Amino acid dipepetide frequency for endosymbiont of Bathymodiolus septemdierum str. Myojin knoll

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.688AlaAla: 4.688 ± 0.17
0.865AlaCys: 0.865 ± 0.052
4.546AlaAsp: 4.546 ± 0.122
4.076AlaGlu: 4.076 ± 0.092
3.3AlaPhe: 3.3 ± 0.092
5.013AlaGly: 5.013 ± 0.131
1.603AlaHis: 1.603 ± 0.068
6.32AlaIle: 6.32 ± 0.148
6.091AlaLys: 6.091 ± 0.135
8.477AlaLeu: 8.477 ± 0.174
2.268AlaMet: 2.268 ± 0.08
3.91AlaAsn: 3.91 ± 0.101
2.166AlaPro: 2.166 ± 0.082
3.456AlaGln: 3.456 ± 0.097
2.855AlaArg: 2.855 ± 0.09
4.73AlaSer: 4.73 ± 0.13
4.43AlaThr: 4.43 ± 0.204
4.866AlaVal: 4.866 ± 0.132
0.745AlaTrp: 0.745 ± 0.045
2.397AlaTyr: 2.397 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.689CysAla: 0.689 ± 0.041
0.125CysCys: 0.125 ± 0.015
0.598CysAsp: 0.598 ± 0.04
0.6CysGlu: 0.6 ± 0.039
0.391CysPhe: 0.391 ± 0.032
0.861CysGly: 0.861 ± 0.051
0.325CysHis: 0.325 ± 0.027
0.705CysIle: 0.705 ± 0.044
0.534CysLys: 0.534 ± 0.042
0.865CysLeu: 0.865 ± 0.047
0.213CysMet: 0.213 ± 0.024
0.418CysAsn: 0.418 ± 0.034
0.534CysPro: 0.534 ± 0.04
0.447CysGln: 0.447 ± 0.036
0.342CysArg: 0.342 ± 0.029
0.605CysSer: 0.605 ± 0.041
0.523CysThr: 0.523 ± 0.035
0.781CysVal: 0.781 ± 0.046
0.06CysTrp: 0.06 ± 0.012
0.251CysTyr: 0.251 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.579AspAla: 4.579 ± 0.125
0.605AspCys: 0.605 ± 0.031
3.262AspAsp: 3.262 ± 0.109
4.096AspGlu: 4.096 ± 0.132
3.327AspPhe: 3.327 ± 0.088
3.85AspGly: 3.85 ± 0.144
0.838AspHis: 0.838 ± 0.043
5.219AspIle: 5.219 ± 0.114
4.786AspLys: 4.786 ± 0.114
5.638AspLeu: 5.638 ± 0.137
1.419AspMet: 1.419 ± 0.06
3.302AspAsn: 3.302 ± 0.091
1.417AspPro: 1.417 ± 0.066
1.345AspGln: 1.345 ± 0.05
1.948AspArg: 1.948 ± 0.067
3.1AspSer: 3.1 ± 0.083
3.305AspThr: 3.305 ± 0.148
3.487AspVal: 3.487 ± 0.093
0.816AspTrp: 0.816 ± 0.05
2.244AspTyr: 2.244 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
4.397GluAla: 4.397 ± 0.112
0.558GluCys: 0.558 ± 0.035
2.855GluAsp: 2.855 ± 0.086
3.249GluGlu: 3.249 ± 0.091
2.426GluPhe: 2.426 ± 0.075
3.371GluGly: 3.371 ± 0.092
1.148GluHis: 1.148 ± 0.056
4.881GluIle: 4.881 ± 0.113
4.964GluLys: 4.964 ± 0.129
5.469GluLeu: 5.469 ± 0.121
1.788GluMet: 1.788 ± 0.068
3.325GluAsn: 3.325 ± 0.092
1.412GluPro: 1.412 ± 0.069
2.867GluGln: 2.867 ± 0.088
2.515GluArg: 2.515 ± 0.071
3.36GluSer: 3.36 ± 0.091
2.746GluThr: 2.746 ± 0.073
4.521GluVal: 4.521 ± 0.104
0.607GluTrp: 0.607 ± 0.06
1.93GluTyr: 1.93 ± 0.077
0.0GluXaa: 0.0 ± 0.0
Phe
3.169PheAla: 3.169 ± 0.083
0.431PheCys: 0.431 ± 0.034
3.149PheAsp: 3.149 ± 0.115
2.811PheGlu: 2.811 ± 0.079
2.03PhePhe: 2.03 ± 0.082
2.953PheGly: 2.953 ± 0.099
0.743PheHis: 0.743 ± 0.043
3.309PheIle: 3.309 ± 0.109
3.096PheLys: 3.096 ± 0.086
3.701PheLeu: 3.701 ± 0.111
1.025PheMet: 1.025 ± 0.052
2.462PheAsn: 2.462 ± 0.083
1.265PhePro: 1.265 ± 0.052
1.192PheGln: 1.192 ± 0.055
1.232PheArg: 1.232 ± 0.059
3.405PheSer: 3.405 ± 0.102
2.291PheThr: 2.291 ± 0.066
2.887PheVal: 2.887 ± 0.082
0.48PheTrp: 0.48 ± 0.036
1.47PheTyr: 1.47 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
5.204GlyAla: 5.204 ± 0.134
0.865GlyCys: 0.865 ± 0.06
3.609GlyAsp: 3.609 ± 0.115
3.967GlyGlu: 3.967 ± 0.093
3.503GlyPhe: 3.503 ± 0.086
4.79GlyGly: 4.79 ± 0.146
1.486GlyHis: 1.486 ± 0.057
5.019GlyIle: 5.019 ± 0.119
4.953GlyLys: 4.953 ± 0.121
6.345GlyLeu: 6.345 ± 0.135
1.824GlyMet: 1.824 ± 0.075
3.102GlyAsn: 3.102 ± 0.142
1.277GlyPro: 1.277 ± 0.062
2.242GlyGln: 2.242 ± 0.074
2.698GlyArg: 2.698 ± 0.092
3.945GlySer: 3.945 ± 0.174
3.418GlyThr: 3.418 ± 0.172
5.586GlyVal: 5.586 ± 0.119
0.754GlyTrp: 0.754 ± 0.042
2.291GlyTyr: 2.291 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.339HisAla: 1.339 ± 0.063
0.289HisCys: 0.289 ± 0.025
0.89HisAsp: 0.89 ± 0.042
0.814HisGlu: 0.814 ± 0.047
0.912HisPhe: 0.912 ± 0.05
1.41HisGly: 1.41 ± 0.057
0.627HisHis: 0.627 ± 0.039
1.737HisIle: 1.737 ± 0.068
1.321HisLys: 1.321 ± 0.056
2.144HisLeu: 2.144 ± 0.078
0.469HisMet: 0.469 ± 0.03
1.121HisAsn: 1.121 ± 0.054
1.176HisPro: 1.176 ± 0.055
1.105HisGln: 1.105 ± 0.064
0.847HisArg: 0.847 ± 0.043
1.394HisSer: 1.394 ± 0.064
1.143HisThr: 1.143 ± 0.052
0.749HisVal: 0.749 ± 0.044
0.278HisTrp: 0.278 ± 0.028
0.832HisTyr: 0.832 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.767IleAla: 6.767 ± 0.122
0.709IleCys: 0.709 ± 0.039
5.695IleAsp: 5.695 ± 0.109
5.404IleGlu: 5.404 ± 0.128
3.158IlePhe: 3.158 ± 0.097
5.54IleGly: 5.54 ± 0.133
1.503IleHis: 1.503 ± 0.062
5.417IleIle: 5.417 ± 0.112
6.076IleLys: 6.076 ± 0.114
6.985IleLeu: 6.985 ± 0.148
1.566IleMet: 1.566 ± 0.064
4.575IleAsn: 4.575 ± 0.1
2.689IlePro: 2.689 ± 0.084
2.549IleGln: 2.549 ± 0.081
2.684IleArg: 2.684 ± 0.074
5.097IleSer: 5.097 ± 0.111
4.804IleThr: 4.804 ± 0.16
4.955IleVal: 4.955 ± 0.1
0.652IleTrp: 0.652 ± 0.046
2.068IleTyr: 2.068 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
5.324LysAla: 5.324 ± 0.116
0.451LysCys: 0.451 ± 0.037
4.381LysAsp: 4.381 ± 0.098
4.239LysGlu: 4.239 ± 0.104
2.424LysPhe: 2.424 ± 0.085
4.399LysGly: 4.399 ± 0.106
1.517LysHis: 1.517 ± 0.06
6.191LysIle: 6.191 ± 0.13
5.991LysLys: 5.991 ± 0.162
6.147LysLeu: 6.147 ± 0.127
2.115LysMet: 2.115 ± 0.067
4.692LysAsn: 4.692 ± 0.112
2.477LysPro: 2.477 ± 0.071
3.554LysGln: 3.554 ± 0.096
2.938LysArg: 2.938 ± 0.082
4.288LysSer: 4.288 ± 0.097
4.65LysThr: 4.65 ± 0.099
5.017LysVal: 5.017 ± 0.108
0.629LysTrp: 0.629 ± 0.045
2.222LysTyr: 2.222 ± 0.082
0.0LysXaa: 0.0 ± 0.0
Leu
7.606LeuAla: 7.606 ± 0.14
0.852LeuCys: 0.852 ± 0.04
5.811LeuAsp: 5.811 ± 0.112
5.662LeuGlu: 5.662 ± 0.141
3.905LeuPhe: 3.905 ± 0.118
6.605LeuGly: 6.605 ± 0.127
1.737LeuHis: 1.737 ± 0.064
7.281LeuIle: 7.281 ± 0.147
7.216LeuLys: 7.216 ± 0.151
9.703LeuLeu: 9.703 ± 0.208
2.477LeuMet: 2.477 ± 0.083
5.253LeuAsn: 5.253 ± 0.123
3.772LeuPro: 3.772 ± 0.091
3.151LeuGln: 3.151 ± 0.086
3.416LeuArg: 3.416 ± 0.096
7.841LeuSer: 7.841 ± 0.142
5.713LeuThr: 5.713 ± 0.133
5.769LeuVal: 5.769 ± 0.103
0.907LeuTrp: 0.907 ± 0.049
2.455LeuTyr: 2.455 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.128MetAla: 2.128 ± 0.077
0.189MetCys: 0.189 ± 0.02
1.379MetAsp: 1.379 ± 0.058
1.17MetGlu: 1.17 ± 0.051
0.852MetPhe: 0.852 ± 0.043
1.826MetGly: 1.826 ± 0.081
0.518MetHis: 0.518 ± 0.034
1.804MetIle: 1.804 ± 0.059
1.657MetLys: 1.657 ± 0.058
2.342MetLeu: 2.342 ± 0.077
0.705MetMet: 0.705 ± 0.044
1.339MetAsn: 1.339 ± 0.056
1.152MetPro: 1.152 ± 0.05
1.256MetGln: 1.256 ± 0.06
1.121MetArg: 1.121 ± 0.049
2.017MetSer: 2.017 ± 0.068
1.459MetThr: 1.459 ± 0.059
1.748MetVal: 1.748 ± 0.061
0.167MetTrp: 0.167 ± 0.018
0.483MetTyr: 0.483 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
4.55AsnAla: 4.55 ± 0.116
0.505AsnCys: 0.505 ± 0.035
3.02AsnAsp: 3.02 ± 0.123
2.929AsnGlu: 2.929 ± 0.089
2.257AsnPhe: 2.257 ± 0.065
3.28AsnGly: 3.28 ± 0.094
1.096AsnHis: 1.096 ± 0.043
4.841AsnIle: 4.841 ± 0.126
4.092AsnLys: 4.092 ± 0.116
4.781AsnLeu: 4.781 ± 0.105
1.016AsnMet: 1.016 ± 0.05
3.34AsnAsn: 3.34 ± 0.107
2.315AsnPro: 2.315 ± 0.084
2.491AsnGln: 2.491 ± 0.079
1.984AsnArg: 1.984 ± 0.069
3.044AsnSer: 3.044 ± 0.092
3.302AsnThr: 3.302 ± 0.103
2.58AsnVal: 2.58 ± 0.069
0.612AsnTrp: 0.612 ± 0.041
1.637AsnTyr: 1.637 ± 0.072
0.0AsnXaa: 0.0 ± 0.0
Pro
2.262ProAla: 2.262 ± 0.081
0.389ProCys: 0.389 ± 0.034
1.877ProAsp: 1.877 ± 0.07
2.239ProGlu: 2.239 ± 0.077
1.468ProPhe: 1.468 ± 0.062
1.799ProGly: 1.799 ± 0.071
0.696ProHis: 0.696 ± 0.043
2.773ProIle: 2.773 ± 0.083
2.466ProLys: 2.466 ± 0.076
3.187ProLeu: 3.187 ± 0.105
0.976ProMet: 0.976 ± 0.046
1.826ProAsn: 1.826 ± 0.074
0.954ProPro: 0.954 ± 0.051
1.123ProGln: 1.123 ± 0.053
1.007ProArg: 1.007 ± 0.051
2.139ProSer: 2.139 ± 0.067
2.044ProThr: 2.044 ± 0.078
2.186ProVal: 2.186 ± 0.079
0.396ProTrp: 0.396 ± 0.03
1.047ProTyr: 1.047 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
3.669GlnAla: 3.669 ± 0.102
0.331GlnCys: 0.331 ± 0.031
2.006GlnAsp: 2.006 ± 0.066
2.146GlnGlu: 2.146 ± 0.071
1.472GlnPhe: 1.472 ± 0.053
2.655GlnGly: 2.655 ± 0.086
0.954GlnHis: 0.954 ± 0.052
3.024GlnIle: 3.024 ± 0.094
2.929GlnLys: 2.929 ± 0.098
4.041GlnLeu: 4.041 ± 0.127
1.03GlnMet: 1.03 ± 0.052
1.928GlnAsn: 1.928 ± 0.079
1.112GlnPro: 1.112 ± 0.051
2.079GlnGln: 2.079 ± 0.091
1.615GlnArg: 1.615 ± 0.064
2.644GlnSer: 2.644 ± 0.076
2.266GlnThr: 2.266 ± 0.075
2.642GlnVal: 2.642 ± 0.07
0.398GlnTrp: 0.398 ± 0.031
1.279GlnTyr: 1.279 ± 0.061
0.0GlnXaa: 0.0 ± 0.0
Arg
2.742ArgAla: 2.742 ± 0.075
0.358ArgCys: 0.358 ± 0.031
2.048ArgAsp: 2.048 ± 0.075
2.208ArgGlu: 2.208 ± 0.071
1.786ArgPhe: 1.786 ± 0.061
2.353ArgGly: 2.353 ± 0.078
0.867ArgHis: 0.867 ± 0.044
3.04ArgIle: 3.04 ± 0.083
2.489ArgLys: 2.489 ± 0.08
3.838ArgLeu: 3.838 ± 0.107
1.063ArgMet: 1.063 ± 0.056
1.801ArgAsn: 1.801 ± 0.076
1.128ArgPro: 1.128 ± 0.049
1.724ArgGln: 1.724 ± 0.065
1.706ArgArg: 1.706 ± 0.076
2.164ArgSer: 2.164 ± 0.07
1.699ArgThr: 1.699 ± 0.064
2.5ArgVal: 2.5 ± 0.073
0.411ArgTrp: 0.411 ± 0.029
1.448ArgTyr: 1.448 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
5.215SerAla: 5.215 ± 0.144
0.638SerCys: 0.638 ± 0.039
3.692SerAsp: 3.692 ± 0.1
3.716SerGlu: 3.716 ± 0.094
2.767SerPhe: 2.767 ± 0.08
4.766SerGly: 4.766 ± 0.126
1.21SerHis: 1.21 ± 0.056
5.075SerIle: 5.075 ± 0.131
4.546SerLys: 4.546 ± 0.104
6.198SerLeu: 6.198 ± 0.135
1.537SerMet: 1.537 ± 0.065
3.54SerAsn: 3.54 ± 0.107
1.824SerPro: 1.824 ± 0.067
2.222SerGln: 2.222 ± 0.073
2.251SerArg: 2.251 ± 0.075
3.954SerSer: 3.954 ± 0.165
3.527SerThr: 3.527 ± 0.122
4.801SerVal: 4.801 ± 0.113
0.545SerTrp: 0.545 ± 0.033
1.759SerTyr: 1.759 ± 0.074
0.0SerXaa: 0.0 ± 0.0
Thr
4.056ThrAla: 4.056 ± 0.181
0.5ThrCys: 0.5 ± 0.036
3.383ThrAsp: 3.383 ± 0.152
2.911ThrGlu: 2.911 ± 0.086
2.004ThrPhe: 2.004 ± 0.072
4.188ThrGly: 4.188 ± 0.161
1.454ThrHis: 1.454 ± 0.064
4.323ThrIle: 4.323 ± 0.134
3.438ThrLys: 3.438 ± 0.093
6.516ThrLeu: 6.516 ± 0.153
1.281ThrMet: 1.281 ± 0.056
2.595ThrAsn: 2.595 ± 0.089
2.58ThrPro: 2.58 ± 0.078
2.824ThrGln: 2.824 ± 0.09
1.857ThrArg: 1.857 ± 0.066
3.098ThrSer: 3.098 ± 0.129
3.583ThrThr: 3.583 ± 0.173
3.572ThrVal: 3.572 ± 0.18
0.523ThrTrp: 0.523 ± 0.056
1.67ThrTyr: 1.67 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
5.406ValAla: 5.406 ± 0.124
0.741ValCys: 0.741 ± 0.041
4.128ValAsp: 4.128 ± 0.101
3.985ValGlu: 3.985 ± 0.102
2.996ValPhe: 2.996 ± 0.1
4.448ValGly: 4.448 ± 0.102
1.159ValHis: 1.159 ± 0.059
5.324ValIle: 5.324 ± 0.125
4.506ValLys: 4.506 ± 0.121
6.245ValLeu: 6.245 ± 0.13
1.603ValMet: 1.603 ± 0.058
3.378ValAsn: 3.378 ± 0.103
2.093ValPro: 2.093 ± 0.074
1.993ValGln: 1.993 ± 0.075
2.513ValArg: 2.513 ± 0.079
4.506ValSer: 4.506 ± 0.111
3.434ValThr: 3.434 ± 0.158
4.837ValVal: 4.837 ± 0.131
0.545ValTrp: 0.545 ± 0.038
1.819ValTyr: 1.819 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.663TrpAla: 0.663 ± 0.039
0.136TrpCys: 0.136 ± 0.018
0.549TrpAsp: 0.549 ± 0.037
0.527TrpGlu: 0.527 ± 0.034
0.532TrpPhe: 0.532 ± 0.051
0.698TrpGly: 0.698 ± 0.043
0.34TrpHis: 0.34 ± 0.025
0.727TrpIle: 0.727 ± 0.044
0.534TrpLys: 0.534 ± 0.034
1.136TrpLeu: 1.136 ± 0.047
0.322TrpMet: 0.322 ± 0.027
0.376TrpAsn: 0.376 ± 0.032
0.167TrpPro: 0.167 ± 0.022
0.66TrpGln: 0.66 ± 0.04
0.485TrpArg: 0.485 ± 0.037
0.547TrpSer: 0.547 ± 0.045
0.425TrpThr: 0.425 ± 0.032
0.667TrpVal: 0.667 ± 0.043
0.142TrpTrp: 0.142 ± 0.019
0.385TrpTyr: 0.385 ± 0.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.351TyrAla: 2.351 ± 0.07
0.329TyrCys: 0.329 ± 0.029
1.706TyrAsp: 1.706 ± 0.079
1.641TyrGlu: 1.641 ± 0.072
1.592TyrPhe: 1.592 ± 0.058
2.073TyrGly: 2.073 ± 0.071
0.776TyrHis: 0.776 ± 0.045
1.879TyrIle: 1.879 ± 0.064
1.964TyrLys: 1.964 ± 0.073
3.376TyrLeu: 3.376 ± 0.087
0.609TyrMet: 0.609 ± 0.032
1.39TyrAsn: 1.39 ± 0.056
1.348TyrPro: 1.348 ± 0.061
1.941TyrGln: 1.941 ± 0.072
1.359TyrArg: 1.359 ± 0.062
1.901TyrSer: 1.901 ± 0.067
1.595TyrThr: 1.595 ± 0.068
1.506TyrVal: 1.506 ± 0.049
0.351TyrTrp: 0.351 ± 0.031
1.179TyrTyr: 1.179 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1467 proteins (449665 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski