Amino acid dipepetide frequency for Paenibacillus prosopidis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.1AlaAla: 9.1 ± 0.117
0.69AlaCys: 0.69 ± 0.02
4.431AlaAsp: 4.431 ± 0.056
5.501AlaGlu: 5.501 ± 0.058
3.397AlaPhe: 3.397 ± 0.044
6.606AlaGly: 6.606 ± 0.071
1.338AlaHis: 1.338 ± 0.028
5.503AlaIle: 5.503 ± 0.067
4.212AlaLys: 4.212 ± 0.053
7.872AlaLeu: 7.872 ± 0.084
2.149AlaMet: 2.149 ± 0.03
2.932AlaAsn: 2.932 ± 0.04
2.604AlaPro: 2.604 ± 0.041
2.473AlaGln: 2.473 ± 0.036
3.222AlaArg: 3.222 ± 0.051
4.968AlaSer: 4.968 ± 0.06
3.54AlaThr: 3.54 ± 0.056
6.505AlaVal: 6.505 ± 0.071
1.007AlaTrp: 1.007 ± 0.025
2.7AlaTyr: 2.7 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.528CysAla: 0.528 ± 0.018
0.104CysCys: 0.104 ± 0.008
0.379CysAsp: 0.379 ± 0.016
0.444CysGlu: 0.444 ± 0.017
0.333CysPhe: 0.333 ± 0.013
0.729CysGly: 0.729 ± 0.022
0.167CysHis: 0.167 ± 0.01
0.484CysIle: 0.484 ± 0.017
0.346CysLys: 0.346 ± 0.015
0.737CysLeu: 0.737 ± 0.023
0.214CysMet: 0.214 ± 0.011
0.292CysAsn: 0.292 ± 0.014
0.344CysPro: 0.344 ± 0.015
0.198CysGln: 0.198 ± 0.01
0.41CysArg: 0.41 ± 0.014
0.609CysSer: 0.609 ± 0.018
0.407CysThr: 0.407 ± 0.016
0.451CysVal: 0.451 ± 0.016
0.102CysTrp: 0.102 ± 0.007
0.266CysTyr: 0.266 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
3.98AspAla: 3.98 ± 0.052
0.393AspCys: 0.393 ± 0.017
2.483AspAsp: 2.483 ± 0.044
3.839AspGlu: 3.839 ± 0.049
2.223AspPhe: 2.223 ± 0.036
4.284AspGly: 4.284 ± 0.065
1.082AspHis: 1.082 ± 0.027
3.592AspIle: 3.592 ± 0.05
2.794AspLys: 2.794 ± 0.041
4.726AspLeu: 4.726 ± 0.051
1.318AspMet: 1.318 ± 0.026
2.024AspAsn: 2.024 ± 0.037
2.372AspPro: 2.372 ± 0.046
1.882AspGln: 1.882 ± 0.036
2.747AspArg: 2.747 ± 0.039
2.937AspSer: 2.937 ± 0.038
2.648AspThr: 2.648 ± 0.036
3.511AspVal: 3.511 ± 0.044
0.938AspTrp: 0.938 ± 0.025
2.175AspTyr: 2.175 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
5.874GluAla: 5.874 ± 0.063
0.405GluCys: 0.405 ± 0.015
2.994GluAsp: 2.994 ± 0.046
4.921GluGlu: 4.921 ± 0.062
2.085GluPhe: 2.085 ± 0.037
4.344GluGly: 4.344 ± 0.053
1.536GluHis: 1.536 ± 0.033
4.264GluIle: 4.264 ± 0.056
3.932GluLys: 3.932 ± 0.053
7.08GluLeu: 7.08 ± 0.068
1.943GluMet: 1.943 ± 0.035
2.578GluAsn: 2.578 ± 0.042
2.304GluPro: 2.304 ± 0.04
3.802GluGln: 3.802 ± 0.061
3.985GluArg: 3.985 ± 0.06
3.668GluSer: 3.668 ± 0.043
3.436GluThr: 3.436 ± 0.05
4.162GluVal: 4.162 ± 0.046
1.066GluTrp: 1.066 ± 0.023
2.04GluTyr: 2.04 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.218PheAla: 3.218 ± 0.041
0.349PheCys: 0.349 ± 0.014
2.413PheAsp: 2.413 ± 0.042
2.585PheGlu: 2.585 ± 0.043
1.935PhePhe: 1.935 ± 0.043
3.34PheGly: 3.34 ± 0.045
0.951PheHis: 0.951 ± 0.023
3.202PheIle: 3.202 ± 0.045
2.164PheLys: 2.164 ± 0.036
3.839PheLeu: 3.839 ± 0.051
1.189PheMet: 1.189 ± 0.027
1.801PheAsn: 1.801 ± 0.037
1.669PhePro: 1.669 ± 0.032
1.464PheGln: 1.464 ± 0.029
2.027PheArg: 2.027 ± 0.029
2.903PheSer: 2.903 ± 0.038
2.567PheThr: 2.567 ± 0.039
3.055PheVal: 3.055 ± 0.043
0.587PheTrp: 0.587 ± 0.018
1.569PheTyr: 1.569 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
5.441GlyAla: 5.441 ± 0.063
0.698GlyCys: 0.698 ± 0.021
3.557GlyAsp: 3.557 ± 0.051
4.466GlyGlu: 4.466 ± 0.052
3.338GlyPhe: 3.338 ± 0.045
5.373GlyGly: 5.373 ± 0.076
1.514GlyHis: 1.514 ± 0.033
5.763GlyIle: 5.763 ± 0.06
4.581GlyLys: 4.581 ± 0.055
6.863GlyLeu: 6.863 ± 0.065
2.297GlyMet: 2.297 ± 0.04
3.051GlyAsn: 3.051 ± 0.066
1.952GlyPro: 1.952 ± 0.038
2.646GlyGln: 2.646 ± 0.042
3.352GlyArg: 3.352 ± 0.047
4.739GlySer: 4.739 ± 0.076
4.491GlyThr: 4.491 ± 0.083
4.994GlyVal: 4.994 ± 0.071
1.192GlyTrp: 1.192 ± 0.03
2.955GlyTyr: 2.955 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
1.586HisAla: 1.586 ± 0.028
0.189HisCys: 0.189 ± 0.011
1.01HisAsp: 1.01 ± 0.025
1.227HisGlu: 1.227 ± 0.025
1.077HisPhe: 1.077 ± 0.027
1.452HisGly: 1.452 ± 0.03
0.613HisHis: 0.613 ± 0.02
1.411HisIle: 1.411 ± 0.026
0.871HisLys: 0.871 ± 0.022
2.046HisLeu: 2.046 ± 0.04
0.565HisMet: 0.565 ± 0.018
0.741HisAsn: 0.741 ± 0.024
1.188HisPro: 1.188 ± 0.026
0.752HisGln: 0.752 ± 0.021
1.014HisArg: 1.014 ± 0.025
1.244HisSer: 1.244 ± 0.027
1.109HisThr: 1.109 ± 0.031
1.405HisVal: 1.405 ± 0.027
0.333HisTrp: 0.333 ± 0.013
0.905HisTyr: 0.905 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.012IleAla: 6.012 ± 0.066
0.603IleCys: 0.603 ± 0.021
4.013IleAsp: 4.013 ± 0.044
4.658IleGlu: 4.658 ± 0.054
2.537IlePhe: 2.537 ± 0.038
5.537IleGly: 5.537 ± 0.067
1.534IleHis: 1.534 ± 0.031
4.764IleIle: 4.764 ± 0.062
3.383IleLys: 3.383 ± 0.05
5.61IleLeu: 5.61 ± 0.072
1.751IleMet: 1.751 ± 0.037
2.834IleAsn: 2.834 ± 0.045
3.184IlePro: 3.184 ± 0.045
2.502IleGln: 2.502 ± 0.039
3.825IleArg: 3.825 ± 0.051
4.57IleSer: 4.57 ± 0.05
4.046IleThr: 4.046 ± 0.052
5.344IleVal: 5.344 ± 0.067
0.786IleTrp: 0.786 ± 0.021
2.251IleTyr: 2.251 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.378LysAla: 4.378 ± 0.047
0.265LysCys: 0.265 ± 0.012
2.851LysAsp: 2.851 ± 0.036
4.255LysGlu: 4.255 ± 0.054
1.715LysPhe: 1.715 ± 0.031
3.566LysGly: 3.566 ± 0.043
1.166LysHis: 1.166 ± 0.025
3.326LysIle: 3.326 ± 0.05
3.329LysLys: 3.329 ± 0.056
5.673LysLeu: 5.673 ± 0.062
1.686LysMet: 1.686 ± 0.03
2.224LysAsn: 2.224 ± 0.039
2.383LysPro: 2.383 ± 0.037
2.702LysGln: 2.702 ± 0.044
3.019LysArg: 3.019 ± 0.039
3.056LysSer: 3.056 ± 0.045
2.93LysThr: 2.93 ± 0.039
3.649LysVal: 3.649 ± 0.051
0.815LysTrp: 0.815 ± 0.024
1.884LysTyr: 1.884 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
7.741LeuAla: 7.741 ± 0.094
0.789LeuCys: 0.789 ± 0.022
4.961LeuAsp: 4.961 ± 0.057
6.118LeuGlu: 6.118 ± 0.077
4.715LeuPhe: 4.715 ± 0.055
6.351LeuGly: 6.351 ± 0.07
2.038LeuHis: 2.038 ± 0.035
6.657LeuIle: 6.657 ± 0.059
5.447LeuLys: 5.447 ± 0.06
10.622LeuLeu: 10.622 ± 0.113
2.588LeuMet: 2.588 ± 0.039
4.069LeuAsn: 4.069 ± 0.051
4.3LeuPro: 4.3 ± 0.046
3.958LeuGln: 3.958 ± 0.048
4.838LeuArg: 4.838 ± 0.056
6.929LeuSer: 6.929 ± 0.062
5.674LeuThr: 5.674 ± 0.059
6.013LeuVal: 6.013 ± 0.058
1.072LeuTrp: 1.072 ± 0.024
3.24LeuTyr: 3.24 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.118MetAla: 2.118 ± 0.032
0.154MetCys: 0.154 ± 0.008
1.409MetAsp: 1.409 ± 0.027
1.794MetGlu: 1.794 ± 0.034
1.084MetPhe: 1.084 ± 0.025
1.67MetGly: 1.67 ± 0.03
0.508MetHis: 0.508 ± 0.014
2.0MetIle: 2.0 ± 0.033
2.041MetLys: 2.041 ± 0.035
2.976MetLeu: 2.976 ± 0.047
0.872MetMet: 0.872 ± 0.022
1.575MetAsn: 1.575 ± 0.029
1.127MetPro: 1.127 ± 0.023
1.018MetGln: 1.018 ± 0.025
1.363MetArg: 1.363 ± 0.03
1.77MetSer: 1.77 ± 0.032
1.74MetThr: 1.74 ± 0.031
1.74MetVal: 1.74 ± 0.031
0.273MetTrp: 0.273 ± 0.012
0.808MetTyr: 0.808 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.089AsnAla: 3.089 ± 0.044
0.276AsnCys: 0.276 ± 0.012
2.272AsnAsp: 2.272 ± 0.037
2.921AsnGlu: 2.921 ± 0.04
1.47AsnPhe: 1.47 ± 0.029
3.809AsnGly: 3.809 ± 0.072
0.936AsnHis: 0.936 ± 0.021
2.665AsnIle: 2.665 ± 0.043
2.368AsnLys: 2.368 ± 0.039
3.274AsnLeu: 3.274 ± 0.046
1.078AsnMet: 1.078 ± 0.024
1.969AsnAsn: 1.969 ± 0.04
2.145AsnPro: 2.145 ± 0.034
1.597AsnGln: 1.597 ± 0.031
2.253AsnArg: 2.253 ± 0.029
2.353AsnSer: 2.353 ± 0.042
2.182AsnThr: 2.182 ± 0.045
2.799AsnVal: 2.799 ± 0.04
0.655AsnTrp: 0.655 ± 0.019
1.579AsnTyr: 1.579 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
3.212ProAla: 3.212 ± 0.044
0.233ProCys: 0.233 ± 0.011
2.563ProAsp: 2.563 ± 0.036
3.154ProGlu: 3.154 ± 0.045
2.016ProPhe: 2.016 ± 0.029
2.829ProGly: 2.829 ± 0.044
0.891ProHis: 0.891 ± 0.023
2.649ProIle: 2.649 ± 0.043
1.768ProLys: 1.768 ± 0.03
3.971ProLeu: 3.971 ± 0.047
0.989ProMet: 0.989 ± 0.025
1.727ProAsn: 1.727 ± 0.035
1.238ProPro: 1.238 ± 0.029
1.327ProGln: 1.327 ± 0.027
1.364ProArg: 1.364 ± 0.026
2.515ProSer: 2.515 ± 0.038
1.929ProThr: 1.929 ± 0.041
3.266ProVal: 3.266 ± 0.043
0.539ProTrp: 0.539 ± 0.018
1.605ProTyr: 1.605 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.225GlnAla: 3.225 ± 0.044
0.206GlnCys: 0.206 ± 0.012
1.58GlnAsp: 1.58 ± 0.029
2.396GlnGlu: 2.396 ± 0.041
1.635GlnPhe: 1.635 ± 0.033
2.355GlnGly: 2.355 ± 0.038
0.779GlnHis: 0.779 ± 0.021
2.531GlnIle: 2.531 ± 0.041
1.988GlnLys: 1.988 ± 0.038
4.395GlnLeu: 4.395 ± 0.059
1.198GlnMet: 1.198 ± 0.024
1.441GlnAsn: 1.441 ± 0.031
1.509GlnPro: 1.509 ± 0.03
1.839GlnGln: 1.839 ± 0.037
1.76GlnArg: 1.76 ± 0.03
2.396GlnSer: 2.396 ± 0.04
2.151GlnThr: 2.151 ± 0.037
2.442GlnVal: 2.442 ± 0.038
0.578GlnTrp: 0.578 ± 0.016
1.422GlnTyr: 1.422 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
3.165ArgAla: 3.165 ± 0.048
0.351ArgCys: 0.351 ± 0.015
2.394ArgAsp: 2.394 ± 0.032
3.417ArgGlu: 3.417 ± 0.049
2.331ArgPhe: 2.331 ± 0.04
2.915ArgGly: 2.915 ± 0.041
1.007ArgHis: 1.007 ± 0.024
3.777ArgIle: 3.777 ± 0.048
3.081ArgLys: 3.081 ± 0.049
5.087ArgLeu: 5.087 ± 0.066
1.663ArgMet: 1.663 ± 0.034
2.152ArgAsn: 2.152 ± 0.033
1.641ArgPro: 1.641 ± 0.031
1.851ArgGln: 1.851 ± 0.033
2.494ArgArg: 2.494 ± 0.046
3.114ArgSer: 3.114 ± 0.049
2.681ArgThr: 2.681 ± 0.035
3.053ArgVal: 3.053 ± 0.045
0.667ArgTrp: 0.667 ± 0.019
1.919ArgTyr: 1.919 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
4.859SerAla: 4.859 ± 0.064
0.461SerCys: 0.461 ± 0.015
3.3SerAsp: 3.3 ± 0.038
3.96SerGlu: 3.96 ± 0.051
3.095SerPhe: 3.095 ± 0.039
5.433SerGly: 5.433 ± 0.063
1.255SerHis: 1.255 ± 0.031
4.619SerIle: 4.619 ± 0.05
3.353SerLys: 3.353 ± 0.043
6.255SerLeu: 6.255 ± 0.062
1.764SerMet: 1.764 ± 0.03
2.591SerAsn: 2.591 ± 0.043
2.439SerPro: 2.439 ± 0.041
1.897SerGln: 1.897 ± 0.033
2.932SerArg: 2.932 ± 0.048
4.268SerSer: 4.268 ± 0.062
3.197SerThr: 3.197 ± 0.045
4.509SerVal: 4.509 ± 0.079
0.883SerTrp: 0.883 ± 0.021
2.376SerTyr: 2.376 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
4.762ThrAla: 4.762 ± 0.068
0.353ThrCys: 0.353 ± 0.013
3.085ThrAsp: 3.085 ± 0.048
3.38ThrGlu: 3.38 ± 0.049
2.514ThrPhe: 2.514 ± 0.043
4.579ThrGly: 4.579 ± 0.068
0.976ThrHis: 0.976 ± 0.025
4.149ThrIle: 4.149 ± 0.067
2.611ThrLys: 2.611 ± 0.037
5.266ThrLeu: 5.266 ± 0.059
1.396ThrMet: 1.396 ± 0.028
2.321ThrAsn: 2.321 ± 0.045
2.462ThrPro: 2.462 ± 0.036
1.542ThrGln: 1.542 ± 0.032
2.087ThrArg: 2.087 ± 0.038
3.366ThrSer: 3.366 ± 0.053
2.838ThrThr: 2.838 ± 0.051
4.547ThrVal: 4.547 ± 0.063
0.694ThrTrp: 0.694 ± 0.02
1.97ThrTyr: 1.97 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
4.932ValAla: 4.932 ± 0.06
0.609ValCys: 0.609 ± 0.017
3.569ValAsp: 3.569 ± 0.04
4.204ValGlu: 4.204 ± 0.052
2.941ValPhe: 2.941 ± 0.044
4.424ValGly: 4.424 ± 0.073
1.399ValHis: 1.399 ± 0.028
5.145ValIle: 5.145 ± 0.057
3.991ValLys: 3.991 ± 0.049
6.921ValLeu: 6.921 ± 0.068
1.987ValMet: 1.987 ± 0.036
3.009ValAsn: 3.009 ± 0.044
2.918ValPro: 2.918 ± 0.04
2.621ValGln: 2.621 ± 0.037
3.384ValArg: 3.384 ± 0.043
4.788ValSer: 4.788 ± 0.053
4.497ValThr: 4.497 ± 0.075
4.723ValVal: 4.723 ± 0.061
0.882ValTrp: 0.882 ± 0.022
2.484ValTyr: 2.484 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.865TrpAla: 0.865 ± 0.023
0.104TrpCys: 0.104 ± 0.007
0.711TrpAsp: 0.711 ± 0.022
0.814TrpGlu: 0.814 ± 0.023
0.646TrpPhe: 0.646 ± 0.019
0.95TrpGly: 0.95 ± 0.027
0.297TrpHis: 0.297 ± 0.013
0.952TrpIle: 0.952 ± 0.022
0.798TrpLys: 0.798 ± 0.02
1.491TrpLeu: 1.491 ± 0.033
0.451TrpMet: 0.451 ± 0.016
0.762TrpAsn: 0.762 ± 0.019
0.433TrpPro: 0.433 ± 0.016
0.533TrpGln: 0.533 ± 0.018
0.65TrpArg: 0.65 ± 0.02
0.925TrpSer: 0.925 ± 0.023
0.836TrpThr: 0.836 ± 0.023
0.851TrpVal: 0.851 ± 0.025
0.212TrpTrp: 0.212 ± 0.012
0.492TrpTyr: 0.492 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.666TyrAla: 2.666 ± 0.042
0.31TyrCys: 0.31 ± 0.014
1.975TyrAsp: 1.975 ± 0.044
2.366TyrGlu: 2.366 ± 0.039
1.739TyrPhe: 1.739 ± 0.033
2.715TyrGly: 2.715 ± 0.042
0.751TyrHis: 0.751 ± 0.019
2.295TyrIle: 2.295 ± 0.036
1.815TyrLys: 1.815 ± 0.036
3.418TyrLeu: 3.418 ± 0.042
0.941TyrMet: 0.941 ± 0.024
1.597TyrAsn: 1.597 ± 0.032
1.574TyrPro: 1.574 ± 0.031
1.222TyrGln: 1.222 ± 0.029
2.031TyrArg: 2.031 ± 0.042
2.326TyrSer: 2.326 ± 0.039
2.002TyrThr: 2.002 ± 0.042
2.404TyrVal: 2.404 ± 0.038
0.492TyrTrp: 0.492 ± 0.014
1.498TyrTyr: 1.498 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6048 proteins (1908774 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski