Amino acid dipepetide frequency for Lumpfish ranavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.293AlaAla: 10.293 ± 0.849
1.842AlaCys: 1.842 ± 0.294
4.144AlaAsp: 4.144 ± 0.366
5.459AlaGlu: 5.459 ± 0.491
2.565AlaPhe: 2.565 ± 0.287
7.498AlaGly: 7.498 ± 0.848
1.776AlaHis: 1.776 ± 0.239
2.302AlaIle: 2.302 ± 0.231
4.144AlaLys: 4.144 ± 0.417
6.807AlaLeu: 6.807 ± 0.515
3.321AlaMet: 3.321 ± 0.306
1.842AlaAsn: 1.842 ± 0.253
4.407AlaPro: 4.407 ± 0.462
2.434AlaGln: 2.434 ± 0.398
4.736AlaArg: 4.736 ± 0.434
5.656AlaSer: 5.656 ± 0.543
3.979AlaThr: 3.979 ± 0.405
8.781AlaVal: 8.781 ± 0.559
1.348AlaTrp: 1.348 ± 0.256
2.532AlaTyr: 2.532 ± 0.318
0.0AlaXaa: 0.0 ± 0.0
Cys
1.809CysAla: 1.809 ± 0.249
0.559CysCys: 0.559 ± 0.148
1.348CysAsp: 1.348 ± 0.207
1.019CysGlu: 1.019 ± 0.187
0.592CysPhe: 0.592 ± 0.157
1.579CysGly: 1.579 ± 0.256
0.493CysHis: 0.493 ± 0.142
0.592CysIle: 0.592 ± 0.166
1.283CysLys: 1.283 ± 0.221
1.414CysLeu: 1.414 ± 0.26
0.559CysMet: 0.559 ± 0.145
0.428CysAsn: 0.428 ± 0.152
1.283CysPro: 1.283 ± 0.271
0.526CysGln: 0.526 ± 0.153
1.283CysArg: 1.283 ± 0.206
1.776CysSer: 1.776 ± 0.282
0.855CysThr: 0.855 ± 0.152
1.611CysVal: 1.611 ± 0.247
0.493CysTrp: 0.493 ± 0.122
0.625CysTyr: 0.625 ± 0.187
0.0CysXaa: 0.0 ± 0.0
Asp
5.295AspAla: 5.295 ± 0.562
1.447AspCys: 1.447 ± 0.235
3.453AspAsp: 3.453 ± 0.39
3.387AspGlu: 3.387 ± 0.387
1.907AspPhe: 1.907 ± 0.285
5.13AspGly: 5.13 ± 0.532
1.085AspHis: 1.085 ± 0.161
2.631AspIle: 2.631 ± 0.354
2.434AspLys: 2.434 ± 0.24
4.933AspLeu: 4.933 ± 0.474
1.842AspMet: 1.842 ± 0.224
1.809AspAsn: 1.809 ± 0.471
4.571AspPro: 4.571 ± 0.462
1.907AspGln: 1.907 ± 0.351
3.749AspArg: 3.749 ± 0.364
4.505AspSer: 4.505 ± 0.399
2.861AspThr: 2.861 ± 0.377
4.834AspVal: 4.834 ± 0.363
1.019AspTrp: 1.019 ± 0.225
2.434AspTyr: 2.434 ± 0.291
0.0AspXaa: 0.0 ± 0.0
Glu
5.492GluAla: 5.492 ± 0.409
1.25GluCys: 1.25 ± 0.233
3.881GluAsp: 3.881 ± 0.453
3.42GluGlu: 3.42 ± 0.437
1.809GluPhe: 1.809 ± 0.23
4.275GluGly: 4.275 ± 0.387
0.921GluHis: 0.921 ± 0.282
1.743GluIle: 1.743 ± 0.247
2.927GluLys: 2.927 ± 0.346
3.946GluLeu: 3.946 ± 0.367
2.335GluMet: 2.335 ± 0.309
1.315GluAsn: 1.315 ± 0.267
2.664GluPro: 2.664 ± 0.361
2.598GluGln: 2.598 ± 0.844
4.012GluArg: 4.012 ± 0.406
4.012GluSer: 4.012 ± 0.463
3.782GluThr: 3.782 ± 0.395
3.749GluVal: 3.749 ± 0.433
1.151GluTrp: 1.151 ± 0.189
2.203GluTyr: 2.203 ± 0.29
0.0GluXaa: 0.0 ± 0.0
Phe
2.795PheAla: 2.795 ± 0.399
0.691PheCys: 0.691 ± 0.154
1.48PheAsp: 1.48 ± 0.224
1.842PheGlu: 1.842 ± 0.231
1.052PhePhe: 1.052 ± 0.209
2.762PheGly: 2.762 ± 0.34
0.625PheHis: 0.625 ± 0.136
0.987PheIle: 0.987 ± 0.184
1.381PheLys: 1.381 ± 0.198
2.73PheLeu: 2.73 ± 0.256
0.921PheMet: 0.921 ± 0.198
1.217PheAsn: 1.217 ± 0.19
1.94PhePro: 1.94 ± 0.272
0.855PheGln: 0.855 ± 0.175
2.335PheArg: 2.335 ± 0.317
2.762PheSer: 2.762 ± 0.303
1.973PheThr: 1.973 ± 0.3
2.795PheVal: 2.795 ± 0.325
0.296PheTrp: 0.296 ± 0.088
1.217PheTyr: 1.217 ± 0.194
0.0PheXaa: 0.0 ± 0.0
Gly
6.15GlyAla: 6.15 ± 0.545
1.48GlyCys: 1.48 ± 0.282
4.999GlyAsp: 4.999 ± 0.506
4.078GlyGlu: 4.078 ± 0.422
2.795GlyPhe: 2.795 ± 0.345
6.413GlyGly: 6.413 ± 0.609
1.94GlyHis: 1.94 ± 0.301
2.138GlyIle: 2.138 ± 0.279
4.44GlyLys: 4.44 ± 0.507
5.722GlyLeu: 5.722 ± 0.484
2.17GlyMet: 2.17 ± 0.283
1.283GlyAsn: 1.283 ± 0.272
6.479GlyPro: 6.479 ± 2.042
1.907GlyGln: 1.907 ± 0.286
5.229GlyArg: 5.229 ± 0.692
5.854GlySer: 5.854 ± 0.42
4.637GlyThr: 4.637 ± 0.436
5.689GlyVal: 5.689 ± 0.483
1.447GlyTrp: 1.447 ± 0.212
2.795GlyTyr: 2.795 ± 0.277
0.0GlyXaa: 0.0 ± 0.0
His
1.644HisAla: 1.644 ± 0.217
0.296HisCys: 0.296 ± 0.089
1.151HisAsp: 1.151 ± 0.192
0.625HisGlu: 0.625 ± 0.147
0.559HisPhe: 0.559 ± 0.118
1.743HisGly: 1.743 ± 0.25
0.625HisHis: 0.625 ± 0.191
0.954HisIle: 0.954 ± 0.21
0.855HisLys: 0.855 ± 0.176
2.302HisLeu: 2.302 ± 0.294
0.723HisMet: 0.723 ± 0.138
0.658HisAsn: 0.658 ± 0.178
1.546HisPro: 1.546 ± 0.234
0.855HisGln: 0.855 ± 0.208
1.348HisArg: 1.348 ± 0.195
1.217HisSer: 1.217 ± 0.266
1.315HisThr: 1.315 ± 0.211
2.269HisVal: 2.269 ± 0.336
0.197HisTrp: 0.197 ± 0.067
0.723HisTyr: 0.723 ± 0.153
0.0HisXaa: 0.0 ± 0.0
Ile
2.466IleAla: 2.466 ± 0.354
0.559IleCys: 0.559 ± 0.13
2.006IleAsp: 2.006 ± 0.242
1.611IleGlu: 1.611 ± 0.242
1.019IlePhe: 1.019 ± 0.195
1.907IleGly: 1.907 ± 0.304
1.085IleHis: 1.085 ± 0.222
0.987IleIle: 0.987 ± 0.176
2.006IleLys: 2.006 ± 0.273
3.256IleLeu: 3.256 ± 0.313
1.019IleMet: 1.019 ± 0.197
1.019IleAsn: 1.019 ± 0.214
2.236IlePro: 2.236 ± 0.278
0.756IleGln: 0.756 ± 0.164
2.861IleArg: 2.861 ± 0.295
2.335IleSer: 2.335 ± 0.306
1.644IleThr: 1.644 ± 0.275
2.697IleVal: 2.697 ± 0.307
0.164IleTrp: 0.164 ± 0.071
0.789IleTyr: 0.789 ± 0.211
0.0IleXaa: 0.0 ± 0.0
Lys
4.801LysAla: 4.801 ± 0.509
0.888LysCys: 0.888 ± 0.192
2.894LysAsp: 2.894 ± 0.325
2.73LysGlu: 2.73 ± 0.345
1.25LysPhe: 1.25 ± 0.194
4.275LysGly: 4.275 ± 0.417
0.789LysHis: 0.789 ± 0.135
2.565LysIle: 2.565 ± 0.315
3.815LysLys: 3.815 ± 0.479
3.946LysLeu: 3.946 ± 0.444
1.611LysMet: 1.611 ± 0.236
1.579LysAsn: 1.579 ± 0.232
3.617LysPro: 3.617 ± 0.596
1.184LysGln: 1.184 ± 0.248
5.097LysArg: 5.097 ± 0.65
3.881LysSer: 3.881 ± 0.684
3.617LysThr: 3.617 ± 0.271
3.716LysVal: 3.716 ± 0.348
0.559LysTrp: 0.559 ± 0.134
1.776LysTyr: 1.776 ± 0.207
0.0LysXaa: 0.0 ± 0.0
Leu
6.15LeuAla: 6.15 ± 0.453
1.875LeuCys: 1.875 ± 0.35
5.295LeuAsp: 5.295 ± 0.461
5.624LeuGlu: 5.624 ± 0.523
2.828LeuPhe: 2.828 ± 0.309
5.229LeuGly: 5.229 ± 0.458
1.809LeuHis: 1.809 ± 0.307
2.401LeuIle: 2.401 ± 0.335
4.933LeuLys: 4.933 ± 0.427
6.479LeuLeu: 6.479 ± 0.674
2.368LeuMet: 2.368 ± 0.27
2.335LeuAsn: 2.335 ± 0.261
3.749LeuPro: 3.749 ± 0.487
1.48LeuGln: 1.48 ± 0.202
6.347LeuArg: 6.347 ± 0.566
5.624LeuSer: 5.624 ± 0.491
4.966LeuThr: 4.966 ± 0.447
6.676LeuVal: 6.676 ± 0.881
0.888LeuTrp: 0.888 ± 0.189
2.236LeuTyr: 2.236 ± 0.221
0.0LeuXaa: 0.0 ± 0.0
Met
3.486MetAla: 3.486 ± 0.397
0.855MetCys: 0.855 ± 0.196
2.269MetAsp: 2.269 ± 0.24
1.842MetGlu: 1.842 ± 0.286
1.283MetPhe: 1.283 ± 0.19
3.026MetGly: 3.026 ± 0.321
0.658MetHis: 0.658 ± 0.192
0.756MetIle: 0.756 ± 0.135
0.789MetLys: 0.789 ± 0.154
2.039MetLeu: 2.039 ± 0.282
0.855MetMet: 0.855 ± 0.196
0.395MetAsn: 0.395 ± 0.123
1.217MetPro: 1.217 ± 0.171
0.822MetGln: 0.822 ± 0.166
2.105MetArg: 2.105 ± 0.24
2.828MetSer: 2.828 ± 0.298
2.138MetThr: 2.138 ± 0.247
2.269MetVal: 2.269 ± 0.327
0.493MetTrp: 0.493 ± 0.152
0.559MetTyr: 0.559 ± 0.175
0.0MetXaa: 0.0 ± 0.0
Asn
1.743AsnAla: 1.743 ± 0.257
0.559AsnCys: 0.559 ± 0.126
0.789AsnAsp: 0.789 ± 0.165
1.085AsnGlu: 1.085 ± 0.192
0.658AsnPhe: 0.658 ± 0.138
1.743AsnGly: 1.743 ± 0.238
0.362AsnHis: 0.362 ± 0.127
1.283AsnIle: 1.283 ± 0.252
0.888AsnLys: 0.888 ± 0.156
2.598AsnLeu: 2.598 ± 0.311
0.954AsnMet: 0.954 ± 0.209
0.723AsnAsn: 0.723 ± 0.195
2.532AsnPro: 2.532 ± 0.505
0.658AsnGln: 0.658 ± 0.129
1.644AsnArg: 1.644 ± 0.251
1.71AsnSer: 1.71 ± 0.231
1.677AsnThr: 1.677 ± 0.27
2.664AsnVal: 2.664 ± 0.322
0.526AsnTrp: 0.526 ± 0.125
0.888AsnTyr: 0.888 ± 0.165
0.0AsnXaa: 0.0 ± 0.0
Pro
5.722ProAla: 5.722 ± 0.572
0.921ProCys: 0.921 ± 0.209
3.881ProAsp: 3.881 ± 0.361
4.736ProGlu: 4.736 ± 0.497
2.039ProPhe: 2.039 ± 0.255
4.045ProGly: 4.045 ± 0.471
1.94ProHis: 1.94 ± 0.289
1.644ProIle: 1.644 ± 0.268
3.913ProLys: 3.913 ± 0.66
3.683ProLeu: 3.683 ± 0.381
1.25ProMet: 1.25 ± 0.159
1.381ProAsn: 1.381 ± 0.229
3.815ProPro: 3.815 ± 0.615
1.776ProGln: 1.776 ± 0.297
4.505ProArg: 4.505 ± 0.691
4.736ProSer: 4.736 ± 0.433
3.223ProThr: 3.223 ± 0.509
6.807ProVal: 6.807 ± 0.724
0.789ProTrp: 0.789 ± 0.167
1.611ProTyr: 1.611 ± 0.253
0.0ProXaa: 0.0 ± 0.0
Gln
2.335GlnAla: 2.335 ± 0.224
0.559GlnCys: 0.559 ± 0.13
1.644GlnAsp: 1.644 ± 0.275
1.973GlnGlu: 1.973 ± 0.645
0.723GlnPhe: 0.723 ± 0.142
2.138GlnGly: 2.138 ± 0.392
0.625GlnHis: 0.625 ± 0.193
0.954GlnIle: 0.954 ± 0.154
1.283GlnLys: 1.283 ± 0.209
2.039GlnLeu: 2.039 ± 0.306
0.723GlnMet: 0.723 ± 0.173
0.625GlnAsn: 0.625 ± 0.138
1.348GlnPro: 1.348 ± 0.251
2.861GlnGln: 2.861 ± 1.401
2.006GlnArg: 2.006 ± 0.326
2.138GlnSer: 2.138 ± 0.332
2.368GlnThr: 2.368 ± 0.803
2.006GlnVal: 2.006 ± 0.324
0.395GlnTrp: 0.395 ± 0.112
0.592GlnTyr: 0.592 ± 0.131
0.0GlnXaa: 0.0 ± 0.0
Arg
5.295ArgAla: 5.295 ± 0.526
1.052ArgCys: 1.052 ± 0.173
4.768ArgAsp: 4.768 ± 0.641
4.078ArgGlu: 4.078 ± 0.357
2.006ArgPhe: 2.006 ± 0.232
5.952ArgGly: 5.952 ± 0.793
1.842ArgHis: 1.842 ± 0.308
2.138ArgIle: 2.138 ± 0.297
4.67ArgLys: 4.67 ± 0.773
5.755ArgLeu: 5.755 ± 0.422
1.973ArgMet: 1.973 ± 0.243
2.335ArgAsn: 2.335 ± 0.364
4.407ArgPro: 4.407 ± 0.57
1.842ArgGln: 1.842 ± 0.258
5.821ArgArg: 5.821 ± 0.53
3.683ArgSer: 3.683 ± 0.474
3.913ArgThr: 3.913 ± 0.471
5.558ArgVal: 5.558 ± 0.567
0.954ArgTrp: 0.954 ± 0.171
1.973ArgTyr: 1.973 ± 0.287
0.0ArgXaa: 0.0 ± 0.0
Ser
5.952SerAla: 5.952 ± 0.488
1.546SerCys: 1.546 ± 0.195
4.9SerAsp: 4.9 ± 0.416
4.111SerGlu: 4.111 ± 0.365
2.828SerPhe: 2.828 ± 0.306
5.624SerGly: 5.624 ± 0.503
1.743SerHis: 1.743 ± 0.277
2.006SerIle: 2.006 ± 0.244
3.321SerLys: 3.321 ± 0.374
6.117SerLeu: 6.117 ± 0.665
2.006SerMet: 2.006 ± 0.298
1.743SerAsn: 1.743 ± 0.217
5.13SerPro: 5.13 ± 1.185
2.039SerGln: 2.039 ± 0.298
4.177SerArg: 4.177 ± 0.488
5.36SerSer: 5.36 ± 0.535
3.585SerThr: 3.585 ± 0.38
6.446SerVal: 6.446 ± 0.595
1.118SerTrp: 1.118 ± 0.178
1.842SerTyr: 1.842 ± 0.223
0.0SerXaa: 0.0 ± 0.0
Thr
5.328ThrAla: 5.328 ± 0.504
1.085ThrCys: 1.085 ± 0.182
3.848ThrAsp: 3.848 ± 0.421
2.73ThrGlu: 2.73 ± 0.374
2.302ThrPhe: 2.302 ± 0.304
5.097ThrGly: 5.097 ± 0.474
0.625ThrHis: 0.625 ± 0.115
1.907ThrIle: 1.907 ± 0.238
2.73ThrLys: 2.73 ± 0.33
5.393ThrLeu: 5.393 ± 0.844
1.875ThrMet: 1.875 ± 0.205
1.25ThrAsn: 1.25 ± 0.207
4.111ThrPro: 4.111 ± 0.406
1.677ThrGln: 1.677 ± 0.25
3.321ThrArg: 3.321 ± 0.362
3.124ThrSer: 3.124 ± 0.342
2.401ThrThr: 2.401 ± 0.382
6.511ThrVal: 6.511 ± 0.429
0.46ThrTrp: 0.46 ± 0.158
1.48ThrTyr: 1.48 ± 0.246
0.0ThrXaa: 0.0 ± 0.0
Val
6.051ValAla: 6.051 ± 0.43
1.776ValCys: 1.776 ± 0.277
4.966ValAsp: 4.966 ± 0.439
4.768ValGlu: 4.768 ± 0.697
3.026ValPhe: 3.026 ± 0.273
5.854ValGly: 5.854 ± 0.897
1.907ValHis: 1.907 ± 0.216
2.664ValIle: 2.664 ± 0.302
6.15ValLys: 6.15 ± 0.569
6.742ValLeu: 6.742 ± 0.621
2.861ValMet: 2.861 ± 0.304
2.434ValAsn: 2.434 ± 0.281
4.604ValPro: 4.604 ± 0.506
1.94ValGln: 1.94 ± 0.233
6.906ValArg: 6.906 ± 0.708
7.169ValSer: 7.169 ± 0.583
5.064ValThr: 5.064 ± 0.495
7.399ValVal: 7.399 ± 0.519
1.118ValTrp: 1.118 ± 0.151
2.631ValTyr: 2.631 ± 0.318
0.0ValXaa: 0.0 ± 0.0
Trp
0.921TrpAla: 0.921 ± 0.208
0.23TrpCys: 0.23 ± 0.08
0.954TrpAsp: 0.954 ± 0.182
0.822TrpGlu: 0.822 ± 0.164
0.625TrpPhe: 0.625 ± 0.145
0.987TrpGly: 0.987 ± 0.182
0.296TrpHis: 0.296 ± 0.107
0.46TrpIle: 0.46 ± 0.122
0.921TrpLys: 0.921 ± 0.16
1.348TrpLeu: 1.348 ± 0.177
0.46TrpMet: 0.46 ± 0.117
0.658TrpAsn: 0.658 ± 0.142
0.658TrpPro: 0.658 ± 0.136
0.197TrpGln: 0.197 ± 0.072
0.855TrpArg: 0.855 ± 0.165
0.789TrpSer: 0.789 ± 0.145
1.381TrpThr: 1.381 ± 0.24
0.691TrpVal: 0.691 ± 0.171
0.197TrpTrp: 0.197 ± 0.082
0.428TrpTyr: 0.428 ± 0.147
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.138TyrAla: 2.138 ± 0.332
0.658TyrCys: 0.658 ± 0.136
2.565TyrAsp: 2.565 ± 0.247
1.546TyrGlu: 1.546 ± 0.244
0.789TyrPhe: 0.789 ± 0.154
2.368TyrGly: 2.368 ± 0.271
0.46TyrHis: 0.46 ± 0.111
1.315TyrIle: 1.315 ± 0.197
1.743TyrLys: 1.743 ± 0.224
2.039TyrLeu: 2.039 ± 0.24
0.822TyrMet: 0.822 ± 0.175
0.658TyrAsn: 0.658 ± 0.16
2.105TyrPro: 2.105 ± 0.281
1.019TyrGln: 1.019 ± 0.162
1.677TyrArg: 1.677 ± 0.22
2.434TyrSer: 2.434 ± 0.275
1.875TyrThr: 1.875 ± 0.225
2.861TyrVal: 2.861 ± 0.254
0.263TyrTrp: 0.263 ± 0.095
0.855TyrTyr: 0.855 ± 0.165
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 97 proteins (30409 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski