 0.128
0.403SerCys: 0.403 ± 0.046
3.569SerAsp: 3.569 ± 0.151
3.96SerGlu: 3.96 ± 0.172
5.122SerPhe: 5.122 ± 0.146
3.717SerGly: 3.717 ± 0.209
0.874SerHis: 0.874 ± 0.063
6.144SerIle: 6.144 ± 0.156
7.058SerLys: 7.058 ± 0.158
7.601SerLeu: 7.601 ± 0.195
0.946SerMet: 0.946 ± 0.052
5.214SerAsn: 5.214 ± 0.216
1.613SerPro: 1.613 ± 0.09
3.657SerGln: 3.657 ± 0.158
2.04SerArg: 2.04 ± 0.088
5.788SerSer: 5.788 ± 0.236
4.323SerThr: 4.323 ± 0.233
3.693SerVal: 3.693 ± 0.136
0.623SerTrp: 0.623 ± 0.051
2.703SerTyr: 2.703 ± 0.123
0.0SerXaa: 0.0 ± 0.0
Thr
2.104ThrAla: 2.104 ± 0.116
0.128ThrCys: 0.128 ± 0.038
2.375ThrAsp: 2.375 ± 0.11
2.395ThrGlu: 2.395 ± 0.132
3.301ThrPhe: 3.301 ± 0.117
2.559ThrGly: 2.559 ± 0.143
0.91ThrHis: 0.91 ± 0.068
4.766ThrIle: 4.766 ± 0.13
5.541ThrLys: 5.541 ± 0.165
4.934ThrLeu: 4.934 ± 0.135
0.595ThrMet: 0.595 ± 0.05
4.239ThrAsn: 4.239 ± 0.237
1.752ThrPro: 1.752 ± 0.107
2.623ThrGln: 2.623 ± 0.147
1.449ThrArg: 1.449 ± 0.076
4.267ThrSer: 4.267 ± 0.204
3.725ThrThr: 3.725 ± 0.222
2.339ThrVal: 2.339 ± 0.11
0.439ThrTrp: 0.439 ± 0.042
1.896ThrTyr: 1.896 ± 0.101
0.0ThrXaa: 0.0 ± 0.0
Val
3.365ValAla: 3.365 ± 0.126
0.343ValCys: 0.343 ± 0.043
3.094ValAsp: 3.094 ± 0.12
3.888ValGlu: 3.888 ± 0.152
3.577ValPhe: 3.577 ± 0.136
2.671ValGly: 2.671 ± 0.116
0.778ValHis: 0.778 ± 0.06
4.906ValIle: 4.906 ± 0.149
4.962ValLys: 4.962 ± 0.14
5.214ValLeu: 5.214 ± 0.158
0.623ValMet: 0.623 ± 0.049
3.489ValAsn: 3.489 ± 0.138
1.393ValPro: 1.393 ± 0.081
1.681ValGln: 1.681 ± 0.067
1.337ValArg: 1.337 ± 0.075
4.072ValSer: 4.072 ± 0.126
2.172ValThr: 2.172 ± 0.104
3.812ValVal: 3.812 ± 0.153
0.471ValTrp: 0.471 ± 0.047
2.088ValTyr: 2.088 ± 0.096
0.0ValXaa: 0.0 ± 0.0
Trp
0.547TrpAla: 0.547 ± 0.051
0.04TrpCys: 0.04 ± 0.014
0.571TrpAsp: 0.571 ± 0.049
0.619TrpGlu: 0.619 ± 0.049
0.515TrpPhe: 0.515 ± 0.047
0.351TrpGly: 0.351 ± 0.039
0.1TrpHis: 0.1 ± 0.017
1.034TrpIle: 1.034 ± 0.061
0.982TrpLys: 0.982 ± 0.055
0.922TrpLeu: 0.922 ± 0.066
0.267TrpMet: 0.267 ± 0.03
0.766TrpAsn: 0.766 ± 0.064
0.263TrpPro: 0.263 ± 0.027
0.371TrpGln: 0.371 ± 0.037
0.283TrpArg: 0.283 ± 0.033
0.659TrpSer: 0.659 ± 0.06
0.739TrpThr: 0.739 ± 0.058
0.507TrpVal: 0.507 ± 0.054
0.176TrpTrp: 0.176 ± 0.027
0.327TrpTyr: 0.327 ± 0.037
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.637TyrAla: 1.637 ± 0.095
0.136TyrCys: 0.136 ± 0.026
2.056TyrAsp: 2.056 ± 0.08
2.351TyrGlu: 2.351 ± 0.106
2.886TyrPhe: 2.886 ± 0.128
1.633TyrGly: 1.633 ± 0.084
0.491TyrHis: 0.491 ± 0.043
2.978TyrIle: 2.978 ± 0.105
4.463TyrLys: 4.463 ± 0.158
4.259TyrLeu: 4.259 ± 0.154
0.351TyrMet: 0.351 ± 0.04
2.711TyrAsn: 2.711 ± 0.117
0.882TyrPro: 0.882 ± 0.06
1.744TyrGln: 1.744 ± 0.089
1.194TyrArg: 1.194 ± 0.07
3.006TyrSer: 3.006 ± 0.113
1.653TyrThr: 1.653 ± 0.092
1.848TyrVal: 1.848 ± 0.098
0.511TyrTrp: 0.511 ± 0.044
1.768TyrTyr: 1.768 ± 0.095
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 751 proteins (250504 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski