Amino acid dipepetide frequency for Fermentimonas caenicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.43AlaAla: 4.43 ± 0.085	0.561AlaCys: 0.561 ± 0.031	3.627AlaAsp: 3.627 ± 0.065	4.293AlaGlu: 4.293 ± 0.083	2.788AlaPhe: 2.788 ± 0.062	4.49AlaGly: 4.49 ± 0.087	1.047AlaHis: 1.047 ± 0.042	5.027AlaIle: 5.027 ± 0.088	3.674AlaLys: 3.674 ± 0.076	5.77AlaLeu: 5.77 ± 0.09	1.552AlaMet: 1.552 ± 0.051	3.024AlaAsn: 3.024 ± 0.059	1.937AlaPro: 1.937 ± 0.053	2.105AlaGln: 2.105 ± 0.053	2.526AlaArg: 2.526 ± 0.056	3.925AlaSer: 3.925 ± 0.064	3.162AlaThr: 3.162 ± 0.069	4.154AlaVal: 4.154 ± 0.074	0.631AlaTrp: 0.631 ± 0.028	2.556AlaTyr: 2.556 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.451CysAla: 0.451 ± 0.028	0.103CysCys: 0.103 ± 0.012	0.466CysAsp: 0.466 ± 0.023	0.495CysGlu: 0.495 ± 0.026	0.425CysPhe: 0.425 ± 0.025	0.711CysGly: 0.711 ± 0.032	0.215CysHis: 0.215 ± 0.019	0.61CysIle: 0.61 ± 0.031	0.476CysLys: 0.476 ± 0.027	0.663CysLeu: 0.663 ± 0.028	0.211CysMet: 0.211 ± 0.016	0.478CysAsn: 0.478 ± 0.027	0.363CysPro: 0.363 ± 0.027	0.184CysGln: 0.184 ± 0.016	0.375CysArg: 0.375 ± 0.024	0.603CysSer: 0.603 ± 0.027	0.472CysThr: 0.472 ± 0.028	0.434CysVal: 0.434 ± 0.025	0.085CysTrp: 0.085 ± 0.011	0.294CysTyr: 0.294 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.447AspAla: 3.447 ± 0.072	0.432AspCys: 0.432 ± 0.027	2.957AspAsp: 2.957 ± 0.06	4.285AspGlu: 4.285 ± 0.081	3.162AspPhe: 3.162 ± 0.056	3.721AspGly: 3.721 ± 0.071	0.933AspHis: 0.933 ± 0.031	5.109AspIle: 5.109 ± 0.088	4.114AspLys: 4.114 ± 0.075	5.064AspLeu: 5.064 ± 0.077	1.414AspMet: 1.414 ± 0.043	3.293AspAsn: 3.293 ± 0.074	2.093AspPro: 2.093 ± 0.05	1.549AspGln: 1.549 ± 0.041	2.454AspArg: 2.454 ± 0.061	3.436AspSer: 3.436 ± 0.07	2.581AspThr: 2.581 ± 0.06	3.496AspVal: 3.496 ± 0.063	0.835AspTrp: 0.835 ± 0.033	2.84AspTyr: 2.84 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	4.239GluAla: 4.239 ± 0.081	0.441GluCys: 0.441 ± 0.025	3.608GluAsp: 3.608 ± 0.068	5.323GluGlu: 5.323 ± 0.102	2.97GluPhe: 2.97 ± 0.064	4.057GluGly: 4.057 ± 0.07	1.04GluHis: 1.04 ± 0.041	6.0GluIle: 6.0 ± 0.102	5.832GluLys: 5.832 ± 0.1	6.454GluLeu: 6.454 ± 0.097	1.994GluMet: 1.994 ± 0.048	4.54GluAsn: 4.54 ± 0.073	1.892GluPro: 1.892 ± 0.048	2.279GluGln: 2.279 ± 0.053	3.169GluArg: 3.169 ± 0.063	4.031GluSer: 4.031 ± 0.061	3.473GluThr: 3.473 ± 0.067	4.5GluVal: 4.5 ± 0.073	0.901GluTrp: 0.901 ± 0.036	2.857GluTyr: 2.857 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	2.787PheAla: 2.787 ± 0.055	0.446PheCys: 0.446 ± 0.023	2.94PheAsp: 2.94 ± 0.063	2.917PheGlu: 2.917 ± 0.067	2.26PhePhe: 2.26 ± 0.051	3.332PheGly: 3.332 ± 0.063	0.808PheHis: 0.808 ± 0.034	4.037PheIle: 4.037 ± 0.088	2.703PheLys: 2.703 ± 0.054	4.063PheLeu: 4.063 ± 0.077	1.268PheMet: 1.268 ± 0.04	2.964PheAsn: 2.964 ± 0.065	1.805PhePro: 1.805 ± 0.047	1.208PheGln: 1.208 ± 0.033	2.119PheArg: 2.119 ± 0.052	3.833PheSer: 3.833 ± 0.074	2.842PheThr: 2.842 ± 0.06	2.824PheVal: 2.824 ± 0.062	0.554PheTrp: 0.554 ± 0.029	1.96PheTyr: 1.96 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	4.084GlyAla: 4.084 ± 0.084	0.656GlyCys: 0.656 ± 0.031	3.675GlyAsp: 3.675 ± 0.073	4.252GlyGlu: 4.252 ± 0.079	3.294GlyPhe: 3.294 ± 0.064	4.712GlyGly: 4.712 ± 0.103	1.205GlyHis: 1.205 ± 0.039	5.653GlyIle: 5.653 ± 0.093	4.869GlyLys: 4.869 ± 0.084	5.629GlyLeu: 5.629 ± 0.09	1.985GlyMet: 1.985 ± 0.052	3.719GlyAsn: 3.719 ± 0.083	1.404GlyPro: 1.404 ± 0.041	1.787GlyGln: 1.787 ± 0.047	2.802GlyArg: 2.802 ± 0.059	4.106GlySer: 4.106 ± 0.074	3.764GlyThr: 3.764 ± 0.071	4.866GlyVal: 4.866 ± 0.088	0.955GlyTrp: 0.955 ± 0.034	3.161GlyTyr: 3.161 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.922HisAla: 0.922 ± 0.03	0.193HisCys: 0.193 ± 0.016	0.903HisAsp: 0.903 ± 0.034	0.994HisGlu: 0.994 ± 0.036	0.958HisPhe: 0.958 ± 0.03	1.125HisGly: 1.125 ± 0.034	0.377HisHis: 0.377 ± 0.022	1.395HisIle: 1.395 ± 0.04	1.012HisLys: 1.012 ± 0.037	1.596HisLeu: 1.596 ± 0.044	0.356HisMet: 0.356 ± 0.023	1.107HisAsn: 1.107 ± 0.031	0.873HisPro: 0.873 ± 0.034	0.539HisGln: 0.539 ± 0.024	0.802HisArg: 0.802 ± 0.034	1.149HisSer: 1.149 ± 0.038	0.927HisThr: 0.927 ± 0.034	0.902HisVal: 0.902 ± 0.033	0.223HisTrp: 0.223 ± 0.018	0.796HisTyr: 0.796 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.487IleAla: 5.487 ± 0.089	0.686IleCys: 0.686 ± 0.027	5.253IleAsp: 5.253 ± 0.072	5.869IleGlu: 5.869 ± 0.102	3.523IlePhe: 3.523 ± 0.077	5.204IleGly: 5.204 ± 0.091	1.381IleHis: 1.381 ± 0.042	6.41IleIle: 6.41 ± 0.121	5.093IleLys: 5.093 ± 0.077	7.129IleLeu: 7.129 ± 0.132	1.734IleMet: 1.734 ± 0.045	4.648IleAsn: 4.648 ± 0.081	3.521IlePro: 3.521 ± 0.076	2.315IleGln: 2.315 ± 0.054	3.407IleArg: 3.407 ± 0.061	6.072IleSer: 6.072 ± 0.099	4.737IleThr: 4.737 ± 0.077	5.0IleVal: 5.0 ± 0.082	0.735IleTrp: 0.735 ± 0.027	3.148IleTyr: 3.148 ± 0.071	0.0IleXaa: 0.0 ± 0.0
Lys	4.056LysAla: 4.056 ± 0.069	0.419LysCys: 0.419 ± 0.024	3.857LysAsp: 3.857 ± 0.066	5.652LysGlu: 5.652 ± 0.108	2.479LysPhe: 2.479 ± 0.061	4.324LysGly: 4.324 ± 0.069	1.113LysHis: 1.113 ± 0.041	5.35LysIle: 5.35 ± 0.092	5.258LysLys: 5.258 ± 0.083	5.737LysLeu: 5.737 ± 0.089	1.897LysMet: 1.897 ± 0.05	4.023LysAsn: 4.023 ± 0.068	2.341LysPro: 2.341 ± 0.057	2.338LysGln: 2.338 ± 0.055	3.143LysArg: 3.143 ± 0.063	4.372LysSer: 4.372 ± 0.078	3.606LysThr: 3.606 ± 0.065	4.209LysVal: 4.209 ± 0.081	0.771LysTrp: 0.771 ± 0.029	2.969LysTyr: 2.969 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	5.315LeuAla: 5.315 ± 0.098	0.745LeuCys: 0.745 ± 0.034	4.668LeuAsp: 4.668 ± 0.082	5.545LeuGlu: 5.545 ± 0.093	4.702LeuPhe: 4.702 ± 0.078	5.471LeuGly: 5.471 ± 0.098	1.565LeuHis: 1.565 ± 0.043	7.186LeuIle: 7.186 ± 0.12	6.486LeuLys: 6.486 ± 0.108	8.709LeuLeu: 8.709 ± 0.137	2.299LeuMet: 2.299 ± 0.056	5.45LeuAsn: 5.45 ± 0.088	3.766LeuPro: 3.766 ± 0.065	2.963LeuGln: 2.963 ± 0.066	3.92LeuArg: 3.92 ± 0.07	7.083LeuSer: 7.083 ± 0.098	5.075LeuThr: 5.075 ± 0.08	4.842LeuVal: 4.842 ± 0.086	0.887LeuTrp: 0.887 ± 0.033	3.397LeuTyr: 3.397 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	1.691MetAla: 1.691 ± 0.044	0.162MetCys: 0.162 ± 0.014	1.354MetAsp: 1.354 ± 0.035	1.654MetGlu: 1.654 ± 0.044	1.01MetPhe: 1.01 ± 0.037	1.796MetGly: 1.796 ± 0.055	0.456MetHis: 0.456 ± 0.023	1.927MetIle: 1.927 ± 0.052	2.178MetLys: 2.178 ± 0.055	2.308MetLeu: 2.308 ± 0.062	0.728MetMet: 0.728 ± 0.03	1.564MetAsn: 1.564 ± 0.046	0.998MetPro: 0.998 ± 0.036	0.948MetGln: 0.948 ± 0.029	1.136MetArg: 1.136 ± 0.039	1.683MetSer: 1.683 ± 0.045	1.249MetThr: 1.249 ± 0.039	1.457MetVal: 1.457 ± 0.043	0.234MetTrp: 0.234 ± 0.016	0.788MetTyr: 0.788 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.276AsnAla: 3.276 ± 0.062	0.427AsnCys: 0.427 ± 0.026	3.107AsnAsp: 3.107 ± 0.059	3.539AsnGlu: 3.539 ± 0.059	2.684AsnPhe: 2.684 ± 0.068	3.874AsnGly: 3.874 ± 0.083	0.953AsnHis: 0.953 ± 0.033	5.112AsnIle: 5.112 ± 0.083	3.707AsnLys: 3.707 ± 0.071	5.053AsnLeu: 5.053 ± 0.076	1.439AsnMet: 1.439 ± 0.044	3.611AsnAsn: 3.611 ± 0.086	2.853AsnPro: 2.853 ± 0.053	1.797AsnGln: 1.797 ± 0.043	3.009AsnArg: 3.009 ± 0.069	4.091AsnSer: 4.091 ± 0.068	2.701AsnThr: 2.701 ± 0.069	3.28AsnVal: 3.28 ± 0.071	0.765AsnTrp: 0.765 ± 0.029	2.625AsnTyr: 2.625 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	2.338ProAla: 2.338 ± 0.06	0.198ProCys: 0.198 ± 0.016	2.648ProAsp: 2.648 ± 0.054	3.611ProGlu: 3.611 ± 0.06	1.965ProPhe: 1.965 ± 0.05	2.496ProGly: 2.496 ± 0.052	0.69ProHis: 0.69 ± 0.027	2.612ProIle: 2.612 ± 0.05	2.052ProLys: 2.052 ± 0.049	3.183ProLeu: 3.183 ± 0.063	0.777ProMet: 0.777 ± 0.028	1.88ProAsn: 1.88 ± 0.052	0.894ProPro: 0.894 ± 0.04	1.212ProGln: 1.212 ± 0.038	1.23ProArg: 1.23 ± 0.044	2.293ProSer: 2.293 ± 0.055	1.812ProThr: 1.812 ± 0.044	2.933ProVal: 2.933 ± 0.06	0.44ProTrp: 0.44 ± 0.027	1.605ProTyr: 1.605 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	1.77GlnAla: 1.77 ± 0.045	0.186GlnCys: 0.186 ± 0.016	1.396GlnAsp: 1.396 ± 0.044	2.056GlnGlu: 2.056 ± 0.053	1.433GlnPhe: 1.433 ± 0.045	1.79GlnGly: 1.79 ± 0.048	0.534GlnHis: 0.534 ± 0.028	2.601GlnIle: 2.601 ± 0.05	2.294GlnLys: 2.294 ± 0.052	3.094GlnLeu: 3.094 ± 0.073	0.905GlnMet: 0.905 ± 0.035	1.879GlnAsn: 1.879 ± 0.05	1.105GlnPro: 1.105 ± 0.032	1.307GlnGln: 1.307 ± 0.048	1.453GlnArg: 1.453 ± 0.043	2.005GlnSer: 2.005 ± 0.054	1.755GlnThr: 1.755 ± 0.045	1.796GlnVal: 1.796 ± 0.037	0.338GlnTrp: 0.338 ± 0.022	1.19GlnTyr: 1.19 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.443ArgAla: 2.443 ± 0.059	0.288ArgCys: 0.288 ± 0.021	2.352ArgAsp: 2.352 ± 0.053	3.304ArgGlu: 3.304 ± 0.064	2.2ArgPhe: 2.2 ± 0.046	2.487ArgGly: 2.487 ± 0.059	0.725ArgHis: 0.725 ± 0.029	3.568ArgIle: 3.568 ± 0.07	3.353ArgLys: 3.353 ± 0.072	4.17ArgLeu: 4.17 ± 0.081	1.204ArgMet: 1.204 ± 0.033	2.669ArgAsn: 2.669 ± 0.059	1.454ArgPro: 1.454 ± 0.048	1.385ArgGln: 1.385 ± 0.043	2.132ArgArg: 2.132 ± 0.057	2.616ArgSer: 2.616 ± 0.063	2.215ArgThr: 2.215 ± 0.051	2.791ArgVal: 2.791 ± 0.055	0.581ArgTrp: 0.581 ± 0.027	1.998ArgTyr: 1.998 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	4.145SerAla: 4.145 ± 0.073	0.666SerCys: 0.666 ± 0.027	4.2SerAsp: 4.2 ± 0.074	4.816SerGlu: 4.816 ± 0.082	3.551SerPhe: 3.551 ± 0.073	4.997SerGly: 4.997 ± 0.07	1.177SerHis: 1.177 ± 0.039	5.252SerIle: 5.252 ± 0.086	4.148SerLys: 4.148 ± 0.074	6.335SerLeu: 6.335 ± 0.098	1.615SerMet: 1.615 ± 0.042	3.368SerAsn: 3.368 ± 0.072	2.436SerPro: 2.436 ± 0.054	2.022SerGln: 2.022 ± 0.049	2.949SerArg: 2.949 ± 0.06	4.77SerSer: 4.77 ± 0.11	3.278SerThr: 3.278 ± 0.075	4.579SerVal: 4.579 ± 0.068	0.757SerTrp: 0.757 ± 0.03	2.886SerTyr: 2.886 ± 0.068	0.0SerXaa: 0.0 ± 0.0
Thr	3.485ThrAla: 3.485 ± 0.066	0.375ThrCys: 0.375 ± 0.02	3.247ThrAsp: 3.247 ± 0.064	3.499ThrGlu: 3.499 ± 0.06	2.602ThrPhe: 2.602 ± 0.054	4.341ThrGly: 4.341 ± 0.082	0.899ThrHis: 0.899 ± 0.033	4.327ThrIle: 4.327 ± 0.07	2.88ThrLys: 2.88 ± 0.062	4.833ThrLeu: 4.833 ± 0.077	1.058ThrMet: 1.058 ± 0.037	2.621ThrAsn: 2.621 ± 0.058	2.572ThrPro: 2.572 ± 0.054	1.49ThrGln: 1.49 ± 0.046	1.968ThrArg: 1.968 ± 0.044	3.534ThrSer: 3.534 ± 0.07	3.111ThrThr: 3.111 ± 0.069	3.766ThrVal: 3.766 ± 0.076	0.599ThrTrp: 0.599 ± 0.029	2.182ThrTyr: 2.182 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	3.965ValAla: 3.965 ± 0.08	0.637ValCys: 0.637 ± 0.033	3.747ValAsp: 3.747 ± 0.071	4.277ValGlu: 4.277 ± 0.082	2.893ValPhe: 2.893 ± 0.058	3.863ValGly: 3.863 ± 0.075	1.006ValHis: 1.006 ± 0.029	5.223ValIle: 5.223 ± 0.095	4.246ValLys: 4.246 ± 0.077	5.389ValLeu: 5.389 ± 0.078	1.562ValMet: 1.562 ± 0.044	3.603ValAsn: 3.603 ± 0.063	2.471ValPro: 2.471 ± 0.056	1.75ValGln: 1.75 ± 0.047	2.683ValArg: 2.683 ± 0.061	4.474ValSer: 4.474 ± 0.07	3.72ValThr: 3.72 ± 0.074	4.365ValVal: 4.365 ± 0.081	0.71ValTrp: 0.71 ± 0.033	2.454ValTyr: 2.454 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.587TrpAla: 0.587 ± 0.026	0.11TrpCys: 0.11 ± 0.012	0.744TrpAsp: 0.744 ± 0.034	0.807TrpGlu: 0.807 ± 0.032	0.538TrpPhe: 0.538 ± 0.024	0.874TrpGly: 0.874 ± 0.041	0.243TrpHis: 0.243 ± 0.018	0.824TrpIle: 0.824 ± 0.033	0.778TrpLys: 0.778 ± 0.029	1.11TrpLeu: 1.11 ± 0.033	0.341TrpMet: 0.341 ± 0.022	0.749TrpAsn: 0.749 ± 0.031	0.269TrpPro: 0.269 ± 0.019	0.433TrpGln: 0.433 ± 0.028	0.551TrpArg: 0.551 ± 0.028	0.705TrpSer: 0.705 ± 0.03	0.612TrpThr: 0.612 ± 0.029	0.712TrpVal: 0.712 ± 0.032	0.149TrpTrp: 0.149 ± 0.016	0.518TrpTyr: 0.518 ± 0.032	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.361TyrAla: 2.361 ± 0.051	0.381TyrCys: 0.381 ± 0.021	2.466TyrAsp: 2.466 ± 0.058	2.413TyrGlu: 2.413 ± 0.049	2.234TyrPhe: 2.234 ± 0.058	2.911TyrGly: 2.911 ± 0.067	0.782TyrHis: 0.782 ± 0.028	3.127TyrIle: 3.127 ± 0.067	2.76TyrLys: 2.76 ± 0.06	3.785TyrLeu: 3.785 ± 0.074	0.981TyrMet: 0.981 ± 0.037	2.715TyrAsn: 2.715 ± 0.062	1.825TyrPro: 1.825 ± 0.05	1.279TyrGln: 1.279 ± 0.039	2.104TyrArg: 2.104 ± 0.059	3.166TyrSer: 3.166 ± 0.064	2.3TyrThr: 2.3 ± 0.056	2.132TyrVal: 2.132 ± 0.053	0.502TyrTrp: 0.502 ± 0.027	1.887TyrTyr: 1.887 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2391 proteins (847865 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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