Amino acid dipepetide frequency for Fictibacillus arsenicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.497AlaAla: 6.497 ± 0.095	0.54AlaCys: 0.54 ± 0.023	3.471AlaAsp: 3.471 ± 0.06	5.001AlaGlu: 5.001 ± 0.065	3.41AlaPhe: 3.41 ± 0.065	5.738AlaGly: 5.738 ± 0.083	1.346AlaHis: 1.346 ± 0.034	5.522AlaIle: 5.522 ± 0.077	4.722AlaLys: 4.722 ± 0.078	7.101AlaLeu: 7.101 ± 0.08	1.967AlaMet: 1.967 ± 0.043	2.551AlaAsn: 2.551 ± 0.047	2.189AlaPro: 2.189 ± 0.051	2.118AlaGln: 2.118 ± 0.044	2.523AlaArg: 2.523 ± 0.051	4.203AlaSer: 4.203 ± 0.062	3.163AlaThr: 3.163 ± 0.049	5.774AlaVal: 5.774 ± 0.078	0.636AlaTrp: 0.636 ± 0.025	2.298AlaTyr: 2.298 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.395CysAla: 0.395 ± 0.019	0.098CysCys: 0.098 ± 0.01	0.386CysAsp: 0.386 ± 0.019	0.463CysGlu: 0.463 ± 0.022	0.318CysPhe: 0.318 ± 0.018	0.688CysGly: 0.688 ± 0.029	0.18CysHis: 0.18 ± 0.012	0.506CysIle: 0.506 ± 0.022	0.371CysLys: 0.371 ± 0.02	0.659CysLeu: 0.659 ± 0.027	0.19CysMet: 0.19 ± 0.014	0.258CysAsn: 0.258 ± 0.014	0.359CysPro: 0.359 ± 0.02	0.214CysGln: 0.214 ± 0.013	0.279CysArg: 0.279 ± 0.017	0.536CysSer: 0.536 ± 0.023	0.379CysThr: 0.379 ± 0.02	0.419CysVal: 0.419 ± 0.02	0.088CysTrp: 0.088 ± 0.009	0.258CysTyr: 0.258 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.235AspAla: 3.235 ± 0.063	0.354AspCys: 0.354 ± 0.02	2.3AspAsp: 2.3 ± 0.049	4.324AspGlu: 4.324 ± 0.061	2.433AspPhe: 2.433 ± 0.052	3.471AspGly: 3.471 ± 0.054	1.204AspHis: 1.204 ± 0.034	3.784AspIle: 3.784 ± 0.068	3.123AspLys: 3.123 ± 0.056	5.018AspLeu: 5.018 ± 0.079	1.299AspMet: 1.299 ± 0.035	1.735AspAsn: 1.735 ± 0.041	2.061AspPro: 2.061 ± 0.047	2.01AspGln: 2.01 ± 0.041	2.116AspArg: 2.116 ± 0.05	2.753AspSer: 2.753 ± 0.051	2.448AspThr: 2.448 ± 0.041	3.772AspVal: 3.772 ± 0.054	0.632AspTrp: 0.632 ± 0.023	2.077AspTyr: 2.077 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.381GluAla: 5.381 ± 0.071	0.395GluCys: 0.395 ± 0.02	3.883GluAsp: 3.883 ± 0.06	7.021GluGlu: 7.021 ± 0.112	2.654GluPhe: 2.654 ± 0.051	4.583GluGly: 4.583 ± 0.066	1.475GluHis: 1.475 ± 0.037	5.469GluIle: 5.469 ± 0.081	7.068GluLys: 7.068 ± 0.098	7.159GluLeu: 7.159 ± 0.096	2.248GluMet: 2.248 ± 0.044	3.845GluAsn: 3.845 ± 0.055	2.06GluPro: 2.06 ± 0.043	3.015GluGln: 3.015 ± 0.06	3.434GluArg: 3.434 ± 0.067	3.854GluSer: 3.854 ± 0.055	4.175GluThr: 4.175 ± 0.062	5.007GluVal: 5.007 ± 0.079	0.876GluTrp: 0.876 ± 0.027	2.242GluTyr: 2.242 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.118PheAla: 3.118 ± 0.058	0.371PheCys: 0.371 ± 0.018	2.216PheAsp: 2.216 ± 0.046	2.962PheGlu: 2.962 ± 0.051	2.44PhePhe: 2.44 ± 0.059	3.41PheGly: 3.41 ± 0.057	0.987PheHis: 0.987 ± 0.026	3.836PheIle: 3.836 ± 0.067	2.657PheLys: 2.657 ± 0.049	4.746PheLeu: 4.746 ± 0.078	1.244PheMet: 1.244 ± 0.034	1.983PheAsn: 1.983 ± 0.041	1.708PhePro: 1.708 ± 0.04	1.59PheGln: 1.59 ± 0.038	1.514PheArg: 1.514 ± 0.035	3.369PheSer: 3.369 ± 0.063	2.651PheThr: 2.651 ± 0.043	3.133PheVal: 3.133 ± 0.057	0.569PheTrp: 0.569 ± 0.024	1.829PheTyr: 1.829 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.007GlyAla: 5.007 ± 0.078	0.625GlyCys: 0.625 ± 0.026	3.211GlyAsp: 3.211 ± 0.06	4.651GlyGlu: 4.651 ± 0.072	3.498GlyPhe: 3.498 ± 0.058	5.03GlyGly: 5.03 ± 0.088	1.403GlyHis: 1.403 ± 0.035	5.923GlyIle: 5.923 ± 0.084	5.284GlyLys: 5.284 ± 0.069	6.814GlyLeu: 6.814 ± 0.067	2.184GlyMet: 2.184 ± 0.055	2.765GlyAsn: 2.765 ± 0.048	1.829GlyPro: 1.829 ± 0.044	2.08GlyGln: 2.08 ± 0.042	2.543GlyArg: 2.543 ± 0.046	4.225GlySer: 4.225 ± 0.067	4.212GlyThr: 4.212 ± 0.064	5.064GlyVal: 5.064 ± 0.075	0.82GlyTrp: 0.82 ± 0.027	2.839GlyTyr: 2.839 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.315HisAla: 1.315 ± 0.041	0.19HisCys: 0.19 ± 0.013	0.987HisAsp: 0.987 ± 0.026	1.504HisGlu: 1.504 ± 0.043	1.13HisPhe: 1.13 ± 0.032	1.405HisGly: 1.405 ± 0.04	0.654HisHis: 0.654 ± 0.026	1.495HisIle: 1.495 ± 0.038	1.104HisLys: 1.104 ± 0.03	2.106HisLeu: 2.106 ± 0.037	0.549HisMet: 0.549 ± 0.025	0.831HisAsn: 0.831 ± 0.027	1.148HisPro: 1.148 ± 0.029	0.784HisGln: 0.784 ± 0.028	0.877HisArg: 0.877 ± 0.027	1.176HisSer: 1.176 ± 0.036	1.112HisThr: 1.112 ± 0.031	1.425HisVal: 1.425 ± 0.033	0.247HisTrp: 0.247 ± 0.016	0.894HisTyr: 0.894 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.832IleAla: 5.832 ± 0.085	0.609IleCys: 0.609 ± 0.022	3.925IleAsp: 3.925 ± 0.057	5.452IleGlu: 5.452 ± 0.071	3.168IlePhe: 3.168 ± 0.058	5.855IleGly: 5.855 ± 0.087	1.617IleHis: 1.617 ± 0.042	5.445IleIle: 5.445 ± 0.088	4.91IleLys: 4.91 ± 0.073	7.017IleLeu: 7.017 ± 0.096	1.808IleMet: 1.808 ± 0.043	3.145IleAsn: 3.145 ± 0.056	3.318IlePro: 3.318 ± 0.06	2.815IleGln: 2.815 ± 0.05	2.848IleArg: 2.848 ± 0.053	4.971IleSer: 4.971 ± 0.068	4.37IleThr: 4.37 ± 0.068	5.096IleVal: 5.096 ± 0.067	0.694IleTrp: 0.694 ± 0.025	2.364IleTyr: 2.364 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.936LysAla: 4.936 ± 0.074	0.306LysCys: 0.306 ± 0.015	4.154LysAsp: 4.154 ± 0.072	7.256LysGlu: 7.256 ± 0.096	2.016LysPhe: 2.016 ± 0.044	4.68LysGly: 4.68 ± 0.059	1.387LysHis: 1.387 ± 0.032	4.671LysIle: 4.671 ± 0.076	6.478LysLys: 6.478 ± 0.097	5.971LysLeu: 5.971 ± 0.084	2.273LysMet: 2.273 ± 0.041	3.565LysAsn: 3.565 ± 0.064	2.445LysPro: 2.445 ± 0.056	2.994LysGln: 2.994 ± 0.06	3.372LysArg: 3.372 ± 0.059	3.765LysSer: 3.765 ± 0.063	3.854LysThr: 3.854 ± 0.059	4.731LysVal: 4.731 ± 0.065	0.915LysTrp: 0.915 ± 0.029	2.159LysTyr: 2.159 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	7.275LeuAla: 7.275 ± 0.088	0.673LeuCys: 0.673 ± 0.027	4.653LeuAsp: 4.653 ± 0.072	6.432LeuGlu: 6.432 ± 0.085	5.072LeuPhe: 5.072 ± 0.086	6.437LeuGly: 6.437 ± 0.084	1.964LeuHis: 1.964 ± 0.051	7.231LeuIle: 7.231 ± 0.092	7.007LeuLys: 7.007 ± 0.094	10.061LeuLeu: 10.061 ± 0.142	2.575LeuMet: 2.575 ± 0.053	4.423LeuAsn: 4.423 ± 0.065	4.067LeuPro: 4.067 ± 0.058	3.493LeuGln: 3.493 ± 0.061	3.432LeuArg: 3.432 ± 0.057	6.934LeuSer: 6.934 ± 0.076	5.65LeuThr: 5.65 ± 0.078	6.245LeuVal: 6.245 ± 0.082	0.845LeuTrp: 0.845 ± 0.033	3.181LeuTyr: 3.181 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.103MetAla: 2.103 ± 0.042	0.154MetCys: 0.154 ± 0.013	1.524MetAsp: 1.524 ± 0.035	2.006MetGlu: 2.006 ± 0.05	1.13MetPhe: 1.13 ± 0.036	1.908MetGly: 1.908 ± 0.049	0.493MetHis: 0.493 ± 0.02	2.134MetIle: 2.134 ± 0.048	2.591MetLys: 2.591 ± 0.046	2.616MetLeu: 2.616 ± 0.053	0.878MetMet: 0.878 ± 0.033	1.649MetAsn: 1.649 ± 0.039	1.082MetPro: 1.082 ± 0.04	0.904MetGln: 0.904 ± 0.03	1.04MetArg: 1.04 ± 0.031	1.637MetSer: 1.637 ± 0.034	1.575MetThr: 1.575 ± 0.034	1.748MetVal: 1.748 ± 0.041	0.239MetTrp: 0.239 ± 0.014	0.782MetTyr: 0.782 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.748AsnAla: 2.748 ± 0.049	0.312AsnCys: 0.312 ± 0.017	2.196AsnAsp: 2.196 ± 0.04	3.601AsnGlu: 3.601 ± 0.058	1.65AsnPhe: 1.65 ± 0.038	3.31AsnGly: 3.31 ± 0.062	1.085AsnHis: 1.085 ± 0.032	3.062AsnIle: 3.062 ± 0.051	3.066AsnLys: 3.066 ± 0.061	3.796AsnLeu: 3.796 ± 0.058	1.264AsnMet: 1.264 ± 0.036	1.944AsnAsn: 1.944 ± 0.048	2.185AsnPro: 2.185 ± 0.047	1.802AsnGln: 1.802 ± 0.036	1.939AsnArg: 1.939 ± 0.037	2.292AsnSer: 2.292 ± 0.047	2.209AsnThr: 2.209 ± 0.048	2.972AsnVal: 2.972 ± 0.047	0.538AsnTrp: 0.538 ± 0.026	1.533AsnTyr: 1.533 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.617ProAla: 2.617 ± 0.056	0.204ProCys: 0.204 ± 0.014	2.19ProAsp: 2.19 ± 0.039	3.314ProGlu: 3.314 ± 0.056	2.127ProPhe: 2.127 ± 0.045	2.551ProGly: 2.551 ± 0.048	0.781ProHis: 0.781 ± 0.029	2.681ProIle: 2.681 ± 0.057	2.232ProLys: 2.232 ± 0.045	3.592ProLeu: 3.592 ± 0.062	0.859ProMet: 0.859 ± 0.031	1.494ProAsn: 1.494 ± 0.04	1.046ProPro: 1.046 ± 0.039	1.136ProGln: 1.136 ± 0.037	1.17ProArg: 1.17 ± 0.032	2.332ProSer: 2.332 ± 0.049	1.688ProThr: 1.688 ± 0.038	3.258ProVal: 3.258 ± 0.062	0.403ProTrp: 0.403 ± 0.019	1.463ProTyr: 1.463 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.362GlnAla: 2.362 ± 0.044	0.193GlnCys: 0.193 ± 0.014	1.604GlnAsp: 1.604 ± 0.036	2.706GlnGlu: 2.706 ± 0.05	1.486GlnPhe: 1.486 ± 0.036	2.064GlnGly: 2.064 ± 0.044	0.733GlnHis: 0.733 ± 0.025	2.486GlnIle: 2.486 ± 0.048	2.961GlnLys: 2.961 ± 0.046	3.704GlnLeu: 3.704 ± 0.063	1.101GlnMet: 1.101 ± 0.037	1.788GlnAsn: 1.788 ± 0.046	1.252GlnPro: 1.252 ± 0.03	1.622GlnGln: 1.622 ± 0.042	1.465GlnArg: 1.465 ± 0.039	2.084GlnSer: 2.084 ± 0.044	1.993GlnThr: 1.993 ± 0.042	2.174GlnVal: 2.174 ± 0.047	0.396GlnTrp: 0.396 ± 0.019	1.293GlnTyr: 1.293 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.318ArgAla: 2.318 ± 0.048	0.265ArgCys: 0.265 ± 0.017	2.027ArgAsp: 2.027 ± 0.041	3.097ArgGlu: 3.097 ± 0.054	1.876ArgPhe: 1.876 ± 0.039	2.303ArgGly: 2.303 ± 0.045	0.767ArgHis: 0.767 ± 0.024	2.975ArgIle: 2.975 ± 0.057	3.018ArgLys: 3.018 ± 0.058	3.837ArgLeu: 3.837 ± 0.06	1.337ArgMet: 1.337 ± 0.04	1.87ArgAsn: 1.87 ± 0.045	1.297ArgPro: 1.297 ± 0.034	1.375ArgGln: 1.375 ± 0.037	1.648ArgArg: 1.648 ± 0.044	2.206ArgSer: 2.206 ± 0.046	2.084ArgThr: 2.084 ± 0.046	2.473ArgVal: 2.473 ± 0.045	0.448ArgTrp: 0.448 ± 0.021	1.572ArgTyr: 1.572 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.064SerAla: 4.064 ± 0.062	0.435SerCys: 0.435 ± 0.021	2.912SerAsp: 2.912 ± 0.059	4.298SerGlu: 4.298 ± 0.063	3.475SerPhe: 3.475 ± 0.058	4.612SerGly: 4.612 ± 0.072	1.283SerHis: 1.283 ± 0.037	4.83SerIle: 4.83 ± 0.07	3.935SerLys: 3.935 ± 0.06	6.311SerLeu: 6.311 ± 0.078	1.811SerMet: 1.811 ± 0.04	2.348SerAsn: 2.348 ± 0.05	2.196SerPro: 2.196 ± 0.053	1.988SerGln: 1.988 ± 0.047	2.209SerArg: 2.209 ± 0.047	4.175SerSer: 4.175 ± 0.077	3.05SerThr: 3.05 ± 0.054	4.445SerVal: 4.445 ± 0.063	0.698SerTrp: 0.698 ± 0.027	2.284SerTyr: 2.284 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.096ThrAla: 4.096 ± 0.064	0.337ThrCys: 0.337 ± 0.019	2.701ThrAsp: 2.701 ± 0.052	3.665ThrGlu: 3.665 ± 0.061	2.659ThrPhe: 2.659 ± 0.049	4.4ThrGly: 4.4 ± 0.066	1.077ThrHis: 1.077 ± 0.034	4.387ThrIle: 4.387 ± 0.068	3.348ThrLys: 3.348 ± 0.058	5.392ThrLeu: 5.392 ± 0.068	1.248ThrMet: 1.248 ± 0.033	2.227ThrAsn: 2.227 ± 0.046	2.32ThrPro: 2.32 ± 0.047	1.454ThrGln: 1.454 ± 0.031	1.793ThrArg: 1.793 ± 0.042	3.301ThrSer: 3.301 ± 0.059	2.678ThrThr: 2.678 ± 0.056	4.197ThrVal: 4.197 ± 0.069	0.583ThrTrp: 0.583 ± 0.026	1.953ThrTyr: 1.953 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	4.678ValAla: 4.678 ± 0.075	0.596ValCys: 0.596 ± 0.024	3.374ValAsp: 3.374 ± 0.062	4.595ValGlu: 4.595 ± 0.07	3.325ValPhe: 3.325 ± 0.053	4.308ValGly: 4.308 ± 0.067	1.42ValHis: 1.42 ± 0.035	5.637ValIle: 5.637 ± 0.073	5.027ValLys: 5.027 ± 0.073	7.085ValLeu: 7.085 ± 0.082	2.048ValMet: 2.048 ± 0.046	3.051ValAsn: 3.051 ± 0.065	2.847ValPro: 2.847 ± 0.049	2.387ValGln: 2.387 ± 0.044	2.594ValArg: 2.594 ± 0.059	4.748ValSer: 4.748 ± 0.072	4.141ValThr: 4.141 ± 0.066	4.866ValVal: 4.866 ± 0.073	0.703ValTrp: 0.703 ± 0.025	2.374ValTyr: 2.374 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.685TrpAla: 0.685 ± 0.024	0.077TrpCys: 0.077 ± 0.009	0.561TrpAsp: 0.561 ± 0.023	0.734TrpGlu: 0.734 ± 0.026	0.556TrpPhe: 0.556 ± 0.024	0.748TrpGly: 0.748 ± 0.026	0.238TrpHis: 0.238 ± 0.014	0.876TrpIle: 0.876 ± 0.031	0.79TrpLys: 0.79 ± 0.029	1.2TrpLeu: 1.2 ± 0.038	0.375TrpMet: 0.375 ± 0.021	0.606TrpAsn: 0.606 ± 0.022	0.292TrpPro: 0.292 ± 0.016	0.349TrpGln: 0.349 ± 0.016	0.403TrpArg: 0.403 ± 0.022	0.636TrpSer: 0.636 ± 0.024	0.533TrpThr: 0.533 ± 0.021	0.738TrpVal: 0.738 ± 0.024	0.147TrpTrp: 0.147 ± 0.013	0.348TrpTyr: 0.348 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.109TyrAla: 2.109 ± 0.036	0.31TyrCys: 0.31 ± 0.019	1.875TyrAsp: 1.875 ± 0.039	2.759TyrGlu: 2.759 ± 0.057	1.911TyrPhe: 1.911 ± 0.044	2.505TyrGly: 2.505 ± 0.048	0.837TyrHis: 0.837 ± 0.027	2.313TyrIle: 2.313 ± 0.047	2.237TyrLys: 2.237 ± 0.05	3.465TyrLeu: 3.465 ± 0.057	0.937TyrMet: 0.937 ± 0.029	1.425TyrAsn: 1.425 ± 0.037	1.436TyrPro: 1.436 ± 0.037	1.339TyrGln: 1.339 ± 0.036	1.593TyrArg: 1.593 ± 0.043	2.162TyrSer: 2.162 ± 0.044	1.854TyrThr: 1.854 ± 0.041	2.262TyrVal: 2.262 ± 0.048	0.414TyrTrp: 0.414 ± 0.019	1.384TyrTyr: 1.384 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3937 proteins (1122737 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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