Amino acid dipepetide frequency for Chitinophagaceae bacterium IBVUCB2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.678AlaAla: 6.678 ± 0.088	0.695AlaCys: 0.695 ± 0.024	4.242AlaAsp: 4.242 ± 0.063	4.228AlaGlu: 4.228 ± 0.076	3.368AlaPhe: 3.368 ± 0.065	5.868AlaGly: 5.868 ± 0.08	1.122AlaHis: 1.122 ± 0.032	5.751AlaIle: 5.751 ± 0.085	4.92AlaLys: 4.92 ± 0.082	6.121AlaLeu: 6.121 ± 0.086	1.852AlaMet: 1.852 ± 0.044	3.717AlaAsn: 3.717 ± 0.068	2.253AlaPro: 2.253 ± 0.045	2.554AlaGln: 2.554 ± 0.05	2.312AlaArg: 2.312 ± 0.048	4.483AlaSer: 4.483 ± 0.071	4.76AlaThr: 4.76 ± 0.097	4.962AlaVal: 4.962 ± 0.066	0.827AlaTrp: 0.827 ± 0.026	2.438AlaTyr: 2.438 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.558CysAla: 0.558 ± 0.025	0.139CysCys: 0.139 ± 0.012	0.453CysAsp: 0.453 ± 0.023	0.441CysGlu: 0.441 ± 0.018	0.491CysPhe: 0.491 ± 0.022	0.725CysGly: 0.725 ± 0.023	0.193CysHis: 0.193 ± 0.014	0.703CysIle: 0.703 ± 0.029	0.543CysLys: 0.543 ± 0.02	0.751CysLeu: 0.751 ± 0.024	0.21CysMet: 0.21 ± 0.015	0.487CysAsn: 0.487 ± 0.02	0.404CysPro: 0.404 ± 0.025	0.223CysGln: 0.223 ± 0.015	0.307CysArg: 0.307 ± 0.017	0.589CysSer: 0.589 ± 0.026	0.522CysThr: 0.522 ± 0.022	0.533CysVal: 0.533 ± 0.021	0.096CysTrp: 0.096 ± 0.009	0.349CysTyr: 0.349 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.032AspAla: 4.032 ± 0.07	0.455AspCys: 0.455 ± 0.019	2.617AspAsp: 2.617 ± 0.056	3.447AspGlu: 3.447 ± 0.062	2.914AspPhe: 2.914 ± 0.051	3.808AspGly: 3.808 ± 0.064	0.802AspHis: 0.802 ± 0.026	3.906AspIle: 3.906 ± 0.06	4.216AspLys: 4.216 ± 0.072	4.267AspLeu: 4.267 ± 0.073	1.236AspMet: 1.236 ± 0.035	2.85AspAsn: 2.85 ± 0.05	1.924AspPro: 1.924 ± 0.042	1.255AspGln: 1.255 ± 0.035	1.821AspArg: 1.821 ± 0.039	3.236AspSer: 3.236 ± 0.061	2.68AspThr: 2.68 ± 0.052	3.292AspVal: 3.292 ± 0.057	0.775AspTrp: 0.775 ± 0.024	2.306AspTyr: 2.306 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.15GluAla: 4.15 ± 0.078	0.37GluCys: 0.37 ± 0.018	2.669GluAsp: 2.669 ± 0.049	4.18GluGlu: 4.18 ± 0.078	2.557GluPhe: 2.557 ± 0.046	3.464GluGly: 3.464 ± 0.057	0.984GluHis: 0.984 ± 0.03	4.392GluIle: 4.392 ± 0.072	5.941GluLys: 5.941 ± 0.101	5.69GluLeu: 5.69 ± 0.071	1.651GluMet: 1.651 ± 0.041	3.407GluAsn: 3.407 ± 0.06	1.629GluPro: 1.629 ± 0.037	2.298GluGln: 2.298 ± 0.048	2.317GluArg: 2.317 ± 0.054	2.708GluSer: 2.708 ± 0.053	3.013GluThr: 3.013 ± 0.052	3.708GluVal: 3.708 ± 0.08	0.815GluTrp: 0.815 ± 0.026	2.179GluTyr: 2.179 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.595PheAla: 3.595 ± 0.061	0.494PheCys: 0.494 ± 0.02	2.787PheAsp: 2.787 ± 0.049	2.676PheGlu: 2.676 ± 0.047	2.815PhePhe: 2.815 ± 0.06	3.442PheGly: 3.442 ± 0.067	0.832PheHis: 0.832 ± 0.025	3.835PheIle: 3.835 ± 0.063	3.084PheLys: 3.084 ± 0.049	4.386PheLeu: 4.386 ± 0.077	1.099PheMet: 1.099 ± 0.031	2.987PheAsn: 2.987 ± 0.056	1.78PhePro: 1.78 ± 0.04	1.499PheGln: 1.499 ± 0.036	1.91PheArg: 1.91 ± 0.045	3.828PheSer: 3.828 ± 0.062	3.333PheThr: 3.333 ± 0.063	2.882PheVal: 2.882 ± 0.052	0.586PheTrp: 0.586 ± 0.024	2.13PheTyr: 2.13 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.572GlyAla: 4.572 ± 0.073	0.747GlyCys: 0.747 ± 0.037	3.427GlyAsp: 3.427 ± 0.056	3.569GlyGlu: 3.569 ± 0.056	3.662GlyPhe: 3.662 ± 0.063	5.354GlyGly: 5.354 ± 0.113	1.18GlyHis: 1.18 ± 0.036	5.306GlyIle: 5.306 ± 0.074	5.697GlyLys: 5.697 ± 0.079	5.937GlyLeu: 5.937 ± 0.075	1.783GlyMet: 1.783 ± 0.046	3.993GlyAsn: 3.993 ± 0.087	1.584GlyPro: 1.584 ± 0.041	2.145GlyGln: 2.145 ± 0.047	2.507GlyArg: 2.507 ± 0.041	4.307GlySer: 4.307 ± 0.084	4.421GlyThr: 4.421 ± 0.08	4.391GlyVal: 4.391 ± 0.075	1.013GlyTrp: 1.013 ± 0.029	2.995GlyTyr: 2.995 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.09HisAla: 1.09 ± 0.032	0.203HisCys: 0.203 ± 0.014	0.805HisAsp: 0.805 ± 0.026	0.909HisGlu: 0.909 ± 0.03	1.13HisPhe: 1.13 ± 0.029	1.143HisGly: 1.143 ± 0.038	0.528HisHis: 0.528 ± 0.023	1.364HisIle: 1.364 ± 0.031	1.028HisLys: 1.028 ± 0.03	1.732HisLeu: 1.732 ± 0.04	0.327HisMet: 0.327 ± 0.018	0.854HisAsn: 0.854 ± 0.021	1.035HisPro: 1.035 ± 0.029	0.687HisGln: 0.687 ± 0.027	0.746HisArg: 0.746 ± 0.027	1.15HisSer: 1.15 ± 0.03	0.998HisThr: 0.998 ± 0.036	0.896HisVal: 0.896 ± 0.027	0.236HisTrp: 0.236 ± 0.015	0.821HisTyr: 0.821 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.945IleAla: 5.945 ± 0.082	0.783IleCys: 0.783 ± 0.028	4.151IleAsp: 4.151 ± 0.057	4.457IleGlu: 4.457 ± 0.07	3.388IlePhe: 3.388 ± 0.062	4.88IleGly: 4.88 ± 0.066	1.327IleHis: 1.327 ± 0.031	5.651IleIle: 5.651 ± 0.094	5.345IleLys: 5.345 ± 0.075	6.094IleLeu: 6.094 ± 0.08	1.431IleMet: 1.431 ± 0.033	4.421IleAsn: 4.421 ± 0.067	3.198IlePro: 3.198 ± 0.059	2.411IleGln: 2.411 ± 0.047	2.918IleArg: 2.918 ± 0.052	5.202IleSer: 5.202 ± 0.062	4.91IleThr: 4.91 ± 0.085	4.666IleVal: 4.666 ± 0.065	0.718IleTrp: 0.718 ± 0.024	2.559IleTyr: 2.559 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	5.327LysAla: 5.327 ± 0.09	0.399LysCys: 0.399 ± 0.019	4.294LysAsp: 4.294 ± 0.071	5.955LysGlu: 5.955 ± 0.103	2.883LysPhe: 2.883 ± 0.045	4.683LysGly: 4.683 ± 0.064	1.192LysHis: 1.192 ± 0.031	5.63LysIle: 5.63 ± 0.077	7.325LysLys: 7.325 ± 0.111	6.439LysLeu: 6.439 ± 0.086	2.297LysMet: 2.297 ± 0.049	4.613LysAsn: 4.613 ± 0.065	2.832LysPro: 2.832 ± 0.054	3.06LysGln: 3.06 ± 0.047	2.793LysArg: 2.793 ± 0.05	3.97LysSer: 3.97 ± 0.064	4.391LysThr: 4.391 ± 0.067	4.514LysVal: 4.514 ± 0.064	0.912LysTrp: 0.912 ± 0.031	2.883LysTyr: 2.883 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	6.267LeuAla: 6.267 ± 0.083	0.77LeuCys: 0.77 ± 0.026	4.248LeuAsp: 4.248 ± 0.06	4.653LeuGlu: 4.653 ± 0.08	4.87LeuPhe: 4.87 ± 0.079	5.443LeuGly: 5.443 ± 0.08	1.744LeuHis: 1.744 ± 0.045	6.246LeuIle: 6.246 ± 0.087	6.988LeuLys: 6.988 ± 0.093	9.596LeuLeu: 9.596 ± 0.142	2.093LeuMet: 2.093 ± 0.045	4.828LeuAsn: 4.828 ± 0.07	3.948LeuPro: 3.948 ± 0.055	3.93LeuGln: 3.93 ± 0.07	3.537LeuArg: 3.537 ± 0.053	6.334LeuSer: 6.334 ± 0.061	5.244LeuThr: 5.244 ± 0.056	5.436LeuVal: 5.436 ± 0.069	0.972LeuTrp: 0.972 ± 0.032	3.184LeuTyr: 3.184 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.839MetAla: 1.839 ± 0.047	0.146MetCys: 0.146 ± 0.011	1.265MetAsp: 1.265 ± 0.036	1.492MetGlu: 1.492 ± 0.034	0.852MetPhe: 0.852 ± 0.027	1.59MetGly: 1.59 ± 0.038	0.462MetHis: 0.462 ± 0.018	1.553MetIle: 1.553 ± 0.038	2.496MetLys: 2.496 ± 0.044	2.171MetLeu: 2.171 ± 0.054	0.761MetMet: 0.761 ± 0.029	1.419MetAsn: 1.419 ± 0.031	1.057MetPro: 1.057 ± 0.033	1.101MetGln: 1.101 ± 0.029	1.012MetArg: 1.012 ± 0.027	1.426MetSer: 1.426 ± 0.034	1.145MetThr: 1.145 ± 0.033	1.408MetVal: 1.408 ± 0.034	0.231MetTrp: 0.231 ± 0.015	0.709MetTyr: 0.709 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.938AsnAla: 3.938 ± 0.067	0.518AsnCys: 0.518 ± 0.021	2.907AsnAsp: 2.907 ± 0.05	3.236AsnGlu: 3.236 ± 0.058	2.785AsnPhe: 2.785 ± 0.052	4.207AsnGly: 4.207 ± 0.084	0.953AsnHis: 0.953 ± 0.032	4.404AsnIle: 4.404 ± 0.068	4.16AsnLys: 4.16 ± 0.057	4.644AsnLeu: 4.644 ± 0.075	1.275AsnMet: 1.275 ± 0.038	3.751AsnAsn: 3.751 ± 0.083	2.821AsnPro: 2.821 ± 0.063	1.91AsnGln: 1.91 ± 0.042	2.186AsnArg: 2.186 ± 0.046	3.509AsnSer: 3.509 ± 0.061	3.374AsnThr: 3.374 ± 0.065	3.133AsnVal: 3.133 ± 0.054	0.844AsnTrp: 0.844 ± 0.029	2.545AsnTyr: 2.545 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	3.44ProAla: 3.44 ± 0.062	0.259ProCys: 0.259 ± 0.017	2.444ProAsp: 2.444 ± 0.045	2.419ProGlu: 2.419 ± 0.048	1.918ProPhe: 1.918 ± 0.043	2.977ProGly: 2.977 ± 0.061	0.654ProHis: 0.654 ± 0.024	2.31ProIle: 2.31 ± 0.051	2.253ProLys: 2.253 ± 0.051	3.164ProLeu: 3.164 ± 0.051	0.766ProMet: 0.766 ± 0.025	1.945ProAsn: 1.945 ± 0.05	1.259ProPro: 1.259 ± 0.042	1.287ProGln: 1.287 ± 0.036	1.052ProArg: 1.052 ± 0.031	2.263ProSer: 2.263 ± 0.05	2.171ProThr: 2.171 ± 0.062	3.412ProVal: 3.412 ± 0.059	0.422ProTrp: 0.422 ± 0.019	1.49ProTyr: 1.49 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.268GlnAla: 2.268 ± 0.045	0.252GlnCys: 0.252 ± 0.015	1.419GlnAsp: 1.419 ± 0.034	1.983GlnGlu: 1.983 ± 0.044	1.756GlnPhe: 1.756 ± 0.039	1.891GlnGly: 1.891 ± 0.039	0.785GlnHis: 0.785 ± 0.027	2.218GlnIle: 2.218 ± 0.042	2.786GlnLys: 2.786 ± 0.057	4.083GlnLeu: 4.083 ± 0.07	0.953GlnMet: 0.953 ± 0.031	1.903GlnAsn: 1.903 ± 0.044	1.513GlnPro: 1.513 ± 0.036	2.352GlnGln: 2.352 ± 0.054	1.486GlnArg: 1.486 ± 0.036	2.204GlnSer: 2.204 ± 0.041	2.043GlnThr: 2.043 ± 0.045	2.206GlnVal: 2.206 ± 0.05	0.492GlnTrp: 0.492 ± 0.019	1.546GlnTyr: 1.546 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	1.956ArgAla: 1.956 ± 0.045	0.27ArgCys: 0.27 ± 0.015	1.826ArgAsp: 1.826 ± 0.042	2.124ArgGlu: 2.124 ± 0.051	2.066ArgPhe: 2.066 ± 0.042	2.082ArgGly: 2.082 ± 0.044	0.657ArgHis: 0.657 ± 0.026	3.09ArgIle: 3.09 ± 0.048	3.128ArgLys: 3.128 ± 0.052	3.453ArgLeu: 3.453 ± 0.058	1.098ArgMet: 1.098 ± 0.032	2.381ArgAsn: 2.381 ± 0.048	1.325ArgPro: 1.325 ± 0.036	1.509ArgGln: 1.509 ± 0.039	1.652ArgArg: 1.652 ± 0.042	2.196ArgSer: 2.196 ± 0.046	2.083ArgThr: 2.083 ± 0.041	2.209ArgVal: 2.209 ± 0.045	0.515ArgTrp: 0.515 ± 0.023	1.636ArgTyr: 1.636 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.351SerAla: 4.351 ± 0.066	0.682SerCys: 0.682 ± 0.024	2.88SerAsp: 2.88 ± 0.055	2.877SerGlu: 2.877 ± 0.048	3.844SerPhe: 3.844 ± 0.052	4.832SerGly: 4.832 ± 0.084	1.113SerHis: 1.113 ± 0.029	5.011SerIle: 5.011 ± 0.076	4.126SerLys: 4.126 ± 0.06	6.235SerLeu: 6.235 ± 0.087	1.411SerMet: 1.411 ± 0.039	3.397SerAsn: 3.397 ± 0.071	2.472SerPro: 2.472 ± 0.055	1.979SerGln: 1.979 ± 0.043	2.276SerArg: 2.276 ± 0.049	4.393SerSer: 4.393 ± 0.078	3.781SerThr: 3.781 ± 0.074	4.016SerVal: 4.016 ± 0.066	0.824SerTrp: 0.824 ± 0.028	2.513SerTyr: 2.513 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	5.028ThrAla: 5.028 ± 0.092	0.431ThrCys: 0.431 ± 0.019	3.3ThrAsp: 3.3 ± 0.057	3.194ThrGlu: 3.194 ± 0.059	2.69ThrPhe: 2.69 ± 0.055	5.133ThrGly: 5.133 ± 0.077	1.004ThrHis: 1.004 ± 0.028	4.943ThrIle: 4.943 ± 0.074	3.74ThrLys: 3.74 ± 0.061	4.947ThrLeu: 4.947 ± 0.074	1.134ThrMet: 1.134 ± 0.031	3.263ThrAsn: 3.263 ± 0.075	2.641ThrPro: 2.641 ± 0.06	1.814ThrGln: 1.814 ± 0.039	1.868ThrArg: 1.868 ± 0.043	3.638ThrSer: 3.638 ± 0.076	4.217ThrThr: 4.217 ± 0.098	4.28ThrVal: 4.28 ± 0.083	0.762ThrTrp: 0.762 ± 0.031	2.239ThrTyr: 2.239 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	4.821ValAla: 4.821 ± 0.083	0.617ValCys: 0.617 ± 0.026	3.251ValAsp: 3.251 ± 0.052	3.538ValGlu: 3.538 ± 0.06	3.098ValPhe: 3.098 ± 0.057	3.71ValGly: 3.71 ± 0.067	1.053ValHis: 1.053 ± 0.036	4.792ValIle: 4.792 ± 0.064	4.727ValLys: 4.727 ± 0.07	5.787ValLeu: 5.787 ± 0.072	1.543ValMet: 1.543 ± 0.04	3.652ValAsn: 3.652 ± 0.057	2.387ValPro: 2.387 ± 0.046	2.115ValGln: 2.115 ± 0.041	2.263ValArg: 2.263 ± 0.048	4.194ValSer: 4.194 ± 0.068	4.073ValThr: 4.073 ± 0.087	4.313ValVal: 4.313 ± 0.069	0.707ValTrp: 0.707 ± 0.026	2.442ValTyr: 2.442 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.712TrpAla: 0.712 ± 0.024	0.116TrpCys: 0.116 ± 0.009	0.691TrpAsp: 0.691 ± 0.032	0.677TrpGlu: 0.677 ± 0.025	0.648TrpPhe: 0.648 ± 0.025	0.773TrpGly: 0.773 ± 0.026	0.26TrpHis: 0.26 ± 0.014	0.806TrpIle: 0.806 ± 0.025	1.043TrpLys: 1.043 ± 0.031	1.226TrpLeu: 1.226 ± 0.031	0.404TrpMet: 0.404 ± 0.02	0.795TrpAsn: 0.795 ± 0.029	0.332TrpPro: 0.332 ± 0.018	0.579TrpGln: 0.579 ± 0.025	0.536TrpArg: 0.536 ± 0.023	0.692TrpSer: 0.692 ± 0.025	0.663TrpThr: 0.663 ± 0.028	0.8TrpVal: 0.8 ± 0.028	0.244TrpTrp: 0.244 ± 0.015	0.516TrpTyr: 0.516 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.583TyrAla: 2.583 ± 0.047	0.369TyrCys: 0.369 ± 0.016	2.164TyrAsp: 2.164 ± 0.05	2.069TyrGlu: 2.069 ± 0.044	2.249TyrPhe: 2.249 ± 0.046	2.585TyrGly: 2.585 ± 0.058	0.84TyrHis: 0.84 ± 0.027	2.546TyrIle: 2.546 ± 0.046	2.846TyrLys: 2.846 ± 0.059	3.608TyrLeu: 3.608 ± 0.058	0.809TyrMet: 0.809 ± 0.031	2.438TyrAsn: 2.438 ± 0.055	1.509TyrPro: 1.509 ± 0.037	1.432TyrGln: 1.432 ± 0.034	1.753TyrArg: 1.753 ± 0.04	2.689TyrSer: 2.689 ± 0.047	2.445TyrThr: 2.445 ± 0.056	2.023TyrVal: 2.023 ± 0.042	0.521TyrTrp: 0.521 ± 0.022	1.854TyrTyr: 1.854 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3527 proteins (1204414 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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