Amino acid dipepetide frequency for Infectious spleen and kidney necrosis virus (ISKNV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.164AlaAla: 9.164 ± 0.712
2.119AlaCys: 2.119 ± 0.247
4.503AlaAsp: 4.503 ± 0.37
3.549AlaGlu: 3.549 ± 0.386
3.205AlaPhe: 3.205 ± 0.331
3.973AlaGly: 3.973 ± 0.43
3.443AlaHis: 3.443 ± 0.423
3.576AlaIle: 3.576 ± 0.286
2.543AlaLys: 2.543 ± 0.263
7.628AlaLeu: 7.628 ± 0.604
3.655AlaMet: 3.655 ± 0.345
2.966AlaAsn: 2.966 ± 0.264
4.609AlaPro: 4.609 ± 0.401
3.629AlaGln: 3.629 ± 0.368
5.668AlaArg: 5.668 ± 0.427
4.926AlaSer: 4.926 ± 0.409
6.622AlaThr: 6.622 ± 0.459
7.787AlaVal: 7.787 ± 0.519
0.98AlaTrp: 0.98 ± 0.181
3.072AlaTyr: 3.072 ± 0.278
0.0AlaXaa: 0.0 ± 0.0
Cys
2.914CysAla: 2.914 ± 0.374
0.98CysCys: 0.98 ± 0.199
2.145CysAsp: 2.145 ± 0.257
1.51CysGlu: 1.51 ± 0.241
0.742CysPhe: 0.742 ± 0.141
2.49CysGly: 2.49 ± 0.308
1.059CysHis: 1.059 ± 0.176
1.086CysIle: 1.086 ± 0.137
1.192CysLys: 1.192 ± 0.21
2.225CysLeu: 2.225 ± 0.277
1.271CysMet: 1.271 ± 0.23
1.245CysAsn: 1.245 ± 0.246
1.801CysPro: 1.801 ± 0.398
0.874CysGln: 0.874 ± 0.166
1.96CysArg: 1.96 ± 0.24
2.172CysSer: 2.172 ± 0.241
2.198CysThr: 2.198 ± 0.303
3.284CysVal: 3.284 ± 0.358
0.291CysTrp: 0.291 ± 0.084
0.927CysTyr: 0.927 ± 0.133
0.0CysXaa: 0.0 ± 0.0
Asp
5.297AspAla: 5.297 ± 0.523
1.536AspCys: 1.536 ± 0.247
4.079AspAsp: 4.079 ± 0.413
2.119AspGlu: 2.119 ± 0.265
1.483AspPhe: 1.483 ± 0.23
3.894AspGly: 3.894 ± 0.402
1.616AspHis: 1.616 ± 0.216
3.814AspIle: 3.814 ± 0.407
2.172AspLys: 2.172 ± 0.231
3.364AspLeu: 3.364 ± 0.353
3.205AspMet: 3.205 ± 0.281
2.516AspAsn: 2.516 ± 0.281
2.702AspPro: 2.702 ± 0.301
1.324AspGln: 1.324 ± 0.188
3.178AspArg: 3.178 ± 0.3
3.311AspSer: 3.311 ± 0.26
4.9AspThr: 4.9 ± 0.449
5.695AspVal: 5.695 ± 0.435
0.53AspTrp: 0.53 ± 0.128
2.172AspTyr: 2.172 ± 0.275
0.0AspXaa: 0.0 ± 0.0
Glu
3.258GluAla: 3.258 ± 0.314
1.669GluCys: 1.669 ± 0.251
2.516GluAsp: 2.516 ± 0.323
1.669GluGlu: 1.669 ± 0.284
0.742GluPhe: 0.742 ± 0.143
2.013GluGly: 2.013 ± 0.264
1.854GluHis: 1.854 ± 0.228
1.324GluIle: 1.324 ± 0.164
1.006GluLys: 1.006 ± 0.176
2.834GluLeu: 2.834 ± 0.299
1.192GluMet: 1.192 ± 0.169
1.139GluAsn: 1.139 ± 0.195
1.986GluPro: 1.986 ± 0.259
2.013GluGln: 2.013 ± 0.231
2.993GluArg: 2.993 ± 0.313
1.748GluSer: 1.748 ± 0.271
2.41GluThr: 2.41 ± 0.256
2.331GluVal: 2.331 ± 0.277
0.742GluTrp: 0.742 ± 0.141
2.092GluTyr: 2.092 ± 0.248
0.0GluXaa: 0.0 ± 0.0
Phe
2.543PheAla: 2.543 ± 0.267
0.662PheCys: 0.662 ± 0.124
2.41PheAsp: 2.41 ± 0.302
1.775PheGlu: 1.775 ± 0.207
1.139PhePhe: 1.139 ± 0.161
1.324PheGly: 1.324 ± 0.179
0.821PheHis: 0.821 ± 0.116
1.404PheIle: 1.404 ± 0.161
1.51PheLys: 1.51 ± 0.204
1.483PheLeu: 1.483 ± 0.217
1.43PheMet: 1.43 ± 0.198
1.377PheAsn: 1.377 ± 0.169
1.165PhePro: 1.165 ± 0.161
0.98PheGln: 0.98 ± 0.159
1.589PheArg: 1.589 ± 0.209
1.722PheSer: 1.722 ± 0.212
2.225PheThr: 2.225 ± 0.263
2.861PheVal: 2.861 ± 0.323
0.344PheTrp: 0.344 ± 0.099
0.662PheTyr: 0.662 ± 0.104
0.0PheXaa: 0.0 ± 0.0
Gly
4.741GlyAla: 4.741 ± 0.462
1.377GlyCys: 1.377 ± 0.193
2.966GlyAsp: 2.966 ± 0.275
1.695GlyGlu: 1.695 ± 0.252
1.775GlyPhe: 1.775 ± 0.233
3.946GlyGly: 3.946 ± 0.394
2.649GlyHis: 2.649 ± 0.291
2.198GlyIle: 2.198 ± 0.265
2.013GlyLys: 2.013 ± 0.245
4.238GlyLeu: 4.238 ± 0.637
2.384GlyMet: 2.384 ± 0.233
2.092GlyAsn: 2.092 ± 0.285
2.966GlyPro: 2.966 ± 0.313
2.066GlyGln: 2.066 ± 0.249
3.629GlyArg: 3.629 ± 0.32
3.099GlySer: 3.099 ± 0.364
4.291GlyThr: 4.291 ± 0.413
5.562GlyVal: 5.562 ± 0.401
0.45GlyTrp: 0.45 ± 0.12
2.463GlyTyr: 2.463 ± 0.275
0.0GlyXaa: 0.0 ± 0.0
His
2.887HisAla: 2.887 ± 0.273
1.245HisCys: 1.245 ± 0.176
2.145HisAsp: 2.145 ± 0.329
1.298HisGlu: 1.298 ± 0.212
0.768HisPhe: 0.768 ± 0.139
2.357HisGly: 2.357 ± 0.252
1.298HisHis: 1.298 ± 0.282
2.41HisIle: 2.41 ± 0.279
1.112HisLys: 1.112 ± 0.191
2.834HisLeu: 2.834 ± 0.263
1.642HisMet: 1.642 ± 0.214
1.907HisAsn: 1.907 ± 0.231
1.218HisPro: 1.218 ± 0.198
1.033HisGln: 1.033 ± 0.173
2.914HisArg: 2.914 ± 0.404
2.145HisSer: 2.145 ± 0.243
3.019HisThr: 3.019 ± 0.347
4.026HisVal: 4.026 ± 0.423
0.344HisTrp: 0.344 ± 0.096
1.112HisTyr: 1.112 ± 0.189
0.0HisXaa: 0.0 ± 0.0
Ile
3.761IleAla: 3.761 ± 0.272
1.245IleCys: 1.245 ± 0.182
2.861IleAsp: 2.861 ± 0.272
1.854IleGlu: 1.854 ± 0.244
1.112IlePhe: 1.112 ± 0.163
2.331IleGly: 2.331 ± 0.243
1.536IleHis: 1.536 ± 0.25
2.49IleIle: 2.49 ± 0.3
2.039IleLys: 2.039 ± 0.263
2.861IleLeu: 2.861 ± 0.295
1.986IleMet: 1.986 ± 0.206
1.775IleAsn: 1.775 ± 0.216
2.251IlePro: 2.251 ± 0.26
1.722IleGln: 1.722 ± 0.244
2.516IleArg: 2.516 ± 0.238
2.861IleSer: 2.861 ± 0.243
2.675IleThr: 2.675 ± 0.273
3.735IleVal: 3.735 ± 0.326
0.344IleTrp: 0.344 ± 0.089
1.324IleTyr: 1.324 ± 0.22
0.0IleXaa: 0.0 ± 0.0
Lys
2.516LysAla: 2.516 ± 0.312
1.086LysCys: 1.086 ± 0.177
1.96LysAsp: 1.96 ± 0.243
1.536LysGlu: 1.536 ± 0.219
0.795LysPhe: 0.795 ± 0.155
1.51LysGly: 1.51 ± 0.221
1.218LysHis: 1.218 ± 0.144
1.245LysIle: 1.245 ± 0.184
1.192LysLys: 1.192 ± 0.245
2.914LysLeu: 2.914 ± 0.285
1.324LysMet: 1.324 ± 0.16
0.98LysAsn: 0.98 ± 0.194
2.145LysPro: 2.145 ± 0.32
1.616LysGln: 1.616 ± 0.262
2.649LysArg: 2.649 ± 0.309
1.51LysSer: 1.51 ± 0.219
2.092LysThr: 2.092 ± 0.222
2.569LysVal: 2.569 ± 0.267
0.503LysTrp: 0.503 ± 0.101
1.377LysTyr: 1.377 ± 0.22
0.0LysXaa: 0.0 ± 0.0
Leu
7.151LeuAla: 7.151 ± 0.519
3.258LeuCys: 3.258 ± 0.323
4.476LeuAsp: 4.476 ± 0.317
3.258LeuGlu: 3.258 ± 0.271
2.755LeuPhe: 2.755 ± 0.2
3.735LeuGly: 3.735 ± 0.318
3.046LeuHis: 3.046 ± 0.252
2.993LeuIle: 2.993 ± 0.252
2.728LeuLys: 2.728 ± 0.266
8.264LeuLeu: 8.264 ± 0.464
3.046LeuMet: 3.046 ± 0.305
2.649LeuAsn: 2.649 ± 0.245
4.132LeuPro: 4.132 ± 0.254
3.549LeuGln: 3.549 ± 0.338
5.801LeuArg: 5.801 ± 0.469
5.165LeuSer: 5.165 ± 0.423
5.748LeuThr: 5.748 ± 0.708
5.006LeuVal: 5.006 ± 0.37
1.351LeuTrp: 1.351 ± 0.21
3.311LeuTyr: 3.311 ± 0.323
0.0LeuXaa: 0.0 ± 0.0
Met
4.079MetAla: 4.079 ± 0.376
1.828MetCys: 1.828 ± 0.244
2.357MetAsp: 2.357 ± 0.229
1.457MetGlu: 1.457 ± 0.197
1.298MetPhe: 1.298 ± 0.194
1.695MetGly: 1.695 ± 0.217
1.245MetHis: 1.245 ± 0.19
1.245MetIle: 1.245 ± 0.186
0.821MetLys: 0.821 ± 0.146
3.761MetLeu: 3.761 ± 0.332
1.139MetMet: 1.139 ± 0.181
0.98MetAsn: 0.98 ± 0.141
2.622MetPro: 2.622 ± 0.248
1.351MetGln: 1.351 ± 0.171
2.649MetArg: 2.649 ± 0.276
3.284MetSer: 3.284 ± 0.313
2.94MetThr: 2.94 ± 0.293
2.569MetVal: 2.569 ± 0.212
0.477MetTrp: 0.477 ± 0.104
2.172MetTyr: 2.172 ± 0.241
0.0MetXaa: 0.0 ± 0.0
Asn
2.834AsnAla: 2.834 ± 0.294
0.768AsnCys: 0.768 ± 0.149
1.483AsnAsp: 1.483 ± 0.211
1.086AsnGlu: 1.086 ± 0.17
0.98AsnPhe: 0.98 ± 0.233
2.49AsnGly: 2.49 ± 0.296
0.768AsnHis: 0.768 ± 0.154
2.463AsnIle: 2.463 ± 0.229
1.589AsnLys: 1.589 ± 0.221
2.41AsnLeu: 2.41 ± 0.26
1.192AsnMet: 1.192 ± 0.159
1.801AsnAsn: 1.801 ± 0.209
1.96AsnPro: 1.96 ± 0.244
0.927AsnGln: 0.927 ± 0.116
1.934AsnArg: 1.934 ± 0.237
2.225AsnSer: 2.225 ± 0.252
3.549AsnThr: 3.549 ± 0.291
3.39AsnVal: 3.39 ± 0.273
0.212AsnTrp: 0.212 ± 0.066
1.165AsnTyr: 1.165 ± 0.181
0.0AsnXaa: 0.0 ± 0.0
Pro
4.132ProAla: 4.132 ± 0.326
1.934ProCys: 1.934 ± 0.344
3.867ProAsp: 3.867 ± 0.551
2.437ProGlu: 2.437 ± 0.405
1.589ProPhe: 1.589 ± 0.213
3.205ProGly: 3.205 ± 0.307
1.934ProHis: 1.934 ± 0.261
2.119ProIle: 2.119 ± 0.25
1.43ProLys: 1.43 ± 0.226
4.582ProLeu: 4.582 ± 0.439
1.775ProMet: 1.775 ± 0.203
1.775ProAsn: 1.775 ± 0.221
3.92ProPro: 3.92 ± 0.646
2.437ProGln: 2.437 ± 0.287
2.543ProArg: 2.543 ± 0.325
3.205ProSer: 3.205 ± 0.242
3.258ProThr: 3.258 ± 0.358
5.615ProVal: 5.615 ± 0.703
0.583ProTrp: 0.583 ± 0.128
2.145ProTyr: 2.145 ± 0.255
0.0ProXaa: 0.0 ± 0.0
Gln
3.099GlnAla: 3.099 ± 0.341
1.748GlnCys: 1.748 ± 0.359
2.225GlnAsp: 2.225 ± 0.345
1.324GlnGlu: 1.324 ± 0.217
1.271GlnPhe: 1.271 ± 0.181
1.748GlnGly: 1.748 ± 0.215
1.986GlnHis: 1.986 ± 0.244
1.033GlnIle: 1.033 ± 0.182
0.821GlnLys: 0.821 ± 0.148
3.841GlnLeu: 3.841 ± 0.401
1.722GlnMet: 1.722 ± 0.19
0.609GlnAsn: 0.609 ± 0.108
1.881GlnPro: 1.881 ± 0.265
2.384GlnGln: 2.384 ± 0.392
2.649GlnArg: 2.649 ± 0.288
2.225GlnSer: 2.225 ± 0.209
1.907GlnThr: 1.907 ± 0.256
2.622GlnVal: 2.622 ± 0.272
0.556GlnTrp: 0.556 ± 0.135
1.881GlnTyr: 1.881 ± 0.217
0.0GlnXaa: 0.0 ± 0.0
Arg
5.748ArgAla: 5.748 ± 0.561
1.986ArgCys: 1.986 ± 0.248
3.549ArgAsp: 3.549 ± 0.366
2.463ArgGlu: 2.463 ± 0.274
1.748ArgPhe: 1.748 ± 0.253
3.046ArgGly: 3.046 ± 0.28
3.072ArgHis: 3.072 ± 0.327
2.596ArgIle: 2.596 ± 0.266
1.536ArgLys: 1.536 ± 0.219
5.403ArgLeu: 5.403 ± 0.41
1.986ArgMet: 1.986 ± 0.21
2.278ArgAsn: 2.278 ± 0.269
4.715ArgPro: 4.715 ± 0.846
2.463ArgGln: 2.463 ± 0.24
5.403ArgArg: 5.403 ± 0.568
3.125ArgSer: 3.125 ± 0.381
4.741ArgThr: 4.741 ± 0.62
6.41ArgVal: 6.41 ± 0.719
0.98ArgTrp: 0.98 ± 0.141
2.463ArgTyr: 2.463 ± 0.235
0.0ArgXaa: 0.0 ± 0.0
Ser
5.006SerAla: 5.006 ± 0.37
2.092SerCys: 2.092 ± 0.308
3.258SerAsp: 3.258 ± 0.231
1.695SerGlu: 1.695 ± 0.228
1.483SerPhe: 1.483 ± 0.188
4.423SerGly: 4.423 ± 0.393
2.119SerHis: 2.119 ± 0.266
2.569SerIle: 2.569 ± 0.225
2.013SerLys: 2.013 ± 0.289
5.271SerLeu: 5.271 ± 0.392
2.596SerMet: 2.596 ± 0.27
2.066SerAsn: 2.066 ± 0.251
3.072SerPro: 3.072 ± 0.336
1.801SerGln: 1.801 ± 0.202
3.417SerArg: 3.417 ± 0.331
4.874SerSer: 4.874 ± 0.54
4.079SerThr: 4.079 ± 0.41
5.456SerVal: 5.456 ± 0.439
0.477SerTrp: 0.477 ± 0.097
1.907SerTyr: 1.907 ± 0.189
0.0SerXaa: 0.0 ± 0.0
Thr
6.277ThrAla: 6.277 ± 0.456
2.145ThrCys: 2.145 ± 0.314
3.946ThrAsp: 3.946 ± 0.342
2.728ThrGlu: 2.728 ± 0.266
2.145ThrPhe: 2.145 ± 0.245
5.297ThrGly: 5.297 ± 0.733
2.94ThrHis: 2.94 ± 0.345
2.702ThrIle: 2.702 ± 0.281
2.251ThrLys: 2.251 ± 0.22
6.701ThrLeu: 6.701 ± 0.459
3.152ThrMet: 3.152 ± 0.287
1.934ThrAsn: 1.934 ± 0.25
4.317ThrPro: 4.317 ± 0.347
2.622ThrGln: 2.622 ± 0.299
4.211ThrArg: 4.211 ± 0.693
3.946ThrSer: 3.946 ± 0.336
5.403ThrThr: 5.403 ± 0.933
6.489ThrVal: 6.489 ± 0.511
0.954ThrTrp: 0.954 ± 0.155
2.41ThrTyr: 2.41 ± 0.257
0.0ThrXaa: 0.0 ± 0.0
Val
7.681ValAla: 7.681 ± 0.481
3.099ValCys: 3.099 ± 0.359
5.006ValAsp: 5.006 ± 0.388
2.278ValGlu: 2.278 ± 0.263
2.887ValPhe: 2.887 ± 0.25
4.158ValGly: 4.158 ± 0.308
3.814ValHis: 3.814 ± 0.319
3.337ValIle: 3.337 ± 0.264
2.596ValLys: 2.596 ± 0.286
7.761ValLeu: 7.761 ± 0.555
3.125ValMet: 3.125 ± 0.306
2.463ValAsn: 2.463 ± 0.331
5.297ValPro: 5.297 ± 0.41
3.099ValGln: 3.099 ± 0.292
7.098ValArg: 7.098 ± 1.328
5.377ValSer: 5.377 ± 0.4
6.118ValThr: 6.118 ± 0.426
7.469ValVal: 7.469 ± 0.913
0.927ValTrp: 0.927 ± 0.141
3.708ValTyr: 3.708 ± 0.395
0.0ValXaa: 0.0 ± 0.0
Trp
1.006TrpAla: 1.006 ± 0.172
0.556TrpCys: 0.556 ± 0.118
0.477TrpAsp: 0.477 ± 0.123
0.371TrpGlu: 0.371 ± 0.104
0.371TrpPhe: 0.371 ± 0.105
0.636TrpGly: 0.636 ± 0.144
0.424TrpHis: 0.424 ± 0.114
0.397TrpIle: 0.397 ± 0.098
0.424TrpLys: 0.424 ± 0.1
1.033TrpLeu: 1.033 ± 0.162
0.318TrpMet: 0.318 ± 0.111
0.477TrpAsn: 0.477 ± 0.102
0.715TrpPro: 0.715 ± 0.149
0.742TrpGln: 0.742 ± 0.147
0.821TrpArg: 0.821 ± 0.135
0.636TrpSer: 0.636 ± 0.149
0.742TrpThr: 0.742 ± 0.141
0.689TrpVal: 0.689 ± 0.127
0.185TrpTrp: 0.185 ± 0.085
0.556TrpTyr: 0.556 ± 0.118
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.523TyrAla: 3.523 ± 0.279
1.033TyrCys: 1.033 ± 0.127
2.675TyrAsp: 2.675 ± 0.27
1.43TyrGlu: 1.43 ± 0.161
1.139TyrPhe: 1.139 ± 0.188
2.331TyrGly: 2.331 ± 0.291
0.874TyrHis: 0.874 ± 0.186
2.278TyrIle: 2.278 ± 0.22
1.748TyrLys: 1.748 ± 0.229
2.039TyrLeu: 2.039 ± 0.185
1.801TyrMet: 1.801 ± 0.211
2.198TyrAsn: 2.198 ± 0.212
1.006TyrPro: 1.006 ± 0.16
0.901TyrGln: 0.901 ± 0.15
2.092TyrArg: 2.092 ± 0.272
2.119TyrSer: 2.119 ± 0.221
3.655TyrThr: 3.655 ± 0.27
3.735TyrVal: 3.735 ± 0.318
0.344TyrTrp: 0.344 ± 0.076
1.43TyrTyr: 1.43 ± 0.207
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 132 proteins (37756 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski