Amino acid dipepetide frequency for Streptomyces carminius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.281AlaAla: 23.281 ± 0.208
1.038AlaCys: 1.038 ± 0.027
8.509AlaAsp: 8.509 ± 0.084
9.745AlaGlu: 9.745 ± 0.111
3.217AlaPhe: 3.217 ± 0.043
14.945AlaGly: 14.945 ± 0.117
2.812AlaHis: 2.812 ± 0.041
2.682AlaIle: 2.682 ± 0.042
2.143AlaLys: 2.143 ± 0.049
14.305AlaLeu: 14.305 ± 0.124
2.253AlaMet: 2.253 ± 0.036
1.693AlaAsn: 1.693 ± 0.036
7.693AlaPro: 7.693 ± 0.091
3.104AlaGln: 3.104 ± 0.042
11.741AlaArg: 11.741 ± 0.097
5.048AlaSer: 5.048 ± 0.052
6.22AlaThr: 6.22 ± 0.065
13.201AlaVal: 13.201 ± 0.107
1.805AlaTrp: 1.805 ± 0.028
2.585AlaTyr: 2.585 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.192CysAla: 1.192 ± 0.028
0.1CysCys: 0.1 ± 0.009
0.497CysAsp: 0.497 ± 0.016
0.478CysGlu: 0.478 ± 0.018
0.21CysPhe: 0.21 ± 0.012
1.024CysGly: 1.024 ± 0.026
0.22CysHis: 0.22 ± 0.011
0.129CysIle: 0.129 ± 0.011
0.095CysLys: 0.095 ± 0.008
0.778CysLeu: 0.778 ± 0.021
0.113CysMet: 0.113 ± 0.008
0.114CysAsn: 0.114 ± 0.008
0.538CysPro: 0.538 ± 0.02
0.154CysGln: 0.154 ± 0.009
0.719CysArg: 0.719 ± 0.024
0.404CysSer: 0.404 ± 0.015
0.48CysThr: 0.48 ± 0.015
0.685CysVal: 0.685 ± 0.021
0.142CysTrp: 0.142 ± 0.008
0.145CysTyr: 0.145 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
7.256AspAla: 7.256 ± 0.069
0.45AspCys: 0.45 ± 0.018
3.291AspAsp: 3.291 ± 0.052
3.895AspGlu: 3.895 ± 0.046
1.545AspPhe: 1.545 ± 0.031
7.157AspGly: 7.157 ± 0.075
1.37AspHis: 1.37 ± 0.028
1.701AspIle: 1.701 ± 0.031
0.926AspLys: 0.926 ± 0.026
5.793AspLeu: 5.793 ± 0.065
0.772AspMet: 0.772 ± 0.02
0.883AspAsn: 0.883 ± 0.023
4.716AspPro: 4.716 ± 0.054
1.255AspGln: 1.255 ± 0.029
5.454AspArg: 5.454 ± 0.065
2.481AspSer: 2.481 ± 0.042
3.4AspThr: 3.4 ± 0.051
4.185AspVal: 4.185 ± 0.045
0.999AspTrp: 0.999 ± 0.025
1.077AspTyr: 1.077 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
7.656GluAla: 7.656 ± 0.095
0.425GluCys: 0.425 ± 0.016
3.118GluAsp: 3.118 ± 0.044
4.387GluGlu: 4.387 ± 0.066
1.465GluPhe: 1.465 ± 0.026
4.644GluGly: 4.644 ± 0.051
1.678GluHis: 1.678 ± 0.039
2.207GluIle: 2.207 ± 0.035
1.488GluLys: 1.488 ± 0.033
7.433GluLeu: 7.433 ± 0.073
0.886GluMet: 0.886 ± 0.021
1.095GluAsn: 1.095 ± 0.025
3.929GluPro: 3.929 ± 0.053
2.145GluGln: 2.145 ± 0.042
6.565GluArg: 6.565 ± 0.065
2.57GluSer: 2.57 ± 0.046
3.203GluThr: 3.203 ± 0.055
4.864GluVal: 4.864 ± 0.046
0.8GluTrp: 0.8 ± 0.022
1.256GluTyr: 1.256 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
3.392PheAla: 3.392 ± 0.047
0.262PheCys: 0.262 ± 0.011
1.829PheAsp: 1.829 ± 0.037
1.386PheGlu: 1.386 ± 0.028
0.788PhePhe: 0.788 ± 0.025
2.875PheGly: 2.875 ± 0.041
0.618PheHis: 0.618 ± 0.02
0.548PheIle: 0.548 ± 0.017
0.382PheLys: 0.382 ± 0.014
2.515PheLeu: 2.515 ± 0.046
0.35PheMet: 0.35 ± 0.013
0.476PheAsn: 0.476 ± 0.017
1.397PhePro: 1.397 ± 0.03
0.587PheGln: 0.587 ± 0.015
1.899PheArg: 1.899 ± 0.036
1.259PheSer: 1.259 ± 0.026
1.975PheThr: 1.975 ± 0.036
1.98PheVal: 1.98 ± 0.035
0.369PheTrp: 0.369 ± 0.014
0.474PheTyr: 0.474 ± 0.016
0.0PheXaa: 0.0 ± 0.0
Gly
11.775GlyAla: 11.775 ± 0.107
0.887GlyCys: 0.887 ± 0.025
5.621GlyAsp: 5.621 ± 0.06
6.358GlyGlu: 6.358 ± 0.065
2.724GlyPhe: 2.724 ± 0.045
10.668GlyGly: 10.668 ± 0.116
2.498GlyHis: 2.498 ± 0.039
3.073GlyIle: 3.073 ± 0.048
2.091GlyLys: 2.091 ± 0.04
9.332GlyLeu: 9.332 ± 0.089
2.022GlyMet: 2.022 ± 0.036
1.729GlyAsn: 1.729 ± 0.038
6.355GlyPro: 6.355 ± 0.069
2.573GlyGln: 2.573 ± 0.04
9.468GlyArg: 9.468 ± 0.085
5.112GlySer: 5.112 ± 0.064
7.264GlyThr: 7.264 ± 0.077
7.395GlyVal: 7.395 ± 0.072
1.69GlyTrp: 1.69 ± 0.029
2.173GlyTyr: 2.173 ± 0.035
0.0GlyXaa: 0.0 ± 0.0
His
2.479HisAla: 2.479 ± 0.04
0.231HisCys: 0.231 ± 0.011
1.31HisAsp: 1.31 ± 0.031
1.179HisGlu: 1.179 ± 0.024
0.619HisPhe: 0.619 ± 0.019
2.535HisGly: 2.535 ± 0.035
0.735HisHis: 0.735 ± 0.022
0.596HisIle: 0.596 ± 0.018
0.312HisLys: 0.312 ± 0.013
2.543HisLeu: 2.543 ± 0.038
0.294HisMet: 0.294 ± 0.013
0.374HisAsn: 0.374 ± 0.014
1.878HisPro: 1.878 ± 0.033
0.614HisGln: 0.614 ± 0.018
2.517HisArg: 2.517 ± 0.039
1.046HisSer: 1.046 ± 0.025
1.4HisThr: 1.4 ± 0.026
1.507HisVal: 1.507 ± 0.032
0.377HisTrp: 0.377 ± 0.017
0.485HisTyr: 0.485 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
4.038IleAla: 4.038 ± 0.054
0.246IleCys: 0.246 ± 0.011
1.916IleAsp: 1.916 ± 0.029
1.758IleGlu: 1.758 ± 0.036
0.553IlePhe: 0.553 ± 0.017
3.012IleGly: 3.012 ± 0.039
0.548IleHis: 0.548 ± 0.017
0.715IleIle: 0.715 ± 0.026
0.513IleLys: 0.513 ± 0.019
2.041IleLeu: 2.041 ± 0.036
0.39IleMet: 0.39 ± 0.015
0.537IleAsn: 0.537 ± 0.02
1.545IlePro: 1.545 ± 0.028
0.565IleGln: 0.565 ± 0.017
2.169IleArg: 2.169 ± 0.035
1.383IleSer: 1.383 ± 0.029
1.976IleThr: 1.976 ± 0.035
2.241IleVal: 2.241 ± 0.042
0.298IleTrp: 0.298 ± 0.012
0.418IleTyr: 0.418 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
2.27LysAla: 2.27 ± 0.043
0.104LysCys: 0.104 ± 0.008
1.033LysAsp: 1.033 ± 0.026
1.08LysGlu: 1.08 ± 0.027
0.372LysPhe: 0.372 ± 0.014
1.492LysGly: 1.492 ± 0.035
0.358LysHis: 0.358 ± 0.014
0.67LysIle: 0.67 ± 0.023
0.675LysLys: 0.675 ± 0.028
1.642LysLeu: 1.642 ± 0.033
0.291LysMet: 0.291 ± 0.012
0.426LysAsn: 0.426 ± 0.015
1.086LysPro: 1.086 ± 0.032
0.517LysGln: 0.517 ± 0.018
1.332LysArg: 1.332 ± 0.032
0.884LysSer: 0.884 ± 0.026
1.095LysThr: 1.095 ± 0.027
1.535LysVal: 1.535 ± 0.037
0.228LysTrp: 0.228 ± 0.012
0.373LysTyr: 0.373 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
15.558LeuAla: 15.558 ± 0.147
0.89LeuCys: 0.89 ± 0.024
6.463LeuAsp: 6.463 ± 0.066
5.089LeuGlu: 5.089 ± 0.057
2.399LeuPhe: 2.399 ± 0.039
9.137LeuGly: 9.137 ± 0.09
2.215LeuHis: 2.215 ± 0.039
2.637LeuIle: 2.637 ± 0.045
1.584LeuLys: 1.584 ± 0.033
11.736LeuLeu: 11.736 ± 0.132
1.416LeuMet: 1.416 ± 0.027
1.498LeuAsn: 1.498 ± 0.032
6.781LeuPro: 6.781 ± 0.061
1.852LeuGln: 1.852 ± 0.031
9.797LeuArg: 9.797 ± 0.086
4.963LeuSer: 4.963 ± 0.046
6.737LeuThr: 6.737 ± 0.066
8.779LeuVal: 8.779 ± 0.094
1.281LeuTrp: 1.281 ± 0.033
1.805LeuTyr: 1.805 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
2.166MetAla: 2.166 ± 0.043
0.138MetCys: 0.138 ± 0.008
0.812MetAsp: 0.812 ± 0.02
0.75MetGlu: 0.75 ± 0.021
0.4MetPhe: 0.4 ± 0.014
1.224MetGly: 1.224 ± 0.027
0.308MetHis: 0.308 ± 0.014
0.524MetIle: 0.524 ± 0.019
0.324MetLys: 0.324 ± 0.015
1.521MetLeu: 1.521 ± 0.027
0.256MetMet: 0.256 ± 0.011
0.365MetAsn: 0.365 ± 0.015
1.067MetPro: 1.067 ± 0.025
0.355MetGln: 0.355 ± 0.014
1.467MetArg: 1.467 ± 0.026
1.187MetSer: 1.187 ± 0.026
1.428MetThr: 1.428 ± 0.029
1.152MetVal: 1.152 ± 0.027
0.203MetTrp: 0.203 ± 0.011
0.3MetTyr: 0.3 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
1.977AsnAla: 1.977 ± 0.03
0.159AsnCys: 0.159 ± 0.008
0.873AsnAsp: 0.873 ± 0.019
0.815AsnGlu: 0.815 ± 0.021
0.433AsnPhe: 0.433 ± 0.016
1.709AsnGly: 1.709 ± 0.038
0.366AsnHis: 0.366 ± 0.014
0.56AsnIle: 0.56 ± 0.02
0.331AsnLys: 0.331 ± 0.015
1.487AsnLeu: 1.487 ± 0.032
0.262AsnMet: 0.262 ± 0.014
0.376AsnAsn: 0.376 ± 0.015
1.258AsnPro: 1.258 ± 0.031
0.424AsnGln: 0.424 ± 0.015
1.314AsnArg: 1.314 ± 0.031
0.809AsnSer: 0.809 ± 0.024
1.037AsnThr: 1.037 ± 0.026
1.226AsnVal: 1.226 ± 0.027
0.27AsnTrp: 0.27 ± 0.013
0.343AsnTyr: 0.343 ± 0.014
0.0AsnXaa: 0.0 ± 0.0
Pro
9.901ProAla: 9.901 ± 0.095
0.398ProCys: 0.398 ± 0.015
4.718ProAsp: 4.718 ± 0.053
4.876ProGlu: 4.876 ± 0.063
1.438ProPhe: 1.438 ± 0.028
8.38ProGly: 8.38 ± 0.084
1.454ProHis: 1.454 ± 0.032
0.981ProIle: 0.981 ± 0.026
0.892ProLys: 0.892 ± 0.025
5.408ProLeu: 5.408 ± 0.059
0.909ProMet: 0.909 ± 0.023
0.799ProAsn: 0.799 ± 0.023
4.501ProPro: 4.501 ± 0.074
1.514ProGln: 1.514 ± 0.044
4.764ProArg: 4.764 ± 0.057
3.016ProSer: 3.016 ± 0.049
2.807ProThr: 2.807 ± 0.047
5.938ProVal: 5.938 ± 0.06
0.933ProTrp: 0.933 ± 0.021
1.406ProTyr: 1.406 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.278GlnAla: 3.278 ± 0.051
0.168GlnCys: 0.168 ± 0.009
1.203GlnAsp: 1.203 ± 0.029
1.467GlnGlu: 1.467 ± 0.033
0.559GlnPhe: 0.559 ± 0.017
1.97GlnGly: 1.97 ± 0.034
0.564GlnHis: 0.564 ± 0.017
0.867GlnIle: 0.867 ± 0.021
0.503GlnLys: 0.503 ± 0.017
2.657GlnLeu: 2.657 ± 0.039
0.363GlnMet: 0.363 ± 0.015
0.429GlnAsn: 0.429 ± 0.015
1.555GlnPro: 1.555 ± 0.041
1.07GlnGln: 1.07 ± 0.041
2.238GlnArg: 2.238 ± 0.036
1.069GlnSer: 1.069 ± 0.027
1.19GlnThr: 1.19 ± 0.027
2.114GlnVal: 2.114 ± 0.032
0.418GlnTrp: 0.418 ± 0.016
0.527GlnTyr: 0.527 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
11.343ArgAla: 11.343 ± 0.097
0.707ArgCys: 0.707 ± 0.022
4.624ArgAsp: 4.624 ± 0.048
5.787ArgGlu: 5.787 ± 0.076
2.423ArgPhe: 2.423 ± 0.046
6.885ArgGly: 6.885 ± 0.06
2.424ArgHis: 2.424 ± 0.039
3.224ArgIle: 3.224 ± 0.047
1.587ArgLys: 1.587 ± 0.033
9.91ArgLeu: 9.91 ± 0.091
1.92ArgMet: 1.92 ± 0.032
1.418ArgAsn: 1.418 ± 0.032
5.951ArgPro: 5.951 ± 0.075
2.477ArgGln: 2.477 ± 0.042
9.693ArgArg: 9.693 ± 0.098
4.189ArgSer: 4.189 ± 0.054
6.075ArgThr: 6.075 ± 0.062
6.431ArgVal: 6.431 ± 0.071
1.55ArgTrp: 1.55 ± 0.031
1.938ArgTyr: 1.938 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.275SerAla: 6.275 ± 0.056
0.4SerCys: 0.4 ± 0.016
2.381SerAsp: 2.381 ± 0.038
2.304SerGlu: 2.304 ± 0.041
1.377SerPhe: 1.377 ± 0.03
5.987SerGly: 5.987 ± 0.07
0.943SerHis: 0.943 ± 0.022
1.076SerIle: 1.076 ± 0.025
0.739SerLys: 0.739 ± 0.024
4.368SerLeu: 4.368 ± 0.048
0.894SerMet: 0.894 ± 0.022
0.722SerAsn: 0.722 ± 0.02
3.271SerPro: 3.271 ± 0.051
1.022SerGln: 1.022 ± 0.027
3.81SerArg: 3.81 ± 0.051
2.466SerSer: 2.466 ± 0.049
2.603SerThr: 2.603 ± 0.042
3.928SerVal: 3.928 ± 0.043
0.819SerTrp: 0.819 ± 0.027
1.077SerTyr: 1.077 ± 0.024
0.0SerXaa: 0.0 ± 0.0
Thr
9.606ThrAla: 9.606 ± 0.088
0.422ThrCys: 0.422 ± 0.017
3.557ThrAsp: 3.557 ± 0.051
3.493ThrGlu: 3.493 ± 0.048
1.431ThrPhe: 1.431 ± 0.031
7.708ThrGly: 7.708 ± 0.071
1.13ThrHis: 1.13 ± 0.027
1.332ThrIle: 1.332 ± 0.03
0.862ThrLys: 0.862 ± 0.027
5.305ThrLeu: 5.305 ± 0.059
0.829ThrMet: 0.829 ± 0.023
0.844ThrAsn: 0.844 ± 0.026
3.779ThrPro: 3.779 ± 0.051
1.094ThrGln: 1.094 ± 0.025
4.04ThrArg: 4.04 ± 0.048
2.701ThrSer: 2.701 ± 0.045
3.668ThrThr: 3.668 ± 0.073
6.498ThrVal: 6.498 ± 0.07
0.837ThrTrp: 0.837 ± 0.027
1.182ThrTyr: 1.182 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
10.368ValAla: 10.368 ± 0.093
0.84ValCys: 0.84 ± 0.025
4.658ValAsp: 4.658 ± 0.055
4.848ValGlu: 4.848 ± 0.051
2.342ValPhe: 2.342 ± 0.041
6.193ValGly: 6.193 ± 0.071
2.028ValHis: 2.028 ± 0.034
2.45ValIle: 2.45 ± 0.044
1.395ValLys: 1.395 ± 0.032
10.056ValLeu: 10.056 ± 0.101
1.29ValMet: 1.29 ± 0.029
1.515ValAsn: 1.515 ± 0.03
5.922ValPro: 5.922 ± 0.063
1.789ValGln: 1.789 ± 0.036
8.123ValArg: 8.123 ± 0.069
4.128ValSer: 4.128 ± 0.053
5.518ValThr: 5.518 ± 0.067
7.822ValVal: 7.822 ± 0.094
1.15ValTrp: 1.15 ± 0.028
1.529ValTyr: 1.529 ± 0.026
0.0ValXaa: 0.0 ± 0.0
Trp
1.672TrpAla: 1.672 ± 0.033
0.17TrpCys: 0.17 ± 0.009
0.779TrpAsp: 0.779 ± 0.023
0.849TrpGlu: 0.849 ± 0.022
0.506TrpPhe: 0.506 ± 0.018
1.009TrpGly: 1.009 ± 0.026
0.37TrpHis: 0.37 ± 0.014
0.482TrpIle: 0.482 ± 0.015
0.313TrpLys: 0.313 ± 0.012
1.742TrpLeu: 1.742 ± 0.032
0.238TrpMet: 0.238 ± 0.012
0.384TrpAsn: 0.384 ± 0.016
0.8TrpPro: 0.8 ± 0.021
0.557TrpGln: 0.557 ± 0.019
1.457TrpArg: 1.457 ± 0.031
0.875TrpSer: 0.875 ± 0.024
1.04TrpThr: 1.04 ± 0.027
0.92TrpVal: 0.92 ± 0.025
0.355TrpTrp: 0.355 ± 0.016
0.34TrpTyr: 0.34 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.537TyrAla: 2.537 ± 0.039
0.185TyrCys: 0.185 ± 0.01
1.413TyrAsp: 1.413 ± 0.041
1.269TyrGlu: 1.269 ± 0.024
0.559TyrPhe: 0.559 ± 0.021
2.25TyrGly: 2.25 ± 0.035
0.393TyrHis: 0.393 ± 0.014
0.407TyrIle: 0.407 ± 0.018
0.307TyrLys: 0.307 ± 0.015
2.047TyrLeu: 2.047 ± 0.036
0.195TyrMet: 0.195 ± 0.01
0.355TyrAsn: 0.355 ± 0.015
1.012TyrPro: 1.012 ± 0.029
0.543TyrGln: 0.543 ± 0.021
1.989TyrArg: 1.989 ± 0.032
0.872TyrSer: 0.872 ± 0.025
1.2TyrThr: 1.2 ± 0.032
1.564TyrVal: 1.564 ± 0.032
0.336TyrTrp: 0.336 ± 0.015
0.386TyrTyr: 0.386 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5703 proteins (1860990 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski