Amino acid dipepetide frequency for Desulfuromusa kysingii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.592AlaAla: 8.592 ± 0.14
0.977AlaCys: 0.977 ± 0.039
5.08AlaAsp: 5.08 ± 0.094
6.065AlaGlu: 6.065 ± 0.083
3.182AlaPhe: 3.182 ± 0.057
6.854AlaGly: 6.854 ± 0.129
1.493AlaHis: 1.493 ± 0.046
5.783AlaIle: 5.783 ± 0.081
3.988AlaLys: 3.988 ± 0.066
9.157AlaLeu: 9.157 ± 0.104
2.251AlaMet: 2.251 ± 0.049
2.723AlaAsn: 2.723 ± 0.056
2.743AlaPro: 2.743 ± 0.055
3.255AlaGln: 3.255 ± 0.066
3.811AlaArg: 3.811 ± 0.067
4.472AlaSer: 4.472 ± 0.083
4.782AlaThr: 4.782 ± 0.073
6.065AlaVal: 6.065 ± 0.096
0.722AlaTrp: 0.722 ± 0.025
2.167AlaTyr: 2.167 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.897CysAla: 0.897 ± 0.031
0.226CysCys: 0.226 ± 0.017
0.651CysAsp: 0.651 ± 0.022
0.571CysGlu: 0.571 ± 0.024
0.504CysPhe: 0.504 ± 0.025
1.136CysGly: 1.136 ± 0.037
0.54CysHis: 0.54 ± 0.035
0.565CysIle: 0.565 ± 0.025
0.462CysLys: 0.462 ± 0.021
1.174CysLeu: 1.174 ± 0.036
0.257CysMet: 0.257 ± 0.016
0.377CysAsn: 0.377 ± 0.019
0.654CysPro: 0.654 ± 0.029
0.554CysGln: 0.554 ± 0.026
0.708CysArg: 0.708 ± 0.025
0.869CysSer: 0.869 ± 0.031
0.511CysThr: 0.511 ± 0.021
0.649CysVal: 0.649 ± 0.025
0.149CysTrp: 0.149 ± 0.012
0.373CysTyr: 0.373 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.064AspAla: 4.064 ± 0.073
0.658AspCys: 0.658 ± 0.024
3.132AspAsp: 3.132 ± 0.088
3.461AspGlu: 3.461 ± 0.059
2.541AspPhe: 2.541 ± 0.055
3.999AspGly: 3.999 ± 0.104
1.196AspHis: 1.196 ± 0.037
3.828AspIle: 3.828 ± 0.063
2.667AspLys: 2.667 ± 0.054
6.347AspLeu: 6.347 ± 0.079
1.196AspMet: 1.196 ± 0.032
2.161AspAsn: 2.161 ± 0.051
2.544AspPro: 2.544 ± 0.053
2.41AspGln: 2.41 ± 0.052
2.702AspArg: 2.702 ± 0.053
3.266AspSer: 3.266 ± 0.064
2.426AspThr: 2.426 ± 0.075
3.593AspVal: 3.593 ± 0.064
0.701AspTrp: 0.701 ± 0.027
1.992AspTyr: 1.992 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
4.934GluAla: 4.934 ± 0.069
0.496GluCys: 0.496 ± 0.022
3.075GluAsp: 3.075 ± 0.056
4.25GluGlu: 4.25 ± 0.084
2.176GluPhe: 2.176 ± 0.046
3.721GluGly: 3.721 ± 0.065
1.175GluHis: 1.175 ± 0.032
4.738GluIle: 4.738 ± 0.077
4.369GluLys: 4.369 ± 0.073
6.95GluLeu: 6.95 ± 0.106
1.85GluMet: 1.85 ± 0.044
2.644GluAsn: 2.644 ± 0.058
1.956GluPro: 1.956 ± 0.046
3.391GluGln: 3.391 ± 0.057
3.337GluArg: 3.337 ± 0.061
3.356GluSer: 3.356 ± 0.052
3.514GluThr: 3.514 ± 0.069
4.267GluVal: 4.267 ± 0.073
0.528GluTrp: 0.528 ± 0.024
1.641GluTyr: 1.641 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.441PheAla: 3.441 ± 0.053
0.594PheCys: 0.594 ± 0.024
2.503PheAsp: 2.503 ± 0.05
2.109PheGlu: 2.109 ± 0.046
1.971PhePhe: 1.971 ± 0.049
3.225PheGly: 3.225 ± 0.058
0.811PheHis: 0.811 ± 0.027
2.721PheIle: 2.721 ± 0.053
1.869PheLys: 1.869 ± 0.042
4.319PheLeu: 4.319 ± 0.075
1.015PheMet: 1.015 ± 0.031
1.711PheAsn: 1.711 ± 0.041
1.709PhePro: 1.709 ± 0.039
1.408PheGln: 1.408 ± 0.041
1.861PheArg: 1.861 ± 0.045
3.473PheSer: 3.473 ± 0.065
2.297PheThr: 2.297 ± 0.045
2.757PheVal: 2.757 ± 0.048
0.55PheTrp: 0.55 ± 0.023
1.354PheTyr: 1.354 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
5.862GlyAla: 5.862 ± 0.123
1.072GlyCys: 1.072 ± 0.033
4.117GlyAsp: 4.117 ± 0.136
4.435GlyGlu: 4.435 ± 0.075
3.279GlyPhe: 3.279 ± 0.047
5.945GlyGly: 5.945 ± 0.337
1.66GlyHis: 1.66 ± 0.039
5.273GlyIle: 5.273 ± 0.08
4.066GlyLys: 4.066 ± 0.066
7.634GlyLeu: 7.634 ± 0.088
2.193GlyMet: 2.193 ± 0.039
2.532GlyAsn: 2.532 ± 0.09
1.878GlyPro: 1.878 ± 0.049
2.961GlyGln: 2.961 ± 0.06
3.591GlyArg: 3.591 ± 0.066
4.555GlySer: 4.555 ± 0.107
4.008GlyThr: 4.008 ± 0.076
5.411GlyVal: 5.411 ± 0.095
0.89GlyTrp: 0.89 ± 0.029
2.554GlyTyr: 2.554 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.467HisAla: 1.467 ± 0.037
0.369HisCys: 0.369 ± 0.02
1.101HisAsp: 1.101 ± 0.031
1.102HisGlu: 1.102 ± 0.033
0.999HisPhe: 0.999 ± 0.033
1.558HisGly: 1.558 ± 0.041
0.583HisHis: 0.583 ± 0.024
1.237HisIle: 1.237 ± 0.038
0.958HisLys: 0.958 ± 0.032
2.35HisLeu: 2.35 ± 0.047
0.44HisMet: 0.44 ± 0.022
0.769HisAsn: 0.769 ± 0.03
1.276HisPro: 1.276 ± 0.038
1.015HisGln: 1.015 ± 0.028
1.129HisArg: 1.129 ± 0.037
1.262HisSer: 1.262 ± 0.036
0.924HisThr: 0.924 ± 0.031
1.157HisVal: 1.157 ± 0.035
0.255HisTrp: 0.255 ± 0.017
0.685HisTyr: 0.685 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.046IleAla: 6.046 ± 0.082
0.89IleCys: 0.89 ± 0.029
4.369IleAsp: 4.369 ± 0.061
4.451IleGlu: 4.451 ± 0.071
2.775IlePhe: 2.775 ± 0.062
5.069IleGly: 5.069 ± 0.081
1.345IleHis: 1.345 ± 0.036
4.318IleIle: 4.318 ± 0.071
3.359IleLys: 3.359 ± 0.056
6.645IleLeu: 6.645 ± 0.094
1.369IleMet: 1.369 ± 0.035
2.914IleAsn: 2.914 ± 0.062
3.226IlePro: 3.226 ± 0.062
2.137IleGln: 2.137 ± 0.041
3.189IleArg: 3.189 ± 0.057
4.852IleSer: 4.852 ± 0.077
3.472IleThr: 3.472 ± 0.064
4.61IleVal: 4.61 ± 0.063
0.544IleTrp: 0.544 ± 0.026
1.927IleTyr: 1.927 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
3.94LysAla: 3.94 ± 0.06
0.414LysCys: 0.414 ± 0.019
2.485LysAsp: 2.485 ± 0.052
3.316LysGlu: 3.316 ± 0.069
1.656LysPhe: 1.656 ± 0.046
3.298LysGly: 3.298 ± 0.061
0.931LysHis: 0.931 ± 0.027
4.017LysIle: 4.017 ± 0.069
3.574LysLys: 3.574 ± 0.072
5.059LysLeu: 5.059 ± 0.072
1.492LysMet: 1.492 ± 0.039
2.281LysAsn: 2.281 ± 0.052
1.919LysPro: 1.919 ± 0.047
2.595LysGln: 2.595 ± 0.056
2.748LysArg: 2.748 ± 0.06
2.873LysSer: 2.873 ± 0.05
3.056LysThr: 3.056 ± 0.048
3.677LysVal: 3.677 ± 0.063
0.382LysTrp: 0.382 ± 0.019
1.435LysTyr: 1.435 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
9.753LeuAla: 9.753 ± 0.104
1.27LeuCys: 1.27 ± 0.035
5.878LeuAsp: 5.878 ± 0.082
6.567LeuGlu: 6.567 ± 0.11
4.837LeuPhe: 4.837 ± 0.087
7.489LeuGly: 7.489 ± 0.099
2.166LeuHis: 2.166 ± 0.049
6.889LeuIle: 6.889 ± 0.103
5.665LeuLys: 5.665 ± 0.091
12.964LeuLeu: 12.964 ± 0.186
2.465LeuMet: 2.465 ± 0.055
4.068LeuAsn: 4.068 ± 0.057
5.041LeuPro: 5.041 ± 0.076
5.204LeuGln: 5.204 ± 0.093
5.451LeuArg: 5.451 ± 0.078
7.463LeuSer: 7.463 ± 0.093
6.06LeuThr: 6.06 ± 0.076
7.128LeuVal: 7.128 ± 0.098
0.991LeuTrp: 0.991 ± 0.035
2.686LeuTyr: 2.686 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.388MetAla: 2.388 ± 0.052
0.176MetCys: 0.176 ± 0.013
1.199MetAsp: 1.199 ± 0.035
1.414MetGlu: 1.414 ± 0.035
0.884MetPhe: 0.884 ± 0.029
1.767MetGly: 1.767 ± 0.049
0.389MetHis: 0.389 ± 0.018
1.692MetIle: 1.692 ± 0.043
1.493MetLys: 1.493 ± 0.037
2.595MetLeu: 2.595 ± 0.052
0.641MetMet: 0.641 ± 0.024
1.049MetAsn: 1.049 ± 0.034
1.069MetPro: 1.069 ± 0.033
1.069MetGln: 1.069 ± 0.032
1.165MetArg: 1.165 ± 0.035
1.614MetSer: 1.614 ± 0.04
1.658MetThr: 1.658 ± 0.045
1.885MetVal: 1.885 ± 0.048
0.132MetTrp: 0.132 ± 0.01
0.46MetTyr: 0.46 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.715AsnAla: 2.715 ± 0.061
0.514AsnCys: 0.514 ± 0.024
1.944AsnAsp: 1.944 ± 0.075
1.864AsnGlu: 1.864 ± 0.044
1.609AsnPhe: 1.609 ± 0.044
2.519AsnGly: 2.519 ± 0.054
0.902AsnHis: 0.902 ± 0.028
2.762AsnIle: 2.762 ± 0.051
1.834AsnLys: 1.834 ± 0.045
4.372AsnLeu: 4.372 ± 0.076
0.931AsnMet: 0.931 ± 0.031
1.752AsnAsn: 1.752 ± 0.051
2.163AsnPro: 2.163 ± 0.039
1.699AsnGln: 1.699 ± 0.041
2.081AsnArg: 2.081 ± 0.044
2.361AsnSer: 2.361 ± 0.058
1.703AsnThr: 1.703 ± 0.052
2.339AsnVal: 2.339 ± 0.061
0.458AsnTrp: 0.458 ± 0.02
1.314AsnTyr: 1.314 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
3.447ProAla: 3.447 ± 0.064
0.416ProCys: 0.416 ± 0.023
2.528ProAsp: 2.528 ± 0.043
3.621ProGlu: 3.621 ± 0.066
1.867ProPhe: 1.867 ± 0.043
2.991ProGly: 2.991 ± 0.062
0.877ProHis: 0.877 ± 0.026
2.431ProIle: 2.431 ± 0.045
1.785ProLys: 1.785 ± 0.046
4.648ProLeu: 4.648 ± 0.077
0.9ProMet: 0.9 ± 0.031
1.193ProAsn: 1.193 ± 0.036
1.563ProPro: 1.563 ± 0.05
1.976ProGln: 1.976 ± 0.051
1.646ProArg: 1.646 ± 0.041
2.128ProSer: 2.128 ± 0.046
2.045ProThr: 2.045 ± 0.05
3.228ProVal: 3.228 ± 0.063
0.452ProTrp: 0.452 ± 0.021
1.255ProTyr: 1.255 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
3.567GlnAla: 3.567 ± 0.063
0.364GlnCys: 0.364 ± 0.02
1.861GlnAsp: 1.861 ± 0.042
2.623GlnGlu: 2.623 ± 0.052
1.492GlnPhe: 1.492 ± 0.04
2.883GlnGly: 2.883 ± 0.052
0.969GlnHis: 0.969 ± 0.032
3.157GlnIle: 3.157 ± 0.059
2.47GlnLys: 2.47 ± 0.055
5.414GlnLeu: 5.414 ± 0.095
1.118GlnMet: 1.118 ± 0.031
1.543GlnAsn: 1.543 ± 0.043
1.691GlnPro: 1.691 ± 0.044
3.345GlnGln: 3.345 ± 0.083
2.669GlnArg: 2.669 ± 0.058
2.475GlnSer: 2.475 ± 0.059
2.202GlnThr: 2.202 ± 0.044
3.278GlnVal: 3.278 ± 0.06
0.442GlnTrp: 0.442 ± 0.023
1.047GlnTyr: 1.047 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
3.437ArgAla: 3.437 ± 0.065
0.616ArgCys: 0.616 ± 0.023
2.592ArgAsp: 2.592 ± 0.049
3.357ArgGlu: 3.357 ± 0.064
2.154ArgPhe: 2.154 ± 0.043
3.123ArgGly: 3.123 ± 0.051
1.153ArgHis: 1.153 ± 0.033
3.608ArgIle: 3.608 ± 0.056
2.816ArgLys: 2.816 ± 0.053
5.587ArgLeu: 5.587 ± 0.099
1.333ArgMet: 1.333 ± 0.041
2.0ArgAsn: 2.0 ± 0.042
1.788ArgPro: 1.788 ± 0.045
2.706ArgGln: 2.706 ± 0.057
2.762ArgArg: 2.762 ± 0.066
2.988ArgSer: 2.988 ± 0.051
2.297ArgThr: 2.297 ± 0.05
3.24ArgVal: 3.24 ± 0.059
0.58ArgTrp: 0.58 ± 0.027
1.773ArgTyr: 1.773 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
5.325SerAla: 5.325 ± 0.083
0.837SerCys: 0.837 ± 0.033
3.104SerAsp: 3.104 ± 0.065
3.503SerGlu: 3.503 ± 0.052
2.903SerPhe: 2.903 ± 0.057
5.867SerGly: 5.867 ± 0.131
1.373SerHis: 1.373 ± 0.041
3.941SerIle: 3.941 ± 0.067
2.621SerLys: 2.621 ± 0.057
7.079SerLeu: 7.079 ± 0.107
1.571SerMet: 1.571 ± 0.037
2.034SerAsn: 2.034 ± 0.049
2.568SerPro: 2.568 ± 0.061
2.574SerGln: 2.574 ± 0.052
3.144SerArg: 3.144 ± 0.057
4.318SerSer: 4.318 ± 0.071
3.114SerThr: 3.114 ± 0.06
4.052SerVal: 4.052 ± 0.065
0.788SerTrp: 0.788 ± 0.03
1.962SerTyr: 1.962 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.814ThrAla: 4.814 ± 0.082
0.599ThrCys: 0.599 ± 0.028
2.973ThrAsp: 2.973 ± 0.062
3.146ThrGlu: 3.146 ± 0.057
2.181ThrPhe: 2.181 ± 0.047
4.623ThrGly: 4.623 ± 0.083
0.997ThrHis: 0.997 ± 0.033
3.707ThrIle: 3.707 ± 0.072
2.138ThrLys: 2.138 ± 0.045
6.127ThrLeu: 6.127 ± 0.082
1.201ThrMet: 1.201 ± 0.031
1.809ThrAsn: 1.809 ± 0.049
2.604ThrPro: 2.604 ± 0.049
1.785ThrGln: 1.785 ± 0.043
2.249ThrArg: 2.249 ± 0.051
3.179ThrSer: 3.179 ± 0.071
3.24ThrThr: 3.24 ± 0.079
3.92ThrVal: 3.92 ± 0.066
0.427ThrTrp: 0.427 ± 0.02
1.479ThrTyr: 1.479 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
6.564ValAla: 6.564 ± 0.116
0.805ValCys: 0.805 ± 0.027
4.198ValAsp: 4.198 ± 0.059
4.475ValGlu: 4.475 ± 0.075
2.805ValPhe: 2.805 ± 0.056
4.942ValGly: 4.942 ± 0.104
1.12ValHis: 1.12 ± 0.031
4.673ValIle: 4.673 ± 0.069
3.336ValLys: 3.336 ± 0.056
6.901ValLeu: 6.901 ± 0.088
1.705ValMet: 1.705 ± 0.04
2.7ValAsn: 2.7 ± 0.059
2.827ValPro: 2.827 ± 0.051
2.327ValGln: 2.327 ± 0.053
3.23ValArg: 3.23 ± 0.053
4.596ValSer: 4.596 ± 0.087
4.039ValThr: 4.039 ± 0.08
5.256ValVal: 5.256 ± 0.087
0.616ValTrp: 0.616 ± 0.023
1.672ValTyr: 1.672 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.652TrpAla: 0.652 ± 0.025
0.14TrpCys: 0.14 ± 0.01
0.523TrpAsp: 0.523 ± 0.024
0.542TrpGlu: 0.542 ± 0.023
0.505TrpPhe: 0.505 ± 0.022
0.728TrpGly: 0.728 ± 0.025
0.219TrpHis: 0.219 ± 0.016
0.617TrpIle: 0.617 ± 0.024
0.504TrpLys: 0.504 ± 0.023
1.21TrpLeu: 1.21 ± 0.039
0.253TrpMet: 0.253 ± 0.016
0.452TrpAsn: 0.452 ± 0.02
0.394TrpPro: 0.394 ± 0.02
0.639TrpGln: 0.639 ± 0.026
0.554TrpArg: 0.554 ± 0.024
0.592TrpSer: 0.592 ± 0.023
0.46TrpThr: 0.46 ± 0.022
0.661TrpVal: 0.661 ± 0.028
0.147TrpTrp: 0.147 ± 0.012
0.294TrpTyr: 0.294 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.258TyrAla: 2.258 ± 0.048
0.395TyrCys: 0.395 ± 0.02
1.574TyrAsp: 1.574 ± 0.041
1.499TyrGlu: 1.499 ± 0.039
1.376TyrPhe: 1.376 ± 0.036
2.182TyrGly: 2.182 ± 0.05
0.734TyrHis: 0.734 ± 0.029
1.551TyrIle: 1.551 ± 0.04
1.174TyrLys: 1.174 ± 0.034
3.503TyrLeu: 3.503 ± 0.057
0.556TyrMet: 0.556 ± 0.024
1.123TyrAsn: 1.123 ± 0.038
1.384TyrPro: 1.384 ± 0.036
1.561TyrGln: 1.561 ± 0.035
1.879TyrArg: 1.879 ± 0.04
1.986TyrSer: 1.986 ± 0.046
1.388TyrThr: 1.388 ± 0.045
1.614TyrVal: 1.614 ± 0.04
0.331TyrTrp: 0.331 ± 0.017
0.908TyrTyr: 0.908 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3339 proteins (1111176 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski