Amino acid dipepetide frequency for Actinoplanes regularis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.437AlaAla: 22.437 ± 0.161	0.992AlaCys: 0.992 ± 0.019	8.409AlaAsp: 8.409 ± 0.063	8.381AlaGlu: 8.381 ± 0.066	3.451AlaPhe: 3.451 ± 0.041	14.412AlaGly: 14.412 ± 0.091	2.436AlaHis: 2.436 ± 0.033	4.519AlaIle: 4.519 ± 0.038	2.608AlaLys: 2.608 ± 0.041	13.805AlaLeu: 13.805 ± 0.112	2.519AlaMet: 2.519 ± 0.03	2.368AlaAsn: 2.368 ± 0.03	6.544AlaPro: 6.544 ± 0.073	3.565AlaGln: 3.565 ± 0.034	9.717AlaArg: 9.717 ± 0.078	5.801AlaSer: 5.801 ± 0.055	8.048AlaThr: 8.048 ± 0.071	12.181AlaVal: 12.181 ± 0.088	1.944AlaTrp: 1.944 ± 0.029	2.773AlaTyr: 2.773 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	0.969CysAla: 0.969 ± 0.018	0.095CysCys: 0.095 ± 0.006	0.48CysAsp: 0.48 ± 0.013	0.324CysGlu: 0.324 ± 0.012	0.217CysPhe: 0.217 ± 0.009	0.916CysGly: 0.916 ± 0.02	0.19CysHis: 0.19 ± 0.009	0.161CysIle: 0.161 ± 0.007	0.112CysLys: 0.112 ± 0.007	0.698CysLeu: 0.698 ± 0.016	0.106CysMet: 0.106 ± 0.006	0.147CysAsn: 0.147 ± 0.007	0.447CysPro: 0.447 ± 0.014	0.193CysGln: 0.193 ± 0.009	0.595CysArg: 0.595 ± 0.015	0.418CysSer: 0.418 ± 0.011	0.473CysThr: 0.473 ± 0.013	0.614CysVal: 0.614 ± 0.014	0.135CysTrp: 0.135 ± 0.007	0.175CysTyr: 0.175 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.012AspAla: 7.012 ± 0.059	0.414AspCys: 0.414 ± 0.011	3.8AspAsp: 3.8 ± 0.039	3.769AspGlu: 3.769 ± 0.042	1.629AspPhe: 1.629 ± 0.03	6.166AspGly: 6.166 ± 0.06	1.322AspHis: 1.322 ± 0.022	1.703AspIle: 1.703 ± 0.027	1.053AspLys: 1.053 ± 0.024	6.876AspLeu: 6.876 ± 0.059	0.719AspMet: 0.719 ± 0.017	1.077AspAsn: 1.077 ± 0.021	4.684AspPro: 4.684 ± 0.048	1.799AspGln: 1.799 ± 0.024	5.139AspArg: 5.139 ± 0.047	2.55AspSer: 2.55 ± 0.03	2.929AspThr: 2.929 ± 0.035	4.719AspVal: 4.719 ± 0.049	1.014AspTrp: 1.014 ± 0.018	1.174AspTyr: 1.174 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.428GluAla: 6.428 ± 0.051	0.318GluCys: 0.318 ± 0.011	2.203GluAsp: 2.203 ± 0.029	2.601GluGlu: 2.601 ± 0.037	1.511GluPhe: 1.511 ± 0.025	3.075GluGly: 3.075 ± 0.036	1.405GluHis: 1.405 ± 0.023	2.495GluIle: 2.495 ± 0.034	1.166GluLys: 1.166 ± 0.025	6.328GluLeu: 6.328 ± 0.056	0.934GluMet: 0.934 ± 0.017	1.055GluAsn: 1.055 ± 0.022	3.436GluPro: 3.436 ± 0.043	2.269GluGln: 2.269 ± 0.029	4.84GluArg: 4.84 ± 0.054	2.515GluSer: 2.515 ± 0.028	2.872GluThr: 2.872 ± 0.034	4.335GluVal: 4.335 ± 0.043	0.751GluTrp: 0.751 ± 0.017	1.044GluTyr: 1.044 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.927PheAla: 3.927 ± 0.04	0.274PheCys: 0.274 ± 0.009	2.057PheAsp: 2.057 ± 0.029	1.367PheGlu: 1.367 ± 0.026	0.888PhePhe: 0.888 ± 0.019	3.111PheGly: 3.111 ± 0.037	0.582PheHis: 0.582 ± 0.015	0.78PheIle: 0.78 ± 0.015	0.506PheLys: 0.506 ± 0.015	2.6PheLeu: 2.6 ± 0.03	0.367PheMet: 0.367 ± 0.011	0.644PheAsn: 0.644 ± 0.018	1.456PhePro: 1.456 ± 0.027	0.732PheGln: 0.732 ± 0.016	1.896PheArg: 1.896 ± 0.025	1.441PheSer: 1.441 ± 0.023	2.039PheThr: 2.039 ± 0.028	2.324PheVal: 2.324 ± 0.029	0.448PheTrp: 0.448 ± 0.013	0.64PheTyr: 0.64 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.436GlyAla: 10.436 ± 0.068	0.813GlyCys: 0.813 ± 0.017	5.427GlyAsp: 5.427 ± 0.051	4.506GlyGlu: 4.506 ± 0.042	2.929GlyPhe: 2.929 ± 0.04	8.215GlyGly: 8.215 ± 0.068	2.119GlyHis: 2.119 ± 0.031	3.388GlyIle: 3.388 ± 0.033	2.207GlyLys: 2.207 ± 0.035	9.602GlyLeu: 9.602 ± 0.064	1.865GlyMet: 1.865 ± 0.024	1.978GlyAsn: 1.978 ± 0.034	4.903GlyPro: 4.903 ± 0.053	2.693GlyGln: 2.693 ± 0.033	7.51GlyArg: 7.51 ± 0.057	5.208GlySer: 5.208 ± 0.053	6.112GlyThr: 6.112 ± 0.063	7.654GlyVal: 7.654 ± 0.067	1.89GlyTrp: 1.89 ± 0.026	2.434GlyTyr: 2.434 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.453HisAla: 2.453 ± 0.031	0.183HisCys: 0.183 ± 0.008	1.331HisAsp: 1.331 ± 0.025	1.089HisGlu: 1.089 ± 0.022	0.583HisPhe: 0.583 ± 0.015	2.101HisGly: 2.101 ± 0.029	0.63HisHis: 0.63 ± 0.015	0.595HisIle: 0.595 ± 0.014	0.293HisLys: 0.293 ± 0.011	2.395HisLeu: 2.395 ± 0.032	0.277HisMet: 0.277 ± 0.011	0.407HisAsn: 0.407 ± 0.011	1.677HisPro: 1.677 ± 0.029	0.652HisGln: 0.652 ± 0.017	2.007HisArg: 2.007 ± 0.028	0.912HisSer: 0.912 ± 0.019	1.107HisThr: 1.107 ± 0.019	1.553HisVal: 1.553 ± 0.025	0.348HisTrp: 0.348 ± 0.011	0.448HisTyr: 0.448 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.518IleAla: 5.518 ± 0.049	0.333IleCys: 0.333 ± 0.011	2.606IleAsp: 2.606 ± 0.03	2.179IleGlu: 2.179 ± 0.029	0.954IlePhe: 0.954 ± 0.021	3.934IleGly: 3.934 ± 0.04	0.602IleHis: 0.602 ± 0.016	1.158IleIle: 1.158 ± 0.024	0.742IleLys: 0.742 ± 0.018	2.924IleLeu: 2.924 ± 0.032	0.513IleMet: 0.513 ± 0.015	0.898IleAsn: 0.898 ± 0.02	1.921IlePro: 1.921 ± 0.028	0.805IleGln: 0.805 ± 0.016	2.724IleArg: 2.724 ± 0.035	2.052IleSer: 2.052 ± 0.026	2.63IleThr: 2.63 ± 0.031	3.141IleVal: 3.141 ± 0.039	0.498IleTrp: 0.498 ± 0.013	0.695IleTyr: 0.695 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.499LysAla: 2.499 ± 0.051	0.128LysCys: 0.128 ± 0.007	0.968LysAsp: 0.968 ± 0.022	0.837LysGlu: 0.837 ± 0.02	0.477LysPhe: 0.477 ± 0.014	1.378LysGly: 1.378 ± 0.027	0.371LysHis: 0.371 ± 0.012	0.969LysIle: 0.969 ± 0.019	0.615LysLys: 0.615 ± 0.021	2.011LysLeu: 2.011 ± 0.029	0.349LysMet: 0.349 ± 0.011	0.491LysAsn: 0.491 ± 0.016	1.301LysPro: 1.301 ± 0.025	0.656LysGln: 0.656 ± 0.016	1.389LysArg: 1.389 ± 0.023	1.097LysSer: 1.097 ± 0.024	1.233LysThr: 1.233 ± 0.027	1.731LysVal: 1.731 ± 0.029	0.273LysTrp: 0.273 ± 0.012	0.467LysTyr: 0.467 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.795LeuAla: 15.795 ± 0.116	0.78LeuCys: 0.78 ± 0.018	6.613LeuAsp: 6.613 ± 0.054	4.271LeuGlu: 4.271 ± 0.043	2.722LeuPhe: 2.722 ± 0.039	9.178LeuGly: 9.178 ± 0.06	2.196LeuHis: 2.196 ± 0.03	4.232LeuIle: 4.232 ± 0.042	1.716LeuLys: 1.716 ± 0.033	11.622LeuLeu: 11.622 ± 0.102	1.48LeuMet: 1.48 ± 0.027	2.0LeuAsn: 2.0 ± 0.026	6.44LeuPro: 6.44 ± 0.049	2.193LeuGln: 2.193 ± 0.029	8.823LeuArg: 8.823 ± 0.066	5.481LeuSer: 5.481 ± 0.046	7.193LeuThr: 7.193 ± 0.048	8.824LeuVal: 8.824 ± 0.076	1.321LeuTrp: 1.321 ± 0.025	1.756LeuTyr: 1.756 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.136MetAla: 2.136 ± 0.027	0.114MetCys: 0.114 ± 0.006	0.751MetAsp: 0.751 ± 0.015	0.592MetGlu: 0.592 ± 0.016	0.492MetPhe: 0.492 ± 0.014	1.086MetGly: 1.086 ± 0.021	0.319MetHis: 0.319 ± 0.01	0.872MetIle: 0.872 ± 0.02	0.381MetLys: 0.381 ± 0.011	1.85MetLeu: 1.85 ± 0.029	0.307MetMet: 0.307 ± 0.011	0.427MetAsn: 0.427 ± 0.012	1.137MetPro: 1.137 ± 0.022	0.426MetGln: 0.426 ± 0.012	1.477MetArg: 1.477 ± 0.024	1.26MetSer: 1.26 ± 0.022	1.588MetThr: 1.588 ± 0.022	1.246MetVal: 1.246 ± 0.024	0.213MetTrp: 0.213 ± 0.009	0.302MetTyr: 0.302 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.422AsnAla: 2.422 ± 0.029	0.172AsnCys: 0.172 ± 0.007	1.133AsnAsp: 1.133 ± 0.025	0.873AsnGlu: 0.873 ± 0.02	0.55AsnPhe: 0.55 ± 0.015	2.203AsnGly: 2.203 ± 0.044	0.382AsnHis: 0.382 ± 0.011	0.69AsnIle: 0.69 ± 0.014	0.401AsnLys: 0.401 ± 0.014	1.999AsnLeu: 1.999 ± 0.029	0.315AsnMet: 0.315 ± 0.01	0.561AsnAsn: 0.561 ± 0.02	1.585AsnPro: 1.585 ± 0.027	0.636AsnGln: 0.636 ± 0.017	1.573AsnArg: 1.573 ± 0.022	1.078AsnSer: 1.078 ± 0.024	1.257AsnThr: 1.257 ± 0.028	1.576AsnVal: 1.576 ± 0.026	0.364AsnTrp: 0.364 ± 0.011	0.483AsnTyr: 0.483 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.471ProAla: 9.471 ± 0.072	0.292ProCys: 0.292 ± 0.011	4.35ProAsp: 4.35 ± 0.045	3.87ProGlu: 3.87 ± 0.045	1.538ProPhe: 1.538 ± 0.025	6.427ProGly: 6.427 ± 0.062	1.191ProHis: 1.191 ± 0.024	1.986ProIle: 1.986 ± 0.029	1.047ProLys: 1.047 ± 0.024	4.974ProLeu: 4.974 ± 0.041	1.005ProMet: 1.005 ± 0.02	1.075ProAsn: 1.075 ± 0.021	3.644ProPro: 3.644 ± 0.06	1.556ProGln: 1.556 ± 0.024	3.708ProArg: 3.708 ± 0.042	3.229ProSer: 3.229 ± 0.039	3.238ProThr: 3.238 ± 0.04	5.633ProVal: 5.633 ± 0.05	0.953ProTrp: 0.953 ± 0.02	1.248ProTyr: 1.248 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.797GlnAla: 3.797 ± 0.039	0.163GlnCys: 0.163 ± 0.008	1.218GlnAsp: 1.218 ± 0.023	1.243GlnGlu: 1.243 ± 0.023	0.763GlnPhe: 0.763 ± 0.018	1.934GlnGly: 1.934 ± 0.027	0.631GlnHis: 0.631 ± 0.015	1.271GlnIle: 1.271 ± 0.023	0.551GlnLys: 0.551 ± 0.014	3.14GlnLeu: 3.14 ± 0.033	0.497GlnMet: 0.497 ± 0.014	0.598GlnAsn: 0.598 ± 0.016	1.885GlnPro: 1.885 ± 0.034	1.234GlnGln: 1.234 ± 0.026	2.616GlnArg: 2.616 ± 0.035	1.296GlnSer: 1.296 ± 0.024	1.47GlnThr: 1.47 ± 0.023	2.664GlnVal: 2.664 ± 0.031	0.48GlnTrp: 0.48 ± 0.013	0.592GlnTyr: 0.592 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.505ArgAla: 9.505 ± 0.074	0.585ArgCys: 0.585 ± 0.015	4.532ArgAsp: 4.532 ± 0.042	4.248ArgGlu: 4.248 ± 0.049	2.447ArgPhe: 2.447 ± 0.03	5.369ArgGly: 5.369 ± 0.051	2.04ArgHis: 2.04 ± 0.03	3.483ArgIle: 3.483 ± 0.035	1.502ArgLys: 1.502 ± 0.024	9.083ArgLeu: 9.083 ± 0.084	1.816ArgMet: 1.816 ± 0.025	1.545ArgAsn: 1.545 ± 0.024	4.882ArgPro: 4.882 ± 0.048	2.475ArgGln: 2.475 ± 0.033	7.727ArgArg: 7.727 ± 0.075	4.091ArgSer: 4.091 ± 0.036	4.723ArgThr: 4.723 ± 0.044	6.108ArgVal: 6.108 ± 0.051	1.547ArgTrp: 1.547 ± 0.025	1.986ArgTyr: 1.986 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.943SerAla: 6.943 ± 0.055	0.383SerCys: 0.383 ± 0.012	2.686SerAsp: 2.686 ± 0.032	2.239SerGlu: 2.239 ± 0.031	1.534SerPhe: 1.534 ± 0.026	5.946SerGly: 5.946 ± 0.061	0.889SerHis: 0.889 ± 0.017	1.843SerIle: 1.843 ± 0.025	0.918SerLys: 0.918 ± 0.022	4.718SerLeu: 4.718 ± 0.045	1.128SerMet: 1.128 ± 0.02	0.984SerAsn: 0.984 ± 0.019	3.234SerPro: 3.234 ± 0.044	1.237SerGln: 1.237 ± 0.021	3.835SerArg: 3.835 ± 0.039	3.013SerSer: 3.013 ± 0.043	3.333SerThr: 3.333 ± 0.04	4.207SerVal: 4.207 ± 0.036	1.033SerTrp: 1.033 ± 0.021	1.258SerTyr: 1.258 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.89ThrAla: 8.89 ± 0.072	0.441ThrCys: 0.441 ± 0.014	3.598ThrAsp: 3.598 ± 0.038	3.067ThrGlu: 3.067 ± 0.032	1.838ThrPhe: 1.838 ± 0.031	7.003ThrGly: 7.003 ± 0.06	1.057ThrHis: 1.057 ± 0.02	2.287ThrIle: 2.287 ± 0.03	1.149ThrLys: 1.149 ± 0.025	5.902ThrLeu: 5.902 ± 0.041	1.023ThrMet: 1.023 ± 0.019	1.213ThrAsn: 1.213 ± 0.025	4.009ThrPro: 4.009 ± 0.043	1.357ThrGln: 1.357 ± 0.024	3.974ThrArg: 3.974 ± 0.038	3.334ThrSer: 3.334 ± 0.039	4.154ThrThr: 4.154 ± 0.05	6.356ThrVal: 6.356 ± 0.053	0.97ThrTrp: 0.97 ± 0.019	1.388ThrTyr: 1.388 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	11.852ValAla: 11.852 ± 0.083	0.655ValCys: 0.655 ± 0.017	5.146ValAsp: 5.146 ± 0.052	4.454ValGlu: 4.454 ± 0.043	2.359ValPhe: 2.359 ± 0.029	6.38ValGly: 6.38 ± 0.048	1.793ValHis: 1.793 ± 0.022	3.261ValIle: 3.261 ± 0.033	1.623ValLys: 1.623 ± 0.03	9.722ValLeu: 9.722 ± 0.074	1.22ValMet: 1.22 ± 0.023	1.821ValAsn: 1.821 ± 0.028	5.162ValPro: 5.162 ± 0.048	2.103ValGln: 2.103 ± 0.026	6.717ValArg: 6.717 ± 0.059	4.477ValSer: 4.477 ± 0.044	6.238ValThr: 6.238 ± 0.051	8.02ValVal: 8.02 ± 0.067	1.109ValTrp: 1.109 ± 0.019	1.538ValTyr: 1.538 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.76TrpAla: 1.76 ± 0.024	0.148TrpCys: 0.148 ± 0.008	0.812TrpAsp: 0.812 ± 0.02	0.651TrpGlu: 0.651 ± 0.016	0.52TrpPhe: 0.52 ± 0.014	0.976TrpGly: 0.976 ± 0.019	0.434TrpHis: 0.434 ± 0.013	0.652TrpIle: 0.652 ± 0.014	0.318TrpLys: 0.318 ± 0.01	1.951TrpLeu: 1.951 ± 0.03	0.308TrpMet: 0.308 ± 0.01	0.486TrpAsn: 0.486 ± 0.013	0.91TrpPro: 0.91 ± 0.018	0.658TrpGln: 0.658 ± 0.016	1.476TrpArg: 1.476 ± 0.026	1.075TrpSer: 1.075 ± 0.021	1.08TrpThr: 1.08 ± 0.021	1.096TrpVal: 1.096 ± 0.017	0.419TrpTrp: 0.419 ± 0.013	0.374TrpTyr: 0.374 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.662TyrAla: 2.662 ± 0.03	0.181TyrCys: 0.181 ± 0.008	1.425TyrAsp: 1.425 ± 0.035	1.021TyrGlu: 1.021 ± 0.022	0.676TyrPhe: 0.676 ± 0.018	2.08TyrGly: 2.08 ± 0.032	0.455TyrHis: 0.455 ± 0.014	0.48TyrIle: 0.48 ± 0.013	0.332TyrLys: 0.332 ± 0.011	2.437TyrLeu: 2.437 ± 0.03	0.229TyrMet: 0.229 ± 0.009	0.477TyrAsn: 0.477 ± 0.015	1.177TyrPro: 1.177 ± 0.02	0.803TyrGln: 0.803 ± 0.019	1.952TyrArg: 1.952 ± 0.028	1.031TyrSer: 1.031 ± 0.021	1.293TyrThr: 1.293 ± 0.025	1.668TyrVal: 1.668 ± 0.027	0.394TyrTrp: 0.394 ± 0.012	0.491TyrTyr: 0.491 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8959 proteins (2964689 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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