Amino acid dipepetide frequency for Atelocyanobacterium thalassa (isolate ALOHA)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.172AlaAla: 4.172 ± 0.135
0.628AlaCys: 0.628 ± 0.043
2.453AlaAsp: 2.453 ± 0.079
3.448AlaGlu: 3.448 ± 0.1
2.275AlaPhe: 2.275 ± 0.089
3.926AlaGly: 3.926 ± 0.117
1.011AlaHis: 1.011 ± 0.057
5.681AlaIle: 5.681 ± 0.133
3.963AlaLys: 3.963 ± 0.115
6.379AlaLeu: 6.379 ± 0.136
1.318AlaMet: 1.318 ± 0.065
2.668AlaAsn: 2.668 ± 0.085
1.688AlaPro: 1.688 ± 0.058
2.562AlaGln: 2.562 ± 0.086
2.512AlaArg: 2.512 ± 0.085
3.841AlaSer: 3.841 ± 0.107
3.029AlaThr: 3.029 ± 0.09
3.802AlaVal: 3.802 ± 0.114
0.721AlaTrp: 0.721 ± 0.045
2.068AlaTyr: 2.068 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.468CysAla: 0.468 ± 0.035
0.14CysCys: 0.14 ± 0.02
0.512CysAsp: 0.512 ± 0.04
0.514CysGlu: 0.514 ± 0.038
0.432CysPhe: 0.432 ± 0.035
0.794CysGly: 0.794 ± 0.046
0.261CysHis: 0.261 ± 0.027
0.861CysIle: 0.861 ± 0.051
0.605CysLys: 0.605 ± 0.039
1.269CysLeu: 1.269 ± 0.061
0.153CysMet: 0.153 ± 0.021
0.607CysAsn: 0.607 ± 0.045
0.54CysPro: 0.54 ± 0.044
0.514CysGln: 0.514 ± 0.043
0.411CysArg: 0.411 ± 0.031
0.76CysSer: 0.76 ± 0.04
0.571CysThr: 0.571 ± 0.041
0.494CysVal: 0.494 ± 0.039
0.137CysTrp: 0.137 ± 0.016
0.439CysTyr: 0.439 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
2.3AspAla: 2.3 ± 0.074
0.489AspCys: 0.489 ± 0.033
2.006AspAsp: 2.006 ± 0.086
2.652AspGlu: 2.652 ± 0.097
2.373AspPhe: 2.373 ± 0.083
2.414AspGly: 2.414 ± 0.089
0.825AspHis: 0.825 ± 0.045
4.66AspIle: 4.66 ± 0.113
3.244AspLys: 3.244 ± 0.096
5.692AspLeu: 5.692 ± 0.137
0.791AspMet: 0.791 ± 0.048
2.722AspAsn: 2.722 ± 0.08
1.972AspPro: 1.972 ± 0.071
1.533AspGln: 1.533 ± 0.064
2.003AspArg: 2.003 ± 0.082
3.164AspSer: 3.164 ± 0.081
2.326AspThr: 2.326 ± 0.077
2.463AspVal: 2.463 ± 0.077
0.646AspTrp: 0.646 ± 0.045
1.998AspTyr: 1.998 ± 0.08
0.0AspXaa: 0.0 ± 0.0
Glu
4.102GluAla: 4.102 ± 0.104
0.434GluCys: 0.434 ± 0.032
2.848GluAsp: 2.848 ± 0.107
4.655GluGlu: 4.655 ± 0.13
2.324GluPhe: 2.324 ± 0.076
3.19GluGly: 3.19 ± 0.092
0.912GluHis: 0.912 ± 0.051
6.167GluIle: 6.167 ± 0.139
5.521GluLys: 5.521 ± 0.128
6.599GluLeu: 6.599 ± 0.148
1.295GluMet: 1.295 ± 0.06
3.508GluAsn: 3.508 ± 0.101
1.778GluPro: 1.778 ± 0.06
2.618GluGln: 2.618 ± 0.086
2.567GluArg: 2.567 ± 0.091
3.549GluSer: 3.549 ± 0.101
3.247GluThr: 3.247 ± 0.089
3.929GluVal: 3.929 ± 0.116
0.669GluTrp: 0.669 ± 0.042
1.853GluTyr: 1.853 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
2.189PheAla: 2.189 ± 0.08
0.613PheCys: 0.613 ± 0.041
2.112PheAsp: 2.112 ± 0.079
2.163PheGlu: 2.163 ± 0.084
2.207PhePhe: 2.207 ± 0.093
2.812PheGly: 2.812 ± 0.093
0.85PheHis: 0.85 ± 0.051
3.722PheIle: 3.722 ± 0.109
2.481PheLys: 2.481 ± 0.087
5.064PheLeu: 5.064 ± 0.129
0.887PheMet: 0.887 ± 0.045
2.536PheAsn: 2.536 ± 0.084
1.817PhePro: 1.817 ± 0.074
1.711PheGln: 1.711 ± 0.066
1.605PheArg: 1.605 ± 0.062
3.686PheSer: 3.686 ± 0.106
2.375PheThr: 2.375 ± 0.079
2.151PheVal: 2.151 ± 0.084
0.644PheTrp: 0.644 ± 0.043
1.724PheTyr: 1.724 ± 0.078
0.0PheXaa: 0.0 ± 0.0
Gly
3.593GlyAla: 3.593 ± 0.121
0.871GlyCys: 0.871 ± 0.055
2.714GlyAsp: 2.714 ± 0.094
3.645GlyGlu: 3.645 ± 0.112
2.792GlyPhe: 2.792 ± 0.081
4.423GlyGly: 4.423 ± 0.133
1.217GlyHis: 1.217 ± 0.057
6.325GlyIle: 6.325 ± 0.136
4.73GlyLys: 4.73 ± 0.115
6.568GlyLeu: 6.568 ± 0.136
1.447GlyMet: 1.447 ± 0.07
2.812GlyAsn: 2.812 ± 0.089
1.515GlyPro: 1.515 ± 0.061
2.262GlyGln: 2.262 ± 0.084
2.68GlyArg: 2.68 ± 0.083
3.802GlySer: 3.802 ± 0.104
3.466GlyThr: 3.466 ± 0.087
4.037GlyVal: 4.037 ± 0.101
0.884GlyTrp: 0.884 ± 0.06
2.337GlyTyr: 2.337 ± 0.09
0.0GlyXaa: 0.0 ± 0.0
His
0.894HisAla: 0.894 ± 0.057
0.233HisCys: 0.233 ± 0.024
0.791HisAsp: 0.791 ± 0.046
0.809HisGlu: 0.809 ± 0.039
0.936HisPhe: 0.936 ± 0.049
1.088HisGly: 1.088 ± 0.054
0.582HisHis: 0.582 ± 0.042
1.499HisIle: 1.499 ± 0.065
1.295HisLys: 1.295 ± 0.061
2.179HisLeu: 2.179 ± 0.084
0.261HisMet: 0.261 ± 0.03
1.078HisAsn: 1.078 ± 0.058
1.068HisPro: 1.068 ± 0.059
0.897HisGln: 0.897 ± 0.048
0.915HisArg: 0.915 ± 0.047
1.365HisSer: 1.365 ± 0.061
0.866HisThr: 0.866 ± 0.046
0.788HisVal: 0.788 ± 0.045
0.24HisTrp: 0.24 ± 0.024
0.688HisTyr: 0.688 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
6.441IleAla: 6.441 ± 0.135
1.018IleCys: 1.018 ± 0.055
4.901IleAsp: 4.901 ± 0.115
5.658IleGlu: 5.658 ± 0.138
4.224IlePhe: 4.224 ± 0.127
5.937IleGly: 5.937 ± 0.143
1.616IleHis: 1.616 ± 0.063
7.63IleIle: 7.63 ± 0.169
5.847IleLys: 5.847 ± 0.135
9.732IleLeu: 9.732 ± 0.186
1.484IleMet: 1.484 ± 0.067
5.482IleAsn: 5.482 ± 0.155
4.363IlePro: 4.363 ± 0.11
3.321IleGln: 3.321 ± 0.093
3.58IleArg: 3.58 ± 0.104
7.142IleSer: 7.142 ± 0.124
4.919IleThr: 4.919 ± 0.11
5.376IleVal: 5.376 ± 0.11
1.003IleTrp: 1.003 ± 0.051
2.655IleTyr: 2.655 ± 0.087
0.0IleXaa: 0.0 ± 0.0
Lys
4.05LysAla: 4.05 ± 0.109
0.535LysCys: 0.535 ± 0.036
3.184LysAsp: 3.184 ± 0.085
5.066LysGlu: 5.066 ± 0.119
2.443LysPhe: 2.443 ± 0.083
3.583LysGly: 3.583 ± 0.095
1.104LysHis: 1.104 ± 0.052
7.015LysIle: 7.015 ± 0.148
5.679LysLys: 5.679 ± 0.132
7.315LysLeu: 7.315 ± 0.161
1.409LysMet: 1.409 ± 0.057
4.57LysAsn: 4.57 ± 0.117
2.288LysPro: 2.288 ± 0.079
3.135LysGln: 3.135 ± 0.104
2.998LysArg: 2.998 ± 0.092
4.485LysSer: 4.485 ± 0.121
3.97LysThr: 3.97 ± 0.101
4.237LysVal: 4.237 ± 0.104
0.69LysTrp: 0.69 ± 0.051
2.507LysTyr: 2.507 ± 0.082
0.0LysXaa: 0.0 ± 0.0
Leu
6.899LeuAla: 6.899 ± 0.159
1.099LeuCys: 1.099 ± 0.054
5.366LeuAsp: 5.366 ± 0.125
7.7LeuGlu: 7.7 ± 0.148
4.283LeuPhe: 4.283 ± 0.126
7.643LeuGly: 7.643 ± 0.154
1.729LeuHis: 1.729 ± 0.077
9.406LeuIle: 9.406 ± 0.188
8.059LeuLys: 8.059 ± 0.152
11.28LeuLeu: 11.28 ± 0.226
2.083LeuMet: 2.083 ± 0.071
5.937LeuAsn: 5.937 ± 0.115
4.797LeuPro: 4.797 ± 0.125
4.459LeuGln: 4.459 ± 0.116
4.585LeuArg: 4.585 ± 0.104
8.669LeuSer: 8.669 ± 0.176
5.955LeuThr: 5.955 ± 0.135
6.775LeuVal: 6.775 ± 0.141
1.186LeuTrp: 1.186 ± 0.068
2.98LeuTyr: 2.98 ± 0.093
0.0LeuXaa: 0.0 ± 0.0
Met
1.458MetAla: 1.458 ± 0.058
0.145MetCys: 0.145 ± 0.019
0.775MetAsp: 0.775 ± 0.048
1.127MetGlu: 1.127 ± 0.053
0.669MetPhe: 0.669 ± 0.045
1.383MetGly: 1.383 ± 0.066
0.279MetHis: 0.279 ± 0.027
1.716MetIle: 1.716 ± 0.066
1.274MetLys: 1.274 ± 0.057
1.972MetLeu: 1.972 ± 0.086
0.439MetMet: 0.439 ± 0.034
1.034MetAsn: 1.034 ± 0.054
0.775MetPro: 0.775 ± 0.037
0.675MetGln: 0.675 ± 0.044
0.806MetArg: 0.806 ± 0.046
1.429MetSer: 1.429 ± 0.056
1.256MetThr: 1.256 ± 0.057
1.259MetVal: 1.259 ± 0.057
0.145MetTrp: 0.145 ± 0.017
0.432MetTyr: 0.432 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
2.453AsnAla: 2.453 ± 0.088
0.613AsnCys: 0.613 ± 0.041
2.143AsnAsp: 2.143 ± 0.073
2.468AsnGlu: 2.468 ± 0.084
2.742AsnPhe: 2.742 ± 0.092
2.427AsnGly: 2.427 ± 0.092
1.114AsnHis: 1.114 ± 0.054
5.702AsnIle: 5.702 ± 0.128
4.154AsnLys: 4.154 ± 0.128
6.658AsnLeu: 6.658 ± 0.136
0.99AsnMet: 0.99 ± 0.049
4.089AsnAsn: 4.089 ± 0.124
2.58AsnPro: 2.58 ± 0.086
2.461AsnGln: 2.461 ± 0.09
2.241AsnArg: 2.241 ± 0.077
4.237AsnSer: 4.237 ± 0.11
2.745AsnThr: 2.745 ± 0.086
2.512AsnVal: 2.512 ± 0.077
0.832AsnTrp: 0.832 ± 0.045
2.288AsnTyr: 2.288 ± 0.078
0.0AsnXaa: 0.0 ± 0.0
Pro
1.784ProAla: 1.784 ± 0.077
0.349ProCys: 0.349 ± 0.03
2.003ProAsp: 2.003 ± 0.062
2.905ProGlu: 2.905 ± 0.084
1.768ProPhe: 1.768 ± 0.068
2.427ProGly: 2.427 ± 0.089
0.866ProHis: 0.866 ± 0.049
3.583ProIle: 3.583 ± 0.093
2.461ProLys: 2.461 ± 0.078
4.327ProLeu: 4.327 ± 0.11
0.657ProMet: 0.657 ± 0.04
2.068ProAsn: 2.068 ± 0.069
1.362ProPro: 1.362 ± 0.067
1.605ProGln: 1.605 ± 0.062
1.311ProArg: 1.311 ± 0.064
2.722ProSer: 2.722 ± 0.084
2.047ProThr: 2.047 ± 0.068
2.471ProVal: 2.471 ± 0.084
0.527ProTrp: 0.527 ± 0.036
1.481ProTyr: 1.481 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
2.58GlnAla: 2.58 ± 0.079
0.284GlnCys: 0.284 ± 0.03
1.933GlnAsp: 1.933 ± 0.065
3.128GlnGlu: 3.128 ± 0.096
1.572GlnPhe: 1.572 ± 0.056
2.381GlnGly: 2.381 ± 0.068
0.669GlnHis: 0.669 ± 0.045
3.544GlnIle: 3.544 ± 0.095
3.572GlnLys: 3.572 ± 0.107
4.547GlnLeu: 4.547 ± 0.12
0.765GlnMet: 0.765 ± 0.047
2.306GlnAsn: 2.306 ± 0.075
1.373GlnPro: 1.373 ± 0.06
1.928GlnGln: 1.928 ± 0.084
1.908GlnArg: 1.908 ± 0.076
2.44GlnSer: 2.44 ± 0.079
2.021GlnThr: 2.021 ± 0.072
2.724GlnVal: 2.724 ± 0.09
0.476GlnTrp: 0.476 ± 0.038
1.228GlnTyr: 1.228 ± 0.062
0.0GlnXaa: 0.0 ± 0.0
Arg
2.171ArgAla: 2.171 ± 0.084
0.421ArgCys: 0.421 ± 0.032
1.877ArgAsp: 1.877 ± 0.08
2.675ArgGlu: 2.675 ± 0.081
1.926ArgPhe: 1.926 ± 0.076
2.445ArgGly: 2.445 ± 0.081
0.918ArgHis: 0.918 ± 0.051
3.782ArgIle: 3.782 ± 0.106
2.74ArgLys: 2.74 ± 0.075
4.924ArgLeu: 4.924 ± 0.114
0.799ArgMet: 0.799 ± 0.045
2.096ArgAsn: 2.096 ± 0.082
1.538ArgPro: 1.538 ± 0.07
1.993ArgGln: 1.993 ± 0.074
2.412ArgArg: 2.412 ± 0.089
2.657ArgSer: 2.657 ± 0.089
2.109ArgThr: 2.109 ± 0.067
2.463ArgVal: 2.463 ± 0.083
0.589ArgTrp: 0.589 ± 0.037
1.595ArgTyr: 1.595 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
3.433SerAla: 3.433 ± 0.099
0.791SerCys: 0.791 ± 0.047
3.071SerAsp: 3.071 ± 0.089
3.815SerGlu: 3.815 ± 0.096
3.521SerPhe: 3.521 ± 0.105
4.417SerGly: 4.417 ± 0.102
1.504SerHis: 1.504 ± 0.059
6.581SerIle: 6.581 ± 0.15
4.668SerLys: 4.668 ± 0.111
8.359SerLeu: 8.359 ± 0.166
1.378SerMet: 1.378 ± 0.055
3.983SerAsn: 3.983 ± 0.108
2.815SerPro: 2.815 ± 0.083
3.275SerGln: 3.275 ± 0.091
2.967SerArg: 2.967 ± 0.072
5.984SerSer: 5.984 ± 0.129
3.645SerThr: 3.645 ± 0.098
3.634SerVal: 3.634 ± 0.098
0.918SerTrp: 0.918 ± 0.054
2.6SerTyr: 2.6 ± 0.1
0.0SerXaa: 0.0 ± 0.0
Thr
3.102ThrAla: 3.102 ± 0.089
0.556ThrCys: 0.556 ± 0.031
2.244ThrAsp: 2.244 ± 0.075
2.991ThrGlu: 2.991 ± 0.078
2.259ThrPhe: 2.259 ± 0.08
3.732ThrGly: 3.732 ± 0.103
0.956ThrHis: 0.956 ± 0.048
5.389ThrIle: 5.389 ± 0.14
3.249ThrLys: 3.249 ± 0.106
6.271ThrLeu: 6.271 ± 0.117
0.853ThrMet: 0.853 ± 0.042
2.655ThrAsn: 2.655 ± 0.079
2.282ThrPro: 2.282 ± 0.085
2.011ThrGln: 2.011 ± 0.062
2.05ThrArg: 2.05 ± 0.076
3.872ThrSer: 3.872 ± 0.1
2.936ThrThr: 2.936 ± 0.093
3.2ThrVal: 3.2 ± 0.094
0.566ThrTrp: 0.566 ± 0.039
1.641ThrTyr: 1.641 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
3.769ValAla: 3.769 ± 0.123
0.654ValCys: 0.654 ± 0.045
3.172ValAsp: 3.172 ± 0.096
3.696ValGlu: 3.696 ± 0.106
2.378ValPhe: 2.378 ± 0.079
4.081ValGly: 4.081 ± 0.112
1.016ValHis: 1.016 ± 0.054
5.426ValIle: 5.426 ± 0.152
3.782ValLys: 3.782 ± 0.111
5.839ValLeu: 5.839 ± 0.118
1.259ValMet: 1.259 ± 0.059
3.076ValAsn: 3.076 ± 0.093
2.285ValPro: 2.285 ± 0.088
2.019ValGln: 2.019 ± 0.07
2.295ValArg: 2.295 ± 0.084
4.156ValSer: 4.156 ± 0.114
3.197ValThr: 3.197 ± 0.093
3.908ValVal: 3.908 ± 0.099
0.732ValTrp: 0.732 ± 0.047
1.791ValTyr: 1.791 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.595TrpAla: 0.595 ± 0.044
0.129TrpCys: 0.129 ± 0.022
0.512TrpAsp: 0.512 ± 0.036
0.747TrpGlu: 0.747 ± 0.045
0.597TrpPhe: 0.597 ± 0.038
0.871TrpGly: 0.871 ± 0.05
0.264TrpHis: 0.264 ± 0.027
1.127TrpIle: 1.127 ± 0.058
0.881TrpLys: 0.881 ± 0.051
1.665TrpLeu: 1.665 ± 0.082
0.258TrpMet: 0.258 ± 0.026
0.682TrpAsn: 0.682 ± 0.048
0.282TrpPro: 0.282 ± 0.028
0.605TrpGln: 0.605 ± 0.041
0.561TrpArg: 0.561 ± 0.039
0.814TrpSer: 0.814 ± 0.047
0.551TrpThr: 0.551 ± 0.04
0.644TrpVal: 0.644 ± 0.039
0.171TrpTrp: 0.171 ± 0.024
0.411TrpTyr: 0.411 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.693TyrAla: 1.693 ± 0.07
0.481TyrCys: 0.481 ± 0.036
1.657TyrAsp: 1.657 ± 0.06
1.902TyrGlu: 1.902 ± 0.069
1.631TyrPhe: 1.631 ± 0.076
2.148TyrGly: 2.148 ± 0.076
0.778TyrHis: 0.778 ± 0.048
2.512TyrIle: 2.512 ± 0.081
2.058TyrLys: 2.058 ± 0.08
4.255TyrLeu: 4.255 ± 0.116
0.522TyrMet: 0.522 ± 0.034
1.541TyrAsn: 1.541 ± 0.06
1.605TyrPro: 1.605 ± 0.066
1.794TyrGln: 1.794 ± 0.071
1.721TyrArg: 1.721 ± 0.071
2.585TyrSer: 2.585 ± 0.081
1.582TyrThr: 1.582 ± 0.067
1.662TyrVal: 1.662 ± 0.063
0.589TyrTrp: 0.589 ± 0.037
1.388TyrTyr: 1.388 ± 0.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1199 proteins (386876 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski