Amino acid dipepetide frequency for Blacklegged tick phlebovirus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.769AlaAla: 5.769 ± 4.041
0.769AlaCys: 0.769 ± 0.339
1.154AlaAsp: 1.154 ± 0.508
4.231AlaGlu: 4.231 ± 3.622
1.538AlaPhe: 1.538 ± 0.678
5.0AlaGly: 5.0 ± 0.008
0.769AlaHis: 0.769 ± 0.339
2.308AlaIle: 2.308 ± 0.081
2.692AlaLys: 2.692 ± 0.089
5.769AlaLeu: 5.769 ± 1.847
3.077AlaMet: 3.077 ± 3.033
1.538AlaAsn: 1.538 ± 0.419
2.692AlaPro: 2.692 ± 2.105
2.692AlaGln: 2.692 ± 0.089
5.769AlaArg: 5.769 ± 0.75
5.0AlaSer: 5.0 ± 2.202
4.231AlaThr: 4.231 ± 2.525
5.0AlaVal: 5.0 ± 0.008
1.154AlaTrp: 1.154 ± 0.508
1.923AlaTyr: 1.923 ± 1.347
0.0AlaXaa: 0.0 ± 0.0
Cys
0.385CysAla: 0.385 ± 0.169
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.385CysGlu: 0.385 ± 0.169
0.0CysPhe: 0.0 ± 0.0
1.154CysGly: 1.154 ± 0.589
0.769CysHis: 0.769 ± 0.758
0.769CysIle: 0.769 ± 0.339
0.769CysLys: 0.769 ± 0.339
3.077CysLeu: 3.077 ± 0.258
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.769CysGln: 0.769 ± 0.339
1.154CysArg: 1.154 ± 0.508
1.538CysSer: 1.538 ± 1.516
0.769CysThr: 0.769 ± 0.339
0.769CysVal: 0.769 ± 0.339
0.385CysTrp: 0.385 ± 0.169
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.692AspAla: 2.692 ± 1.186
0.769AspCys: 0.769 ± 0.758
4.231AspAsp: 4.231 ± 1.863
3.462AspGlu: 3.462 ± 0.669
2.308AspPhe: 2.308 ± 0.081
1.154AspGly: 1.154 ± 0.589
0.769AspHis: 0.769 ± 0.339
4.615AspIle: 4.615 ± 2.355
2.308AspLys: 2.308 ± 0.081
7.308AspLeu: 7.308 ± 3.219
0.385AspMet: 0.385 ± 0.928
0.769AspAsn: 0.769 ± 0.339
3.077AspPro: 3.077 ± 1.355
1.923AspGln: 1.923 ± 1.347
3.846AspArg: 3.846 ± 1.694
2.308AspSer: 2.308 ± 1.016
2.308AspThr: 2.308 ± 2.275
4.231AspVal: 4.231 ± 1.863
1.538AspTrp: 1.538 ± 0.678
0.769AspTyr: 0.769 ± 0.339
0.0AspXaa: 0.0 ± 0.0
Glu
3.462GluAla: 3.462 ± 0.669
0.769GluCys: 0.769 ± 0.339
4.615GluAsp: 4.615 ± 0.936
12.692GluGlu: 12.692 ± 0.992
5.769GluPhe: 5.769 ± 2.541
5.385GluGly: 5.385 ± 2.016
2.308GluHis: 2.308 ± 1.016
3.846GluIle: 3.846 ± 0.597
3.462GluLys: 3.462 ± 0.669
5.769GluLeu: 5.769 ± 0.347
1.923GluMet: 1.923 ± 0.847
2.308GluAsn: 2.308 ± 1.016
3.077GluPro: 3.077 ± 0.258
3.077GluGln: 3.077 ± 0.839
5.0GluArg: 5.0 ± 2.202
5.0GluSer: 5.0 ± 1.105
3.846GluThr: 3.846 ± 0.5
7.308GluVal: 7.308 ± 4.461
0.769GluTrp: 0.769 ± 0.339
1.538GluTyr: 1.538 ± 1.516
0.0GluXaa: 0.0 ± 0.0
Phe
2.308PheAla: 2.308 ± 0.081
0.385PheCys: 0.385 ± 0.169
1.538PheAsp: 1.538 ± 0.678
1.538PheGlu: 1.538 ± 0.678
2.692PhePhe: 2.692 ± 1.186
1.923PheGly: 1.923 ± 0.847
1.154PheHis: 1.154 ± 0.508
1.154PheIle: 1.154 ± 0.508
4.231PheLys: 4.231 ± 0.331
3.462PheLeu: 3.462 ± 1.525
1.923PheMet: 1.923 ± 0.847
2.308PheAsn: 2.308 ± 0.081
3.077PhePro: 3.077 ± 0.839
1.154PheGln: 1.154 ± 0.589
0.769PheArg: 0.769 ± 0.758
5.0PheSer: 5.0 ± 2.202
3.462PheThr: 3.462 ± 1.525
1.923PheVal: 1.923 ± 0.25
0.769PheTrp: 0.769 ± 0.339
1.154PheTyr: 1.154 ± 0.508
0.0PheXaa: 0.0 ± 0.0
Gly
4.231GlyAla: 4.231 ± 0.766
0.769GlyCys: 0.769 ± 0.339
2.692GlyAsp: 2.692 ± 1.186
3.077GlyGlu: 3.077 ± 1.355
3.077GlyPhe: 3.077 ± 0.839
4.231GlyGly: 4.231 ± 0.766
1.538GlyHis: 1.538 ± 0.678
1.923GlyIle: 1.923 ± 0.847
3.846GlyLys: 3.846 ± 1.597
7.308GlyLeu: 7.308 ± 2.266
2.308GlyMet: 2.308 ± 0.081
1.923GlyAsn: 1.923 ± 0.25
2.308GlyPro: 2.308 ± 2.275
1.154GlyGln: 1.154 ± 0.508
4.231GlyArg: 4.231 ± 0.766
4.615GlySer: 4.615 ± 0.936
3.846GlyThr: 3.846 ± 1.694
5.0GlyVal: 5.0 ± 2.186
0.0GlyTrp: 0.0 ± 0.0
3.462GlyTyr: 3.462 ± 0.669
0.0GlyXaa: 0.0 ± 0.0
His
1.923HisAla: 1.923 ± 0.847
0.769HisCys: 0.769 ± 0.339
3.077HisAsp: 3.077 ± 0.258
2.692HisGlu: 2.692 ± 0.089
0.769HisPhe: 0.769 ± 0.339
1.154HisGly: 1.154 ± 0.508
0.0HisHis: 0.0 ± 0.0
1.154HisIle: 1.154 ± 0.589
1.154HisLys: 1.154 ± 0.508
1.923HisLeu: 1.923 ± 0.847
1.154HisMet: 1.154 ± 0.508
1.154HisAsn: 1.154 ± 0.508
2.692HisPro: 2.692 ± 1.186
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
1.923HisSer: 1.923 ± 0.847
0.769HisThr: 0.769 ± 0.339
2.692HisVal: 2.692 ± 0.089
0.385HisTrp: 0.385 ± 0.169
1.154HisTyr: 1.154 ± 0.508
0.0HisXaa: 0.0 ± 0.0
Ile
2.308IleAla: 2.308 ± 1.178
0.385IleCys: 0.385 ± 0.169
2.692IleAsp: 2.692 ± 0.089
3.462IleGlu: 3.462 ± 0.428
2.692IlePhe: 2.692 ± 1.186
1.923IleGly: 1.923 ± 0.25
1.154IleHis: 1.154 ± 0.589
1.923IleIle: 1.923 ± 1.347
1.538IleLys: 1.538 ± 0.678
4.231IleLeu: 4.231 ± 1.428
2.308IleMet: 2.308 ± 0.081
1.154IleAsn: 1.154 ± 0.589
2.692IlePro: 2.692 ± 1.008
1.923IleGln: 1.923 ± 0.847
3.462IleArg: 3.462 ± 0.669
3.077IleSer: 3.077 ± 1.355
2.692IleThr: 2.692 ± 0.089
1.923IleVal: 1.923 ± 0.847
0.385IleTrp: 0.385 ± 0.928
1.154IleTyr: 1.154 ± 0.508
0.0IleXaa: 0.0 ± 0.0
Lys
7.308LysAla: 7.308 ± 0.072
1.154LysCys: 1.154 ± 0.508
2.308LysAsp: 2.308 ± 1.016
4.615LysGlu: 4.615 ± 0.936
2.692LysPhe: 2.692 ± 1.186
1.923LysGly: 1.923 ± 0.25
1.923LysHis: 1.923 ± 1.347
1.154LysIle: 1.154 ± 1.686
4.615LysLys: 4.615 ± 0.161
6.538LysLeu: 6.538 ± 1.783
1.154LysMet: 1.154 ± 0.508
2.308LysAsn: 2.308 ± 0.081
2.692LysPro: 2.692 ± 1.186
1.923LysGln: 1.923 ± 0.25
4.615LysArg: 4.615 ± 2.355
2.692LysSer: 2.692 ± 1.186
4.231LysThr: 4.231 ± 0.331
4.231LysVal: 4.231 ± 0.766
1.154LysTrp: 1.154 ± 0.508
1.923LysTyr: 1.923 ± 0.847
0.0LysXaa: 0.0 ± 0.0
Leu
6.154LeuAla: 6.154 ± 0.581
1.923LeuCys: 1.923 ± 0.847
5.0LeuAsp: 5.0 ± 0.008
7.692LeuGlu: 7.692 ± 0.097
3.846LeuPhe: 3.846 ± 0.597
10.385LeuGly: 10.385 ± 2.38
4.231LeuHis: 4.231 ± 1.863
5.0LeuIle: 5.0 ± 2.186
8.077LeuLys: 8.077 ± 2.461
6.923LeuLeu: 6.923 ± 0.855
2.308LeuMet: 2.308 ± 1.27
4.231LeuAsn: 4.231 ± 1.428
2.692LeuPro: 2.692 ± 0.089
3.462LeuGln: 3.462 ± 0.428
5.769LeuArg: 5.769 ± 0.347
6.154LeuSer: 6.154 ± 0.516
5.769LeuThr: 5.769 ± 1.847
5.0LeuVal: 5.0 ± 0.008
0.385LeuTrp: 0.385 ± 0.169
1.538LeuTyr: 1.538 ± 0.419
0.0LeuXaa: 0.0 ± 0.0
Met
0.769MetAla: 0.769 ± 0.339
0.385MetCys: 0.385 ± 0.928
1.923MetAsp: 1.923 ± 2.444
3.846MetGlu: 3.846 ± 0.5
1.923MetPhe: 1.923 ± 0.847
1.538MetGly: 1.538 ± 1.516
0.769MetHis: 0.769 ± 0.339
0.769MetIle: 0.769 ± 0.339
2.308MetLys: 2.308 ± 1.016
3.077MetLeu: 3.077 ± 0.258
1.538MetMet: 1.538 ± 0.419
0.769MetAsn: 0.769 ± 0.758
0.0MetPro: 0.0 ± 0.0
1.154MetGln: 1.154 ± 0.589
1.538MetArg: 1.538 ± 0.678
3.846MetSer: 3.846 ± 0.597
3.462MetThr: 3.462 ± 0.669
2.308MetVal: 2.308 ± 0.081
0.769MetTrp: 0.769 ± 0.339
0.385MetTyr: 0.385 ± 0.169
0.0MetXaa: 0.0 ± 0.0
Asn
1.923AsnAla: 1.923 ± 2.444
0.769AsnCys: 0.769 ± 0.339
0.769AsnAsp: 0.769 ± 0.339
1.923AsnGlu: 1.923 ± 0.847
1.923AsnPhe: 1.923 ± 0.25
0.769AsnGly: 0.769 ± 0.339
0.0AsnHis: 0.0 ± 0.0
0.385AsnIle: 0.385 ± 0.928
2.692AsnLys: 2.692 ± 1.186
4.231AsnLeu: 4.231 ± 0.766
0.769AsnMet: 0.769 ± 0.339
1.538AsnAsn: 1.538 ± 0.678
1.154AsnPro: 1.154 ± 1.686
1.538AsnGln: 1.538 ± 0.678
0.769AsnArg: 0.769 ± 0.339
4.231AsnSer: 4.231 ± 0.331
1.923AsnThr: 1.923 ± 0.25
3.846AsnVal: 3.846 ± 0.597
0.769AsnTrp: 0.769 ± 0.758
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
2.692ProAla: 2.692 ± 1.008
0.385ProCys: 0.385 ± 0.928
4.231ProAsp: 4.231 ± 3.622
4.231ProGlu: 4.231 ± 0.331
1.538ProPhe: 1.538 ± 0.678
3.077ProGly: 3.077 ± 0.839
1.538ProHis: 1.538 ± 0.678
1.154ProIle: 1.154 ± 0.508
2.692ProLys: 2.692 ± 0.089
3.846ProLeu: 3.846 ± 1.694
1.154ProMet: 1.154 ± 0.508
0.769ProAsn: 0.769 ± 0.339
1.538ProPro: 1.538 ± 2.613
3.077ProGln: 3.077 ± 0.258
2.308ProArg: 2.308 ± 1.178
4.231ProSer: 4.231 ± 2.525
0.769ProThr: 0.769 ± 0.758
3.077ProVal: 3.077 ± 0.258
1.538ProTrp: 1.538 ± 0.678
1.538ProTyr: 1.538 ± 0.678
0.0ProXaa: 0.0 ± 0.0
Gln
1.154GlnAla: 1.154 ± 0.589
0.0GlnCys: 0.0 ± 0.0
2.692GlnAsp: 2.692 ± 1.008
5.385GlnGlu: 5.385 ± 0.178
0.769GlnPhe: 0.769 ± 0.758
2.308GlnGly: 2.308 ± 1.016
1.923GlnHis: 1.923 ± 0.847
2.692GlnIle: 2.692 ± 1.186
2.308GlnLys: 2.308 ± 1.178
4.231GlnLeu: 4.231 ± 1.428
2.308GlnMet: 2.308 ± 0.081
0.385GlnAsn: 0.385 ± 0.169
0.769GlnPro: 0.769 ± 0.339
1.538GlnGln: 1.538 ± 0.678
2.308GlnArg: 2.308 ± 0.081
1.923GlnSer: 1.923 ± 1.347
0.769GlnThr: 0.769 ± 0.339
3.077GlnVal: 3.077 ± 0.839
0.0GlnTrp: 0.0 ± 0.0
0.769GlnTyr: 0.769 ± 0.339
0.0GlnXaa: 0.0 ± 0.0
Arg
5.0ArgAla: 5.0 ± 2.186
0.385ArgCys: 0.385 ± 0.928
0.769ArgAsp: 0.769 ± 0.339
3.077ArgGlu: 3.077 ± 0.839
1.923ArgPhe: 1.923 ± 0.847
5.769ArgGly: 5.769 ± 0.75
1.538ArgHis: 1.538 ± 0.678
3.462ArgIle: 3.462 ± 0.669
4.231ArgLys: 4.231 ± 0.331
5.385ArgLeu: 5.385 ± 2.372
1.538ArgMet: 1.538 ± 0.678
1.923ArgAsn: 1.923 ± 0.847
3.846ArgPro: 3.846 ± 1.694
2.692ArgGln: 2.692 ± 1.008
4.615ArgArg: 4.615 ± 0.936
4.231ArgSer: 4.231 ± 0.766
2.692ArgThr: 2.692 ± 1.008
5.385ArgVal: 5.385 ± 0.919
1.538ArgTrp: 1.538 ± 0.678
1.923ArgTyr: 1.923 ± 0.25
0.0ArgXaa: 0.0 ± 0.0
Ser
3.846SerAla: 3.846 ± 0.5
0.769SerCys: 0.769 ± 0.339
4.615SerAsp: 4.615 ± 0.936
5.385SerGlu: 5.385 ± 0.178
3.462SerPhe: 3.462 ± 1.525
6.154SerGly: 6.154 ± 0.516
2.692SerHis: 2.692 ± 1.186
3.077SerIle: 3.077 ± 1.355
3.846SerLys: 3.846 ± 0.597
9.231SerLeu: 9.231 ± 0.322
1.154SerMet: 1.154 ± 0.508
2.692SerAsn: 2.692 ± 1.186
3.462SerPro: 3.462 ± 0.428
2.308SerGln: 2.308 ± 1.016
5.769SerArg: 5.769 ± 0.75
7.692SerSer: 7.692 ± 1.194
3.077SerThr: 3.077 ± 0.258
6.154SerVal: 6.154 ± 0.516
0.0SerTrp: 0.0 ± 0.0
2.692SerTyr: 2.692 ± 0.089
0.0SerXaa: 0.0 ± 0.0
Thr
3.462ThrAla: 3.462 ± 1.766
0.385ThrCys: 0.385 ± 0.169
1.538ThrAsp: 1.538 ± 0.678
5.385ThrGlu: 5.385 ± 1.275
2.308ThrPhe: 2.308 ± 0.081
3.462ThrGly: 3.462 ± 0.428
1.538ThrHis: 1.538 ± 0.678
2.308ThrIle: 2.308 ± 1.016
3.846ThrLys: 3.846 ± 0.597
3.846ThrLeu: 3.846 ± 0.5
4.231ThrMet: 4.231 ± 2.525
1.923ThrAsn: 1.923 ± 1.347
5.0ThrPro: 5.0 ± 1.089
1.538ThrGln: 1.538 ± 0.419
2.308ThrArg: 2.308 ± 1.178
3.846ThrSer: 3.846 ± 0.597
4.615ThrThr: 4.615 ± 1.258
2.692ThrVal: 2.692 ± 0.089
0.0ThrTrp: 0.0 ± 0.0
1.923ThrTyr: 1.923 ± 1.347
0.0ThrXaa: 0.0 ± 0.0
Val
6.538ValAla: 6.538 ± 2.605
0.385ValCys: 0.385 ± 0.169
4.231ValAsp: 4.231 ± 1.863
5.0ValGlu: 5.0 ± 1.089
1.154ValPhe: 1.154 ± 0.589
2.692ValGly: 2.692 ± 0.089
1.923ValHis: 1.923 ± 0.847
3.846ValIle: 3.846 ± 0.597
5.385ValLys: 5.385 ± 0.178
6.538ValLeu: 6.538 ± 1.508
2.692ValMet: 2.692 ± 1.186
2.308ValAsn: 2.308 ± 1.178
3.077ValPro: 3.077 ± 1.936
3.846ValGln: 3.846 ± 1.597
3.462ValArg: 3.462 ± 1.525
8.077ValSer: 8.077 ± 0.266
4.615ValThr: 4.615 ± 0.161
8.077ValVal: 8.077 ± 1.928
1.923ValTrp: 1.923 ± 0.25
1.154ValTyr: 1.154 ± 0.508
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.385TrpAsp: 0.385 ± 0.169
2.308TrpGlu: 2.308 ± 1.016
0.385TrpPhe: 0.385 ± 0.169
1.154TrpGly: 1.154 ± 0.508
0.0TrpHis: 0.0 ± 0.0
0.385TrpIle: 0.385 ± 0.169
0.385TrpLys: 0.385 ± 0.169
1.538TrpLeu: 1.538 ± 0.419
0.385TrpMet: 0.385 ± 0.169
1.154TrpAsn: 1.154 ± 0.508
0.769TrpPro: 0.769 ± 0.339
0.385TrpGln: 0.385 ± 0.169
2.308TrpArg: 2.308 ± 0.081
0.385TrpSer: 0.385 ± 0.169
0.769TrpThr: 0.769 ± 0.339
1.154TrpVal: 1.154 ± 0.589
0.769TrpTrp: 0.769 ± 0.339
0.385TrpTyr: 0.385 ± 0.169
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.154TyrAla: 1.154 ± 0.589
1.538TyrCys: 1.538 ± 0.419
2.308TyrAsp: 2.308 ± 1.016
1.538TyrGlu: 1.538 ± 0.678
1.154TyrPhe: 1.154 ± 0.589
0.385TyrGly: 0.385 ± 0.928
0.0TyrHis: 0.0 ± 0.0
1.154TyrIle: 1.154 ± 0.508
0.769TyrLys: 0.769 ± 0.339
2.308TyrLeu: 2.308 ± 1.178
0.385TyrMet: 0.385 ± 0.329
0.769TyrAsn: 0.769 ± 0.339
0.769TyrPro: 0.769 ± 0.758
1.154TyrGln: 1.154 ± 0.589
1.923TyrArg: 1.923 ± 0.25
2.308TyrSer: 2.308 ± 1.016
1.538TyrThr: 1.538 ± 0.678
3.077TyrVal: 3.077 ± 0.258
0.769TyrTrp: 0.769 ± 0.339
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2601 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski