Amino acid dipepetide frequency for Alteromonadaceae bacterium 2052S.S.stab0a.01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.122AlaAla: 10.122 ± 0.114	1.096AlaCys: 1.096 ± 0.03	5.833AlaAsp: 5.833 ± 0.074	6.387AlaGlu: 6.387 ± 0.071	3.498AlaPhe: 3.498 ± 0.049	7.676AlaGly: 7.676 ± 0.083	1.775AlaHis: 1.775 ± 0.036	5.134AlaIle: 5.134 ± 0.061	3.205AlaLys: 3.205 ± 0.065	9.962AlaLeu: 9.962 ± 0.107	2.446AlaMet: 2.446 ± 0.048	3.426AlaAsn: 3.426 ± 0.054	3.484AlaPro: 3.484 ± 0.052	3.435AlaGln: 3.435 ± 0.05	5.209AlaArg: 5.209 ± 0.08	6.269AlaSer: 6.269 ± 0.084	5.203AlaThr: 5.203 ± 0.078	6.859AlaVal: 6.859 ± 0.077	1.151AlaTrp: 1.151 ± 0.029	2.49AlaTyr: 2.49 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.935CysAla: 0.935 ± 0.028	0.171CysCys: 0.171 ± 0.011	0.662CysAsp: 0.662 ± 0.024	0.657CysGlu: 0.657 ± 0.022	0.422CysPhe: 0.422 ± 0.017	1.014CysGly: 1.014 ± 0.028	0.402CysHis: 0.402 ± 0.025	0.517CysIle: 0.517 ± 0.021	0.304CysLys: 0.304 ± 0.015	1.047CysLeu: 1.047 ± 0.032	0.205CysMet: 0.205 ± 0.01	0.399CysAsn: 0.399 ± 0.017	0.457CysPro: 0.457 ± 0.018	0.446CysGln: 0.446 ± 0.015	0.574CysArg: 0.574 ± 0.02	0.793CysSer: 0.793 ± 0.024	0.522CysThr: 0.522 ± 0.016	0.711CysVal: 0.711 ± 0.021	0.147CysTrp: 0.147 ± 0.011	0.306CysTyr: 0.306 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.244AspAla: 5.244 ± 0.064	0.628AspCys: 0.628 ± 0.025	3.648AspAsp: 3.648 ± 0.066	3.5AspGlu: 3.5 ± 0.057	2.466AspPhe: 2.466 ± 0.041	4.749AspGly: 4.749 ± 0.111	1.234AspHis: 1.234 ± 0.028	3.591AspIle: 3.591 ± 0.052	2.237AspLys: 2.237 ± 0.046	5.519AspLeu: 5.519 ± 0.077	1.26AspMet: 1.26 ± 0.029	2.477AspAsn: 2.477 ± 0.05	2.71AspPro: 2.71 ± 0.044	2.386AspGln: 2.386 ± 0.05	3.09AspArg: 3.09 ± 0.048	3.989AspSer: 3.989 ± 0.07	3.282AspThr: 3.282 ± 0.057	3.893AspVal: 3.893 ± 0.059	0.979AspTrp: 0.979 ± 0.026	2.307AspTyr: 2.307 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.762GluAla: 5.762 ± 0.075	0.483GluCys: 0.483 ± 0.016	3.246GluAsp: 3.246 ± 0.058	3.563GluGlu: 3.563 ± 0.064	2.469GluPhe: 2.469 ± 0.038	3.849GluGly: 3.849 ± 0.053	1.44GluHis: 1.44 ± 0.025	3.441GluIle: 3.441 ± 0.05	3.124GluLys: 3.124 ± 0.051	6.634GluLeu: 6.634 ± 0.077	1.449GluMet: 1.449 ± 0.03	2.575GluAsn: 2.575 ± 0.044	2.52GluPro: 2.52 ± 0.047	3.176GluGln: 3.176 ± 0.055	3.437GluArg: 3.437 ± 0.053	3.787GluSer: 3.787 ± 0.052	3.346GluThr: 3.346 ± 0.057	3.967GluVal: 3.967 ± 0.061	0.827GluTrp: 0.827 ± 0.024	1.753GluTyr: 1.753 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.486PheAla: 3.486 ± 0.045	0.501PheCys: 0.501 ± 0.017	2.789PheAsp: 2.789 ± 0.044	2.337PheGlu: 2.337 ± 0.041	1.652PhePhe: 1.652 ± 0.041	3.108PheGly: 3.108 ± 0.047	0.872PheHis: 0.872 ± 0.022	2.087PheIle: 2.087 ± 0.037	1.408PheLys: 1.408 ± 0.031	3.398PheLeu: 3.398 ± 0.053	0.853PheMet: 0.853 ± 0.022	1.746PheAsn: 1.746 ± 0.035	1.575PhePro: 1.575 ± 0.033	1.402PheGln: 1.402 ± 0.03	1.981PheArg: 1.981 ± 0.032	3.215PheSer: 3.215 ± 0.046	2.407PheThr: 2.407 ± 0.043	2.719PheVal: 2.719 ± 0.042	0.574PheTrp: 0.574 ± 0.019	1.39PheTyr: 1.39 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.119GlyAla: 6.119 ± 0.085	0.988GlyCys: 0.988 ± 0.028	4.754GlyAsp: 4.754 ± 0.071	4.832GlyGlu: 4.832 ± 0.058	3.465GlyPhe: 3.465 ± 0.052	6.044GlyGly: 6.044 ± 0.109	1.647GlyHis: 1.647 ± 0.031	4.239GlyIle: 4.239 ± 0.053	3.195GlyLys: 3.195 ± 0.053	7.222GlyLeu: 7.222 ± 0.085	1.916GlyMet: 1.916 ± 0.038	3.089GlyAsn: 3.089 ± 0.067	2.155GlyPro: 2.155 ± 0.044	2.791GlyGln: 2.791 ± 0.045	3.911GlyArg: 3.911 ± 0.059	5.273GlySer: 5.273 ± 0.094	4.088GlyThr: 4.088 ± 0.091	5.621GlyVal: 5.621 ± 0.064	1.313GlyTrp: 1.313 ± 0.04	2.703GlyTyr: 2.703 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	1.602HisAla: 1.602 ± 0.035	0.327HisCys: 0.327 ± 0.015	1.046HisAsp: 1.046 ± 0.024	1.038HisGlu: 1.038 ± 0.027	1.032HisPhe: 1.032 ± 0.028	1.58HisGly: 1.58 ± 0.034	0.714HisHis: 0.714 ± 0.025	1.08HisIle: 1.08 ± 0.025	0.77HisLys: 0.77 ± 0.025	2.292HisLeu: 2.292 ± 0.042	0.511HisMet: 0.511 ± 0.019	0.885HisAsn: 0.885 ± 0.025	1.253HisPro: 1.253 ± 0.031	1.198HisGln: 1.198 ± 0.027	1.343HisArg: 1.343 ± 0.035	1.463HisSer: 1.463 ± 0.028	1.164HisThr: 1.164 ± 0.027	1.156HisVal: 1.156 ± 0.028	0.463HisTrp: 0.463 ± 0.017	0.946HisTyr: 0.946 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.47IleAla: 5.47 ± 0.073	0.601IleCys: 0.601 ± 0.02	3.556IleAsp: 3.556 ± 0.055	3.393IleGlu: 3.393 ± 0.05	1.895IlePhe: 1.895 ± 0.037	3.895IleGly: 3.895 ± 0.051	1.222IleHis: 1.222 ± 0.031	2.476IleIle: 2.476 ± 0.049	2.044IleLys: 2.044 ± 0.039	4.304IleLeu: 4.304 ± 0.061	0.947IleMet: 0.947 ± 0.029	2.345IleAsn: 2.345 ± 0.041	2.472IlePro: 2.472 ± 0.04	1.866IleGln: 1.866 ± 0.036	3.017IleArg: 3.017 ± 0.041	3.847IleSer: 3.847 ± 0.055	3.218IleThr: 3.218 ± 0.064	3.474IleVal: 3.474 ± 0.059	0.558IleTrp: 0.558 ± 0.021	1.456IleTyr: 1.456 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.758LysAla: 3.758 ± 0.065	0.26LysCys: 0.26 ± 0.013	1.885LysAsp: 1.885 ± 0.036	1.873LysGlu: 1.873 ± 0.047	1.177LysPhe: 1.177 ± 0.031	2.38LysGly: 2.38 ± 0.051	0.82LysHis: 0.82 ± 0.023	2.257LysIle: 2.257 ± 0.041	2.003LysLys: 2.003 ± 0.05	4.066LysLeu: 4.066 ± 0.068	0.914LysMet: 0.914 ± 0.024	1.609LysAsn: 1.609 ± 0.03	2.1LysPro: 2.1 ± 0.041	1.667LysGln: 1.667 ± 0.04	2.219LysArg: 2.219 ± 0.044	2.453LysSer: 2.453 ± 0.045	2.313LysThr: 2.313 ± 0.043	2.765LysVal: 2.765 ± 0.051	0.425LysTrp: 0.425 ± 0.016	0.971LysTyr: 0.971 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	10.869LeuAla: 10.869 ± 0.11	1.05LeuCys: 1.05 ± 0.031	6.021LeuAsp: 6.021 ± 0.078	6.544LeuGlu: 6.544 ± 0.072	3.803LeuPhe: 3.803 ± 0.052	7.2LeuGly: 7.2 ± 0.084	2.056LeuHis: 2.056 ± 0.038	4.823LeuIle: 4.823 ± 0.067	4.298LeuLys: 4.298 ± 0.067	10.796LeuLeu: 10.796 ± 0.137	2.466LeuMet: 2.466 ± 0.047	4.009LeuAsn: 4.009 ± 0.055	5.05LeuPro: 5.05 ± 0.059	4.561LeuGln: 4.561 ± 0.06	5.248LeuArg: 5.248 ± 0.075	6.972LeuSer: 6.972 ± 0.066	5.634LeuThr: 5.634 ± 0.07	7.426LeuVal: 7.426 ± 0.084	1.279LeuTrp: 1.279 ± 0.03	2.702LeuTyr: 2.702 ± 0.045	0.001LeuXaa: 0.001 ± 0.001
Met	2.495MetAla: 2.495 ± 0.049	0.199MetCys: 0.199 ± 0.012	1.295MetAsp: 1.295 ± 0.032	1.315MetGlu: 1.315 ± 0.03	0.747MetPhe: 0.747 ± 0.024	1.64MetGly: 1.64 ± 0.034	0.483MetHis: 0.483 ± 0.018	1.111MetIle: 1.111 ± 0.028	1.077MetLys: 1.077 ± 0.024	2.224MetLeu: 2.224 ± 0.049	0.563MetMet: 0.563 ± 0.021	0.954MetAsn: 0.954 ± 0.022	1.114MetPro: 1.114 ± 0.028	0.878MetGln: 0.878 ± 0.02	1.177MetArg: 1.177 ± 0.025	1.639MetSer: 1.639 ± 0.032	1.413MetThr: 1.413 ± 0.03	1.645MetVal: 1.645 ± 0.031	0.195MetTrp: 0.195 ± 0.012	0.448MetTyr: 0.448 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.495AsnAla: 3.495 ± 0.059	0.464AsnCys: 0.464 ± 0.017	2.146AsnAsp: 2.146 ± 0.05	1.915AsnGlu: 1.915 ± 0.035	1.524AsnPhe: 1.524 ± 0.032	3.235AsnGly: 3.235 ± 0.063	0.855AsnHis: 0.855 ± 0.02	2.224AsnIle: 2.224 ± 0.041	1.279AsnLys: 1.279 ± 0.032	3.859AsnLeu: 3.859 ± 0.051	0.794AsnMet: 0.794 ± 0.025	1.73AsnAsn: 1.73 ± 0.052	2.37AsnPro: 2.37 ± 0.05	1.675AsnGln: 1.675 ± 0.034	2.428AsnArg: 2.428 ± 0.044	2.628AsnSer: 2.628 ± 0.051	2.29AsnThr: 2.29 ± 0.042	2.22AsnVal: 2.22 ± 0.041	0.689AsnTrp: 0.689 ± 0.024	1.262AsnTyr: 1.262 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.533ProAla: 4.533 ± 0.065	0.335ProCys: 0.335 ± 0.017	2.983ProAsp: 2.983 ± 0.045	3.621ProGlu: 3.621 ± 0.052	1.711ProPhe: 1.711 ± 0.033	3.749ProGly: 3.749 ± 0.054	0.855ProHis: 0.855 ± 0.024	1.835ProIle: 1.835 ± 0.039	1.397ProLys: 1.397 ± 0.032	4.589ProLeu: 4.589 ± 0.07	0.99ProMet: 0.99 ± 0.029	1.443ProAsn: 1.443 ± 0.033	1.822ProPro: 1.822 ± 0.045	1.769ProGln: 1.769 ± 0.041	1.971ProArg: 1.971 ± 0.039	2.5ProSer: 2.5 ± 0.041	2.292ProThr: 2.292 ± 0.068	3.983ProVal: 3.983 ± 0.05	0.657ProTrp: 0.657 ± 0.024	1.216ProTyr: 1.216 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.141GlnAla: 4.141 ± 0.058	0.409GlnCys: 0.409 ± 0.016	1.752GlnAsp: 1.752 ± 0.034	2.117GlnGlu: 2.117 ± 0.038	1.535GlnPhe: 1.535 ± 0.033	2.631GlnGly: 2.631 ± 0.039	0.983GlnHis: 0.983 ± 0.026	2.012GlnIle: 2.012 ± 0.04	1.651GlnLys: 1.651 ± 0.033	5.543GlnLeu: 5.543 ± 0.08	1.024GlnMet: 1.024 ± 0.024	1.361GlnAsn: 1.361 ± 0.03	2.156GlnPro: 2.156 ± 0.036	2.901GlnGln: 2.901 ± 0.062	2.517GlnArg: 2.517 ± 0.044	2.532GlnSer: 2.532 ± 0.043	2.173GlnThr: 2.173 ± 0.035	3.095GlnVal: 3.095 ± 0.044	0.786GlnTrp: 0.786 ± 0.024	1.264GlnTyr: 1.264 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	4.474ArgAla: 4.474 ± 0.064	0.526ArgCys: 0.526 ± 0.017	3.176ArgAsp: 3.176 ± 0.043	3.835ArgGlu: 3.835 ± 0.059	2.507ArgPhe: 2.507 ± 0.039	3.312ArgGly: 3.312 ± 0.054	1.4ArgHis: 1.4 ± 0.034	3.11ArgIle: 3.11 ± 0.051	2.27ArgLys: 2.27 ± 0.051	6.043ArgLeu: 6.043 ± 0.072	1.332ArgMet: 1.332 ± 0.028	2.086ArgAsn: 2.086 ± 0.038	2.12ArgPro: 2.12 ± 0.038	2.803ArgGln: 2.803 ± 0.047	3.166ArgArg: 3.166 ± 0.059	3.143ArgSer: 3.143 ± 0.054	2.536ArgThr: 2.536 ± 0.038	3.956ArgVal: 3.956 ± 0.055	0.948ArgTrp: 0.948 ± 0.026	2.176ArgTyr: 2.176 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.368SerAla: 6.368 ± 0.081	0.742SerCys: 0.742 ± 0.023	3.916SerAsp: 3.916 ± 0.066	3.919SerGlu: 3.919 ± 0.061	2.611SerPhe: 2.611 ± 0.044	6.277SerGly: 6.277 ± 0.101	1.488SerHis: 1.488 ± 0.027	3.305SerIle: 3.305 ± 0.045	2.104SerLys: 2.104 ± 0.038	6.994SerLeu: 6.994 ± 0.079	1.369SerMet: 1.369 ± 0.032	2.353SerAsn: 2.353 ± 0.05	2.946SerPro: 2.946 ± 0.053	2.609SerGln: 2.609 ± 0.042	3.785SerArg: 3.785 ± 0.054	8.356SerSer: 8.356 ± 0.499	3.511SerThr: 3.511 ± 0.059	4.745SerVal: 4.745 ± 0.059	1.03SerTrp: 1.03 ± 0.032	2.037SerTyr: 2.037 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.371ThrAla: 5.371 ± 0.075	0.563ThrCys: 0.563 ± 0.018	3.382ThrAsp: 3.382 ± 0.073	3.137ThrGlu: 3.137 ± 0.053	2.115ThrPhe: 2.115 ± 0.044	5.011ThrGly: 5.011 ± 0.094	1.166ThrHis: 1.166 ± 0.029	2.858ThrIle: 2.858 ± 0.052	1.332ThrLys: 1.332 ± 0.029	6.422ThrLeu: 6.422 ± 0.078	0.961ThrMet: 0.961 ± 0.025	1.809ThrAsn: 1.809 ± 0.038	3.133ThrPro: 3.133 ± 0.059	1.932ThrGln: 1.932 ± 0.037	3.086ThrArg: 3.086 ± 0.047	3.498ThrSer: 3.498 ± 0.059	3.207ThrThr: 3.207 ± 0.059	4.145ThrVal: 4.145 ± 0.062	0.67ThrTrp: 0.67 ± 0.022	1.518ThrTyr: 1.518 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	7.058ValAla: 7.058 ± 0.069	0.794ValCys: 0.794 ± 0.025	4.627ValAsp: 4.627 ± 0.066	4.534ValGlu: 4.534 ± 0.061	2.854ValPhe: 2.854 ± 0.048	4.708ValGly: 4.708 ± 0.054	1.373ValHis: 1.373 ± 0.03	3.933ValIle: 3.933 ± 0.053	2.732ValLys: 2.732 ± 0.051	6.862ValLeu: 6.862 ± 0.072	1.687ValMet: 1.687 ± 0.036	2.998ValAsn: 2.998 ± 0.057	2.899ValPro: 2.899 ± 0.051	2.294ValGln: 2.294 ± 0.044	3.655ValArg: 3.655 ± 0.052	5.009ValSer: 5.009 ± 0.064	4.297ValThr: 4.297 ± 0.065	5.702ValVal: 5.702 ± 0.067	0.847ValTrp: 0.847 ± 0.024	2.044ValTyr: 2.044 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.013TrpAla: 1.013 ± 0.027	0.155TrpCys: 0.155 ± 0.009	0.715TrpAsp: 0.715 ± 0.021	0.747TrpGlu: 0.747 ± 0.023	0.587TrpPhe: 0.587 ± 0.021	1.03TrpGly: 1.03 ± 0.031	0.368TrpHis: 0.368 ± 0.015	0.657TrpIle: 0.657 ± 0.02	0.49TrpLys: 0.49 ± 0.016	1.742TrpLeu: 1.742 ± 0.044	0.368TrpMet: 0.368 ± 0.014	0.615TrpAsn: 0.615 ± 0.022	0.544TrpPro: 0.544 ± 0.019	1.054TrpGln: 1.054 ± 0.028	0.912TrpArg: 0.912 ± 0.027	0.908TrpSer: 0.908 ± 0.03	0.663TrpThr: 0.663 ± 0.027	1.001TrpVal: 1.001 ± 0.03	0.235TrpTrp: 0.235 ± 0.012	0.499TrpTyr: 0.499 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.348TyrAla: 2.348 ± 0.037	0.399TyrCys: 0.399 ± 0.016	1.758TyrAsp: 1.758 ± 0.045	1.585TyrGlu: 1.585 ± 0.033	1.43TyrPhe: 1.43 ± 0.033	2.278TyrGly: 2.278 ± 0.041	0.708TyrHis: 0.708 ± 0.02	1.366TyrIle: 1.366 ± 0.028	0.995TyrLys: 0.995 ± 0.027	3.288TyrLeu: 3.288 ± 0.047	0.555TyrMet: 0.555 ± 0.02	1.173TyrAsn: 1.173 ± 0.03	1.368TyrPro: 1.368 ± 0.031	1.739TyrGln: 1.739 ± 0.035	2.193TyrArg: 2.193 ± 0.036	2.193TyrSer: 2.193 ± 0.041	1.757TyrThr: 1.757 ± 0.053	1.824TyrVal: 1.824 ± 0.04	0.531TyrTrp: 0.531 ± 0.018	1.166TyrTyr: 1.166 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.007XaaXaa: 0.007 ± 0.006

Statistics based on 4578 proteins (1627577 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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