Amino acid dipepetide frequency for Muribaculaceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.379AlaAla: 7.379 ± 0.126	1.082AlaCys: 1.082 ± 0.041	5.26AlaAsp: 5.26 ± 0.091	4.852AlaGlu: 4.852 ± 0.099	3.216AlaPhe: 3.216 ± 0.068	5.782AlaGly: 5.782 ± 0.085	1.42AlaHis: 1.42 ± 0.045	5.702AlaIle: 5.702 ± 0.085	4.107AlaLys: 4.107 ± 0.089	7.377AlaLeu: 7.377 ± 0.107	2.457AlaMet: 2.457 ± 0.054	3.403AlaAsn: 3.403 ± 0.079	2.843AlaPro: 2.843 ± 0.074	2.73AlaGln: 2.73 ± 0.067	3.836AlaArg: 3.836 ± 0.076	5.061AlaSer: 5.061 ± 0.08	4.594AlaThr: 4.594 ± 0.08	5.994AlaVal: 5.994 ± 0.099	0.837AlaTrp: 0.837 ± 0.032	2.948AlaTyr: 2.948 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	0.967CysAla: 0.967 ± 0.031	0.23CysCys: 0.23 ± 0.021	0.639CysAsp: 0.639 ± 0.028	0.718CysGlu: 0.718 ± 0.032	0.629CysPhe: 0.629 ± 0.028	1.21CysGly: 1.21 ± 0.046	0.351CysHis: 0.351 ± 0.022	0.887CysIle: 0.887 ± 0.037	0.554CysLys: 0.554 ± 0.027	1.043CysLeu: 1.043 ± 0.042	0.347CysMet: 0.347 ± 0.025	0.71CysAsn: 0.71 ± 0.028	0.62CysPro: 0.62 ± 0.033	0.442CysGln: 0.442 ± 0.024	0.857CysArg: 0.857 ± 0.042	0.859CysSer: 0.859 ± 0.035	0.713CysThr: 0.713 ± 0.034	0.89CysVal: 0.89 ± 0.036	0.152CysTrp: 0.152 ± 0.013	0.527CysTyr: 0.527 ± 0.03	0.0CysXaa: 0.0 ± 0.0
Asp	4.45AspAla: 4.45 ± 0.082	0.713AspCys: 0.713 ± 0.034	2.715AspAsp: 2.715 ± 0.074	3.277AspGlu: 3.277 ± 0.078	2.778AspPhe: 2.778 ± 0.062	4.355AspGly: 4.355 ± 0.096	0.87AspHis: 0.87 ± 0.037	4.596AspIle: 4.596 ± 0.076	3.498AspLys: 3.498 ± 0.074	4.163AspLeu: 4.163 ± 0.071	1.712AspMet: 1.712 ± 0.051	3.351AspAsn: 3.351 ± 0.065	2.047AspPro: 2.047 ± 0.056	1.187AspGln: 1.187 ± 0.047	2.572AspArg: 2.572 ± 0.063	3.878AspSer: 3.878 ± 0.087	3.24AspThr: 3.24 ± 0.073	3.472AspVal: 3.472 ± 0.069	0.71AspTrp: 0.71 ± 0.033	2.688AspTyr: 2.688 ± 0.076	0.0AspXaa: 0.0 ± 0.0
Glu	4.495GluAla: 4.495 ± 0.102	0.687GluCys: 0.687 ± 0.032	2.287GluAsp: 2.287 ± 0.052	2.979GluGlu: 2.979 ± 0.08	2.455GluPhe: 2.455 ± 0.054	3.258GluGly: 3.258 ± 0.072	1.183GluHis: 1.183 ± 0.037	4.457GluIle: 4.457 ± 0.079	4.133GluLys: 4.133 ± 0.087	5.492GluLeu: 5.492 ± 0.096	1.67GluMet: 1.67 ± 0.047	3.232GluAsn: 3.232 ± 0.066	2.056GluPro: 2.056 ± 0.058	2.346GluGln: 2.346 ± 0.068	2.998GluArg: 2.998 ± 0.075	3.113GluSer: 3.113 ± 0.064	3.175GluThr: 3.175 ± 0.06	3.488GluVal: 3.488 ± 0.077	0.671GluTrp: 0.671 ± 0.029	2.422GluTyr: 2.422 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	3.243PheAla: 3.243 ± 0.07	0.717PheCys: 0.717 ± 0.029	2.808PheAsp: 2.808 ± 0.067	2.276PheGlu: 2.276 ± 0.056	1.819PhePhe: 1.819 ± 0.054	3.208PheGly: 3.208 ± 0.063	0.791PheHis: 0.791 ± 0.033	2.961PheIle: 2.961 ± 0.07	2.161PheLys: 2.161 ± 0.054	3.469PheLeu: 3.469 ± 0.074	1.2PheMet: 1.2 ± 0.04	2.487PheAsn: 2.487 ± 0.057	1.687PhePro: 1.687 ± 0.046	1.027PheGln: 1.027 ± 0.033	2.11PheArg: 2.11 ± 0.05	3.22PheSer: 3.22 ± 0.066	2.539PheThr: 2.539 ± 0.061	2.736PheVal: 2.736 ± 0.065	0.509PheTrp: 0.509 ± 0.026	1.593PheTyr: 1.593 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	5.137GlyAla: 5.137 ± 0.097	1.211GlyCys: 1.211 ± 0.043	3.289GlyAsp: 3.289 ± 0.069	3.587GlyGlu: 3.587 ± 0.07	3.263GlyPhe: 3.263 ± 0.062	4.71GlyGly: 4.71 ± 0.105	1.519GlyHis: 1.519 ± 0.048	5.748GlyIle: 5.748 ± 0.1	4.515GlyLys: 4.515 ± 0.081	5.895GlyLeu: 5.895 ± 0.097	2.171GlyMet: 2.171 ± 0.061	3.884GlyAsn: 3.884 ± 0.089	1.655GlyPro: 1.655 ± 0.054	2.251GlyGln: 2.251 ± 0.06	3.622GlyArg: 3.622 ± 0.07	4.304GlySer: 4.304 ± 0.081	4.412GlyThr: 4.412 ± 0.09	4.961GlyVal: 4.961 ± 0.092	1.025GlyTrp: 1.025 ± 0.04	3.22GlyTyr: 3.22 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.313HisAla: 1.313 ± 0.045	0.305HisCys: 0.305 ± 0.02	1.134HisAsp: 1.134 ± 0.036	0.927HisGlu: 0.927 ± 0.031	0.905HisPhe: 0.905 ± 0.035	1.451HisGly: 1.451 ± 0.045	0.488HisHis: 0.488 ± 0.031	1.555HisIle: 1.555 ± 0.048	1.108HisLys: 1.108 ± 0.04	1.623HisLeu: 1.623 ± 0.052	0.516HisMet: 0.516 ± 0.026	1.104HisAsn: 1.104 ± 0.04	1.034HisPro: 1.034 ± 0.037	0.54HisGln: 0.54 ± 0.026	1.053HisArg: 1.053 ± 0.038	1.269HisSer: 1.269 ± 0.039	1.165HisThr: 1.165 ± 0.04	1.155HisVal: 1.155 ± 0.041	0.233HisTrp: 0.233 ± 0.018	0.87HisTyr: 0.87 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.945IleAla: 5.945 ± 0.102	0.982IleCys: 0.982 ± 0.035	4.897IleAsp: 4.897 ± 0.086	4.342IleGlu: 4.342 ± 0.083	2.778IlePhe: 2.778 ± 0.06	5.038IleGly: 5.038 ± 0.09	1.199IleHis: 1.199 ± 0.045	5.133IleIle: 5.133 ± 0.097	4.111IleLys: 4.111 ± 0.086	5.494IleLeu: 5.494 ± 0.095	1.757IleMet: 1.757 ± 0.049	3.84IleAsn: 3.84 ± 0.073	3.173IlePro: 3.173 ± 0.075	1.952IleGln: 1.952 ± 0.055	3.038IleArg: 3.038 ± 0.066	4.832IleSer: 4.832 ± 0.073	4.4IleThr: 4.4 ± 0.087	4.775IleVal: 4.775 ± 0.088	0.694IleTrp: 0.694 ± 0.033	2.461IleTyr: 2.461 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	4.789LysAla: 4.789 ± 0.085	0.574LysCys: 0.574 ± 0.033	2.773LysAsp: 2.773 ± 0.063	3.727LysGlu: 3.727 ± 0.087	2.14LysPhe: 2.14 ± 0.055	3.632LysGly: 3.632 ± 0.073	1.096LysHis: 1.096 ± 0.038	3.947LysIle: 3.947 ± 0.078	3.651LysLys: 3.651 ± 0.087	4.924LysLeu: 4.924 ± 0.084	1.753LysMet: 1.753 ± 0.049	3.08LysAsn: 3.08 ± 0.066	2.528LysPro: 2.528 ± 0.056	2.048LysGln: 2.048 ± 0.061	2.809LysArg: 2.809 ± 0.066	3.357LysSer: 3.357 ± 0.069	3.117LysThr: 3.117 ± 0.064	3.472LysVal: 3.472 ± 0.081	0.717LysTrp: 0.717 ± 0.03	2.417LysTyr: 2.417 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	7.182LeuAla: 7.182 ± 0.113	1.302LeuCys: 1.302 ± 0.047	4.714LeuAsp: 4.714 ± 0.08	4.476LeuGlu: 4.476 ± 0.087	3.746LeuPhe: 3.746 ± 0.094	5.799LeuGly: 5.799 ± 0.091	1.723LeuHis: 1.723 ± 0.052	5.314LeuIle: 5.314 ± 0.098	5.142LeuLys: 5.142 ± 0.095	8.014LeuLeu: 8.014 ± 0.152	2.377LeuMet: 2.377 ± 0.056	4.472LeuAsn: 4.472 ± 0.079	4.274LeuPro: 4.274 ± 0.073	2.935LeuGln: 2.935 ± 0.062	4.701LeuArg: 4.701 ± 0.077	6.727LeuSer: 6.727 ± 0.099	5.236LeuThr: 5.236 ± 0.077	5.084LeuVal: 5.084 ± 0.088	1.031LeuTrp: 1.031 ± 0.047	3.252LeuTyr: 3.252 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	2.856MetAla: 2.856 ± 0.076	0.291MetCys: 0.291 ± 0.02	1.29MetAsp: 1.29 ± 0.043	1.643MetGlu: 1.643 ± 0.049	1.082MetPhe: 1.082 ± 0.037	1.794MetGly: 1.794 ± 0.053	0.622MetHis: 0.622 ± 0.031	1.513MetIle: 1.513 ± 0.042	1.758MetLys: 1.758 ± 0.051	2.717MetLeu: 2.717 ± 0.061	0.745MetMet: 0.745 ± 0.037	1.306MetAsn: 1.306 ± 0.047	1.55MetPro: 1.55 ± 0.047	0.983MetGln: 0.983 ± 0.038	1.584MetArg: 1.584 ± 0.043	1.949MetSer: 1.949 ± 0.05	1.636MetThr: 1.636 ± 0.042	1.688MetVal: 1.688 ± 0.05	0.322MetTrp: 0.322 ± 0.023	0.82MetTyr: 0.82 ± 0.036	0.0MetXaa: 0.0 ± 0.0
Asn	4.016AsnAla: 4.016 ± 0.067	0.661AsnCys: 0.661 ± 0.034	2.73AsnAsp: 2.73 ± 0.066	2.673AsnGlu: 2.673 ± 0.058	2.005AsnPhe: 2.005 ± 0.054	4.081AsnGly: 4.081 ± 0.086	1.023AsnHis: 1.023 ± 0.044	4.109AsnIle: 4.109 ± 0.086	2.86AsnLys: 2.86 ± 0.061	4.088AsnLeu: 4.088 ± 0.089	1.459AsnMet: 1.459 ± 0.042	2.875AsnAsn: 2.875 ± 0.086	2.846AsnPro: 2.846 ± 0.073	1.464AsnGln: 1.464 ± 0.044	2.675AsnArg: 2.675 ± 0.069	3.204AsnSer: 3.204 ± 0.068	2.956AsnThr: 2.956 ± 0.068	3.206AsnVal: 3.206 ± 0.068	0.627AsnTrp: 0.627 ± 0.033	2.083AsnTyr: 2.083 ± 0.066	0.0AsnXaa: 0.0 ± 0.0
Pro	3.445ProAla: 3.445 ± 0.071	0.416ProCys: 0.416 ± 0.026	3.319ProAsp: 3.319 ± 0.07	3.387ProGlu: 3.387 ± 0.081	1.708ProPhe: 1.708 ± 0.045	3.212ProGly: 3.212 ± 0.065	0.822ProHis: 0.822 ± 0.037	2.148ProIle: 2.148 ± 0.058	1.852ProLys: 1.852 ± 0.051	3.481ProLeu: 3.481 ± 0.068	1.035ProMet: 1.035 ± 0.04	1.634ProAsn: 1.634 ± 0.048	0.958ProPro: 0.958 ± 0.037	1.651ProGln: 1.651 ± 0.053	1.687ProArg: 1.687 ± 0.048	2.633ProSer: 2.633 ± 0.063	2.083ProThr: 2.083 ± 0.053	3.697ProVal: 3.697 ± 0.083	0.546ProTrp: 0.546 ± 0.03	1.749ProTyr: 1.749 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.719GlnAla: 2.719 ± 0.064	0.364GlnCys: 0.364 ± 0.021	1.252GlnAsp: 1.252 ± 0.046	1.718GlnGlu: 1.718 ± 0.053	1.283GlnPhe: 1.283 ± 0.037	2.029GlnGly: 2.029 ± 0.058	0.661GlnHis: 0.661 ± 0.031	2.253GlnIle: 2.253 ± 0.057	1.934GlnLys: 1.934 ± 0.055	3.317GlnLeu: 3.317 ± 0.071	1.08GlnMet: 1.08 ± 0.038	1.661GlnAsn: 1.661 ± 0.046	1.44GlnPro: 1.44 ± 0.041	1.757GlnGln: 1.757 ± 0.058	1.781GlnArg: 1.781 ± 0.053	1.876GlnSer: 1.876 ± 0.058	1.884GlnThr: 1.884 ± 0.056	1.827GlnVal: 1.827 ± 0.06	0.585GlnTrp: 0.585 ± 0.03	1.355GlnTyr: 1.355 ± 0.047	0.0GlnXaa: 0.0 ± 0.0
Arg	3.255ArgAla: 3.255 ± 0.08	0.554ArgCys: 0.554 ± 0.032	2.41ArgAsp: 2.41 ± 0.057	2.761ArgGlu: 2.761 ± 0.076	2.376ArgPhe: 2.376 ± 0.062	2.86ArgGly: 2.86 ± 0.06	1.402ArgHis: 1.402 ± 0.041	3.842ArgIle: 3.842 ± 0.078	2.949ArgLys: 2.949 ± 0.076	4.912ArgLeu: 4.912 ± 0.095	1.582ArgMet: 1.582 ± 0.042	2.754ArgAsn: 2.754 ± 0.066	1.934ArgPro: 1.934 ± 0.056	2.293ArgGln: 2.293 ± 0.064	3.144ArgArg: 3.144 ± 0.073	2.543ArgSer: 2.543 ± 0.059	2.57ArgThr: 2.57 ± 0.064	3.002ArgVal: 3.002 ± 0.063	0.673ArgTrp: 0.673 ± 0.031	2.384ArgTyr: 2.384 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	5.257SerAla: 5.257 ± 0.088	0.779SerCys: 0.779 ± 0.034	3.804SerAsp: 3.804 ± 0.081	3.556SerGlu: 3.556 ± 0.069	2.846SerPhe: 2.846 ± 0.063	5.045SerGly: 5.045 ± 0.086	1.328SerHis: 1.328 ± 0.046	4.474SerIle: 4.474 ± 0.086	3.163SerLys: 3.163 ± 0.061	5.948SerLeu: 5.948 ± 0.097	1.681SerMet: 1.681 ± 0.045	2.815SerAsn: 2.815 ± 0.061	2.713SerPro: 2.713 ± 0.064	2.219SerGln: 2.219 ± 0.061	3.259SerArg: 3.259 ± 0.079	3.744SerSer: 3.744 ± 0.082	3.45SerThr: 3.45 ± 0.068	4.863SerVal: 4.863 ± 0.079	0.729SerTrp: 0.729 ± 0.035	2.528SerTyr: 2.528 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	4.973ThrAla: 4.973 ± 0.086	0.618ThrCys: 0.618 ± 0.028	3.886ThrAsp: 3.886 ± 0.08	2.996ThrGlu: 2.996 ± 0.064	2.399ThrPhe: 2.399 ± 0.059	4.707ThrGly: 4.707 ± 0.087	1.096ThrHis: 1.096 ± 0.037	4.161ThrIle: 4.161 ± 0.083	2.358ThrLys: 2.358 ± 0.055	5.366ThrLeu: 5.366 ± 0.088	1.292ThrMet: 1.292 ± 0.039	2.49ThrAsn: 2.49 ± 0.056	3.102ThrPro: 3.102 ± 0.076	1.714ThrGln: 1.714 ± 0.049	2.471ThrArg: 2.471 ± 0.059	3.479ThrSer: 3.479 ± 0.084	3.456ThrThr: 3.456 ± 0.076	4.356ThrVal: 4.356 ± 0.087	0.63ThrTrp: 0.63 ± 0.035	2.176ThrTyr: 2.176 ± 0.064	0.0ThrXaa: 0.0 ± 0.0
Val	5.699ValAla: 5.699 ± 0.109	1.08ValCys: 1.08 ± 0.043	4.002ValAsp: 4.002 ± 0.081	4.063ValGlu: 4.063 ± 0.088	2.784ValPhe: 2.784 ± 0.059	4.254ValGly: 4.254 ± 0.077	1.105ValHis: 1.105 ± 0.042	4.575ValIle: 4.575 ± 0.09	3.832ValLys: 3.832 ± 0.072	5.676ValLeu: 5.676 ± 0.106	1.792ValMet: 1.792 ± 0.052	3.284ValAsn: 3.284 ± 0.063	2.912ValPro: 2.912 ± 0.065	1.624ValGln: 1.624 ± 0.048	3.219ValArg: 3.219 ± 0.069	4.744ValSer: 4.744 ± 0.086	4.012ValThr: 4.012 ± 0.079	4.79ValVal: 4.79 ± 0.097	0.769ValTrp: 0.769 ± 0.033	2.51ValTyr: 2.51 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.825TrpAla: 0.825 ± 0.04	0.173TrpCys: 0.173 ± 0.016	0.675TrpAsp: 0.675 ± 0.03	0.656TrpGlu: 0.656 ± 0.029	0.532TrpPhe: 0.532 ± 0.029	0.943TrpGly: 0.943 ± 0.043	0.303TrpHis: 0.303 ± 0.02	0.82TrpIle: 0.82 ± 0.038	0.677TrpLys: 0.677 ± 0.032	1.223TrpLeu: 1.223 ± 0.046	0.383TrpMet: 0.383 ± 0.024	0.788TrpAsn: 0.788 ± 0.037	0.362TrpPro: 0.362 ± 0.021	0.52TrpGln: 0.52 ± 0.023	0.679TrpArg: 0.679 ± 0.035	0.629TrpSer: 0.629 ± 0.032	0.661TrpThr: 0.661 ± 0.037	0.687TrpVal: 0.687 ± 0.029	0.221TrpTrp: 0.221 ± 0.019	0.447TrpTyr: 0.447 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.935TyrAla: 2.935 ± 0.069	0.606TyrCys: 0.606 ± 0.03	2.39TyrAsp: 2.39 ± 0.065	1.985TyrGlu: 1.985 ± 0.053	1.817TyrPhe: 1.817 ± 0.051	3.014TyrGly: 3.014 ± 0.077	0.746TyrHis: 0.746 ± 0.032	2.647TyrIle: 2.647 ± 0.056	2.186TyrLys: 2.186 ± 0.053	3.277TyrLeu: 3.277 ± 0.073	1.137TyrMet: 1.137 ± 0.044	2.472TyrAsn: 2.472 ± 0.063	1.728TyrPro: 1.728 ± 0.054	1.093TyrGln: 1.093 ± 0.043	2.104TyrArg: 2.104 ± 0.06	2.781TyrSer: 2.781 ± 0.065	2.427TyrThr: 2.427 ± 0.056	2.581TyrVal: 2.581 ± 0.057	0.523TyrTrp: 0.523 ± 0.03	1.803TyrTyr: 1.803 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2214 proteins (738216 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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