Amino acid dipepetide frequency for Sewage-associated circular DNA virus-13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.461AlaAla: 12.461 ± 0.985
0.0AlaCys: 0.0 ± 0.0
3.115AlaAsp: 3.115 ± 0.307
1.558AlaGlu: 1.558 ± 0.952
1.558AlaPhe: 1.558 ± 1.259
0.0AlaGly: 0.0 ± 0.0
1.558AlaHis: 1.558 ± 1.259
4.673AlaIle: 4.673 ± 0.646
9.346AlaLys: 9.346 ± 1.292
3.115AlaLeu: 3.115 ± 2.518
1.558AlaMet: 1.558 ± 0.952
10.903AlaAsn: 10.903 ± 2.244
7.788AlaPro: 7.788 ± 4.084
0.0AlaGln: 0.0 ± 0.0
12.461AlaArg: 12.461 ± 3.197
6.231AlaSer: 6.231 ± 0.613
3.115AlaThr: 3.115 ± 0.307
9.346AlaVal: 9.346 ± 3.131
0.0AlaTrp: 0.0 ± 0.0
1.558AlaTyr: 1.558 ± 0.952
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.558CysAsp: 1.558 ± 0.952
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
3.115CysLys: 3.115 ± 0.307
1.558CysLeu: 1.558 ± 0.952
1.558CysMet: 1.558 ± 1.534
1.558CysAsn: 1.558 ± 0.952
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.558CysArg: 1.558 ± 0.952
1.558CysSer: 1.558 ± 1.259
1.558CysThr: 1.558 ± 0.952
0.0CysVal: 0.0 ± 0.0
1.558CysTrp: 1.558 ± 0.952
1.558CysTyr: 1.558 ± 0.952
0.0CysXaa: 0.0 ± 0.0
Asp
1.558AspAla: 1.558 ± 1.259
1.558AspCys: 1.558 ± 0.952
0.0AspAsp: 0.0 ± 0.0
1.558AspGlu: 1.558 ± 0.952
4.673AspPhe: 4.673 ± 2.857
3.115AspGly: 3.115 ± 1.905
1.558AspHis: 1.558 ± 0.952
1.558AspIle: 1.558 ± 0.952
4.673AspLys: 4.673 ± 0.646
9.346AspLeu: 9.346 ± 1.292
0.0AspMet: 0.0 ± 0.0
0.0AspAsn: 0.0 ± 0.0
3.115AspPro: 3.115 ± 0.307
0.0AspGln: 0.0 ± 0.0
1.558AspArg: 1.558 ± 0.952
6.231AspSer: 6.231 ± 1.598
3.115AspThr: 3.115 ± 1.905
1.558AspVal: 1.558 ± 1.259
0.0AspTrp: 0.0 ± 0.0
3.115AspTyr: 3.115 ± 2.518
0.0AspXaa: 0.0 ± 0.0
Glu
7.788GluAla: 7.788 ± 2.551
3.115GluCys: 3.115 ± 0.307
3.115GluAsp: 3.115 ± 1.905
1.558GluGlu: 1.558 ± 0.952
4.673GluPhe: 4.673 ± 0.646
4.673GluGly: 4.673 ± 2.857
0.0GluHis: 0.0 ± 0.0
1.558GluIle: 1.558 ± 0.952
3.115GluLys: 3.115 ± 1.905
6.231GluLeu: 6.231 ± 0.613
0.0GluMet: 0.0 ± 0.0
1.558GluAsn: 1.558 ± 1.259
3.115GluPro: 3.115 ± 1.905
1.558GluGln: 1.558 ± 1.259
1.558GluArg: 1.558 ± 0.952
4.673GluSer: 4.673 ± 0.646
0.0GluThr: 0.0 ± 0.0
3.115GluVal: 3.115 ± 0.307
0.0GluTrp: 0.0 ± 0.0
3.115GluTyr: 3.115 ± 2.518
0.0GluXaa: 0.0 ± 0.0
Phe
1.558PheAla: 1.558 ± 0.952
1.558PheCys: 1.558 ± 0.952
4.673PheAsp: 4.673 ± 0.646
4.673PheGlu: 4.673 ± 0.646
1.558PhePhe: 1.558 ± 0.952
3.115PheGly: 3.115 ± 0.307
0.0PheHis: 0.0 ± 0.0
3.115PheIle: 3.115 ± 1.905
1.558PheLys: 1.558 ± 1.259
0.0PheLeu: 0.0 ± 0.0
0.0PheMet: 0.0 ± 0.0
0.0PheAsn: 0.0 ± 0.0
1.558PhePro: 1.558 ± 1.259
0.0PheGln: 0.0 ± 0.0
6.231PheArg: 6.231 ± 1.598
4.673PheSer: 4.673 ± 3.777
0.0PheThr: 0.0 ± 0.0
3.115PheVal: 3.115 ± 1.905
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
6.231GlyAla: 6.231 ± 2.825
0.0GlyCys: 0.0 ± 0.0
9.346GlyAsp: 9.346 ± 5.343
1.558GlyGlu: 1.558 ± 1.259
1.558GlyPhe: 1.558 ± 1.259
3.115GlyGly: 3.115 ± 2.518
1.558GlyHis: 1.558 ± 1.259
0.0GlyIle: 0.0 ± 0.0
10.903GlyLys: 10.903 ± 4.456
3.115GlyLeu: 3.115 ± 2.518
0.0GlyMet: 0.0 ± 0.0
4.673GlyAsn: 4.673 ± 0.646
0.0GlyPro: 0.0 ± 0.0
0.0GlyGln: 0.0 ± 0.0
1.558GlyArg: 1.558 ± 0.952
4.673GlySer: 4.673 ± 2.857
6.231GlyThr: 6.231 ± 5.036
3.115GlyVal: 3.115 ± 2.518
3.115GlyTrp: 3.115 ± 1.905
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
1.558HisGly: 1.558 ± 1.259
1.558HisHis: 1.558 ± 1.259
0.0HisIle: 0.0 ± 0.0
1.558HisLys: 1.558 ± 0.952
1.558HisLeu: 1.558 ± 1.259
1.558HisMet: 1.558 ± 0.952
0.0HisAsn: 0.0 ± 0.0
3.115HisPro: 3.115 ± 0.307
0.0HisGln: 0.0 ± 0.0
3.115HisArg: 3.115 ± 0.307
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
3.115HisVal: 3.115 ± 0.307
1.558HisTrp: 1.558 ± 0.952
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
6.231IleAla: 6.231 ± 1.598
1.558IleCys: 1.558 ± 0.952
0.0IleAsp: 0.0 ± 0.0
3.115IleGlu: 3.115 ± 0.307
0.0IlePhe: 0.0 ± 0.0
4.673IleGly: 4.673 ± 3.777
1.558IleHis: 1.558 ± 0.952
1.558IleIle: 1.558 ± 1.259
1.558IleLys: 1.558 ± 1.259
4.673IleLeu: 4.673 ± 2.857
1.558IleMet: 1.558 ± 1.259
0.0IleAsn: 0.0 ± 0.0
0.0IlePro: 0.0 ± 0.0
4.673IleGln: 4.673 ± 1.566
6.231IleArg: 6.231 ± 1.598
0.0IleSer: 0.0 ± 0.0
1.558IleThr: 1.558 ± 0.952
4.673IleVal: 4.673 ± 2.857
0.0IleTrp: 0.0 ± 0.0
1.558IleTyr: 1.558 ± 0.952
0.0IleXaa: 0.0 ± 0.0
Lys
9.346LysAla: 9.346 ± 1.292
3.115LysCys: 3.115 ± 1.905
3.115LysAsp: 3.115 ± 1.905
4.673LysGlu: 4.673 ± 2.857
1.558LysPhe: 1.558 ± 1.259
0.0LysGly: 0.0 ± 0.0
1.558LysHis: 1.558 ± 0.952
3.115LysIle: 3.115 ± 1.905
6.231LysLys: 6.231 ± 1.598
6.231LysLeu: 6.231 ± 3.81
1.558LysMet: 1.558 ± 1.259
0.0LysAsn: 0.0 ± 0.0
3.115LysPro: 3.115 ± 0.307
3.115LysGln: 3.115 ± 0.307
7.788LysArg: 7.788 ± 4.084
10.903LysSer: 10.903 ± 0.033
4.673LysThr: 4.673 ± 0.646
3.115LysVal: 3.115 ± 1.905
0.0LysTrp: 0.0 ± 0.0
3.115LysTyr: 3.115 ± 1.905
0.0LysXaa: 0.0 ± 0.0
Leu
7.788LeuAla: 7.788 ± 4.762
3.115LeuCys: 3.115 ± 1.905
4.673LeuAsp: 4.673 ± 2.857
4.673LeuGlu: 4.673 ± 0.646
4.673LeuPhe: 4.673 ± 0.646
12.461LeuGly: 12.461 ± 5.65
1.558LeuHis: 1.558 ± 1.259
1.558LeuIle: 1.558 ± 0.952
1.558LeuLys: 1.558 ± 0.952
6.231LeuLeu: 6.231 ± 1.598
1.558LeuMet: 1.558 ± 1.259
4.673LeuAsn: 4.673 ± 0.646
1.558LeuPro: 1.558 ± 0.952
3.115LeuGln: 3.115 ± 0.307
1.558LeuArg: 1.558 ± 1.259
6.231LeuSer: 6.231 ± 0.613
4.673LeuThr: 4.673 ± 0.646
1.558LeuVal: 1.558 ± 0.952
0.0LeuTrp: 0.0 ± 0.0
1.558LeuTyr: 1.558 ± 1.259
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
1.558MetAsp: 1.558 ± 0.952
1.558MetGlu: 1.558 ± 1.259
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
1.558MetHis: 1.558 ± 0.952
1.558MetIle: 1.558 ± 0.952
3.115MetLys: 3.115 ± 1.905
1.558MetLeu: 1.558 ± 1.259
0.0MetMet: 0.0 ± 0.0
1.558MetAsn: 1.558 ± 0.952
1.558MetPro: 1.558 ± 1.259
0.0MetGln: 0.0 ± 0.0
1.558MetArg: 1.558 ± 0.952
6.231MetSer: 6.231 ± 5.036
1.558MetThr: 1.558 ± 0.952
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.115AsnAla: 3.115 ± 0.307
0.0AsnCys: 0.0 ± 0.0
0.0AsnAsp: 0.0 ± 0.0
1.558AsnGlu: 1.558 ± 0.952
1.558AsnPhe: 1.558 ± 1.259
0.0AsnGly: 0.0 ± 0.0
0.0AsnHis: 0.0 ± 0.0
3.115AsnIle: 3.115 ± 1.905
0.0AsnLys: 0.0 ± 0.0
3.115AsnLeu: 3.115 ± 1.905
1.558AsnMet: 1.558 ± 0.952
3.115AsnAsn: 3.115 ± 0.307
1.558AsnPro: 1.558 ± 1.259
3.115AsnGln: 3.115 ± 0.307
1.558AsnArg: 1.558 ± 0.952
9.346AsnSer: 9.346 ± 3.131
3.115AsnThr: 3.115 ± 1.905
3.115AsnVal: 3.115 ± 0.307
3.115AsnTrp: 3.115 ± 1.905
1.558AsnTyr: 1.558 ± 1.259
0.0AsnXaa: 0.0 ± 0.0
Pro
3.115ProAla: 3.115 ± 2.518
0.0ProCys: 0.0 ± 0.0
0.0ProAsp: 0.0 ± 0.0
1.558ProGlu: 1.558 ± 0.952
1.558ProPhe: 1.558 ± 1.259
3.115ProGly: 3.115 ± 2.518
0.0ProHis: 0.0 ± 0.0
7.788ProIle: 7.788 ± 0.339
4.673ProLys: 4.673 ± 0.646
3.115ProLeu: 3.115 ± 0.307
0.0ProMet: 0.0 ± 0.0
1.558ProAsn: 1.558 ± 0.952
1.558ProPro: 1.558 ± 1.259
0.0ProGln: 0.0 ± 0.0
4.673ProArg: 4.673 ± 0.646
6.231ProSer: 6.231 ± 0.613
0.0ProThr: 0.0 ± 0.0
1.558ProVal: 1.558 ± 0.952
3.115ProTrp: 3.115 ± 0.307
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
1.558GlnAla: 1.558 ± 1.259
0.0GlnCys: 0.0 ± 0.0
1.558GlnAsp: 1.558 ± 0.952
1.558GlnGlu: 1.558 ± 0.952
0.0GlnPhe: 0.0 ± 0.0
3.115GlnGly: 3.115 ± 2.518
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
1.558GlnLys: 1.558 ± 0.952
0.0GlnLeu: 0.0 ± 0.0
1.558GlnMet: 1.558 ± 0.952
3.115GlnAsn: 3.115 ± 2.518
0.0GlnPro: 0.0 ± 0.0
3.115GlnGln: 3.115 ± 0.307
3.115GlnArg: 3.115 ± 1.905
0.0GlnSer: 0.0 ± 0.0
6.231GlnThr: 6.231 ± 2.825
1.558GlnVal: 1.558 ± 1.259
0.0GlnTrp: 0.0 ± 0.0
3.115GlnTyr: 3.115 ± 2.518
0.0GlnXaa: 0.0 ± 0.0
Arg
4.673ArgAla: 4.673 ± 1.566
1.558ArgCys: 1.558 ± 0.952
1.558ArgAsp: 1.558 ± 0.952
6.231ArgGlu: 6.231 ± 1.598
3.115ArgPhe: 3.115 ± 1.905
6.231ArgGly: 6.231 ± 0.613
1.558ArgHis: 1.558 ± 0.952
3.115ArgIle: 3.115 ± 1.905
1.558ArgLys: 1.558 ± 1.259
6.231ArgLeu: 6.231 ± 1.598
0.0ArgMet: 0.0 ± 0.0
1.558ArgAsn: 1.558 ± 1.259
4.673ArgPro: 4.673 ± 0.646
1.558ArgGln: 1.558 ± 0.952
3.115ArgArg: 3.115 ± 1.905
3.115ArgSer: 3.115 ± 1.905
10.903ArgThr: 10.903 ± 4.39
3.115ArgVal: 3.115 ± 1.905
1.558ArgTrp: 1.558 ± 0.952
1.558ArgTyr: 1.558 ± 1.259
0.0ArgXaa: 0.0 ± 0.0
Ser
7.788SerAla: 7.788 ± 0.339
1.558SerCys: 1.558 ± 1.259
7.788SerAsp: 7.788 ± 0.339
1.558SerGlu: 1.558 ± 1.259
4.673SerPhe: 4.673 ± 0.646
3.115SerGly: 3.115 ± 1.905
3.115SerHis: 3.115 ± 0.307
3.115SerIle: 3.115 ± 2.518
6.231SerLys: 6.231 ± 1.598
7.788SerLeu: 7.788 ± 1.872
4.673SerMet: 4.673 ± 1.566
1.558SerAsn: 1.558 ± 1.259
4.673SerPro: 4.673 ± 2.857
4.673SerGln: 4.673 ± 3.777
3.115SerArg: 3.115 ± 0.307
9.346SerSer: 9.346 ± 5.343
7.788SerThr: 7.788 ± 4.084
1.558SerVal: 1.558 ± 0.952
3.115SerTrp: 3.115 ± 1.905
3.115SerTyr: 3.115 ± 0.307
0.0SerXaa: 0.0 ± 0.0
Thr
6.231ThrAla: 6.231 ± 2.825
1.558ThrCys: 1.558 ± 0.952
1.558ThrAsp: 1.558 ± 0.952
3.115ThrGlu: 3.115 ± 1.905
0.0ThrPhe: 0.0 ± 0.0
7.788ThrGly: 7.788 ± 1.872
0.0ThrHis: 0.0 ± 0.0
3.115ThrIle: 3.115 ± 0.307
4.673ThrLys: 4.673 ± 1.566
1.558ThrLeu: 1.558 ± 1.259
3.115ThrMet: 3.115 ± 0.307
4.673ThrAsn: 4.673 ± 2.857
1.558ThrPro: 1.558 ± 0.952
1.558ThrGln: 1.558 ± 1.259
1.558ThrArg: 1.558 ± 1.259
3.115ThrSer: 3.115 ± 1.905
3.115ThrThr: 3.115 ± 2.518
6.231ThrVal: 6.231 ± 5.036
0.0ThrTrp: 0.0 ± 0.0
6.231ThrTyr: 6.231 ± 2.825
0.0ThrXaa: 0.0 ± 0.0
Val
3.115ValAla: 3.115 ± 0.307
0.0ValCys: 0.0 ± 0.0
4.673ValAsp: 4.673 ± 2.857
6.231ValGlu: 6.231 ± 1.598
4.673ValPhe: 4.673 ± 0.646
3.115ValGly: 3.115 ± 0.307
1.558ValHis: 1.558 ± 1.259
4.673ValIle: 4.673 ± 3.777
4.673ValLys: 4.673 ± 0.646
6.231ValLeu: 6.231 ± 1.598
1.558ValMet: 1.558 ± 0.842
0.0ValAsn: 0.0 ± 0.0
1.558ValPro: 1.558 ± 1.259
1.558ValGln: 1.558 ± 1.259
3.115ValArg: 3.115 ± 0.307
6.231ValSer: 6.231 ± 2.825
0.0ValThr: 0.0 ± 0.0
6.231ValVal: 6.231 ± 0.613
0.0ValTrp: 0.0 ± 0.0
1.558ValTyr: 1.558 ± 1.259
0.0ValXaa: 0.0 ± 0.0
Trp
1.558TrpAla: 1.558 ± 0.952
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
1.558TrpPhe: 1.558 ± 0.952
1.558TrpGly: 1.558 ± 0.952
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
3.115TrpLys: 3.115 ± 1.905
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
1.558TrpAsn: 1.558 ± 0.952
1.558TrpPro: 1.558 ± 0.952
1.558TrpGln: 1.558 ± 0.952
0.0TrpArg: 0.0 ± 0.0
1.558TrpSer: 1.558 ± 0.952
0.0TrpThr: 0.0 ± 0.0
1.558TrpVal: 1.558 ± 1.259
1.558TrpTrp: 1.558 ± 0.952
3.115TrpTyr: 3.115 ± 1.905
0.0TrpXaa: 0.0 ± 0.0
Tyr
6.231TyrAla: 6.231 ± 2.825
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
7.788TyrGlu: 7.788 ± 1.872
0.0TyrPhe: 0.0 ± 0.0
0.0TyrGly: 0.0 ± 0.0
0.0TyrHis: 0.0 ± 0.0
1.558TyrIle: 1.558 ± 1.259
3.115TyrLys: 3.115 ± 0.307
3.115TyrLeu: 3.115 ± 1.905
0.0TyrMet: 0.0 ± 0.0
1.558TyrAsn: 1.558 ± 1.259
1.558TyrPro: 1.558 ± 1.259
1.558TyrGln: 1.558 ± 0.952
1.558TyrArg: 1.558 ± 1.259
0.0TyrSer: 0.0 ± 0.0
3.115TyrThr: 3.115 ± 0.307
3.115TyrVal: 3.115 ± 2.518
1.558TyrTrp: 1.558 ± 0.952
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (643 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski