Amino acid dipepetide frequency for Penicillium polonicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.383AlaAla: 8.383 ± 0.066	1.081AlaCys: 1.081 ± 0.017	4.2AlaAsp: 4.2 ± 0.031	4.984AlaGlu: 4.984 ± 0.048	3.194AlaPhe: 3.194 ± 0.03	5.676AlaGly: 5.676 ± 0.038	1.792AlaHis: 1.792 ± 0.02	4.459AlaIle: 4.459 ± 0.036	3.832AlaLys: 3.832 ± 0.036	7.738AlaLeu: 7.738 ± 0.05	2.05AlaMet: 2.05 ± 0.022	2.958AlaAsn: 2.958 ± 0.026	4.726AlaPro: 4.726 ± 0.046	3.366AlaGln: 3.366 ± 0.03	4.693AlaArg: 4.693 ± 0.033	7.092AlaSer: 7.092 ± 0.043	5.227AlaThr: 5.227 ± 0.035	5.303AlaVal: 5.303 ± 0.037	1.154AlaTrp: 1.154 ± 0.016	2.158AlaTyr: 2.158 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.969CysAla: 0.969 ± 0.014	0.231CysCys: 0.231 ± 0.008	0.693CysAsp: 0.693 ± 0.012	0.603CysGlu: 0.603 ± 0.012	0.564CysPhe: 0.564 ± 0.01	0.926CysGly: 0.926 ± 0.017	0.346CysHis: 0.346 ± 0.009	0.735CysIle: 0.735 ± 0.012	0.481CysLys: 0.481 ± 0.009	1.318CysLeu: 1.318 ± 0.017	0.284CysMet: 0.284 ± 0.008	0.435CysAsn: 0.435 ± 0.011	0.635CysPro: 0.635 ± 0.015	0.476CysGln: 0.476 ± 0.011	0.747CysArg: 0.747 ± 0.013	0.924CysSer: 0.924 ± 0.014	0.693CysThr: 0.693 ± 0.012	0.839CysVal: 0.839 ± 0.014	0.209CysTrp: 0.209 ± 0.007	0.355CysTyr: 0.355 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.496AspAla: 4.496 ± 0.029	0.615AspCys: 0.615 ± 0.012	3.861AspAsp: 3.861 ± 0.035	4.246AspGlu: 4.246 ± 0.037	2.177AspPhe: 2.177 ± 0.021	3.843AspGly: 3.843 ± 0.033	1.352AspHis: 1.352 ± 0.016	3.243AspIle: 3.243 ± 0.028	2.255AspLys: 2.255 ± 0.025	5.223AspLeu: 5.223 ± 0.035	1.297AspMet: 1.297 ± 0.016	1.937AspAsn: 1.937 ± 0.021	3.418AspPro: 3.418 ± 0.029	2.049AspGln: 2.049 ± 0.016	3.062AspArg: 3.062 ± 0.031	4.232AspSer: 4.232 ± 0.03	3.092AspThr: 3.092 ± 0.022	3.593AspVal: 3.593 ± 0.028	0.918AspTrp: 0.918 ± 0.014	1.605AspTyr: 1.605 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.115GluAla: 5.115 ± 0.039	0.635GluCys: 0.635 ± 0.011	4.099GluAsp: 4.099 ± 0.034	5.168GluGlu: 5.168 ± 0.057	1.987GluPhe: 1.987 ± 0.019	3.591GluGly: 3.591 ± 0.028	1.425GluHis: 1.425 ± 0.018	3.22GluIle: 3.22 ± 0.025	3.455GluLys: 3.455 ± 0.032	5.142GluLeu: 5.142 ± 0.036	1.504GluMet: 1.504 ± 0.018	2.371GluAsn: 2.371 ± 0.024	2.885GluPro: 2.885 ± 0.045	2.453GluGln: 2.453 ± 0.027	3.711GluArg: 3.711 ± 0.033	4.45GluSer: 4.45 ± 0.033	3.682GluThr: 3.682 ± 0.025	3.464GluVal: 3.464 ± 0.031	0.874GluTrp: 0.874 ± 0.011	1.698GluTyr: 1.698 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.089PheAla: 3.089 ± 0.029	0.578PheCys: 0.578 ± 0.011	2.357PheAsp: 2.357 ± 0.022	2.174PheGlu: 2.174 ± 0.021	1.715PhePhe: 1.715 ± 0.024	2.936PheGly: 2.936 ± 0.032	0.96PheHis: 0.96 ± 0.015	1.964PheIle: 1.964 ± 0.022	1.491PheLys: 1.491 ± 0.018	3.584PheLeu: 3.584 ± 0.029	0.865PheMet: 0.865 ± 0.013	1.505PheAsn: 1.505 ± 0.017	2.047PhePro: 2.047 ± 0.02	1.481PheGln: 1.481 ± 0.019	1.965PheArg: 1.965 ± 0.023	3.079PheSer: 3.079 ± 0.027	2.216PheThr: 2.216 ± 0.019	2.444PheVal: 2.444 ± 0.025	0.677PheTrp: 0.677 ± 0.012	1.176PheTyr: 1.176 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.23GlyAla: 5.23 ± 0.041	0.909GlyCys: 0.909 ± 0.015	3.561GlyAsp: 3.561 ± 0.026	3.483GlyGlu: 3.483 ± 0.03	2.893GlyPhe: 2.893 ± 0.031	5.343GlyGly: 5.343 ± 0.049	1.701GlyHis: 1.701 ± 0.023	3.674GlyIle: 3.674 ± 0.032	3.244GlyLys: 3.244 ± 0.03	6.234GlyLeu: 6.234 ± 0.041	1.638GlyMet: 1.638 ± 0.02	2.557GlyAsn: 2.557 ± 0.027	3.375GlyPro: 3.375 ± 0.031	2.597GlyGln: 2.597 ± 0.027	3.865GlyArg: 3.865 ± 0.03	5.713GlySer: 5.713 ± 0.042	3.967GlyThr: 3.967 ± 0.032	4.387GlyVal: 4.387 ± 0.03	1.183GlyTrp: 1.183 ± 0.018	2.168GlyTyr: 2.168 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.862HisAla: 1.862 ± 0.021	0.35HisCys: 0.35 ± 0.009	1.338HisAsp: 1.338 ± 0.015	1.385HisGlu: 1.385 ± 0.018	0.946HisPhe: 0.946 ± 0.012	1.758HisGly: 1.758 ± 0.022	0.829HisHis: 0.829 ± 0.017	1.296HisIle: 1.296 ± 0.016	0.89HisLys: 0.89 ± 0.013	2.275HisLeu: 2.275 ± 0.025	0.527HisMet: 0.527 ± 0.01	0.911HisAsn: 0.911 ± 0.012	1.682HisPro: 1.682 ± 0.021	1.006HisGln: 1.006 ± 0.015	1.554HisArg: 1.554 ± 0.02	1.915HisSer: 1.915 ± 0.02	1.343HisThr: 1.343 ± 0.015	1.456HisVal: 1.456 ± 0.016	0.375HisTrp: 0.375 ± 0.009	0.703HisTyr: 0.703 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.408IleAla: 4.408 ± 0.035	0.823IleCys: 0.823 ± 0.013	2.955IleAsp: 2.955 ± 0.026	2.969IleGlu: 2.969 ± 0.025	2.176IlePhe: 2.176 ± 0.026	3.424IleGly: 3.424 ± 0.031	1.301IleHis: 1.301 ± 0.014	2.7IleIle: 2.7 ± 0.03	2.148IleLys: 2.148 ± 0.023	4.765IleLeu: 4.765 ± 0.036	1.111IleMet: 1.111 ± 0.016	1.86IleAsn: 1.86 ± 0.021	3.33IlePro: 3.33 ± 0.025	2.034IleGln: 2.034 ± 0.021	2.814IleArg: 2.814 ± 0.017	4.156IleSer: 4.156 ± 0.029	2.904IleThr: 2.904 ± 0.027	3.295IleVal: 3.295 ± 0.033	0.782IleTrp: 0.782 ± 0.013	1.527IleTyr: 1.527 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.939LysAla: 3.939 ± 0.035	0.495LysCys: 0.495 ± 0.011	2.692LysAsp: 2.692 ± 0.024	3.135LysGlu: 3.135 ± 0.028	1.471LysPhe: 1.471 ± 0.018	2.812LysGly: 2.812 ± 0.027	1.084LysHis: 1.084 ± 0.015	2.241LysIle: 2.241 ± 0.022	2.998LysLys: 2.998 ± 0.043	3.875LysLeu: 3.875 ± 0.028	1.011LysMet: 1.011 ± 0.014	1.735LysAsn: 1.735 ± 0.021	2.644LysPro: 2.644 ± 0.028	1.792LysGln: 1.792 ± 0.021	3.102LysArg: 3.102 ± 0.032	3.492LysSer: 3.492 ± 0.031	2.728LysThr: 2.728 ± 0.027	2.685LysVal: 2.685 ± 0.024	0.684LysTrp: 0.684 ± 0.013	1.341LysTyr: 1.341 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.853LeuAla: 7.853 ± 0.048	1.245LeuCys: 1.245 ± 0.017	5.255LeuAsp: 5.255 ± 0.036	5.514LeuGlu: 5.514 ± 0.036	3.514LeuPhe: 3.514 ± 0.029	6.106LeuGly: 6.106 ± 0.039	2.289LeuHis: 2.289 ± 0.023	4.19LeuIle: 4.19 ± 0.032	4.031LeuLys: 4.031 ± 0.032	8.504LeuLeu: 8.504 ± 0.063	1.898LeuMet: 1.898 ± 0.019	3.297LeuAsn: 3.297 ± 0.025	5.453LeuPro: 5.453 ± 0.031	3.923LeuGln: 3.923 ± 0.033	5.599LeuArg: 5.599 ± 0.041	7.501LeuSer: 7.501 ± 0.045	4.836LeuThr: 4.836 ± 0.035	5.545LeuVal: 5.545 ± 0.04	1.231LeuTrp: 1.231 ± 0.017	2.405LeuTyr: 2.405 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.254MetAla: 2.254 ± 0.023	0.266MetCys: 0.266 ± 0.007	1.302MetAsp: 1.302 ± 0.017	1.345MetGlu: 1.345 ± 0.019	0.816MetPhe: 0.816 ± 0.014	1.578MetGly: 1.578 ± 0.018	0.506MetHis: 0.506 ± 0.01	1.116MetIle: 1.116 ± 0.016	1.005MetLys: 1.005 ± 0.014	1.924MetLeu: 1.924 ± 0.019	0.598MetMet: 0.598 ± 0.011	0.86MetAsn: 0.86 ± 0.012	1.284MetPro: 1.284 ± 0.016	0.926MetGln: 0.926 ± 0.013	1.259MetArg: 1.259 ± 0.018	2.013MetSer: 2.013 ± 0.02	1.384MetThr: 1.384 ± 0.015	1.387MetVal: 1.387 ± 0.017	0.284MetTrp: 0.284 ± 0.008	0.521MetTyr: 0.521 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.139AsnAla: 3.139 ± 0.025	0.466AsnCys: 0.466 ± 0.009	1.987AsnAsp: 1.987 ± 0.021	2.12AsnGlu: 2.12 ± 0.023	1.418AsnPhe: 1.418 ± 0.018	2.878AsnGly: 2.878 ± 0.028	0.882AsnHis: 0.882 ± 0.014	2.177AsnIle: 2.177 ± 0.022	1.521AsnLys: 1.521 ± 0.018	3.349AsnLeu: 3.349 ± 0.029	0.911AsnMet: 0.911 ± 0.014	1.48AsnAsn: 1.48 ± 0.018	2.625AsnPro: 2.625 ± 0.025	1.417AsnGln: 1.417 ± 0.019	1.962AsnArg: 1.962 ± 0.021	2.78AsnSer: 2.78 ± 0.027	2.274AsnThr: 2.274 ± 0.021	2.359AsnVal: 2.359 ± 0.022	0.587AsnTrp: 0.587 ± 0.011	1.093AsnTyr: 1.093 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.173ProAla: 5.173 ± 0.051	0.534ProCys: 0.534 ± 0.011	3.223ProAsp: 3.223 ± 0.027	3.936ProGlu: 3.936 ± 0.045	2.14ProPhe: 2.14 ± 0.021	3.871ProGly: 3.871 ± 0.036	1.37ProHis: 1.37 ± 0.018	2.699ProIle: 2.699 ± 0.025	2.607ProLys: 2.607 ± 0.028	4.796ProLeu: 4.796 ± 0.034	1.177ProMet: 1.177 ± 0.015	2.279ProAsn: 2.279 ± 0.021	4.596ProPro: 4.596 ± 0.069	2.483ProGln: 2.483 ± 0.028	3.357ProArg: 3.357 ± 0.036	6.103ProSer: 6.103 ± 0.05	4.118ProThr: 4.118 ± 0.035	3.711ProVal: 3.711 ± 0.036	0.786ProTrp: 0.786 ± 0.013	1.511ProTyr: 1.511 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.36GlnAla: 3.36 ± 0.03	0.466GlnCys: 0.466 ± 0.011	2.073GlnAsp: 2.073 ± 0.021	2.373GlnGlu: 2.373 ± 0.026	1.385GlnPhe: 1.385 ± 0.017	2.445GlnGly: 2.445 ± 0.024	1.075GlnHis: 1.075 ± 0.015	2.02GlnIle: 2.02 ± 0.02	1.964GlnLys: 1.964 ± 0.021	3.505GlnLeu: 3.505 ± 0.029	0.955GlnMet: 0.955 ± 0.013	1.635GlnAsn: 1.635 ± 0.02	2.601GlnPro: 2.601 ± 0.032	2.2GlnGln: 2.2 ± 0.043	2.585GlnArg: 2.585 ± 0.023	3.338GlnSer: 3.338 ± 0.029	2.482GlnThr: 2.482 ± 0.021	2.26GlnVal: 2.26 ± 0.023	0.611GlnTrp: 0.611 ± 0.01	1.222GlnTyr: 1.222 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.465ArgAla: 4.465 ± 0.031	0.691ArgCys: 0.691 ± 0.013	3.275ArgAsp: 3.275 ± 0.031	3.654ArgGlu: 3.654 ± 0.035	2.144ArgPhe: 2.144 ± 0.021	3.633ArgGly: 3.633 ± 0.032	1.504ArgHis: 1.504 ± 0.018	2.875ArgIle: 2.875 ± 0.024	3.217ArgLys: 3.217 ± 0.03	5.383ArgLeu: 5.383 ± 0.038	1.309ArgMet: 1.309 ± 0.017	2.183ArgAsn: 2.183 ± 0.02	3.405ArgPro: 3.405 ± 0.032	2.529ArgGln: 2.529 ± 0.024	4.683ArgArg: 4.683 ± 0.049	4.668ArgSer: 4.668 ± 0.036	3.24ArgThr: 3.24 ± 0.026	3.389ArgVal: 3.389 ± 0.029	0.933ArgTrp: 0.933 ± 0.014	1.615ArgTyr: 1.615 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.633SerAla: 6.633 ± 0.04	0.888SerCys: 0.888 ± 0.013	4.383SerAsp: 4.383 ± 0.042	4.322SerGlu: 4.322 ± 0.034	3.141SerPhe: 3.141 ± 0.023	5.575SerGly: 5.575 ± 0.045	2.066SerHis: 2.066 ± 0.019	4.207SerIle: 4.207 ± 0.029	3.624SerLys: 3.624 ± 0.03	7.476SerLeu: 7.476 ± 0.046	1.827SerMet: 1.827 ± 0.019	3.135SerAsn: 3.135 ± 0.026	5.566SerPro: 5.566 ± 0.054	3.394SerGln: 3.394 ± 0.032	4.861SerArg: 4.861 ± 0.039	8.605SerSer: 8.605 ± 0.076	5.684SerThr: 5.684 ± 0.045	4.777SerVal: 4.777 ± 0.031	1.194SerTrp: 1.194 ± 0.015	2.122SerTyr: 2.122 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.158ThrAla: 5.158 ± 0.033	0.743ThrCys: 0.743 ± 0.012	2.982ThrAsp: 2.982 ± 0.027	3.339ThrGlu: 3.339 ± 0.027	2.294ThrPhe: 2.294 ± 0.025	4.265ThrGly: 4.265 ± 0.032	1.318ThrHis: 1.318 ± 0.016	3.202ThrIle: 3.202 ± 0.03	2.597ThrLys: 2.597 ± 0.026	5.332ThrLeu: 5.332 ± 0.035	1.243ThrMet: 1.243 ± 0.016	2.152ThrAsn: 2.152 ± 0.021	4.395ThrPro: 4.395 ± 0.04	2.252ThrGln: 2.252 ± 0.023	3.122ThrArg: 3.122 ± 0.025	5.347ThrSer: 5.347 ± 0.043	4.224ThrThr: 4.224 ± 0.047	3.773ThrVal: 3.773 ± 0.033	0.876ThrTrp: 0.876 ± 0.013	1.627ThrTyr: 1.627 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.189ValAla: 5.189 ± 0.036	0.844ValCys: 0.844 ± 0.012	3.746ValAsp: 3.746 ± 0.031	3.783ValGlu: 3.783 ± 0.035	2.566ValPhe: 2.566 ± 0.026	4.02ValGly: 4.02 ± 0.031	1.458ValHis: 1.458 ± 0.018	3.175ValIle: 3.175 ± 0.03	2.711ValLys: 2.711 ± 0.025	5.658ValLeu: 5.658 ± 0.043	1.361ValMet: 1.361 ± 0.016	2.318ValAsn: 2.318 ± 0.022	3.632ValPro: 3.632 ± 0.03	2.443ValGln: 2.443 ± 0.026	3.291ValArg: 3.291 ± 0.025	4.834ValSer: 4.834 ± 0.03	3.541ValThr: 3.541 ± 0.03	4.244ValVal: 4.244 ± 0.039	0.862ValTrp: 0.862 ± 0.015	1.755ValTyr: 1.755 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.176TrpAla: 1.176 ± 0.014	0.2TrpCys: 0.2 ± 0.006	0.911TrpAsp: 0.911 ± 0.016	0.872TrpGlu: 0.872 ± 0.012	0.54TrpPhe: 0.54 ± 0.011	0.952TrpGly: 0.952 ± 0.015	0.361TrpHis: 0.361 ± 0.008	0.82TrpIle: 0.82 ± 0.013	0.811TrpLys: 0.811 ± 0.013	1.379TrpLeu: 1.379 ± 0.016	0.399TrpMet: 0.399 ± 0.008	0.667TrpAsn: 0.667 ± 0.012	0.62TrpPro: 0.62 ± 0.01	0.57TrpGln: 0.57 ± 0.012	0.946TrpArg: 0.946 ± 0.012	1.123TrpSer: 1.123 ± 0.017	0.942TrpThr: 0.942 ± 0.016	0.916TrpVal: 0.916 ± 0.015	0.287TrpTrp: 0.287 ± 0.009	0.461TrpTyr: 0.461 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.174TyrAla: 2.174 ± 0.023	0.404TyrCys: 0.404 ± 0.01	1.621TyrAsp: 1.621 ± 0.018	1.526TyrGlu: 1.526 ± 0.019	1.223TyrPhe: 1.223 ± 0.017	2.092TyrGly: 2.092 ± 0.027	0.782TyrHis: 0.782 ± 0.012	1.47TyrIle: 1.47 ± 0.018	1.073TyrLys: 1.073 ± 0.015	2.726TyrLeu: 2.726 ± 0.027	0.662TyrMet: 0.662 ± 0.011	1.152TyrAsn: 1.152 ± 0.016	1.55TyrPro: 1.55 ± 0.02	1.163TyrGln: 1.163 ± 0.018	1.618TyrArg: 1.618 ± 0.019	2.113TyrSer: 2.113 ± 0.022	1.664TyrThr: 1.664 ± 0.016	1.603TyrVal: 1.603 ± 0.019	0.445TyrTrp: 0.445 ± 0.009	0.94TyrTyr: 0.94 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 10627 proteins (5256275 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---