Amino acid dipepetide frequency for Streptococcus phage Javan578

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.097AlaAla: 3.097 ± 0.629
0.364AlaCys: 0.364 ± 0.156
5.282AlaAsp: 5.282 ± 0.753
6.648AlaGlu: 6.648 ± 0.751
1.366AlaPhe: 1.366 ± 0.393
6.284AlaGly: 6.284 ± 1.273
0.911AlaHis: 0.911 ± 0.384
6.74AlaIle: 6.74 ± 0.863
6.648AlaLys: 6.648 ± 0.782
6.011AlaLeu: 6.011 ± 0.746
2.277AlaMet: 2.277 ± 0.48
4.281AlaAsn: 4.281 ± 0.851
1.002AlaPro: 1.002 ± 0.26
3.097AlaGln: 3.097 ± 0.589
2.641AlaArg: 2.641 ± 0.446
3.825AlaSer: 3.825 ± 0.623
5.556AlaThr: 5.556 ± 0.735
5.191AlaVal: 5.191 ± 0.729
0.729AlaTrp: 0.729 ± 0.321
2.095AlaTyr: 2.095 ± 0.399
0.0AlaXaa: 0.0 ± 0.0
Cys
0.364CysAla: 0.364 ± 0.225
0.273CysCys: 0.273 ± 0.173
0.546CysAsp: 0.546 ± 0.232
0.182CysGlu: 0.182 ± 0.138
0.364CysPhe: 0.364 ± 0.188
0.729CysGly: 0.729 ± 0.276
0.091CysHis: 0.091 ± 0.089
0.091CysIle: 0.091 ± 0.091
0.546CysLys: 0.546 ± 0.275
0.455CysLeu: 0.455 ± 0.24
0.182CysMet: 0.182 ± 0.12
0.364CysAsn: 0.364 ± 0.161
0.273CysPro: 0.273 ± 0.147
0.273CysGln: 0.273 ± 0.15
0.273CysArg: 0.273 ± 0.154
0.729CysSer: 0.729 ± 0.242
0.091CysThr: 0.091 ± 0.086
0.182CysVal: 0.182 ± 0.15
0.0CysTrp: 0.0 ± 0.0
0.273CysTyr: 0.273 ± 0.213
0.0CysXaa: 0.0 ± 0.0
Asp
3.279AspAla: 3.279 ± 0.57
0.455AspCys: 0.455 ± 0.242
3.916AspAsp: 3.916 ± 0.81
4.007AspGlu: 4.007 ± 0.705
3.461AspPhe: 3.461 ± 0.538
4.918AspGly: 4.918 ± 0.64
0.638AspHis: 0.638 ± 0.231
4.827AspIle: 4.827 ± 0.668
5.829AspLys: 5.829 ± 0.83
6.193AspLeu: 6.193 ± 0.722
2.277AspMet: 2.277 ± 0.477
3.552AspAsn: 3.552 ± 0.473
1.366AspPro: 1.366 ± 0.536
1.548AspGln: 1.548 ± 0.325
2.641AspArg: 2.641 ± 0.459
3.097AspSer: 3.097 ± 0.487
3.734AspThr: 3.734 ± 0.612
5.556AspVal: 5.556 ± 0.8
1.002AspTrp: 1.002 ± 0.342
2.277AspTyr: 2.277 ± 0.56
0.0AspXaa: 0.0 ± 0.0
Glu
6.648GluAla: 6.648 ± 0.791
0.0GluCys: 0.0 ± 0.0
3.005GluAsp: 3.005 ± 0.604
4.645GluGlu: 4.645 ± 0.975
2.823GluPhe: 2.823 ± 0.434
3.279GluGly: 3.279 ± 0.566
1.821GluHis: 1.821 ± 0.427
5.738GluIle: 5.738 ± 0.679
5.282GluLys: 5.282 ± 1.161
6.375GluLeu: 6.375 ± 1.068
1.913GluMet: 1.913 ± 0.531
4.827GluAsn: 4.827 ± 0.646
2.55GluPro: 2.55 ± 0.699
3.279GluGln: 3.279 ± 0.575
3.37GluArg: 3.37 ± 0.415
3.552GluSer: 3.552 ± 0.532
3.37GluThr: 3.37 ± 0.618
4.645GluVal: 4.645 ± 0.501
0.82GluTrp: 0.82 ± 0.316
3.005GluTyr: 3.005 ± 0.808
0.0GluXaa: 0.0 ± 0.0
Phe
2.095PheAla: 2.095 ± 0.466
0.364PheCys: 0.364 ± 0.201
3.734PheAsp: 3.734 ± 0.659
4.098PheGlu: 4.098 ± 0.579
1.366PhePhe: 1.366 ± 0.321
2.823PheGly: 2.823 ± 0.702
0.911PheHis: 0.911 ± 0.273
2.55PheIle: 2.55 ± 0.478
2.914PheLys: 2.914 ± 0.378
2.277PheLeu: 2.277 ± 0.5
0.729PheMet: 0.729 ± 0.233
2.095PheAsn: 2.095 ± 0.51
0.82PhePro: 0.82 ± 0.272
1.366PheGln: 1.366 ± 0.498
1.093PheArg: 1.093 ± 0.304
2.004PheSer: 2.004 ± 0.465
2.277PheThr: 2.277 ± 0.524
2.55PheVal: 2.55 ± 0.344
0.364PheTrp: 0.364 ± 0.174
1.548PheTyr: 1.548 ± 0.423
0.0PheXaa: 0.0 ± 0.0
Gly
4.463GlyAla: 4.463 ± 1.272
0.273GlyCys: 0.273 ± 0.177
3.552GlyAsp: 3.552 ± 0.483
3.37GlyGlu: 3.37 ± 0.516
2.277GlyPhe: 2.277 ± 0.607
5.647GlyGly: 5.647 ± 0.922
1.002GlyHis: 1.002 ± 0.244
5.1GlyIle: 5.1 ± 0.889
5.738GlyLys: 5.738 ± 0.778
4.827GlyLeu: 4.827 ± 0.847
2.004GlyMet: 2.004 ± 0.498
3.279GlyAsn: 3.279 ± 0.897
1.093GlyPro: 1.093 ± 0.356
3.734GlyGln: 3.734 ± 0.503
3.37GlyArg: 3.37 ± 0.439
3.643GlySer: 3.643 ± 0.861
3.188GlyThr: 3.188 ± 0.49
4.189GlyVal: 4.189 ± 0.923
1.093GlyTrp: 1.093 ± 0.241
3.643GlyTyr: 3.643 ± 0.693
0.0GlyXaa: 0.0 ± 0.0
His
0.638HisAla: 0.638 ± 0.255
0.182HisCys: 0.182 ± 0.13
0.82HisAsp: 0.82 ± 0.272
1.275HisGlu: 1.275 ± 0.285
0.911HisPhe: 0.911 ± 0.35
1.002HisGly: 1.002 ± 0.376
0.182HisHis: 0.182 ± 0.133
0.82HisIle: 0.82 ± 0.242
0.82HisLys: 0.82 ± 0.334
1.275HisLeu: 1.275 ± 0.401
0.182HisMet: 0.182 ± 0.134
0.546HisAsn: 0.546 ± 0.204
0.638HisPro: 0.638 ± 0.188
0.729HisGln: 0.729 ± 0.244
0.638HisArg: 0.638 ± 0.235
0.911HisSer: 0.911 ± 0.226
0.455HisThr: 0.455 ± 0.193
0.82HisVal: 0.82 ± 0.26
0.182HisTrp: 0.182 ± 0.117
0.729HisTyr: 0.729 ± 0.318
0.0HisXaa: 0.0 ± 0.0
Ile
5.1IleAla: 5.1 ± 0.625
0.546IleCys: 0.546 ± 0.227
5.373IleAsp: 5.373 ± 0.555
5.92IleGlu: 5.92 ± 0.828
2.095IlePhe: 2.095 ± 0.495
3.916IleGly: 3.916 ± 0.61
0.911IleHis: 0.911 ± 0.294
5.009IleIle: 5.009 ± 0.815
6.284IleLys: 6.284 ± 0.682
4.554IleLeu: 4.554 ± 0.652
1.457IleMet: 1.457 ± 0.594
4.189IleAsn: 4.189 ± 0.858
2.459IlePro: 2.459 ± 0.518
2.823IleGln: 2.823 ± 0.572
3.097IleArg: 3.097 ± 0.413
4.554IleSer: 4.554 ± 0.611
4.281IleThr: 4.281 ± 0.674
3.916IleVal: 3.916 ± 0.662
0.638IleTrp: 0.638 ± 0.208
2.095IleTyr: 2.095 ± 0.417
0.0IleXaa: 0.0 ± 0.0
Lys
5.464LysAla: 5.464 ± 0.661
0.546LysCys: 0.546 ± 0.246
4.645LysAsp: 4.645 ± 0.822
4.098LysGlu: 4.098 ± 0.788
2.368LysPhe: 2.368 ± 0.459
4.645LysGly: 4.645 ± 0.613
1.002LysHis: 1.002 ± 0.269
5.647LysIle: 5.647 ± 0.678
7.286LysLys: 7.286 ± 1.246
6.375LysLeu: 6.375 ± 0.922
1.73LysMet: 1.73 ± 0.38
3.825LysAsn: 3.825 ± 0.611
3.097LysPro: 3.097 ± 0.692
4.736LysGln: 4.736 ± 0.705
5.373LysArg: 5.373 ± 0.803
5.1LysSer: 5.1 ± 0.649
5.647LysThr: 5.647 ± 0.974
5.373LysVal: 5.373 ± 0.669
0.911LysTrp: 0.911 ± 0.338
3.005LysTyr: 3.005 ± 0.615
0.0LysXaa: 0.0 ± 0.0
Leu
8.47LeuAla: 8.47 ± 0.922
0.364LeuCys: 0.364 ± 0.159
5.1LeuAsp: 5.1 ± 0.676
6.557LeuGlu: 6.557 ± 0.992
3.37LeuPhe: 3.37 ± 0.577
5.1LeuGly: 5.1 ± 1.318
1.184LeuHis: 1.184 ± 0.342
3.643LeuIle: 3.643 ± 0.578
7.559LeuLys: 7.559 ± 1.089
6.193LeuLeu: 6.193 ± 0.851
1.457LeuMet: 1.457 ± 0.373
4.372LeuAsn: 4.372 ± 0.808
2.277LeuPro: 2.277 ± 0.575
3.279LeuGln: 3.279 ± 0.53
4.645LeuArg: 4.645 ± 0.731
5.92LeuSer: 5.92 ± 0.962
5.373LeuThr: 5.373 ± 0.939
4.463LeuVal: 4.463 ± 0.621
0.638LeuTrp: 0.638 ± 0.263
1.275LeuTyr: 1.275 ± 0.359
0.0LeuXaa: 0.0 ± 0.0
Met
2.732MetAla: 2.732 ± 0.543
0.455MetCys: 0.455 ± 0.21
1.73MetAsp: 1.73 ± 0.344
1.184MetGlu: 1.184 ± 0.381
0.729MetPhe: 0.729 ± 0.233
1.548MetGly: 1.548 ± 0.709
0.546MetHis: 0.546 ± 0.246
1.275MetIle: 1.275 ± 0.26
1.639MetLys: 1.639 ± 0.392
1.639MetLeu: 1.639 ± 0.432
0.182MetMet: 0.182 ± 0.121
1.002MetAsn: 1.002 ± 0.31
0.82MetPro: 0.82 ± 0.25
0.82MetGln: 0.82 ± 0.225
0.729MetArg: 0.729 ± 0.282
1.73MetSer: 1.73 ± 0.439
2.823MetThr: 2.823 ± 0.545
1.457MetVal: 1.457 ± 0.327
0.091MetTrp: 0.091 ± 0.09
1.002MetTyr: 1.002 ± 0.486
0.0MetXaa: 0.0 ± 0.0
Asn
2.914AsnAla: 2.914 ± 0.632
0.729AsnCys: 0.729 ± 0.287
2.55AsnAsp: 2.55 ± 0.461
3.461AsnGlu: 3.461 ± 0.512
2.459AsnPhe: 2.459 ± 0.435
5.1AsnGly: 5.1 ± 1.026
0.364AsnHis: 0.364 ± 0.136
3.37AsnIle: 3.37 ± 0.695
3.552AsnLys: 3.552 ± 0.648
4.554AsnLeu: 4.554 ± 0.846
1.002AsnMet: 1.002 ± 0.257
2.186AsnAsn: 2.186 ± 0.489
2.823AsnPro: 2.823 ± 0.753
3.37AsnGln: 3.37 ± 0.611
2.732AsnArg: 2.732 ± 0.615
3.005AsnSer: 3.005 ± 0.68
3.005AsnThr: 3.005 ± 0.592
2.641AsnVal: 2.641 ± 0.428
0.638AsnTrp: 0.638 ± 0.219
2.641AsnTyr: 2.641 ± 0.566
0.0AsnXaa: 0.0 ± 0.0
Pro
1.821ProAla: 1.821 ± 0.333
0.182ProCys: 0.182 ± 0.124
2.641ProAsp: 2.641 ± 0.595
1.639ProGlu: 1.639 ± 0.388
2.095ProPhe: 2.095 ± 0.416
1.093ProGly: 1.093 ± 0.353
0.455ProHis: 0.455 ± 0.211
2.55ProIle: 2.55 ± 0.64
2.277ProLys: 2.277 ± 0.527
2.641ProLeu: 2.641 ± 0.503
1.002ProMet: 1.002 ± 0.248
1.366ProAsn: 1.366 ± 0.42
0.273ProPro: 0.273 ± 0.156
1.275ProGln: 1.275 ± 0.337
0.911ProArg: 0.911 ± 0.292
2.459ProSer: 2.459 ± 0.596
2.004ProThr: 2.004 ± 0.456
1.73ProVal: 1.73 ± 0.406
0.455ProTrp: 0.455 ± 0.18
0.455ProTyr: 0.455 ± 0.2
0.0ProXaa: 0.0 ± 0.0
Gln
4.827GlnAla: 4.827 ± 0.847
0.091GlnCys: 0.091 ± 0.084
1.821GlnAsp: 1.821 ± 0.358
3.643GlnGlu: 3.643 ± 0.547
1.002GlnPhe: 1.002 ± 0.307
1.275GlnGly: 1.275 ± 0.482
0.091GlnHis: 0.091 ± 0.077
2.732GlnIle: 2.732 ± 0.531
3.643GlnLys: 3.643 ± 0.711
4.007GlnLeu: 4.007 ± 0.664
0.82GlnMet: 0.82 ± 0.263
2.732GlnAsn: 2.732 ± 0.607
1.366GlnPro: 1.366 ± 0.295
2.004GlnGln: 2.004 ± 0.59
1.639GlnArg: 1.639 ± 0.364
4.281GlnSer: 4.281 ± 0.804
3.188GlnThr: 3.188 ± 0.751
4.645GlnVal: 4.645 ± 0.577
0.455GlnTrp: 0.455 ± 0.199
1.184GlnTyr: 1.184 ± 0.299
0.0GlnXaa: 0.0 ± 0.0
Arg
2.914ArgAla: 2.914 ± 0.551
0.455ArgCys: 0.455 ± 0.224
2.55ArgAsp: 2.55 ± 0.556
3.643ArgGlu: 3.643 ± 0.858
1.275ArgPhe: 1.275 ± 0.3
1.821ArgGly: 1.821 ± 0.338
0.911ArgHis: 0.911 ± 0.281
3.461ArgIle: 3.461 ± 0.608
4.098ArgLys: 4.098 ± 0.674
5.009ArgLeu: 5.009 ± 0.722
0.546ArgMet: 0.546 ± 0.225
2.914ArgAsn: 2.914 ± 0.557
1.639ArgPro: 1.639 ± 0.411
1.913ArgGln: 1.913 ± 0.399
1.913ArgArg: 1.913 ± 0.579
1.457ArgSer: 1.457 ± 0.494
3.097ArgThr: 3.097 ± 0.572
2.186ArgVal: 2.186 ± 0.41
0.546ArgTrp: 0.546 ± 0.215
1.913ArgTyr: 1.913 ± 0.468
0.0ArgXaa: 0.0 ± 0.0
Ser
5.009SerAla: 5.009 ± 1.173
0.273SerCys: 0.273 ± 0.146
4.918SerAsp: 4.918 ± 0.686
4.736SerGlu: 4.736 ± 0.806
2.914SerPhe: 2.914 ± 0.593
4.554SerGly: 4.554 ± 0.977
0.82SerHis: 0.82 ± 0.381
3.734SerIle: 3.734 ± 0.57
4.463SerLys: 4.463 ± 0.752
5.647SerLeu: 5.647 ± 0.935
2.095SerMet: 2.095 ± 0.371
3.005SerAsn: 3.005 ± 0.481
1.639SerPro: 1.639 ± 0.349
2.641SerGln: 2.641 ± 0.665
2.004SerArg: 2.004 ± 0.487
4.372SerSer: 4.372 ± 0.749
3.734SerThr: 3.734 ± 0.776
4.098SerVal: 4.098 ± 0.721
0.364SerTrp: 0.364 ± 0.142
2.641SerTyr: 2.641 ± 0.435
0.0SerXaa: 0.0 ± 0.0
Thr
5.738ThrAla: 5.738 ± 1.495
0.182ThrCys: 0.182 ± 0.144
4.189ThrAsp: 4.189 ± 0.495
4.827ThrGlu: 4.827 ± 0.915
2.732ThrPhe: 2.732 ± 0.409
4.554ThrGly: 4.554 ± 0.638
0.546ThrHis: 0.546 ± 0.214
4.281ThrIle: 4.281 ± 0.769
4.554ThrLys: 4.554 ± 0.726
5.282ThrLeu: 5.282 ± 0.575
0.82ThrMet: 0.82 ± 0.206
2.823ThrAsn: 2.823 ± 0.618
1.366ThrPro: 1.366 ± 0.326
3.005ThrGln: 3.005 ± 0.944
2.368ThrArg: 2.368 ± 0.44
4.098ThrSer: 4.098 ± 0.557
3.279ThrThr: 3.279 ± 0.852
5.647ThrVal: 5.647 ± 1.026
0.364ThrTrp: 0.364 ± 0.167
2.368ThrTyr: 2.368 ± 0.434
0.0ThrXaa: 0.0 ± 0.0
Val
4.918ValAla: 4.918 ± 0.697
0.273ValCys: 0.273 ± 0.154
4.918ValAsp: 4.918 ± 0.665
4.554ValGlu: 4.554 ± 0.71
2.095ValPhe: 2.095 ± 0.453
4.189ValGly: 4.189 ± 0.771
0.82ValHis: 0.82 ± 0.28
4.007ValIle: 4.007 ± 0.579
5.009ValLys: 5.009 ± 0.636
4.281ValLeu: 4.281 ± 0.78
1.639ValMet: 1.639 ± 0.356
3.734ValAsn: 3.734 ± 0.586
2.55ValPro: 2.55 ± 0.445
2.823ValGln: 2.823 ± 0.609
2.277ValArg: 2.277 ± 0.386
6.648ValSer: 6.648 ± 0.8
4.645ValThr: 4.645 ± 0.76
3.825ValVal: 3.825 ± 0.591
0.455ValTrp: 0.455 ± 0.162
2.368ValTyr: 2.368 ± 0.385
0.0ValXaa: 0.0 ± 0.0
Trp
1.093TrpAla: 1.093 ± 0.296
0.091TrpCys: 0.091 ± 0.086
0.273TrpAsp: 0.273 ± 0.131
0.638TrpGlu: 0.638 ± 0.23
0.273TrpPhe: 0.273 ± 0.165
0.911TrpGly: 0.911 ± 0.411
0.091TrpHis: 0.091 ± 0.091
0.911TrpIle: 0.911 ± 0.284
0.638TrpLys: 0.638 ± 0.2
0.638TrpLeu: 0.638 ± 0.314
0.364TrpMet: 0.364 ± 0.169
0.729TrpAsn: 0.729 ± 0.225
0.091TrpPro: 0.091 ± 0.091
0.638TrpGln: 0.638 ± 0.246
0.455TrpArg: 0.455 ± 0.204
0.546TrpSer: 0.546 ± 0.231
0.729TrpThr: 0.729 ± 0.295
0.638TrpVal: 0.638 ± 0.271
0.0TrpTrp: 0.0 ± 0.0
0.546TrpTyr: 0.546 ± 0.196
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.459TyrAla: 2.459 ± 0.447
0.182TyrCys: 0.182 ± 0.13
3.005TyrAsp: 3.005 ± 0.674
1.821TyrGlu: 1.821 ± 0.353
2.004TyrPhe: 2.004 ± 0.518
2.095TyrGly: 2.095 ± 0.413
0.455TyrHis: 0.455 ± 0.176
2.732TyrIle: 2.732 ± 0.544
2.095TyrLys: 2.095 ± 0.398
3.097TyrLeu: 3.097 ± 0.517
1.366TyrMet: 1.366 ± 0.392
1.275TyrAsn: 1.275 ± 0.293
1.184TyrPro: 1.184 ± 0.368
2.095TyrGln: 2.095 ± 0.422
2.095TyrArg: 2.095 ± 0.563
1.73TyrSer: 1.73 ± 0.368
2.55TyrThr: 2.55 ± 0.463
2.277TyrVal: 2.277 ± 0.42
0.546TyrTrp: 0.546 ± 0.204
1.275TyrTyr: 1.275 ± 0.419
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 59 proteins (10981 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski