Amino acid dipepetide frequency for Primula malacoides virus China/Mar2007

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.168AlaAla: 7.168 ± 3.293
0.717AlaCys: 0.717 ± 0.499
2.151AlaAsp: 2.151 ± 0.574
2.151AlaGlu: 2.151 ± 0.574
1.434AlaPhe: 1.434 ± 1.073
2.867AlaGly: 2.867 ± 1.11
4.301AlaHis: 4.301 ± 0.111
2.867AlaIle: 2.867 ± 1.11
3.584AlaLys: 3.584 ± 0.425
5.018AlaLeu: 5.018 ± 1.684
0.717AlaMet: 0.717 ± 0.499
4.301AlaAsn: 4.301 ± 1.147
4.301AlaPro: 4.301 ± 0.111
2.151AlaGln: 2.151 ± 0.574
5.735AlaArg: 5.735 ± 0.887
3.584AlaSer: 3.584 ± 1.646
8.602AlaThr: 8.602 ± 0.223
5.018AlaVal: 5.018 ± 1.684
0.0AlaTrp: 0.0 ± 0.0
2.867AlaTyr: 2.867 ± 0.962
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.717CysCys: 0.717 ± 0.499
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.434CysPhe: 1.434 ± 0.037
0.717CysGly: 0.717 ± 0.499
0.0CysHis: 0.0 ± 0.0
1.434CysIle: 1.434 ± 0.999
0.717CysLys: 0.717 ± 0.499
1.434CysLeu: 1.434 ± 1.073
0.717CysMet: 0.717 ± 0.536
0.717CysAsn: 0.717 ± 0.499
0.717CysPro: 0.717 ± 0.499
0.717CysGln: 0.717 ± 0.499
0.717CysArg: 0.717 ± 0.499
0.0CysSer: 0.0 ± 0.0
0.717CysThr: 0.717 ± 0.536
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.867AspAla: 2.867 ± 1.997
0.717AspCys: 0.717 ± 0.536
2.151AspAsp: 2.151 ± 0.462
2.867AspGlu: 2.867 ± 1.997
4.301AspPhe: 4.301 ± 1.147
2.867AspGly: 2.867 ± 1.11
1.434AspHis: 1.434 ± 1.073
3.584AspIle: 3.584 ± 1.461
2.151AspLys: 2.151 ± 0.462
7.885AspLeu: 7.885 ± 0.722
0.717AspMet: 0.717 ± 0.536
3.584AspAsn: 3.584 ± 1.461
2.867AspPro: 2.867 ± 0.962
2.867AspGln: 2.867 ± 0.962
4.301AspArg: 4.301 ± 0.111
4.301AspSer: 4.301 ± 0.111
3.584AspThr: 3.584 ± 1.646
4.301AspVal: 4.301 ± 0.111
0.717AspTrp: 0.717 ± 0.499
3.584AspTyr: 3.584 ± 0.425
0.0AspXaa: 0.0 ± 0.0
Glu
2.867GluAla: 2.867 ± 0.074
0.717GluCys: 0.717 ± 0.499
0.717GluAsp: 0.717 ± 0.499
2.867GluGlu: 2.867 ± 1.997
3.584GluPhe: 3.584 ± 0.425
0.717GluGly: 0.717 ± 0.499
0.717GluHis: 0.717 ± 0.499
2.867GluIle: 2.867 ± 0.074
0.0GluLys: 0.0 ± 0.0
4.301GluLeu: 4.301 ± 0.924
0.717GluMet: 0.717 ± 0.536
2.151GluAsn: 2.151 ± 0.462
2.151GluPro: 2.151 ± 0.462
1.434GluGln: 1.434 ± 0.999
1.434GluArg: 1.434 ± 0.037
2.151GluSer: 2.151 ± 1.609
2.867GluThr: 2.867 ± 0.962
0.717GluVal: 0.717 ± 0.536
0.0GluTrp: 0.0 ± 0.0
2.151GluTyr: 2.151 ± 1.498
0.0GluXaa: 0.0 ± 0.0
Phe
2.867PheAla: 2.867 ± 1.11
0.717PheCys: 0.717 ± 0.499
0.717PheAsp: 0.717 ± 0.536
3.584PheGlu: 3.584 ± 0.425
2.867PhePhe: 2.867 ± 0.074
2.867PheGly: 2.867 ± 1.11
2.151PheHis: 2.151 ± 0.574
2.151PheIle: 2.151 ± 1.498
1.434PheLys: 1.434 ± 0.999
12.186PheLeu: 12.186 ± 1.869
0.0PheMet: 0.0 ± 0.0
5.018PheAsn: 5.018 ± 1.424
5.735PhePro: 5.735 ± 1.184
4.301PheGln: 4.301 ± 1.147
1.434PheArg: 1.434 ± 0.037
4.301PheSer: 4.301 ± 1.147
4.301PheThr: 4.301 ± 0.924
1.434PheVal: 1.434 ± 0.037
0.0PheTrp: 0.0 ± 0.0
0.717PheTyr: 0.717 ± 0.499
0.0PheXaa: 0.0 ± 0.0
Gly
1.434GlyAla: 1.434 ± 1.073
0.0GlyCys: 0.0 ± 0.0
1.434GlyAsp: 1.434 ± 0.037
0.717GlyGlu: 0.717 ± 0.536
2.151GlyPhe: 2.151 ± 1.609
0.717GlyGly: 0.717 ± 0.499
1.434GlyHis: 1.434 ± 0.037
0.717GlyIle: 0.717 ± 0.499
1.434GlyLys: 1.434 ± 1.073
5.018GlyLeu: 5.018 ± 1.424
2.151GlyMet: 2.151 ± 0.574
1.434GlyAsn: 1.434 ± 0.037
0.717GlyPro: 0.717 ± 0.499
0.717GlyGln: 0.717 ± 0.499
0.717GlyArg: 0.717 ± 0.536
3.584GlySer: 3.584 ± 0.611
3.584GlyThr: 3.584 ± 0.425
2.151GlyVal: 2.151 ± 0.462
0.0GlyTrp: 0.0 ± 0.0
5.018GlyTyr: 5.018 ± 1.424
0.0GlyXaa: 0.0 ± 0.0
His
2.151HisAla: 2.151 ± 0.574
0.717HisCys: 0.717 ± 0.499
2.867HisAsp: 2.867 ± 0.074
0.0HisGlu: 0.0 ± 0.0
2.867HisPhe: 2.867 ± 0.074
1.434HisGly: 1.434 ± 0.037
0.0HisHis: 0.0 ± 0.0
0.717HisIle: 0.717 ± 0.499
1.434HisLys: 1.434 ± 0.999
3.584HisLeu: 3.584 ± 0.611
0.0HisMet: 0.0 ± 0.0
1.434HisAsn: 1.434 ± 0.037
2.151HisPro: 2.151 ± 0.574
2.151HisGln: 2.151 ± 0.462
1.434HisArg: 1.434 ± 1.073
0.717HisSer: 0.717 ± 0.499
2.867HisThr: 2.867 ± 0.074
1.434HisVal: 1.434 ± 0.037
0.0HisTrp: 0.0 ± 0.0
2.151HisTyr: 2.151 ± 0.462
0.0HisXaa: 0.0 ± 0.0
Ile
1.434IleAla: 1.434 ± 0.037
1.434IleCys: 1.434 ± 1.073
6.452IleAsp: 6.452 ± 1.387
3.584IleGlu: 3.584 ± 0.611
2.867IlePhe: 2.867 ± 0.074
1.434IleGly: 1.434 ± 0.037
2.867IleHis: 2.867 ± 0.962
3.584IleIle: 3.584 ± 1.461
1.434IleLys: 1.434 ± 0.037
2.151IleLeu: 2.151 ± 1.498
3.584IleMet: 3.584 ± 0.425
2.867IleAsn: 2.867 ± 0.962
3.584IlePro: 3.584 ± 0.425
1.434IleGln: 1.434 ± 0.037
1.434IleArg: 1.434 ± 0.999
4.301IleSer: 4.301 ± 0.924
4.301IleThr: 4.301 ± 1.147
2.867IleVal: 2.867 ± 0.074
0.0IleTrp: 0.0 ± 0.0
1.434IleTyr: 1.434 ± 0.999
0.0IleXaa: 0.0 ± 0.0
Lys
1.434LysAla: 1.434 ± 0.999
0.717LysCys: 0.717 ± 0.499
0.0LysAsp: 0.0 ± 0.0
0.717LysGlu: 0.717 ± 0.499
2.151LysPhe: 2.151 ± 1.498
0.717LysGly: 0.717 ± 0.499
2.867LysHis: 2.867 ± 0.074
2.151LysIle: 2.151 ± 0.574
0.0LysLys: 0.0 ± 0.0
3.584LysLeu: 3.584 ± 1.461
0.0LysMet: 0.0 ± 0.0
2.151LysAsn: 2.151 ± 0.574
2.867LysPro: 2.867 ± 0.962
1.434LysGln: 1.434 ± 0.999
3.584LysArg: 3.584 ± 0.425
3.584LysSer: 3.584 ± 0.611
3.584LysThr: 3.584 ± 1.461
3.584LysVal: 3.584 ± 0.611
0.717LysTrp: 0.717 ± 0.499
2.151LysTyr: 2.151 ± 1.498
0.0LysXaa: 0.0 ± 0.0
Leu
6.452LeuAla: 6.452 ± 0.351
0.717LeuCys: 0.717 ± 0.499
5.735LeuAsp: 5.735 ± 0.887
2.867LeuGlu: 2.867 ± 1.997
5.018LeuPhe: 5.018 ± 0.648
2.867LeuGly: 2.867 ± 0.074
2.867LeuHis: 2.867 ± 0.962
5.018LeuIle: 5.018 ± 1.424
5.735LeuLys: 5.735 ± 1.923
7.885LeuLeu: 7.885 ± 1.758
2.867LeuMet: 2.867 ± 0.962
3.584LeuAsn: 3.584 ± 0.611
10.036LeuPro: 10.036 ± 2.331
4.301LeuGln: 4.301 ± 3.219
4.301LeuArg: 4.301 ± 0.111
6.452LeuSer: 6.452 ± 1.721
9.319LeuThr: 9.319 ± 2.831
7.168LeuVal: 7.168 ± 0.85
0.717LeuTrp: 0.717 ± 0.536
7.885LeuTyr: 7.885 ± 1.349
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
0.717MetAsp: 0.717 ± 0.499
0.0MetGlu: 0.0 ± 0.0
1.434MetPhe: 1.434 ± 0.037
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.434MetIle: 1.434 ± 0.037
0.0MetLys: 0.0 ± 0.0
2.151MetLeu: 2.151 ± 0.574
0.0MetMet: 0.0 ± 0.0
1.434MetAsn: 1.434 ± 1.073
2.151MetPro: 2.151 ± 0.574
0.717MetGln: 0.717 ± 0.499
0.717MetArg: 0.717 ± 0.499
2.151MetSer: 2.151 ± 0.462
3.584MetThr: 3.584 ± 0.425
1.434MetVal: 1.434 ± 0.037
0.0MetTrp: 0.0 ± 0.0
2.867MetTyr: 2.867 ± 0.074
0.0MetXaa: 0.0 ± 0.0
Asn
5.018AsnAla: 5.018 ± 0.648
0.717AsnCys: 0.717 ± 0.536
5.735AsnAsp: 5.735 ± 0.148
0.717AsnGlu: 0.717 ± 0.499
2.151AsnPhe: 2.151 ± 0.574
2.151AsnGly: 2.151 ± 0.574
2.867AsnHis: 2.867 ± 0.962
1.434AsnIle: 1.434 ± 0.037
1.434AsnLys: 1.434 ± 0.037
6.452AsnLeu: 6.452 ± 1.387
4.301AsnMet: 4.301 ± 0.111
2.151AsnAsn: 2.151 ± 0.574
2.151AsnPro: 2.151 ± 1.609
2.867AsnGln: 2.867 ± 0.074
2.867AsnArg: 2.867 ± 0.074
2.151AsnSer: 2.151 ± 0.462
5.018AsnThr: 5.018 ± 0.388
1.434AsnVal: 1.434 ± 1.073
0.0AsnTrp: 0.0 ± 0.0
2.151AsnTyr: 2.151 ± 0.462
0.0AsnXaa: 0.0 ± 0.0
Pro
3.584ProAla: 3.584 ± 0.611
0.0ProCys: 0.0 ± 0.0
10.036ProAsp: 10.036 ± 2.847
2.151ProGlu: 2.151 ± 0.462
5.018ProPhe: 5.018 ± 0.648
4.301ProGly: 4.301 ± 2.183
0.0ProHis: 0.0 ± 0.0
5.018ProIle: 5.018 ± 2.46
3.584ProLys: 3.584 ± 1.461
7.168ProLeu: 7.168 ± 0.85
0.717ProMet: 0.717 ± 0.347
4.301ProAsn: 4.301 ± 3.219
1.434ProPro: 1.434 ± 0.037
0.717ProGln: 0.717 ± 0.536
3.584ProArg: 3.584 ± 1.646
5.735ProSer: 5.735 ± 0.887
5.018ProThr: 5.018 ± 0.388
4.301ProVal: 4.301 ± 2.183
0.717ProTrp: 0.717 ± 0.536
3.584ProTyr: 3.584 ± 0.425
0.0ProXaa: 0.0 ± 0.0
Gln
2.867GlnAla: 2.867 ± 1.11
0.0GlnCys: 0.0 ± 0.0
3.584GlnAsp: 3.584 ± 0.425
0.717GlnGlu: 0.717 ± 0.536
4.301GlnPhe: 4.301 ± 0.924
0.717GlnGly: 0.717 ± 0.499
1.434GlnHis: 1.434 ± 1.073
2.151GlnIle: 2.151 ± 1.498
0.717GlnLys: 0.717 ± 0.499
2.867GlnLeu: 2.867 ± 0.074
0.0GlnMet: 0.0 ± 0.0
0.717GlnAsn: 0.717 ± 0.536
4.301GlnPro: 4.301 ± 1.96
1.434GlnGln: 1.434 ± 0.999
2.867GlnArg: 2.867 ± 0.962
2.151GlnSer: 2.151 ± 1.609
1.434GlnThr: 1.434 ± 0.037
2.867GlnVal: 2.867 ± 2.146
0.717GlnTrp: 0.717 ± 0.536
1.434GlnTyr: 1.434 ± 0.999
0.0GlnXaa: 0.0 ± 0.0
Arg
5.018ArgAla: 5.018 ± 0.648
0.0ArgCys: 0.0 ± 0.0
2.867ArgAsp: 2.867 ± 1.11
2.151ArgGlu: 2.151 ± 0.574
0.0ArgPhe: 0.0 ± 0.0
0.717ArgGly: 0.717 ± 0.499
2.151ArgHis: 2.151 ± 1.609
2.867ArgIle: 2.867 ± 0.074
2.151ArgLys: 2.151 ± 1.498
3.584ArgLeu: 3.584 ± 0.425
0.717ArgMet: 0.717 ± 0.499
1.434ArgAsn: 1.434 ± 0.999
6.452ArgPro: 6.452 ± 1.721
2.151ArgGln: 2.151 ± 1.498
2.151ArgArg: 2.151 ± 0.462
4.301ArgSer: 4.301 ± 0.924
6.452ArgThr: 6.452 ± 0.351
3.584ArgVal: 3.584 ± 0.611
0.0ArgTrp: 0.0 ± 0.0
3.584ArgTyr: 3.584 ± 1.461
0.0ArgXaa: 0.0 ± 0.0
Ser
11.47SerAla: 11.47 ± 3.404
0.717SerCys: 0.717 ± 0.499
3.584SerAsp: 3.584 ± 0.611
0.717SerGlu: 0.717 ± 0.536
5.018SerPhe: 5.018 ± 0.388
2.867SerGly: 2.867 ± 0.074
0.717SerHis: 0.717 ± 0.499
2.867SerIle: 2.867 ± 1.11
6.452SerLys: 6.452 ± 1.387
6.452SerLeu: 6.452 ± 0.685
0.0SerMet: 0.0 ± 0.0
5.018SerAsn: 5.018 ± 0.648
2.867SerPro: 2.867 ± 1.11
1.434SerGln: 1.434 ± 0.037
3.584SerArg: 3.584 ± 0.611
5.735SerSer: 5.735 ± 1.184
5.018SerThr: 5.018 ± 0.388
3.584SerVal: 3.584 ± 0.611
0.717SerTrp: 0.717 ± 0.536
3.584SerTyr: 3.584 ± 0.611
0.0SerXaa: 0.0 ± 0.0
Thr
5.735ThrAla: 5.735 ± 3.256
0.717ThrCys: 0.717 ± 0.536
6.452ThrAsp: 6.452 ± 0.351
2.867ThrGlu: 2.867 ± 0.074
4.301ThrPhe: 4.301 ± 2.996
3.584ThrGly: 3.584 ± 1.461
0.717ThrHis: 0.717 ± 0.499
7.168ThrIle: 7.168 ± 3.293
3.584ThrLys: 3.584 ± 0.611
9.319ThrLeu: 9.319 ± 0.277
2.151ThrMet: 2.151 ± 0.462
2.867ThrAsn: 2.867 ± 1.11
6.452ThrPro: 6.452 ± 1.721
1.434ThrGln: 1.434 ± 0.999
3.584ThrArg: 3.584 ± 0.611
5.735ThrSer: 5.735 ± 1.184
5.018ThrThr: 5.018 ± 3.755
4.301ThrVal: 4.301 ± 0.111
1.434ThrTrp: 1.434 ± 0.037
5.735ThrTyr: 5.735 ± 1.923
0.0ThrXaa: 0.0 ± 0.0
Val
1.434ValAla: 1.434 ± 0.037
0.0ValCys: 0.0 ± 0.0
3.584ValAsp: 3.584 ± 0.611
2.151ValGlu: 2.151 ± 0.462
3.584ValPhe: 3.584 ± 2.682
0.0ValGly: 0.0 ± 0.0
1.434ValHis: 1.434 ± 0.037
2.151ValIle: 2.151 ± 1.498
0.717ValLys: 0.717 ± 0.499
7.885ValLeu: 7.885 ± 3.829
0.0ValMet: 0.0 ± 0.36
1.434ValAsn: 1.434 ± 1.073
6.452ValPro: 6.452 ± 1.387
2.867ValGln: 2.867 ± 2.146
5.018ValArg: 5.018 ± 1.424
2.151ValSer: 2.151 ± 1.609
4.301ValThr: 4.301 ± 1.147
2.867ValVal: 2.867 ± 1.11
0.0ValTrp: 0.0 ± 0.0
4.301ValTyr: 4.301 ± 0.111
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.717TrpIle: 0.717 ± 0.536
0.717TrpLys: 0.717 ± 0.536
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.717TrpAsn: 0.717 ± 0.499
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
2.151TrpSer: 2.151 ± 0.574
0.717TrpThr: 0.717 ± 0.536
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.717TrpTyr: 0.717 ± 0.499
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.735TyrAla: 5.735 ± 0.887
1.434TyrCys: 1.434 ± 0.999
2.867TyrAsp: 2.867 ± 0.074
4.301TyrGlu: 4.301 ± 1.96
4.301TyrPhe: 4.301 ± 0.111
3.584TyrGly: 3.584 ± 1.461
2.151TyrHis: 2.151 ± 0.462
2.151TyrIle: 2.151 ± 0.462
0.717TyrLys: 0.717 ± 0.499
2.867TyrLeu: 2.867 ± 1.997
0.717TyrMet: 0.717 ± 0.536
6.452TyrAsn: 6.452 ± 2.422
3.584TyrPro: 3.584 ± 2.497
2.151TyrGln: 2.151 ± 0.462
2.867TyrArg: 2.867 ± 0.962
7.168TyrSer: 7.168 ± 0.85
2.867TyrThr: 2.867 ± 1.11
0.0TyrVal: 0.0 ± 0.0
0.0TyrTrp: 0.0 ± 0.0
1.434TyrTyr: 1.434 ± 0.999
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (1396 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski