Amino acid dipepetide frequency for Enterococcus cecorum DSM 20682 = ATCC 43198

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.002AlaAla: 5.002 ± 0.116
0.679AlaCys: 0.679 ± 0.031
3.8AlaAsp: 3.8 ± 0.078
4.275AlaGlu: 4.275 ± 0.085
3.278AlaPhe: 3.278 ± 0.073
4.401AlaGly: 4.401 ± 0.095
1.331AlaHis: 1.331 ± 0.04
5.914AlaIle: 5.914 ± 0.096
6.059AlaLys: 6.059 ± 0.109
7.194AlaLeu: 7.194 ± 0.109
2.066AlaMet: 2.066 ± 0.052
3.571AlaAsn: 3.571 ± 0.088
1.958AlaPro: 1.958 ± 0.06
3.655AlaGln: 3.655 ± 0.079
2.505AlaArg: 2.505 ± 0.068
4.21AlaSer: 4.21 ± 0.083
4.015AlaThr: 4.015 ± 0.076
4.631AlaVal: 4.631 ± 0.096
0.572AlaTrp: 0.572 ± 0.028
2.681AlaTyr: 2.681 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.511CysAla: 0.511 ± 0.031
0.106CysCys: 0.106 ± 0.014
0.398CysAsp: 0.398 ± 0.023
0.482CysGlu: 0.482 ± 0.031
0.397CysPhe: 0.397 ± 0.023
0.691CysGly: 0.691 ± 0.035
0.235CysHis: 0.235 ± 0.02
0.548CysIle: 0.548 ± 0.03
0.385CysLys: 0.385 ± 0.027
0.884CysLeu: 0.884 ± 0.041
0.165CysMet: 0.165 ± 0.015
0.269CysAsn: 0.269 ± 0.019
0.346CysPro: 0.346 ± 0.024
0.397CysGln: 0.397 ± 0.024
0.271CysArg: 0.271 ± 0.02
0.445CysSer: 0.445 ± 0.024
0.388CysThr: 0.388 ± 0.021
0.478CysVal: 0.478 ± 0.025
0.075CysTrp: 0.075 ± 0.012
0.342CysTyr: 0.342 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.375AspAla: 3.375 ± 0.081
0.464AspCys: 0.464 ± 0.027
2.49AspAsp: 2.49 ± 0.064
4.763AspGlu: 4.763 ± 0.084
3.046AspPhe: 3.046 ± 0.069
3.388AspGly: 3.388 ± 0.08
0.963AspHis: 0.963 ± 0.042
3.76AspIle: 3.76 ± 0.069
3.362AspLys: 3.362 ± 0.087
5.648AspLeu: 5.648 ± 0.094
1.269AspMet: 1.269 ± 0.038
2.106AspAsn: 2.106 ± 0.061
1.651AspPro: 1.651 ± 0.045
2.138AspGln: 2.138 ± 0.064
1.744AspArg: 1.744 ± 0.046
2.655AspSer: 2.655 ± 0.068
2.668AspThr: 2.668 ± 0.069
3.408AspVal: 3.408 ± 0.078
0.619AspTrp: 0.619 ± 0.026
2.767AspTyr: 2.767 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
4.892GluAla: 4.892 ± 0.1
0.442GluCys: 0.442 ± 0.027
3.417GluAsp: 3.417 ± 0.082
5.857GluGlu: 5.857 ± 0.116
2.603GluPhe: 2.603 ± 0.062
3.436GluGly: 3.436 ± 0.079
1.217GluHis: 1.217 ± 0.04
5.715GluIle: 5.715 ± 0.098
6.561GluLys: 6.561 ± 0.108
7.199GluLeu: 7.199 ± 0.107
2.264GluMet: 2.264 ± 0.052
4.243GluAsn: 4.243 ± 0.086
1.493GluPro: 1.493 ± 0.049
3.465GluGln: 3.465 ± 0.08
2.784GluArg: 2.784 ± 0.07
3.319GluSer: 3.319 ± 0.069
3.34GluThr: 3.34 ± 0.073
5.019GluVal: 5.019 ± 0.089
0.572GluTrp: 0.572 ± 0.027
2.394GluTyr: 2.394 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.304PheAla: 3.304 ± 0.08
0.413PheCys: 0.413 ± 0.029
2.796PheAsp: 2.796 ± 0.059
3.258PheGlu: 3.258 ± 0.069
2.187PhePhe: 2.187 ± 0.059
3.329PheGly: 3.329 ± 0.069
0.997PheHis: 0.997 ± 0.04
3.437PheIle: 3.437 ± 0.077
2.658PheLys: 2.658 ± 0.057
4.48PheLeu: 4.48 ± 0.094
1.252PheMet: 1.252 ± 0.046
2.084PheAsn: 2.084 ± 0.051
1.549PhePro: 1.549 ± 0.05
1.819PheGln: 1.819 ± 0.059
1.488PheArg: 1.488 ± 0.05
3.039PheSer: 3.039 ± 0.075
2.59PheThr: 2.59 ± 0.062
3.281PheVal: 3.281 ± 0.073
0.42PheTrp: 0.42 ± 0.025
1.916PheTyr: 1.916 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.081GlyAla: 4.081 ± 0.1
0.598GlyCys: 0.598 ± 0.029
2.759GlyAsp: 2.759 ± 0.062
3.74GlyGlu: 3.74 ± 0.079
3.075GlyPhe: 3.075 ± 0.066
4.046GlyGly: 4.046 ± 0.097
1.207GlyHis: 1.207 ± 0.045
5.429GlyIle: 5.429 ± 0.089
4.751GlyLys: 4.751 ± 0.074
6.255GlyLeu: 6.255 ± 0.107
1.895GlyMet: 1.895 ± 0.059
2.681GlyAsn: 2.681 ± 0.073
1.359GlyPro: 1.359 ± 0.048
2.564GlyGln: 2.564 ± 0.072
2.342GlyArg: 2.342 ± 0.071
3.408GlySer: 3.408 ± 0.076
3.448GlyThr: 3.448 ± 0.08
4.454GlyVal: 4.454 ± 0.079
0.607GlyTrp: 0.607 ± 0.031
2.674GlyTyr: 2.674 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.227HisAla: 1.227 ± 0.039
0.181HisCys: 0.181 ± 0.015
0.947HisAsp: 0.947 ± 0.04
1.309HisGlu: 1.309 ± 0.049
1.225HisPhe: 1.225 ± 0.043
1.324HisGly: 1.324 ± 0.046
0.665HisHis: 0.665 ± 0.04
1.34HisIle: 1.34 ± 0.043
0.972HisLys: 0.972 ± 0.043
2.367HisLeu: 2.367 ± 0.061
0.459HisMet: 0.459 ± 0.027
0.726HisAsn: 0.726 ± 0.029
1.098HisPro: 1.098 ± 0.04
1.275HisGln: 1.275 ± 0.045
0.884HisArg: 0.884 ± 0.038
1.105HisSer: 1.105 ± 0.04
1.049HisThr: 1.049 ± 0.035
1.198HisVal: 1.198 ± 0.047
0.183HisTrp: 0.183 ± 0.017
0.942HisTyr: 0.942 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.952IleAla: 5.952 ± 0.098
0.802IleCys: 0.802 ± 0.031
4.524IleAsp: 4.524 ± 0.089
5.335IleGlu: 5.335 ± 0.11
3.604IlePhe: 3.604 ± 0.083
4.961IleGly: 4.961 ± 0.103
1.631IleHis: 1.631 ± 0.048
5.312IleIle: 5.312 ± 0.091
4.438IleLys: 4.438 ± 0.08
7.346IleLeu: 7.346 ± 0.119
1.727IleMet: 1.727 ± 0.049
3.21IleAsn: 3.21 ± 0.068
2.964IlePro: 2.964 ± 0.068
3.623IleGln: 3.623 ± 0.081
2.844IleArg: 2.844 ± 0.062
4.606IleSer: 4.606 ± 0.088
4.089IleThr: 4.089 ± 0.073
5.086IleVal: 5.086 ± 0.091
0.511IleTrp: 0.511 ± 0.031
2.861IleTyr: 2.861 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
5.271LysAla: 5.271 ± 0.098
0.338LysCys: 0.338 ± 0.026
3.984LysAsp: 3.984 ± 0.085
6.475LysGlu: 6.475 ± 0.108
2.253LysPhe: 2.253 ± 0.064
3.831LysGly: 3.831 ± 0.07
1.246LysHis: 1.246 ± 0.045
5.273LysIle: 5.273 ± 0.072
6.027LysLys: 6.027 ± 0.125
6.055LysLeu: 6.055 ± 0.102
2.48LysMet: 2.48 ± 0.063
4.002LysAsn: 4.002 ± 0.096
1.857LysPro: 1.857 ± 0.051
3.94LysGln: 3.94 ± 0.095
3.268LysArg: 3.268 ± 0.069
3.463LysSer: 3.463 ± 0.074
3.571LysThr: 3.571 ± 0.08
5.031LysVal: 5.031 ± 0.08
0.6LysTrp: 0.6 ± 0.03
2.852LysTyr: 2.852 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
8.861LeuAla: 8.861 ± 0.132
0.762LeuCys: 0.762 ± 0.032
5.483LeuAsp: 5.483 ± 0.094
6.138LeuGlu: 6.138 ± 0.109
4.732LeuPhe: 4.732 ± 0.111
6.171LeuGly: 6.171 ± 0.107
1.873LeuHis: 1.873 ± 0.052
6.801LeuIle: 6.801 ± 0.117
6.869LeuLys: 6.869 ± 0.092
9.956LeuLeu: 9.956 ± 0.151
2.536LeuMet: 2.536 ± 0.067
4.715LeuAsn: 4.715 ± 0.083
4.22LeuPro: 4.22 ± 0.081
4.101LeuGln: 4.101 ± 0.091
3.565LeuArg: 3.565 ± 0.079
6.913LeuSer: 6.913 ± 0.115
6.074LeuThr: 6.074 ± 0.099
6.413LeuVal: 6.413 ± 0.116
0.71LeuTrp: 0.71 ± 0.031
3.242LeuTyr: 3.242 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
1.998MetAla: 1.998 ± 0.063
0.165MetCys: 0.165 ± 0.015
1.421MetAsp: 1.421 ± 0.045
1.598MetGlu: 1.598 ± 0.051
0.93MetPhe: 0.93 ± 0.038
1.546MetGly: 1.546 ± 0.055
0.548MetHis: 0.548 ± 0.022
2.328MetIle: 2.328 ± 0.059
2.312MetLys: 2.312 ± 0.061
2.292MetLeu: 2.292 ± 0.06
0.85MetMet: 0.85 ± 0.038
1.689MetAsn: 1.689 ± 0.058
0.988MetPro: 0.988 ± 0.032
1.344MetGln: 1.344 ± 0.049
1.023MetArg: 1.023 ± 0.039
1.722MetSer: 1.722 ± 0.052
1.635MetThr: 1.635 ± 0.049
1.727MetVal: 1.727 ± 0.049
0.155MetTrp: 0.155 ± 0.015
0.836MetTyr: 0.836 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.041AsnAla: 3.041 ± 0.08
0.371AsnCys: 0.371 ± 0.022
2.303AsnAsp: 2.303 ± 0.062
3.475AsnGlu: 3.475 ± 0.069
1.954AsnPhe: 1.954 ± 0.06
3.227AsnGly: 3.227 ± 0.084
1.392AsnHis: 1.392 ± 0.047
3.297AsnIle: 3.297 ± 0.07
2.893AsnLys: 2.893 ± 0.071
4.296AsnLeu: 4.296 ± 0.075
1.114AsnMet: 1.114 ± 0.041
2.04AsnAsn: 2.04 ± 0.066
2.168AsnPro: 2.168 ± 0.056
3.481AsnGln: 3.481 ± 0.085
2.09AsnArg: 2.09 ± 0.052
2.323AsnSer: 2.323 ± 0.062
2.264AsnThr: 2.264 ± 0.07
2.99AsnVal: 2.99 ± 0.079
0.494AsnTrp: 0.494 ± 0.027
2.18AsnTyr: 2.18 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.005ProAla: 2.005 ± 0.052
0.196ProCys: 0.196 ± 0.019
1.918ProAsp: 1.918 ± 0.05
2.775ProGlu: 2.775 ± 0.063
1.854ProPhe: 1.854 ± 0.065
1.883ProGly: 1.883 ± 0.049
0.61ProHis: 0.61 ± 0.027
2.633ProIle: 2.633 ± 0.059
2.484ProLys: 2.484 ± 0.074
3.136ProLeu: 3.136 ± 0.072
0.743ProMet: 0.743 ± 0.031
1.741ProAsn: 1.741 ± 0.053
0.582ProPro: 0.582 ± 0.029
1.389ProGln: 1.389 ± 0.047
1.013ProArg: 1.013 ± 0.038
2.06ProSer: 2.06 ± 0.057
2.096ProThr: 2.096 ± 0.055
2.535ProVal: 2.535 ± 0.071
0.319ProTrp: 0.319 ± 0.021
1.424ProTyr: 1.424 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.483GlnAla: 4.483 ± 0.101
0.22GlnCys: 0.22 ± 0.017
1.992GlnAsp: 1.992 ± 0.049
3.658GlnGlu: 3.658 ± 0.081
1.97GlnPhe: 1.97 ± 0.058
2.493GlnGly: 2.493 ± 0.062
0.814GlnHis: 0.814 ± 0.033
3.687GlnIle: 3.687 ± 0.075
4.079GlnLys: 4.079 ± 0.072
5.567GlnLeu: 5.567 ± 0.134
1.457GlnMet: 1.457 ± 0.05
2.286GlnAsn: 2.286 ± 0.066
1.408GlnPro: 1.408 ± 0.047
2.687GlnGln: 2.687 ± 0.091
1.863GlnArg: 1.863 ± 0.056
2.486GlnSer: 2.486 ± 0.075
2.868GlnThr: 2.868 ± 0.068
3.426GlnVal: 3.426 ± 0.076
0.455GlnTrp: 0.455 ± 0.026
1.689GlnTyr: 1.689 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.323ArgAla: 2.323 ± 0.06
0.307ArgCys: 0.307 ± 0.023
1.698ArgAsp: 1.698 ± 0.054
2.823ArgGlu: 2.823 ± 0.073
2.003ArgPhe: 2.003 ± 0.054
1.966ArgGly: 1.966 ± 0.063
0.798ArgHis: 0.798 ± 0.033
2.981ArgIle: 2.981 ± 0.072
3.274ArgLys: 3.274 ± 0.072
4.079ArgLeu: 4.079 ± 0.085
1.131ArgMet: 1.131 ± 0.048
1.757ArgAsn: 1.757 ± 0.059
1.286ArgPro: 1.286 ± 0.045
2.027ArgGln: 2.027 ± 0.056
1.808ArgArg: 1.808 ± 0.064
1.869ArgSer: 1.869 ± 0.05
1.785ArgThr: 1.785 ± 0.063
2.299ArgVal: 2.299 ± 0.062
0.326ArgTrp: 0.326 ± 0.023
1.748ArgTyr: 1.748 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
3.643SerAla: 3.643 ± 0.081
0.366SerCys: 0.366 ± 0.024
2.93SerAsp: 2.93 ± 0.068
3.758SerGlu: 3.758 ± 0.078
2.993SerPhe: 2.993 ± 0.062
3.889SerGly: 3.889 ± 0.081
1.188SerHis: 1.188 ± 0.043
4.304SerIle: 4.304 ± 0.076
3.927SerLys: 3.927 ± 0.085
5.629SerLeu: 5.629 ± 0.108
1.543SerMet: 1.543 ± 0.047
2.52SerAsn: 2.52 ± 0.062
1.696SerPro: 1.696 ± 0.049
2.994SerGln: 2.994 ± 0.075
2.276SerArg: 2.276 ± 0.065
3.264SerSer: 3.264 ± 0.084
3.135SerThr: 3.135 ± 0.078
3.681SerVal: 3.681 ± 0.07
0.529SerTrp: 0.529 ± 0.026
2.4SerTyr: 2.4 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
3.616ThrAla: 3.616 ± 0.071
0.385ThrCys: 0.385 ± 0.024
2.857ThrAsp: 2.857 ± 0.064
3.078ThrGlu: 3.078 ± 0.077
2.667ThrPhe: 2.667 ± 0.063
3.604ThrGly: 3.604 ± 0.071
1.221ThrHis: 1.221 ± 0.038
4.53ThrIle: 4.53 ± 0.075
3.721ThrLys: 3.721 ± 0.073
5.56ThrLeu: 5.56 ± 0.091
1.272ThrMet: 1.272 ± 0.04
2.657ThrAsn: 2.657 ± 0.069
2.447ThrPro: 2.447 ± 0.055
2.348ThrGln: 2.348 ± 0.062
1.816ThrArg: 1.816 ± 0.052
3.172ThrSer: 3.172 ± 0.076
3.274ThrThr: 3.274 ± 0.093
3.687ThrVal: 3.687 ± 0.075
0.445ThrTrp: 0.445 ± 0.025
2.128ThrTyr: 2.128 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
5.258ValAla: 5.258 ± 0.091
0.604ValCys: 0.604 ± 0.03
4.008ValAsp: 4.008 ± 0.084
4.38ValGlu: 4.38 ± 0.101
2.913ValPhe: 2.913 ± 0.072
4.324ValGly: 4.324 ± 0.083
1.23ValHis: 1.23 ± 0.044
5.047ValIle: 5.047 ± 0.099
4.648ValLys: 4.648 ± 0.084
6.41ValLeu: 6.41 ± 0.115
1.776ValMet: 1.776 ± 0.058
3.158ValAsn: 3.158 ± 0.065
2.512ValPro: 2.512 ± 0.057
2.7ValGln: 2.7 ± 0.071
2.457ValArg: 2.457 ± 0.063
3.968ValSer: 3.968 ± 0.071
3.833ValThr: 3.833 ± 0.076
4.993ValVal: 4.993 ± 0.1
0.497ValTrp: 0.497 ± 0.031
2.39ValTyr: 2.39 ± 0.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.472TrpAla: 0.472 ± 0.027
0.058TrpCys: 0.058 ± 0.008
0.408TrpAsp: 0.408 ± 0.024
0.469TrpGlu: 0.469 ± 0.025
0.427TrpPhe: 0.427 ± 0.024
0.52TrpGly: 0.52 ± 0.025
0.23TrpHis: 0.23 ± 0.018
0.645TrpIle: 0.645 ± 0.031
0.501TrpLys: 0.501 ± 0.026
1.047TrpLeu: 1.047 ± 0.04
0.287TrpMet: 0.287 ± 0.022
0.407TrpAsn: 0.407 ± 0.022
0.207TrpPro: 0.207 ± 0.016
0.776TrpGln: 0.776 ± 0.034
0.343TrpArg: 0.343 ± 0.019
0.504TrpSer: 0.504 ± 0.032
0.377TrpThr: 0.377 ± 0.022
0.461TrpVal: 0.461 ± 0.024
0.109TrpTrp: 0.109 ± 0.013
0.361TrpTyr: 0.361 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.483TyrAla: 2.483 ± 0.064
0.356TyrCys: 0.356 ± 0.023
2.153TyrAsp: 2.153 ± 0.056
2.586TyrGlu: 2.586 ± 0.058
2.184TyrPhe: 2.184 ± 0.054
2.344TyrGly: 2.344 ± 0.062
1.081TyrHis: 1.081 ± 0.043
2.447TyrIle: 2.447 ± 0.057
1.893TyrLys: 1.893 ± 0.059
4.734TyrLeu: 4.734 ± 0.091
0.818TyrMet: 0.818 ± 0.035
1.531TyrAsn: 1.531 ± 0.045
1.606TyrPro: 1.606 ± 0.05
2.864TyrGln: 2.864 ± 0.068
1.906TyrArg: 1.906 ± 0.053
2.134TyrSer: 2.134 ± 0.06
1.985TyrThr: 1.985 ± 0.052
2.309TyrVal: 2.309 ± 0.054
0.414TyrTrp: 0.414 ± 0.022
1.889TyrTyr: 1.889 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2361 proteins (690344 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski