Amino acid dipepetide frequency for Circoviridae 8 LDMD-2013

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.445AlaAla: 2.445 ± 1.862
0.0AlaCys: 0.0 ± 0.0
3.26AlaAsp: 3.26 ± 1.228
2.445AlaGlu: 2.445 ± 1.708
0.815AlaPhe: 0.815 ± 0.801
4.075AlaGly: 4.075 ± 2.368
0.815AlaHis: 0.815 ± 0.569
1.63AlaIle: 1.63 ± 1.236
2.445AlaLys: 2.445 ± 0.934
4.075AlaLeu: 4.075 ± 1.568
1.63AlaMet: 1.63 ± 1.139
4.075AlaAsn: 4.075 ± 1.252
3.26AlaPro: 3.26 ± 1.347
0.0AlaGln: 0.0 ± 0.0
2.445AlaArg: 2.445 ± 0.699
1.63AlaSer: 1.63 ± 1.093
1.63AlaThr: 1.63 ± 1.602
6.52AlaVal: 6.52 ± 1.258
0.815AlaTrp: 0.815 ± 0.705
0.815AlaTyr: 0.815 ± 0.801
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
1.63CysCys: 1.63 ± 1.865
0.815CysAsp: 0.815 ± 0.569
0.815CysGlu: 0.815 ± 0.771
1.63CysPhe: 1.63 ± 1.093
1.63CysGly: 1.63 ± 0.666
1.63CysHis: 1.63 ± 0.974
1.63CysIle: 1.63 ± 0.666
0.0CysLys: 0.0 ± 0.0
0.815CysLeu: 0.815 ± 0.771
0.0CysMet: 0.0 ± 0.935
1.63CysAsn: 1.63 ± 0.737
0.815CysPro: 0.815 ± 0.569
0.0CysGln: 0.0 ± 0.0
0.815CysArg: 0.815 ± 0.569
1.63CysSer: 1.63 ± 0.666
1.63CysThr: 1.63 ± 1.139
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.63AspAla: 1.63 ± 1.602
0.815AspCys: 0.815 ± 0.771
1.63AspAsp: 1.63 ± 0.614
5.705AspGlu: 5.705 ± 2.146
3.26AspPhe: 3.26 ± 1.024
3.26AspGly: 3.26 ± 1.442
0.815AspHis: 0.815 ± 0.569
5.705AspIle: 5.705 ± 2.194
1.63AspLys: 1.63 ± 0.614
0.815AspLeu: 0.815 ± 0.771
1.63AspMet: 1.63 ± 0.666
0.0AspAsn: 0.0 ± 0.0
2.445AspPro: 2.445 ± 0.951
0.815AspGln: 0.815 ± 0.705
4.075AspArg: 4.075 ± 0.451
0.0AspSer: 0.0 ± 0.0
1.63AspThr: 1.63 ± 0.737
3.26AspVal: 3.26 ± 2.277
2.445AspTrp: 2.445 ± 2.116
3.26AspTyr: 3.26 ± 1.444
0.0AspXaa: 0.0 ± 0.0
Glu
1.63GluAla: 1.63 ± 0.614
0.0GluCys: 0.0 ± 0.0
5.705GluAsp: 5.705 ± 1.489
6.52GluGlu: 6.52 ± 1.969
0.815GluPhe: 0.815 ± 0.569
2.445GluGly: 2.445 ± 1.046
0.815GluHis: 0.815 ± 0.569
1.63GluIle: 1.63 ± 0.614
2.445GluLys: 2.445 ± 1.611
8.965GluLeu: 8.965 ± 3.406
1.63GluMet: 1.63 ± 1.045
1.63GluAsn: 1.63 ± 0.737
2.445GluPro: 2.445 ± 1.708
0.0GluGln: 0.0 ± 0.0
5.705GluArg: 5.705 ± 2.194
4.075GluSer: 4.075 ± 1.422
3.26GluThr: 3.26 ± 1.332
3.26GluVal: 3.26 ± 1.514
1.63GluTrp: 1.63 ± 0.737
4.075GluTyr: 4.075 ± 1.46
0.0GluXaa: 0.0 ± 0.0
Phe
1.63PheAla: 1.63 ± 1.236
0.815PheCys: 0.815 ± 0.569
4.075PheAsp: 4.075 ± 1.232
0.0PheGlu: 0.0 ± 0.0
1.63PhePhe: 1.63 ± 0.666
0.0PheGly: 0.0 ± 0.0
0.0PheHis: 0.0 ± 0.0
4.075PheIle: 4.075 ± 1.318
1.63PheLys: 1.63 ± 1.015
6.52PheLeu: 6.52 ± 3.576
0.815PheMet: 0.815 ± 0.771
0.815PheAsn: 0.815 ± 0.569
0.0PhePro: 0.0 ± 0.0
1.63PheGln: 1.63 ± 0.737
0.0PheArg: 0.0 ± 0.0
4.89PheSer: 4.89 ± 1.658
0.815PheThr: 0.815 ± 0.801
3.26PheVal: 3.26 ± 0.771
0.815PheTrp: 0.815 ± 0.569
1.63PheTyr: 1.63 ± 0.737
0.0PheXaa: 0.0 ± 0.0
Gly
2.445GlyAla: 2.445 ± 2.403
4.075GlyCys: 4.075 ± 1.422
1.63GlyAsp: 1.63 ± 0.737
4.89GlyGlu: 4.89 ± 0.695
2.445GlyPhe: 2.445 ± 0.699
4.075GlyGly: 4.075 ± 1.718
2.445GlyHis: 2.445 ± 0.96
4.075GlyIle: 4.075 ± 1.998
6.52GlyLys: 6.52 ± 0.576
1.63GlyLeu: 1.63 ± 0.614
0.815GlyMet: 0.815 ± 0.569
2.445GlyAsn: 2.445 ± 1.261
0.815GlyPro: 0.815 ± 0.569
3.26GlyGln: 3.26 ± 1.746
4.075GlyArg: 4.075 ± 1.462
5.705GlySer: 5.705 ± 1.624
4.89GlyThr: 4.89 ± 1.658
0.0GlyVal: 0.0 ± 0.0
0.0GlyTrp: 0.0 ± 0.0
4.075GlyTyr: 4.075 ± 1.834
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.815HisCys: 0.815 ± 0.933
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
4.075HisPhe: 4.075 ± 1.388
1.63HisGly: 1.63 ± 1.139
1.63HisHis: 1.63 ± 0.666
0.815HisIle: 0.815 ± 0.933
3.26HisLys: 3.26 ± 0.771
2.445HisLeu: 2.445 ± 0.789
0.0HisMet: 0.0 ± 0.0
0.815HisAsn: 0.815 ± 0.801
4.89HisPro: 4.89 ± 1.717
2.445HisGln: 2.445 ± 1.43
3.26HisArg: 3.26 ± 1.726
2.445HisSer: 2.445 ± 1.69
4.89HisThr: 4.89 ± 1.923
0.0HisVal: 0.0 ± 0.0
0.815HisTrp: 0.815 ± 0.569
1.63HisTyr: 1.63 ± 0.666
0.0HisXaa: 0.0 ± 0.0
Ile
1.63IleAla: 1.63 ± 1.135
2.445IleCys: 2.445 ± 1.046
3.26IleAsp: 3.26 ± 1.445
0.815IleGlu: 0.815 ± 0.569
2.445IlePhe: 2.445 ± 1.755
1.63IleGly: 1.63 ± 0.666
3.26IleHis: 3.26 ± 1.764
4.89IleIle: 4.89 ± 1.419
4.075IleLys: 4.075 ± 1.043
4.075IleLeu: 4.075 ± 1.318
1.63IleMet: 1.63 ± 1.139
2.445IleAsn: 2.445 ± 0.934
5.705IlePro: 5.705 ± 1.811
0.0IleGln: 0.0 ± 0.0
4.075IleArg: 4.075 ± 0.451
6.52IleSer: 6.52 ± 2.448
3.26IleThr: 3.26 ± 1.22
2.445IleVal: 2.445 ± 1.046
0.815IleTrp: 0.815 ± 0.705
1.63IleTyr: 1.63 ± 1.411
0.0IleXaa: 0.0 ± 0.0
Lys
3.26LysAla: 3.26 ± 1.195
0.0LysCys: 0.0 ± 0.0
0.815LysAsp: 0.815 ± 0.705
2.445LysGlu: 2.445 ± 0.97
1.63LysPhe: 1.63 ± 1.015
5.705LysGly: 5.705 ± 1.408
3.26LysHis: 3.26 ± 1.852
2.445LysIle: 2.445 ± 0.699
7.335LysLys: 7.335 ± 2.677
5.705LysLeu: 5.705 ± 2.394
2.445LysMet: 2.445 ± 1.046
5.705LysAsn: 5.705 ± 1.646
4.89LysPro: 4.89 ± 1.397
0.0LysGln: 0.0 ± 0.0
7.335LysArg: 7.335 ± 3.755
4.89LysSer: 4.89 ± 1.581
4.89LysThr: 4.89 ± 1.089
3.26LysVal: 3.26 ± 1.375
1.63LysTrp: 1.63 ± 1.411
4.075LysTyr: 4.075 ± 2.175
0.815LysXaa: 0.815 ± 0.771
Leu
4.075LeuAla: 4.075 ± 1.318
1.63LeuCys: 1.63 ± 0.666
3.26LeuAsp: 3.26 ± 0.757
4.89LeuGlu: 4.89 ± 3.416
3.26LeuPhe: 3.26 ± 0.745
3.26LeuGly: 3.26 ± 1.374
4.075LeuHis: 4.075 ± 3.27
3.26LeuIle: 3.26 ± 0.835
8.15LeuLys: 8.15 ± 3.01
2.445LeuLeu: 2.445 ± 1.323
1.63LeuMet: 1.63 ± 0.99
1.63LeuAsn: 1.63 ± 1.139
7.335LeuPro: 7.335 ± 2.651
2.445LeuGln: 2.445 ± 1.643
2.445LeuArg: 2.445 ± 1.323
6.52LeuSer: 6.52 ± 2.516
2.445LeuThr: 2.445 ± 1.708
4.075LeuVal: 4.075 ± 0.947
1.63LeuTrp: 1.63 ± 0.666
1.63LeuTyr: 1.63 ± 1.411
0.0LeuXaa: 0.0 ± 0.0
Met
0.815MetAla: 0.815 ± 0.569
0.815MetCys: 0.815 ± 0.569
3.26MetAsp: 3.26 ± 1.445
2.445MetGlu: 2.445 ± 1.046
0.815MetPhe: 0.815 ± 0.569
1.63MetGly: 1.63 ± 1.411
0.0MetHis: 0.0 ± 0.0
1.63MetIle: 1.63 ± 0.974
0.0MetLys: 0.0 ± 0.0
0.815MetLeu: 0.815 ± 0.569
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.815MetPro: 0.815 ± 0.801
1.63MetGln: 1.63 ± 1.047
0.815MetArg: 0.815 ± 0.569
1.63MetSer: 1.63 ± 0.666
1.63MetThr: 1.63 ± 0.614
0.0MetVal: 0.0 ± 0.0
0.815MetTrp: 0.815 ± 0.705
2.445MetTyr: 2.445 ± 1.708
0.0MetXaa: 0.0 ± 0.0
Asn
1.63AsnAla: 1.63 ± 0.614
0.815AsnCys: 0.815 ± 0.771
1.63AsnAsp: 1.63 ± 1.602
3.26AsnGlu: 3.26 ± 1.514
4.075AsnPhe: 4.075 ± 1.18
4.89AsnGly: 4.89 ± 1.777
0.0AsnHis: 0.0 ± 0.0
2.445AsnIle: 2.445 ± 0.97
2.445AsnLys: 2.445 ± 1.954
5.705AsnLeu: 5.705 ± 1.624
1.63AsnMet: 1.63 ± 0.614
1.63AsnAsn: 1.63 ± 1.139
2.445AsnPro: 2.445 ± 0.708
0.815AsnGln: 0.815 ± 0.771
2.445AsnArg: 2.445 ± 0.699
2.445AsnSer: 2.445 ± 1.046
4.89AsnThr: 4.89 ± 0.568
1.63AsnVal: 1.63 ± 1.139
1.63AsnTrp: 1.63 ± 0.974
1.63AsnTyr: 1.63 ± 0.614
0.0AsnXaa: 0.0 ± 0.0
Pro
2.445ProAla: 2.445 ± 1.261
0.0ProCys: 0.0 ± 0.0
0.0ProAsp: 0.0 ± 0.0
4.075ProGlu: 4.075 ± 1.608
0.0ProPhe: 0.0 ± 0.0
5.705ProGly: 5.705 ± 1.751
3.26ProHis: 3.26 ± 2.061
4.075ProIle: 4.075 ± 1.079
1.63ProLys: 1.63 ± 1.865
3.26ProLeu: 3.26 ± 2.095
0.815ProMet: 0.815 ± 0.569
4.89ProAsn: 4.89 ± 1.222
6.52ProPro: 6.52 ± 2.175
3.26ProGln: 3.26 ± 1.375
4.075ProArg: 4.075 ± 2.034
6.52ProSer: 6.52 ± 2.378
4.075ProThr: 4.075 ± 1.898
4.075ProVal: 4.075 ± 1.388
2.445ProTrp: 2.445 ± 0.96
1.63ProTyr: 1.63 ± 1.411
0.0ProXaa: 0.0 ± 0.0
Gln
2.445GlnAla: 2.445 ± 1.294
0.815GlnCys: 0.815 ± 0.801
0.815GlnAsp: 0.815 ± 0.569
1.63GlnGlu: 1.63 ± 1.541
0.0GlnPhe: 0.0 ± 0.0
4.075GlnGly: 4.075 ± 2.135
0.815GlnHis: 0.815 ± 0.569
0.815GlnIle: 0.815 ± 0.771
1.63GlnLys: 1.63 ± 1.126
1.63GlnLeu: 1.63 ± 0.737
0.815GlnMet: 0.815 ± 0.741
1.63GlnAsn: 1.63 ± 1.015
0.815GlnPro: 0.815 ± 0.705
0.815GlnGln: 0.815 ± 0.569
4.89GlnArg: 4.89 ± 2.578
3.26GlnSer: 3.26 ± 1.374
1.63GlnThr: 1.63 ± 1.411
3.26GlnVal: 3.26 ± 0.922
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
2.445ArgAla: 2.445 ± 0.951
0.815ArgCys: 0.815 ± 0.569
4.89ArgAsp: 4.89 ± 1.378
2.445ArgGlu: 2.445 ± 0.951
2.445ArgPhe: 2.445 ± 1.713
0.815ArgGly: 0.815 ± 0.569
4.075ArgHis: 4.075 ± 0.811
5.705ArgIle: 5.705 ± 1.646
7.335ArgLys: 7.335 ± 1.366
4.075ArgLeu: 4.075 ± 2.206
0.0ArgMet: 0.0 ± 0.0
1.63ArgAsn: 1.63 ± 1.139
4.075ArgPro: 4.075 ± 1.762
3.26ArgGln: 3.26 ± 2.031
11.41ArgArg: 11.41 ± 3.486
9.78ArgSer: 9.78 ± 2.274
4.89ArgThr: 4.89 ± 1.141
2.445ArgVal: 2.445 ± 1.046
0.0ArgTrp: 0.0 ± 0.0
4.89ArgTyr: 4.89 ± 1.859
0.0ArgXaa: 0.0 ± 0.0
Ser
5.705SerAla: 5.705 ± 0.596
0.0SerCys: 0.0 ± 0.0
1.63SerAsp: 1.63 ± 0.666
5.705SerGlu: 5.705 ± 1.489
3.26SerPhe: 3.26 ± 2.277
4.89SerGly: 4.89 ± 1.671
3.26SerHis: 3.26 ± 1.06
4.89SerIle: 4.89 ± 2.548
5.705SerLys: 5.705 ± 2.392
1.63SerLeu: 1.63 ± 0.666
0.815SerMet: 0.815 ± 0.569
5.705SerAsn: 5.705 ± 2.594
3.26SerPro: 3.26 ± 1.444
4.075SerGln: 4.075 ± 1.695
8.965SerArg: 8.965 ± 2.233
8.15SerSer: 8.15 ± 1.238
5.705SerThr: 5.705 ± 2.594
4.89SerVal: 4.89 ± 2.452
0.0SerTrp: 0.0 ± 0.0
4.075SerTyr: 4.075 ± 1.976
0.0SerXaa: 0.0 ± 0.0
Thr
0.815ThrAla: 0.815 ± 0.801
1.63ThrCys: 1.63 ± 1.541
2.445ThrAsp: 2.445 ± 0.97
3.26ThrGlu: 3.26 ± 0.771
0.815ThrPhe: 0.815 ± 0.569
1.63ThrGly: 1.63 ± 0.974
0.0ThrHis: 0.0 ± 0.0
1.63ThrIle: 1.63 ± 1.139
4.075ThrLys: 4.075 ± 1.422
5.705ThrLeu: 5.705 ± 1.58
1.63ThrMet: 1.63 ± 0.614
5.705ThrAsn: 5.705 ± 1.094
4.89ThrPro: 4.89 ± 1.089
2.445ThrGln: 2.445 ± 0.789
4.89ThrArg: 4.89 ± 1.663
5.705ThrSer: 5.705 ± 1.485
3.26ThrThr: 3.26 ± 2.095
4.075ThrVal: 4.075 ± 1.422
1.63ThrTrp: 1.63 ± 1.093
2.445ThrTyr: 2.445 ± 0.699
0.0ThrXaa: 0.0 ± 0.0
Val
4.89ValAla: 4.89 ± 2.08
0.0ValCys: 0.0 ± 0.0
4.075ValAsp: 4.075 ± 2.034
1.63ValGlu: 1.63 ± 0.614
1.63ValPhe: 1.63 ± 0.737
3.26ValGly: 3.26 ± 0.835
0.815ValHis: 0.815 ± 0.801
3.26ValIle: 3.26 ± 1.22
1.63ValLys: 1.63 ± 0.614
6.52ValLeu: 6.52 ± 2.547
1.63ValMet: 1.63 ± 1.139
5.705ValAsn: 5.705 ± 1.188
1.63ValPro: 1.63 ± 0.974
1.63ValGln: 1.63 ± 1.093
4.89ValArg: 4.89 ± 1.842
3.26ValSer: 3.26 ± 1.834
1.63ValThr: 1.63 ± 1.139
3.26ValVal: 3.26 ± 0.745
0.815ValTrp: 0.815 ± 0.705
1.63ValTyr: 1.63 ± 1.126
0.0ValXaa: 0.0 ± 0.0
Trp
1.63TrpAla: 1.63 ± 1.047
0.0TrpCys: 0.0 ± 0.0
0.815TrpAsp: 0.815 ± 0.705
1.63TrpGlu: 1.63 ± 0.974
0.0TrpPhe: 0.0 ± 0.0
2.445TrpGly: 2.445 ± 1.554
0.0TrpHis: 0.0 ± 0.0
0.815TrpIle: 0.815 ± 0.705
4.89TrpLys: 4.89 ± 1.606
1.63TrpLeu: 1.63 ± 0.974
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.815TrpGln: 0.815 ± 0.771
0.0TrpArg: 0.0 ± 0.0
1.63TrpSer: 1.63 ± 1.139
0.0TrpThr: 0.0 ± 0.0
1.63TrpVal: 1.63 ± 1.411
0.815TrpTrp: 0.815 ± 0.705
0.815TrpTyr: 0.815 ± 0.569
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.26TyrAla: 3.26 ± 1.726
0.815TyrCys: 0.815 ± 0.569
0.815TyrAsp: 0.815 ± 0.705
4.075TyrGlu: 4.075 ± 1.976
0.0TyrPhe: 0.0 ± 0.0
3.26TyrGly: 3.26 ± 1.228
4.89TyrHis: 4.89 ± 1.398
1.63TyrIle: 1.63 ± 1.093
4.89TyrLys: 4.89 ± 1.658
1.63TyrLeu: 1.63 ± 1.093
1.63TyrMet: 1.63 ± 1.349
0.0TyrAsn: 0.0 ± 0.0
5.705TyrPro: 5.705 ± 2.83
2.445TyrGln: 2.445 ± 1.323
0.815TyrArg: 0.815 ± 0.705
1.63TyrSer: 1.63 ± 1.139
1.63TyrThr: 1.63 ± 1.411
2.445TyrVal: 2.445 ± 0.699
0.815TyrTrp: 0.815 ± 0.569
4.075TyrTyr: 4.075 ± 2.368
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.815XaaLys: 0.815 ± 0.771
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1228 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski