Amino acid dipepetide frequency for Dinoroseobacter phage vB_DshS-R5C

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.173AlaAla: 11.173 ± 0.845
1.101AlaCys: 1.101 ± 0.243
7.136AlaAsp: 7.136 ± 0.613
6.198AlaGlu: 6.198 ± 0.459
4.853AlaPhe: 4.853 ± 0.513
6.728AlaGly: 6.728 ± 0.662
2.365AlaHis: 2.365 ± 0.309
5.138AlaIle: 5.138 ± 0.523
4.73AlaLys: 4.73 ± 0.532
8.115AlaLeu: 8.115 ± 0.694
3.344AlaMet: 3.344 ± 0.362
3.466AlaAsn: 3.466 ± 0.425
2.977AlaPro: 2.977 ± 0.343
4.526AlaGln: 4.526 ± 0.393
6.891AlaArg: 6.891 ± 0.518
5.709AlaSer: 5.709 ± 0.513
6.361AlaThr: 6.361 ± 0.539
6.117AlaVal: 6.117 ± 0.558
2.039AlaTrp: 2.039 ± 0.218
2.569AlaTyr: 2.569 ± 0.258
0.0AlaXaa: 0.0 ± 0.0
Cys
0.612CysAla: 0.612 ± 0.152
0.163CysCys: 0.163 ± 0.075
0.816CysAsp: 0.816 ± 0.17
0.734CysGlu: 0.734 ± 0.165
0.163CysPhe: 0.163 ± 0.065
0.734CysGly: 0.734 ± 0.156
0.367CysHis: 0.367 ± 0.123
0.408CysIle: 0.408 ± 0.129
0.408CysLys: 0.408 ± 0.123
0.734CysLeu: 0.734 ± 0.198
0.245CysMet: 0.245 ± 0.097
0.245CysAsn: 0.245 ± 0.105
0.367CysPro: 0.367 ± 0.143
0.163CysGln: 0.163 ± 0.081
0.734CysArg: 0.734 ± 0.184
0.489CysSer: 0.489 ± 0.136
0.571CysThr: 0.571 ± 0.146
0.816CysVal: 0.816 ± 0.181
0.163CysTrp: 0.163 ± 0.09
0.367CysTyr: 0.367 ± 0.125
0.0CysXaa: 0.0 ± 0.0
Asp
7.829AspAla: 7.829 ± 0.678
0.612AspCys: 0.612 ± 0.173
6.769AspAsp: 6.769 ± 0.644
5.383AspGlu: 5.383 ± 0.53
3.099AspPhe: 3.099 ± 0.414
6.361AspGly: 6.361 ± 0.479
1.427AspHis: 1.427 ± 0.264
3.833AspIle: 3.833 ± 0.382
2.324AspLys: 2.324 ± 0.32
6.321AspLeu: 6.321 ± 0.479
2.08AspMet: 2.08 ± 0.245
2.569AspAsn: 2.569 ± 0.354
3.14AspPro: 3.14 ± 0.372
1.957AspGln: 1.957 ± 0.357
4.567AspArg: 4.567 ± 0.453
2.487AspSer: 2.487 ± 0.304
3.752AspThr: 3.752 ± 0.428
5.138AspVal: 5.138 ± 0.377
1.672AspTrp: 1.672 ± 0.254
1.998AspTyr: 1.998 ± 0.262
0.0AspXaa: 0.0 ± 0.0
Glu
6.728GluAla: 6.728 ± 0.55
0.449GluCys: 0.449 ± 0.177
3.833GluAsp: 3.833 ± 0.476
4.404GluGlu: 4.404 ± 0.446
3.018GluPhe: 3.018 ± 0.411
5.546GluGly: 5.546 ± 0.453
1.59GluHis: 1.59 ± 0.264
3.507GluIle: 3.507 ± 0.326
3.262GluLys: 3.262 ± 0.396
5.75GluLeu: 5.75 ± 0.515
1.957GluMet: 1.957 ± 0.273
3.058GluAsn: 3.058 ± 0.293
2.814GluPro: 2.814 ± 0.4
2.365GluGln: 2.365 ± 0.407
4.445GluArg: 4.445 ± 0.443
2.691GluSer: 2.691 ± 0.373
2.691GluThr: 2.691 ± 0.42
5.301GluVal: 5.301 ± 0.466
1.468GluTrp: 1.468 ± 0.219
1.713GluTyr: 1.713 ± 0.271
0.0GluXaa: 0.0 ± 0.0
Phe
3.099PheAla: 3.099 ± 0.388
0.489PheCys: 0.489 ± 0.142
4.078PheAsp: 4.078 ± 0.378
2.977PheGlu: 2.977 ± 0.32
0.979PhePhe: 0.979 ± 0.189
3.874PheGly: 3.874 ± 0.415
0.693PheHis: 0.693 ± 0.193
2.039PheIle: 2.039 ± 0.313
2.12PheLys: 2.12 ± 0.299
2.691PheLeu: 2.691 ± 0.352
1.142PheMet: 1.142 ± 0.267
1.917PheAsn: 1.917 ± 0.283
1.509PhePro: 1.509 ± 0.222
1.223PheGln: 1.223 ± 0.189
1.631PheArg: 1.631 ± 0.243
1.509PheSer: 1.509 ± 0.219
2.854PheThr: 2.854 ± 0.406
2.691PheVal: 2.691 ± 0.311
0.652PheTrp: 0.652 ± 0.166
0.897PheTyr: 0.897 ± 0.175
0.0PheXaa: 0.0 ± 0.0
Gly
6.81GlyAla: 6.81 ± 0.603
0.856GlyCys: 0.856 ± 0.189
5.342GlyAsp: 5.342 ± 0.421
5.22GlyGlu: 5.22 ± 0.437
2.651GlyPhe: 2.651 ± 0.376
6.117GlyGly: 6.117 ± 0.572
1.672GlyHis: 1.672 ± 0.223
4.078GlyIle: 4.078 ± 0.275
3.629GlyLys: 3.629 ± 0.415
6.239GlyLeu: 6.239 ± 0.585
2.487GlyMet: 2.487 ± 0.357
3.058GlyAsn: 3.058 ± 0.477
2.284GlyPro: 2.284 ± 0.3
2.284GlyGln: 2.284 ± 0.321
5.301GlyArg: 5.301 ± 0.395
5.097GlySer: 5.097 ± 0.678
5.505GlyThr: 5.505 ± 0.611
6.157GlyVal: 6.157 ± 0.524
1.223GlyTrp: 1.223 ± 0.232
2.12GlyTyr: 2.12 ± 0.315
0.0GlyXaa: 0.0 ± 0.0
His
2.284HisAla: 2.284 ± 0.277
0.326HisCys: 0.326 ± 0.121
1.55HisAsp: 1.55 ± 0.24
1.509HisGlu: 1.509 ± 0.286
0.979HisPhe: 0.979 ± 0.191
1.06HisGly: 1.06 ± 0.203
0.449HisHis: 0.449 ± 0.141
1.101HisIle: 1.101 ± 0.227
0.652HisLys: 0.652 ± 0.18
1.468HisLeu: 1.468 ± 0.255
0.408HisMet: 0.408 ± 0.137
0.734HisAsn: 0.734 ± 0.166
0.693HisPro: 0.693 ± 0.166
0.693HisGln: 0.693 ± 0.157
1.672HisArg: 1.672 ± 0.226
0.979HisSer: 0.979 ± 0.174
1.019HisThr: 1.019 ± 0.259
1.713HisVal: 1.713 ± 0.274
0.408HisTrp: 0.408 ± 0.137
0.53HisTyr: 0.53 ± 0.132
0.0HisXaa: 0.0 ± 0.0
Ile
5.22IleAla: 5.22 ± 0.421
0.693IleCys: 0.693 ± 0.164
4.2IleAsp: 4.2 ± 0.455
4.73IleGlu: 4.73 ± 0.432
1.427IlePhe: 1.427 ± 0.265
3.874IleGly: 3.874 ± 0.376
1.06IleHis: 1.06 ± 0.223
2.691IleIle: 2.691 ± 0.316
2.651IleLys: 2.651 ± 0.323
3.507IleLeu: 3.507 ± 0.319
1.183IleMet: 1.183 ± 0.228
1.917IleAsn: 1.917 ± 0.263
2.202IlePro: 2.202 ± 0.278
1.672IleGln: 1.672 ± 0.23
2.854IleArg: 2.854 ± 0.296
2.487IleSer: 2.487 ± 0.338
3.996IleThr: 3.996 ± 0.416
3.425IleVal: 3.425 ± 0.337
0.938IleTrp: 0.938 ± 0.205
1.06IleTyr: 1.06 ± 0.226
0.0IleXaa: 0.0 ± 0.0
Lys
5.179LysAla: 5.179 ± 0.528
0.285LysCys: 0.285 ± 0.136
3.058LysAsp: 3.058 ± 0.385
2.528LysGlu: 2.528 ± 0.331
1.917LysPhe: 1.917 ± 0.266
3.221LysGly: 3.221 ± 0.335
1.142LysHis: 1.142 ± 0.236
1.998LysIle: 1.998 ± 0.294
2.12LysLys: 2.12 ± 0.341
3.262LysLeu: 3.262 ± 0.373
1.427LysMet: 1.427 ± 0.21
1.631LysAsn: 1.631 ± 0.232
2.324LysPro: 2.324 ± 0.318
1.672LysGln: 1.672 ± 0.269
3.344LysArg: 3.344 ± 0.394
2.08LysSer: 2.08 ± 0.272
2.61LysThr: 2.61 ± 0.281
2.977LysVal: 2.977 ± 0.298
0.979LysTrp: 0.979 ± 0.171
1.427LysTyr: 1.427 ± 0.231
0.0LysXaa: 0.0 ± 0.0
Leu
7.952LeuAla: 7.952 ± 0.642
0.652LeuCys: 0.652 ± 0.177
6.728LeuAsp: 6.728 ± 0.616
6.035LeuGlu: 6.035 ± 0.538
2.12LeuPhe: 2.12 ± 0.302
5.954LeuGly: 5.954 ± 0.537
1.264LeuHis: 1.264 ± 0.204
3.058LeuIle: 3.058 ± 0.333
3.385LeuLys: 3.385 ± 0.398
5.301LeuLeu: 5.301 ± 0.533
1.876LeuMet: 1.876 ± 0.237
3.67LeuAsn: 3.67 ± 0.343
3.548LeuPro: 3.548 ± 0.373
2.202LeuGln: 2.202 ± 0.298
5.954LeuArg: 5.954 ± 0.52
3.955LeuSer: 3.955 ± 0.426
5.179LeuThr: 5.179 ± 0.416
5.016LeuVal: 5.016 ± 0.433
1.427LeuTrp: 1.427 ± 0.22
1.386LeuTyr: 1.386 ± 0.233
0.0LeuXaa: 0.0 ± 0.0
Met
3.262MetAla: 3.262 ± 0.413
0.285MetCys: 0.285 ± 0.105
1.427MetAsp: 1.427 ± 0.275
1.427MetGlu: 1.427 ± 0.24
1.101MetPhe: 1.101 ± 0.187
1.917MetGly: 1.917 ± 0.352
0.245MetHis: 0.245 ± 0.114
1.957MetIle: 1.957 ± 0.273
1.672MetLys: 1.672 ± 0.282
1.794MetLeu: 1.794 ± 0.282
0.571MetMet: 0.571 ± 0.163
1.101MetAsn: 1.101 ± 0.186
1.59MetPro: 1.59 ± 0.25
1.06MetGln: 1.06 ± 0.209
2.447MetArg: 2.447 ± 0.355
1.753MetSer: 1.753 ± 0.288
2.08MetThr: 2.08 ± 0.274
1.917MetVal: 1.917 ± 0.268
0.652MetTrp: 0.652 ± 0.176
0.163MetTyr: 0.163 ± 0.075
0.0MetXaa: 0.0 ± 0.0
Asn
4.608AsnAla: 4.608 ± 0.435
0.326AsnCys: 0.326 ± 0.099
2.814AsnAsp: 2.814 ± 0.366
2.243AsnGlu: 2.243 ± 0.322
1.06AsnPhe: 1.06 ± 0.243
4.159AsnGly: 4.159 ± 0.308
0.571AsnHis: 0.571 ± 0.145
1.672AsnIle: 1.672 ± 0.265
1.101AsnLys: 1.101 ± 0.23
3.303AsnLeu: 3.303 ± 0.412
0.816AsnMet: 0.816 ± 0.143
1.55AsnAsn: 1.55 ± 0.252
1.835AsnPro: 1.835 ± 0.286
1.672AsnGln: 1.672 ± 0.287
1.957AsnArg: 1.957 ± 0.275
1.753AsnSer: 1.753 ± 0.299
1.917AsnThr: 1.917 ± 0.35
2.487AsnVal: 2.487 ± 0.269
1.223AsnTrp: 1.223 ± 0.221
1.019AsnTyr: 1.019 ± 0.178
0.0AsnXaa: 0.0 ± 0.0
Pro
3.996ProAla: 3.996 ± 0.353
0.326ProCys: 0.326 ± 0.111
3.181ProAsp: 3.181 ± 0.404
2.365ProGlu: 2.365 ± 0.267
1.59ProPhe: 1.59 ± 0.213
2.977ProGly: 2.977 ± 0.328
0.938ProHis: 0.938 ± 0.208
1.55ProIle: 1.55 ± 0.281
2.365ProLys: 2.365 ± 0.321
2.447ProLeu: 2.447 ± 0.273
1.223ProMet: 1.223 ± 0.222
1.713ProAsn: 1.713 ± 0.265
1.957ProPro: 1.957 ± 0.34
1.305ProGln: 1.305 ± 0.216
2.161ProArg: 2.161 ± 0.284
2.854ProSer: 2.854 ± 0.303
2.895ProThr: 2.895 ± 0.292
3.099ProVal: 3.099 ± 0.354
0.775ProTrp: 0.775 ± 0.146
1.386ProTyr: 1.386 ± 0.241
0.0ProXaa: 0.0 ± 0.0
Gln
3.67GlnAla: 3.67 ± 0.418
0.163GlnCys: 0.163 ± 0.081
1.753GlnAsp: 1.753 ± 0.231
2.406GlnGlu: 2.406 ± 0.288
1.55GlnPhe: 1.55 ± 0.276
2.284GlnGly: 2.284 ± 0.292
0.571GlnHis: 0.571 ± 0.168
2.447GlnIle: 2.447 ± 0.285
1.55GlnLys: 1.55 ± 0.231
2.447GlnLeu: 2.447 ± 0.302
1.019GlnMet: 1.019 ± 0.202
1.183GlnAsn: 1.183 ± 0.247
1.101GlnPro: 1.101 ± 0.194
1.55GlnGln: 1.55 ± 0.245
2.447GlnArg: 2.447 ± 0.317
2.12GlnSer: 2.12 ± 0.27
1.794GlnThr: 1.794 ± 0.285
2.365GlnVal: 2.365 ± 0.287
1.019GlnTrp: 1.019 ± 0.205
1.06GlnTyr: 1.06 ± 0.218
0.0GlnXaa: 0.0 ± 0.0
Arg
6.932ArgAla: 6.932 ± 0.597
0.612ArgCys: 0.612 ± 0.131
4.363ArgAsp: 4.363 ± 0.389
4.812ArgGlu: 4.812 ± 0.506
2.528ArgPhe: 2.528 ± 0.297
4.567ArgGly: 4.567 ± 0.463
1.386ArgHis: 1.386 ± 0.303
4.2ArgIle: 4.2 ± 0.395
3.221ArgLys: 3.221 ± 0.391
5.994ArgLeu: 5.994 ± 0.561
3.018ArgMet: 3.018 ± 0.389
2.324ArgAsn: 2.324 ± 0.376
2.161ArgPro: 2.161 ± 0.283
2.161ArgGln: 2.161 ± 0.318
3.792ArgArg: 3.792 ± 0.433
3.385ArgSer: 3.385 ± 0.39
3.099ArgThr: 3.099 ± 0.358
4.119ArgVal: 4.119 ± 0.478
1.101ArgTrp: 1.101 ± 0.217
1.917ArgTyr: 1.917 ± 0.284
0.0ArgXaa: 0.0 ± 0.0
Ser
4.893SerAla: 4.893 ± 0.548
0.489SerCys: 0.489 ± 0.15
2.977SerAsp: 2.977 ± 0.324
2.895SerGlu: 2.895 ± 0.423
2.773SerPhe: 2.773 ± 0.414
5.627SerGly: 5.627 ± 0.58
1.223SerHis: 1.223 ± 0.219
3.018SerIle: 3.018 ± 0.374
2.12SerLys: 2.12 ± 0.348
4.037SerLeu: 4.037 ± 0.465
1.223SerMet: 1.223 ± 0.213
2.08SerAsn: 2.08 ± 0.221
2.12SerPro: 2.12 ± 0.326
1.753SerGln: 1.753 ± 0.251
2.895SerArg: 2.895 ± 0.364
3.099SerSer: 3.099 ± 0.361
4.404SerThr: 4.404 ± 0.594
2.61SerVal: 2.61 ± 0.333
0.938SerTrp: 0.938 ± 0.229
1.468SerTyr: 1.468 ± 0.231
0.0SerXaa: 0.0 ± 0.0
Thr
6.157ThrAla: 6.157 ± 0.71
0.489ThrCys: 0.489 ± 0.119
4.282ThrAsp: 4.282 ± 0.42
3.221ThrGlu: 3.221 ± 0.502
2.691ThrPhe: 2.691 ± 0.368
5.301ThrGly: 5.301 ± 0.603
1.06ThrHis: 1.06 ± 0.222
3.588ThrIle: 3.588 ± 0.486
2.569ThrLys: 2.569 ± 0.345
4.404ThrLeu: 4.404 ± 0.457
1.753ThrMet: 1.753 ± 0.217
2.406ThrAsn: 2.406 ± 0.346
3.711ThrPro: 3.711 ± 0.444
1.753ThrGln: 1.753 ± 0.295
3.548ThrArg: 3.548 ± 0.433
3.711ThrSer: 3.711 ± 0.517
4.649ThrThr: 4.649 ± 0.49
4.445ThrVal: 4.445 ± 0.464
1.346ThrTrp: 1.346 ± 0.237
1.835ThrTyr: 1.835 ± 0.251
0.0ThrXaa: 0.0 ± 0.0
Val
7.095ValAla: 7.095 ± 0.556
0.449ValCys: 0.449 ± 0.129
5.26ValAsp: 5.26 ± 0.367
4.608ValGlu: 4.608 ± 0.395
2.487ValPhe: 2.487 ± 0.291
4.689ValGly: 4.689 ± 0.478
1.264ValHis: 1.264 ± 0.207
3.058ValIle: 3.058 ± 0.29
3.262ValLys: 3.262 ± 0.326
5.22ValLeu: 5.22 ± 0.412
1.917ValMet: 1.917 ± 0.318
1.917ValAsn: 1.917 ± 0.297
2.977ValPro: 2.977 ± 0.362
2.61ValGln: 2.61 ± 0.343
5.138ValArg: 5.138 ± 0.513
3.752ValSer: 3.752 ± 0.343
4.812ValThr: 4.812 ± 0.489
4.893ValVal: 4.893 ± 0.562
1.264ValTrp: 1.264 ± 0.212
2.08ValTyr: 2.08 ± 0.338
0.0ValXaa: 0.0 ± 0.0
Trp
2.039TrpAla: 2.039 ± 0.248
0.122TrpCys: 0.122 ± 0.065
1.427TrpAsp: 1.427 ± 0.215
1.264TrpGlu: 1.264 ± 0.249
0.897TrpPhe: 0.897 ± 0.162
0.979TrpGly: 0.979 ± 0.164
0.367TrpHis: 0.367 ± 0.138
1.101TrpIle: 1.101 ± 0.204
0.979TrpLys: 0.979 ± 0.217
2.161TrpLeu: 2.161 ± 0.328
0.408TrpMet: 0.408 ± 0.139
0.652TrpAsn: 0.652 ± 0.159
0.612TrpPro: 0.612 ± 0.143
0.816TrpGln: 0.816 ± 0.201
1.631TrpArg: 1.631 ± 0.314
1.305TrpSer: 1.305 ± 0.234
1.142TrpThr: 1.142 ± 0.244
1.346TrpVal: 1.346 ± 0.252
0.285TrpTrp: 0.285 ± 0.14
0.571TrpTyr: 0.571 ± 0.132
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.998TyrAla: 1.998 ± 0.267
0.408TyrCys: 0.408 ± 0.154
2.324TyrAsp: 2.324 ± 0.311
1.672TyrGlu: 1.672 ± 0.256
1.183TyrPhe: 1.183 ± 0.228
2.161TyrGly: 2.161 ± 0.292
0.571TyrHis: 0.571 ± 0.148
1.346TyrIle: 1.346 ± 0.246
1.06TyrLys: 1.06 ± 0.201
1.468TyrLeu: 1.468 ± 0.229
0.285TyrMet: 0.285 ± 0.116
0.897TyrAsn: 0.897 ± 0.186
1.183TyrPro: 1.183 ± 0.247
1.06TyrGln: 1.06 ± 0.208
2.284TyrArg: 2.284 ± 0.287
1.427TyrSer: 1.427 ± 0.247
1.59TyrThr: 1.59 ± 0.285
2.12TyrVal: 2.12 ± 0.284
0.53TyrTrp: 0.53 ± 0.135
0.408TyrTyr: 0.408 ± 0.132
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 123 proteins (24524 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski