Amino acid dipepetide frequency for Arthrobacter phage KBurrousTX

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.513AlaAla: 20.513 ± 1.838
0.666AlaCys: 0.666 ± 0.201
7.104AlaAsp: 7.104 ± 0.601
7.548AlaGlu: 7.548 ± 0.781
3.33AlaPhe: 3.33 ± 0.55
8.214AlaGly: 8.214 ± 0.555
2.486AlaHis: 2.486 ± 0.384
4.573AlaIle: 4.573 ± 0.544
6.083AlaLys: 6.083 ± 0.691
9.413AlaLeu: 9.413 ± 0.767
3.064AlaMet: 3.064 ± 0.363
5.017AlaAsn: 5.017 ± 0.502
6.527AlaPro: 6.527 ± 0.542
3.552AlaGln: 3.552 ± 0.462
6.749AlaArg: 6.749 ± 0.682
5.284AlaSer: 5.284 ± 0.5
8.125AlaThr: 8.125 ± 0.951
8.703AlaVal: 8.703 ± 0.742
1.598AlaTrp: 1.598 ± 0.274
2.575AlaTyr: 2.575 ± 0.245
0.0AlaXaa: 0.0 ± 0.0
Cys
0.666CysAla: 0.666 ± 0.176
0.133CysCys: 0.133 ± 0.068
0.266CysAsp: 0.266 ± 0.092
0.488CysGlu: 0.488 ± 0.128
0.311CysPhe: 0.311 ± 0.121
0.799CysGly: 0.799 ± 0.198
0.311CysHis: 0.311 ± 0.127
0.488CysIle: 0.488 ± 0.17
0.4CysLys: 0.4 ± 0.137
0.444CysLeu: 0.444 ± 0.128
0.222CysMet: 0.222 ± 0.104
0.222CysAsn: 0.222 ± 0.102
0.755CysPro: 0.755 ± 0.2
0.622CysGln: 0.622 ± 0.166
0.533CysArg: 0.533 ± 0.144
0.178CysSer: 0.178 ± 0.081
0.488CysThr: 0.488 ± 0.138
0.622CysVal: 0.622 ± 0.197
0.311CysTrp: 0.311 ± 0.143
0.133CysTyr: 0.133 ± 0.074
0.0CysXaa: 0.0 ± 0.0
Asp
7.681AspAla: 7.681 ± 0.622
0.355AspCys: 0.355 ± 0.119
2.442AspAsp: 2.442 ± 0.373
2.398AspGlu: 2.398 ± 0.334
1.643AspPhe: 1.643 ± 0.374
6.438AspGly: 6.438 ± 0.485
1.51AspHis: 1.51 ± 0.27
3.197AspIle: 3.197 ± 0.465
3.197AspLys: 3.197 ± 0.381
5.151AspLeu: 5.151 ± 0.468
1.598AspMet: 1.598 ± 0.291
1.51AspAsn: 1.51 ± 0.263
4.751AspPro: 4.751 ± 0.52
2.575AspGln: 2.575 ± 0.392
2.664AspArg: 2.664 ± 0.366
2.886AspSer: 2.886 ± 0.315
3.641AspThr: 3.641 ± 0.411
3.641AspVal: 3.641 ± 0.384
1.376AspTrp: 1.376 ± 0.331
1.954AspTyr: 1.954 ± 0.345
0.0AspXaa: 0.0 ± 0.0
Glu
8.081GluAla: 8.081 ± 0.868
0.888GluCys: 0.888 ± 0.203
4.307GluAsp: 4.307 ± 0.563
3.952GluGlu: 3.952 ± 0.433
1.82GluPhe: 1.82 ± 0.316
4.262GluGly: 4.262 ± 0.504
1.288GluHis: 1.288 ± 0.286
2.664GluIle: 2.664 ± 0.348
1.998GluLys: 1.998 ± 0.327
5.817GluLeu: 5.817 ± 0.632
1.243GluMet: 1.243 ± 0.218
1.909GluAsn: 1.909 ± 0.26
3.508GluPro: 3.508 ± 0.434
1.998GluGln: 1.998 ± 0.335
4.085GluArg: 4.085 ± 0.502
2.797GluSer: 2.797 ± 0.402
3.064GluThr: 3.064 ± 0.393
5.461GluVal: 5.461 ± 0.441
1.465GluTrp: 1.465 ± 0.237
1.598GluTyr: 1.598 ± 0.255
0.0GluXaa: 0.0 ± 0.0
Phe
3.152PheAla: 3.152 ± 0.463
0.222PheCys: 0.222 ± 0.098
1.732PheAsp: 1.732 ± 0.24
2.22PheGlu: 2.22 ± 0.363
0.844PhePhe: 0.844 ± 0.188
2.131PheGly: 2.131 ± 0.344
0.755PheHis: 0.755 ± 0.209
1.199PheIle: 1.199 ± 0.213
1.021PheLys: 1.021 ± 0.186
2.442PheLeu: 2.442 ± 0.302
0.755PheMet: 0.755 ± 0.193
1.288PheAsn: 1.288 ± 0.294
1.687PhePro: 1.687 ± 0.254
1.288PheGln: 1.288 ± 0.189
1.465PheArg: 1.465 ± 0.234
1.554PheSer: 1.554 ± 0.249
2.398PheThr: 2.398 ± 0.288
1.909PheVal: 1.909 ± 0.3
0.444PheTrp: 0.444 ± 0.148
0.622PheTyr: 0.622 ± 0.159
0.0PheXaa: 0.0 ± 0.0
Gly
7.149GlyAla: 7.149 ± 0.563
0.71GlyCys: 0.71 ± 0.201
4.84GlyAsp: 4.84 ± 0.48
4.44GlyGlu: 4.44 ± 0.44
2.93GlyPhe: 2.93 ± 0.495
8.436GlyGly: 8.436 ± 0.864
2.131GlyHis: 2.131 ± 0.355
3.952GlyIle: 3.952 ± 0.507
4.085GlyLys: 4.085 ± 0.356
5.861GlyLeu: 5.861 ± 0.577
1.554GlyMet: 1.554 ± 0.309
3.108GlyAsn: 3.108 ± 0.427
3.641GlyPro: 3.641 ± 0.417
2.353GlyGln: 2.353 ± 0.308
5.062GlyArg: 5.062 ± 0.41
4.795GlySer: 4.795 ± 0.542
6.971GlyThr: 6.971 ± 0.562
6.483GlyVal: 6.483 ± 0.546
1.909GlyTrp: 1.909 ± 0.348
2.264GlyTyr: 2.264 ± 0.297
0.0GlyXaa: 0.0 ± 0.0
His
2.309HisAla: 2.309 ± 0.307
0.178HisCys: 0.178 ± 0.08
1.421HisAsp: 1.421 ± 0.263
1.732HisGlu: 1.732 ± 0.337
0.533HisPhe: 0.533 ± 0.178
1.465HisGly: 1.465 ± 0.278
0.533HisHis: 0.533 ± 0.178
0.844HisIle: 0.844 ± 0.205
1.021HisLys: 1.021 ± 0.233
1.998HisLeu: 1.998 ± 0.344
0.755HisMet: 0.755 ± 0.176
0.799HisAsn: 0.799 ± 0.221
1.51HisPro: 1.51 ± 0.269
0.844HisGln: 0.844 ± 0.212
1.066HisArg: 1.066 ± 0.289
0.977HisSer: 0.977 ± 0.214
1.776HisThr: 1.776 ± 0.496
1.554HisVal: 1.554 ± 0.247
0.355HisTrp: 0.355 ± 0.121
0.622HisTyr: 0.622 ± 0.214
0.0HisXaa: 0.0 ± 0.0
Ile
4.529IleAla: 4.529 ± 0.41
0.222IleCys: 0.222 ± 0.092
3.019IleAsp: 3.019 ± 0.402
2.664IleGlu: 2.664 ± 0.309
0.932IlePhe: 0.932 ± 0.262
2.708IleGly: 2.708 ± 0.453
0.977IleHis: 0.977 ± 0.181
1.732IleIle: 1.732 ± 0.292
2.22IleLys: 2.22 ± 0.353
3.241IleLeu: 3.241 ± 0.386
0.755IleMet: 0.755 ± 0.168
1.421IleAsn: 1.421 ± 0.267
2.575IlePro: 2.575 ± 0.295
1.421IleGln: 1.421 ± 0.227
2.398IleArg: 2.398 ± 0.342
1.82IleSer: 1.82 ± 0.247
3.73IleThr: 3.73 ± 0.532
3.463IleVal: 3.463 ± 0.466
0.755IleTrp: 0.755 ± 0.168
0.932IleTyr: 0.932 ± 0.219
0.0IleXaa: 0.0 ± 0.0
Lys
6.749LysAla: 6.749 ± 0.599
0.222LysCys: 0.222 ± 0.098
1.998LysAsp: 1.998 ± 0.276
2.264LysGlu: 2.264 ± 0.354
1.11LysPhe: 1.11 ± 0.266
3.463LysGly: 3.463 ± 0.463
0.533LysHis: 0.533 ± 0.172
1.066LysIle: 1.066 ± 0.226
1.51LysLys: 1.51 ± 0.473
3.907LysLeu: 3.907 ± 0.415
1.11LysMet: 1.11 ± 0.234
1.243LysAsn: 1.243 ± 0.228
3.064LysPro: 3.064 ± 0.458
1.421LysGln: 1.421 ± 0.287
2.797LysArg: 2.797 ± 0.362
2.042LysSer: 2.042 ± 0.311
3.197LysThr: 3.197 ± 0.344
3.33LysVal: 3.33 ± 0.396
0.355LysTrp: 0.355 ± 0.121
0.888LysTyr: 0.888 ± 0.219
0.0LysXaa: 0.0 ± 0.0
Leu
8.569LeuAla: 8.569 ± 0.623
0.577LeuCys: 0.577 ± 0.132
5.239LeuAsp: 5.239 ± 0.411
4.707LeuGlu: 4.707 ± 0.589
1.909LeuPhe: 1.909 ± 0.329
4.973LeuGly: 4.973 ± 0.693
1.82LeuHis: 1.82 ± 0.386
3.463LeuIle: 3.463 ± 0.447
2.975LeuLys: 2.975 ± 0.391
5.461LeuLeu: 5.461 ± 0.591
1.865LeuMet: 1.865 ± 0.282
3.419LeuAsn: 3.419 ± 0.6
5.106LeuPro: 5.106 ± 0.63
2.708LeuGln: 2.708 ± 0.303
4.707LeuArg: 4.707 ± 0.602
4.218LeuSer: 4.218 ± 0.411
6.216LeuThr: 6.216 ± 0.489
5.639LeuVal: 5.639 ± 0.434
0.888LeuTrp: 0.888 ± 0.19
1.51LeuTyr: 1.51 ± 0.282
0.0LeuXaa: 0.0 ± 0.0
Met
2.131MetAla: 2.131 ± 0.287
0.178MetCys: 0.178 ± 0.084
1.554MetAsp: 1.554 ± 0.309
1.199MetGlu: 1.199 ± 0.253
0.71MetPhe: 0.71 ± 0.139
1.954MetGly: 1.954 ± 0.35
0.488MetHis: 0.488 ± 0.149
0.799MetIle: 0.799 ± 0.154
1.154MetLys: 1.154 ± 0.23
2.042MetLeu: 2.042 ± 0.307
0.222MetMet: 0.222 ± 0.099
0.71MetAsn: 0.71 ± 0.199
1.776MetPro: 1.776 ± 0.305
0.533MetGln: 0.533 ± 0.159
1.643MetArg: 1.643 ± 0.283
1.865MetSer: 1.865 ± 0.305
2.309MetThr: 2.309 ± 0.281
1.199MetVal: 1.199 ± 0.224
0.444MetTrp: 0.444 ± 0.155
0.311MetTyr: 0.311 ± 0.104
0.0MetXaa: 0.0 ± 0.0
Asn
3.996AsnAla: 3.996 ± 0.359
0.444AsnCys: 0.444 ± 0.135
1.465AsnAsp: 1.465 ± 0.244
2.087AsnGlu: 2.087 ± 0.289
0.71AsnPhe: 0.71 ± 0.162
4.129AsnGly: 4.129 ± 0.311
0.71AsnHis: 0.71 ± 0.188
1.465AsnIle: 1.465 ± 0.205
0.977AsnLys: 0.977 ± 0.252
2.264AsnLeu: 2.264 ± 0.345
0.932AsnMet: 0.932 ± 0.221
1.465AsnAsn: 1.465 ± 0.264
3.596AsnPro: 3.596 ± 0.442
1.288AsnGln: 1.288 ± 0.207
2.353AsnArg: 2.353 ± 0.312
1.865AsnSer: 1.865 ± 0.287
3.019AsnThr: 3.019 ± 0.499
2.842AsnVal: 2.842 ± 0.332
0.71AsnTrp: 0.71 ± 0.186
0.977AsnTyr: 0.977 ± 0.252
0.0AsnXaa: 0.0 ± 0.0
Pro
7.149ProAla: 7.149 ± 0.536
0.533ProCys: 0.533 ± 0.156
4.307ProAsp: 4.307 ± 0.495
4.485ProGlu: 4.485 ± 0.522
1.51ProPhe: 1.51 ± 0.253
6.083ProGly: 6.083 ± 0.546
1.376ProHis: 1.376 ± 0.249
2.93ProIle: 2.93 ± 0.343
2.62ProLys: 2.62 ± 0.418
3.774ProLeu: 3.774 ± 0.371
1.421ProMet: 1.421 ± 0.237
2.042ProAsn: 2.042 ± 0.302
3.152ProPro: 3.152 ± 0.421
1.998ProGln: 1.998 ± 0.329
2.62ProArg: 2.62 ± 0.27
2.708ProSer: 2.708 ± 0.459
4.529ProThr: 4.529 ± 0.672
4.662ProVal: 4.662 ± 0.468
1.11ProTrp: 1.11 ± 0.247
1.066ProTyr: 1.066 ± 0.246
0.0ProXaa: 0.0 ± 0.0
Gln
4.085GlnAla: 4.085 ± 0.375
0.311GlnCys: 0.311 ± 0.163
2.087GlnAsp: 2.087 ± 0.328
1.51GlnGlu: 1.51 ± 0.227
0.977GlnPhe: 0.977 ± 0.284
2.753GlnGly: 2.753 ± 0.302
0.666GlnHis: 0.666 ± 0.189
1.421GlnIle: 1.421 ± 0.224
1.066GlnLys: 1.066 ± 0.23
2.664GlnLeu: 2.664 ± 0.344
0.577GlnMet: 0.577 ± 0.15
1.154GlnAsn: 1.154 ± 0.181
1.598GlnPro: 1.598 ± 0.258
1.199GlnGln: 1.199 ± 0.227
2.797GlnArg: 2.797 ± 0.321
1.376GlnSer: 1.376 ± 0.27
2.486GlnThr: 2.486 ± 0.317
3.596GlnVal: 3.596 ± 0.405
0.755GlnTrp: 0.755 ± 0.172
1.11GlnTyr: 1.11 ± 0.201
0.0GlnXaa: 0.0 ± 0.0
Arg
7.237ArgAla: 7.237 ± 0.581
0.666ArgCys: 0.666 ± 0.181
3.73ArgAsp: 3.73 ± 0.394
5.195ArgGlu: 5.195 ± 0.663
2.442ArgPhe: 2.442 ± 0.4
4.307ArgGly: 4.307 ± 0.359
1.154ArgHis: 1.154 ± 0.232
1.909ArgIle: 1.909 ± 0.366
2.442ArgLys: 2.442 ± 0.365
4.44ArgLeu: 4.44 ± 0.48
1.199ArgMet: 1.199 ± 0.239
2.131ArgAsn: 2.131 ± 0.342
2.886ArgPro: 2.886 ± 0.361
1.909ArgGln: 1.909 ± 0.259
4.262ArgArg: 4.262 ± 0.571
2.309ArgSer: 2.309 ± 0.288
3.241ArgThr: 3.241 ± 0.389
4.218ArgVal: 4.218 ± 0.47
1.243ArgTrp: 1.243 ± 0.231
1.909ArgTyr: 1.909 ± 0.339
0.0ArgXaa: 0.0 ± 0.0
Ser
6.483SerAla: 6.483 ± 0.874
0.222SerCys: 0.222 ± 0.122
2.93SerAsp: 2.93 ± 0.375
3.108SerGlu: 3.108 ± 0.388
1.288SerPhe: 1.288 ± 0.251
4.262SerGly: 4.262 ± 0.547
1.288SerHis: 1.288 ± 0.242
1.82SerIle: 1.82 ± 0.289
1.687SerLys: 1.687 ± 0.238
3.596SerLeu: 3.596 ± 0.354
1.998SerMet: 1.998 ± 0.25
1.865SerAsn: 1.865 ± 0.316
1.954SerPro: 1.954 ± 0.28
1.11SerGln: 1.11 ± 0.305
2.797SerArg: 2.797 ± 0.386
1.954SerSer: 1.954 ± 0.354
4.04SerThr: 4.04 ± 0.473
3.419SerVal: 3.419 ± 0.344
0.932SerTrp: 0.932 ± 0.179
1.776SerTyr: 1.776 ± 0.323
0.0SerXaa: 0.0 ± 0.0
Thr
8.081ThrAla: 8.081 ± 0.846
0.4ThrCys: 0.4 ± 0.144
3.863ThrAsp: 3.863 ± 0.294
4.129ThrGlu: 4.129 ± 0.457
2.264ThrPhe: 2.264 ± 0.349
6.705ThrGly: 6.705 ± 0.75
1.687ThrHis: 1.687 ± 0.452
3.286ThrIle: 3.286 ± 0.38
3.33ThrLys: 3.33 ± 0.383
4.573ThrLeu: 4.573 ± 0.437
0.932ThrMet: 0.932 ± 0.185
2.975ThrAsn: 2.975 ± 0.384
4.884ThrPro: 4.884 ± 0.685
2.398ThrGln: 2.398 ± 0.34
3.996ThrArg: 3.996 ± 0.425
3.419ThrSer: 3.419 ± 0.518
5.239ThrThr: 5.239 ± 0.487
6.705ThrVal: 6.705 ± 0.573
1.643ThrTrp: 1.643 ± 0.325
2.087ThrTyr: 2.087 ± 0.311
0.0ThrXaa: 0.0 ± 0.0
Val
9.102ValAla: 9.102 ± 0.659
0.799ValCys: 0.799 ± 0.196
5.639ValAsp: 5.639 ± 0.414
5.151ValGlu: 5.151 ± 0.583
2.309ValPhe: 2.309 ± 0.252
5.817ValGly: 5.817 ± 0.689
1.421ValHis: 1.421 ± 0.236
3.152ValIle: 3.152 ± 0.339
2.93ValLys: 2.93 ± 0.304
5.772ValLeu: 5.772 ± 0.465
1.998ValMet: 1.998 ± 0.273
2.531ValAsn: 2.531 ± 0.31
4.396ValPro: 4.396 ± 0.372
2.398ValGln: 2.398 ± 0.333
4.262ValArg: 4.262 ± 0.47
4.351ValSer: 4.351 ± 0.482
5.772ValThr: 5.772 ± 0.559
5.373ValVal: 5.373 ± 0.381
1.154ValTrp: 1.154 ± 0.257
1.554ValTyr: 1.554 ± 0.308
0.0ValXaa: 0.0 ± 0.0
Trp
1.376TrpAla: 1.376 ± 0.263
0.355TrpCys: 0.355 ± 0.122
0.932TrpAsp: 0.932 ± 0.205
0.932TrpGlu: 0.932 ± 0.179
0.977TrpPhe: 0.977 ± 0.262
1.332TrpGly: 1.332 ± 0.267
0.71TrpHis: 0.71 ± 0.222
0.932TrpIle: 0.932 ± 0.303
0.799TrpLys: 0.799 ± 0.167
1.687TrpLeu: 1.687 ± 0.344
0.4TrpMet: 0.4 ± 0.141
1.11TrpAsn: 1.11 ± 0.327
0.888TrpPro: 0.888 ± 0.193
1.243TrpGln: 1.243 ± 0.243
0.932TrpArg: 0.932 ± 0.205
0.666TrpSer: 0.666 ± 0.143
0.977TrpThr: 0.977 ± 0.252
1.243TrpVal: 1.243 ± 0.265
0.666TrpTrp: 0.666 ± 0.263
0.178TrpTyr: 0.178 ± 0.087
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.131TyrAla: 2.131 ± 0.29
0.311TyrCys: 0.311 ± 0.13
1.732TyrAsp: 1.732 ± 0.253
1.998TyrGlu: 1.998 ± 0.247
0.577TyrPhe: 0.577 ± 0.166
2.442TyrGly: 2.442 ± 0.418
0.444TyrHis: 0.444 ± 0.154
0.622TyrIle: 0.622 ± 0.173
0.755TyrLys: 0.755 ± 0.197
1.421TyrLeu: 1.421 ± 0.233
0.577TyrMet: 0.577 ± 0.124
1.376TyrAsn: 1.376 ± 0.234
1.82TyrPro: 1.82 ± 0.373
1.332TyrGln: 1.332 ± 0.292
1.643TyrArg: 1.643 ± 0.307
1.465TyrSer: 1.465 ± 0.248
1.376TyrThr: 1.376 ± 0.22
1.82TyrVal: 1.82 ± 0.358
0.222TyrTrp: 0.222 ± 0.092
0.799TyrTyr: 0.799 ± 0.182
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 107 proteins (22523 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski