Amino acid dipepetide frequency for Oceanospirillum multiglobuliferum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.898AlaAla: 8.898 ± 0.12	0.958AlaCys: 0.958 ± 0.033	5.196AlaAsp: 5.196 ± 0.083	6.695AlaGlu: 6.695 ± 0.09	3.429AlaPhe: 3.429 ± 0.056	6.455AlaGly: 6.455 ± 0.093	1.789AlaHis: 1.789 ± 0.04	5.637AlaIle: 5.637 ± 0.078	4.481AlaLys: 4.481 ± 0.079	11.348AlaLeu: 11.348 ± 0.141	2.582AlaMet: 2.582 ± 0.056	3.264AlaAsn: 3.264 ± 0.06	3.188AlaPro: 3.188 ± 0.066	5.113AlaGln: 5.113 ± 0.08	4.415AlaArg: 4.415 ± 0.064	5.343AlaSer: 5.343 ± 0.073	4.276AlaThr: 4.276 ± 0.071	6.401AlaVal: 6.401 ± 0.096	1.041AlaTrp: 1.041 ± 0.03	2.397AlaTyr: 2.397 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.87CysAla: 0.87 ± 0.031	0.161CysCys: 0.161 ± 0.012	0.508CysAsp: 0.508 ± 0.027	0.548CysGlu: 0.548 ± 0.024	0.439CysPhe: 0.439 ± 0.023	0.753CysGly: 0.753 ± 0.03	0.359CysHis: 0.359 ± 0.02	0.56CysIle: 0.56 ± 0.024	0.406CysLys: 0.406 ± 0.022	0.996CysLeu: 0.996 ± 0.035	0.208CysMet: 0.208 ± 0.014	0.351CysAsn: 0.351 ± 0.017	0.454CysPro: 0.454 ± 0.022	0.556CysGln: 0.556 ± 0.026	0.472CysArg: 0.472 ± 0.022	0.641CysSer: 0.641 ± 0.026	0.5CysThr: 0.5 ± 0.021	0.589CysVal: 0.589 ± 0.024	0.127CysTrp: 0.127 ± 0.01	0.333CysTyr: 0.333 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.566AspAla: 4.566 ± 0.067	0.505AspCys: 0.505 ± 0.022	2.741AspAsp: 2.741 ± 0.067	3.699AspGlu: 3.699 ± 0.063	2.187AspPhe: 2.187 ± 0.05	3.264AspGly: 3.264 ± 0.079	1.207AspHis: 1.207 ± 0.038	3.498AspIle: 3.498 ± 0.068	2.61AspLys: 2.61 ± 0.092	5.832AspLeu: 5.832 ± 0.091	1.193AspMet: 1.193 ± 0.042	2.069AspAsn: 2.069 ± 0.058	2.121AspPro: 2.121 ± 0.048	3.016AspGln: 3.016 ± 0.059	2.556AspArg: 2.556 ± 0.051	3.111AspSer: 3.111 ± 0.066	2.525AspThr: 2.525 ± 0.056	3.269AspVal: 3.269 ± 0.062	0.808AspTrp: 0.808 ± 0.03	1.779AspTyr: 1.779 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	6.063GluAla: 6.063 ± 0.08	0.422GluCys: 0.422 ± 0.021	2.64GluAsp: 2.64 ± 0.053	3.514GluGlu: 3.514 ± 0.075	2.094GluPhe: 2.094 ± 0.043	3.981GluGly: 3.981 ± 0.064	1.65GluHis: 1.65 ± 0.04	3.916GluIle: 3.916 ± 0.065	3.303GluLys: 3.303 ± 0.066	7.144GluLeu: 7.144 ± 0.078	1.671GluMet: 1.671 ± 0.043	2.241GluAsn: 2.241 ± 0.049	2.142GluPro: 2.142 ± 0.048	5.031GluGln: 5.031 ± 0.088	3.688GluArg: 3.688 ± 0.067	3.522GluSer: 3.522 ± 0.061	3.117GluThr: 3.117 ± 0.051	4.449GluVal: 4.449 ± 0.076	0.709GluTrp: 0.709 ± 0.029	1.645GluTyr: 1.645 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.436PheAla: 3.436 ± 0.054	0.491PheCys: 0.491 ± 0.022	2.484PheAsp: 2.484 ± 0.05	2.323PheGlu: 2.323 ± 0.048	1.564PhePhe: 1.564 ± 0.049	2.842PheGly: 2.842 ± 0.06	0.741PheHis: 0.741 ± 0.027	2.4PheIle: 2.4 ± 0.047	1.788PheLys: 1.788 ± 0.044	3.351PheLeu: 3.351 ± 0.064	0.961PheMet: 0.961 ± 0.029	1.764PheAsn: 1.764 ± 0.043	1.344PhePro: 1.344 ± 0.038	1.415PheGln: 1.415 ± 0.033	1.617PheArg: 1.617 ± 0.043	3.195PheSer: 3.195 ± 0.065	2.122PheThr: 2.122 ± 0.047	2.518PheVal: 2.518 ± 0.047	0.57PheTrp: 0.57 ± 0.026	1.246PheTyr: 1.246 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.451GlyAla: 5.451 ± 0.09	0.91GlyCys: 0.91 ± 0.031	3.448GlyAsp: 3.448 ± 0.07	4.156GlyGlu: 4.156 ± 0.063	3.206GlyPhe: 3.206 ± 0.055	4.544GlyGly: 4.544 ± 0.096	1.614GlyHis: 1.614 ± 0.044	4.513GlyIle: 4.513 ± 0.071	3.43GlyLys: 3.43 ± 0.058	7.515GlyLeu: 7.515 ± 0.097	1.968GlyMet: 1.968 ± 0.049	2.295GlyAsn: 2.295 ± 0.053	1.555GlyPro: 1.555 ± 0.046	3.356GlyGln: 3.356 ± 0.053	3.574GlyArg: 3.574 ± 0.06	3.941GlySer: 3.941 ± 0.064	3.277GlyThr: 3.277 ± 0.067	5.004GlyVal: 5.004 ± 0.078	0.975GlyTrp: 0.975 ± 0.03	2.392GlyTyr: 2.392 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.718HisAla: 1.718 ± 0.038	0.304HisCys: 0.304 ± 0.019	1.059HisAsp: 1.059 ± 0.032	1.241HisGlu: 1.241 ± 0.039	1.058HisPhe: 1.058 ± 0.035	1.448HisGly: 1.448 ± 0.039	0.73HisHis: 0.73 ± 0.03	1.371HisIle: 1.371 ± 0.037	0.95HisLys: 0.95 ± 0.033	2.591HisLeu: 2.591 ± 0.045	0.453HisMet: 0.453 ± 0.023	0.956HisAsn: 0.956 ± 0.031	1.277HisPro: 1.277 ± 0.033	1.397HisGln: 1.397 ± 0.039	1.18HisArg: 1.18 ± 0.037	1.403HisSer: 1.403 ± 0.04	1.083HisThr: 1.083 ± 0.034	1.153HisVal: 1.153 ± 0.036	0.465HisTrp: 0.465 ± 0.02	0.947HisTyr: 0.947 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.218IleAla: 6.218 ± 0.092	0.666IleCys: 0.666 ± 0.027	3.795IleAsp: 3.795 ± 0.065	4.507IleGlu: 4.507 ± 0.081	1.982IlePhe: 1.982 ± 0.05	4.453IleGly: 4.453 ± 0.076	1.257IleHis: 1.257 ± 0.036	3.181IleIle: 3.181 ± 0.064	3.046IleLys: 3.046 ± 0.062	5.267IleLeu: 5.267 ± 0.075	1.208IleMet: 1.208 ± 0.032	2.769IleAsn: 2.769 ± 0.049	2.573IlePro: 2.573 ± 0.055	2.672IleGln: 2.672 ± 0.053	3.059IleArg: 3.059 ± 0.053	4.576IleSer: 4.576 ± 0.077	3.5IleThr: 3.5 ± 0.064	3.779IleVal: 3.779 ± 0.066	0.632IleTrp: 0.632 ± 0.024	1.548IleTyr: 1.548 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.025LysAla: 5.025 ± 0.084	0.241LysCys: 0.241 ± 0.016	2.31LysAsp: 2.31 ± 0.05	2.975LysGlu: 2.975 ± 0.057	1.157LysPhe: 1.157 ± 0.036	3.342LysGly: 3.342 ± 0.061	1.022LysHis: 1.022 ± 0.034	2.771LysIle: 2.771 ± 0.055	2.626LysLys: 2.626 ± 0.066	4.924LysLeu: 4.924 ± 0.078	1.214LysMet: 1.214 ± 0.037	1.903LysAsn: 1.903 ± 0.049	2.298LysPro: 2.298 ± 0.048	2.838LysGln: 2.838 ± 0.055	2.629LysArg: 2.629 ± 0.057	2.877LysSer: 2.877 ± 0.072	2.748LysThr: 2.748 ± 0.054	3.52LysVal: 3.52 ± 0.06	0.414LysTrp: 0.414 ± 0.023	0.995LysTyr: 0.995 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	10.762LeuAla: 10.762 ± 0.116	1.066LeuCys: 1.066 ± 0.032	5.758LeuAsp: 5.758 ± 0.083	6.65LeuGlu: 6.65 ± 0.11	4.251LeuPhe: 4.251 ± 0.075	7.083LeuGly: 7.083 ± 0.104	2.268LeuHis: 2.268 ± 0.053	6.551LeuIle: 6.551 ± 0.086	5.797LeuLys: 5.797 ± 0.084	12.075LeuLeu: 12.075 ± 0.184	2.848LeuMet: 2.848 ± 0.058	4.952LeuAsn: 4.952 ± 0.071	5.17LeuPro: 5.17 ± 0.083	5.182LeuGln: 5.182 ± 0.101	5.054LeuArg: 5.054 ± 0.061	8.568LeuSer: 8.568 ± 0.105	5.978LeuThr: 5.978 ± 0.073	7.091LeuVal: 7.091 ± 0.107	1.248LeuTrp: 1.248 ± 0.04	2.714LeuTyr: 2.714 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.593MetAla: 2.593 ± 0.058	0.169MetCys: 0.169 ± 0.012	1.153MetAsp: 1.153 ± 0.036	1.208MetGlu: 1.208 ± 0.034	0.73MetPhe: 0.73 ± 0.027	1.782MetGly: 1.782 ± 0.046	0.516MetHis: 0.516 ± 0.027	1.483MetIle: 1.483 ± 0.038	1.185MetLys: 1.185 ± 0.035	2.84MetLeu: 2.84 ± 0.062	0.741MetMet: 0.741 ± 0.026	1.008MetAsn: 1.008 ± 0.034	1.355MetPro: 1.355 ± 0.032	1.355MetGln: 1.355 ± 0.039	1.261MetArg: 1.261 ± 0.039	1.845MetSer: 1.845 ± 0.036	1.574MetThr: 1.574 ± 0.042	1.657MetVal: 1.657 ± 0.041	0.197MetTrp: 0.197 ± 0.014	0.467MetTyr: 0.467 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.514AsnAla: 3.514 ± 0.061	0.409AsnCys: 0.409 ± 0.02	1.976AsnAsp: 1.976 ± 0.053	2.15AsnGlu: 2.15 ± 0.049	1.375AsnPhe: 1.375 ± 0.039	2.719AsnGly: 2.719 ± 0.068	0.922AsnHis: 0.922 ± 0.028	2.592AsnIle: 2.592 ± 0.051	1.877AsnLys: 1.877 ± 0.048	4.033AsnLeu: 4.033 ± 0.06	0.905AsnMet: 0.905 ± 0.031	1.648AsnAsn: 1.648 ± 0.045	2.071AsnPro: 2.071 ± 0.048	2.173AsnGln: 2.173 ± 0.05	2.11AsnArg: 2.11 ± 0.041	2.504AsnSer: 2.504 ± 0.049	2.223AsnThr: 2.223 ± 0.052	2.049AsnVal: 2.049 ± 0.047	0.535AsnTrp: 0.535 ± 0.018	1.106AsnTyr: 1.106 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	3.595ProAla: 3.595 ± 0.067	0.347ProCys: 0.347 ± 0.019	2.667ProAsp: 2.667 ± 0.052	3.924ProGlu: 3.924 ± 0.061	1.659ProPhe: 1.659 ± 0.042	1.985ProGly: 1.985 ± 0.048	0.884ProHis: 0.884 ± 0.027	2.574ProIle: 2.574 ± 0.046	2.064ProLys: 2.064 ± 0.054	4.314ProLeu: 4.314 ± 0.067	1.083ProMet: 1.083 ± 0.032	1.694ProAsn: 1.694 ± 0.039	1.324ProPro: 1.324 ± 0.053	1.607ProGln: 1.607 ± 0.037	1.482ProArg: 1.482 ± 0.042	2.52ProSer: 2.52 ± 0.052	2.046ProThr: 2.046 ± 0.055	3.338ProVal: 3.338 ± 0.059	0.559ProTrp: 0.559 ± 0.023	1.181ProTyr: 1.181 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.618GlnAla: 5.618 ± 0.094	0.4GlnCys: 0.4 ± 0.021	2.186GlnAsp: 2.186 ± 0.045	2.595GlnGlu: 2.595 ± 0.056	1.881GlnPhe: 1.881 ± 0.041	3.534GlnGly: 3.534 ± 0.059	1.524GlnHis: 1.524 ± 0.043	3.172GlnIle: 3.172 ± 0.063	2.547GlnLys: 2.547 ± 0.057	6.698GlnLeu: 6.698 ± 0.109	1.329GlnMet: 1.329 ± 0.037	1.802GlnAsn: 1.802 ± 0.042	2.37GlnPro: 2.37 ± 0.058	4.5GlnGln: 4.5 ± 0.121	2.951GlnArg: 2.951 ± 0.061	3.17GlnSer: 3.17 ± 0.061	2.569GlnThr: 2.569 ± 0.056	3.824GlnVal: 3.824 ± 0.063	0.798GlnTrp: 0.798 ± 0.033	1.498GlnTyr: 1.498 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	3.997ArgAla: 3.997 ± 0.065	0.526ArgCys: 0.526 ± 0.023	2.402ArgAsp: 2.402 ± 0.05	2.972ArgGlu: 2.972 ± 0.053	2.388ArgPhe: 2.388 ± 0.05	2.6ArgGly: 2.6 ± 0.05	1.308ArgHis: 1.308 ± 0.035	3.305ArgIle: 3.305 ± 0.055	2.418ArgLys: 2.418 ± 0.055	5.991ArgLeu: 5.991 ± 0.087	1.414ArgMet: 1.414 ± 0.041	2.015ArgAsn: 2.015 ± 0.05	1.837ArgPro: 1.837 ± 0.044	2.727ArgGln: 2.727 ± 0.054	2.527ArgArg: 2.527 ± 0.056	2.969ArgSer: 2.969 ± 0.055	2.435ArgThr: 2.435 ± 0.051	3.382ArgVal: 3.382 ± 0.058	0.777ArgTrp: 0.777 ± 0.03	1.905ArgTyr: 1.905 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.138SerAla: 6.138 ± 0.075	0.649SerCys: 0.649 ± 0.026	3.503SerAsp: 3.503 ± 0.086	4.004SerGlu: 4.004 ± 0.065	2.635SerPhe: 2.635 ± 0.047	5.03SerGly: 5.03 ± 0.088	1.472SerHis: 1.472 ± 0.045	3.958SerIle: 3.958 ± 0.072	2.81SerLys: 2.81 ± 0.056	7.084SerLeu: 7.084 ± 0.09	1.523SerMet: 1.523 ± 0.041	2.417SerAsn: 2.417 ± 0.056	2.487SerPro: 2.487 ± 0.058	3.211SerGln: 3.211 ± 0.056	3.148SerArg: 3.148 ± 0.059	4.205SerSer: 4.205 ± 0.088	3.497SerThr: 3.497 ± 0.063	4.351SerVal: 4.351 ± 0.073	0.759SerTrp: 0.759 ± 0.026	1.804SerTyr: 1.804 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.984ThrAla: 4.984 ± 0.074	0.441ThrCys: 0.441 ± 0.023	2.982ThrAsp: 2.982 ± 0.062	3.514ThrGlu: 3.514 ± 0.066	1.737ThrPhe: 1.737 ± 0.041	4.242ThrGly: 4.242 ± 0.082	1.153ThrHis: 1.153 ± 0.036	2.798ThrIle: 2.798 ± 0.056	1.782ThrLys: 1.782 ± 0.04	6.425ThrLeu: 6.425 ± 0.09	0.995ThrMet: 0.995 ± 0.03	1.71ThrAsn: 1.71 ± 0.045	2.805ThrPro: 2.805 ± 0.064	2.575ThrGln: 2.575 ± 0.055	2.384ThrArg: 2.384 ± 0.047	3.049ThrSer: 3.049 ± 0.064	2.706ThrThr: 2.706 ± 0.07	3.633ThrVal: 3.633 ± 0.069	0.504ThrTrp: 0.504 ± 0.027	1.223ThrTyr: 1.223 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	6.336ValAla: 6.336 ± 0.088	0.658ValCys: 0.658 ± 0.025	3.788ValAsp: 3.788 ± 0.065	4.307ValGlu: 4.307 ± 0.073	2.603ValPhe: 2.603 ± 0.049	4.283ValGly: 4.283 ± 0.065	1.318ValHis: 1.318 ± 0.038	4.379ValIle: 4.379 ± 0.072	3.139ValLys: 3.139 ± 0.058	7.356ValLeu: 7.356 ± 0.099	1.923ValMet: 1.923 ± 0.043	2.728ValAsn: 2.728 ± 0.055	2.558ValPro: 2.558 ± 0.054	3.009ValGln: 3.009 ± 0.06	3.323ValArg: 3.323 ± 0.064	4.58ValSer: 4.58 ± 0.071	3.702ValThr: 3.702 ± 0.075	5.116ValVal: 5.116 ± 0.084	0.667ValTrp: 0.667 ± 0.023	1.746ValTyr: 1.746 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.844TrpAla: 0.844 ± 0.028	0.165TrpCys: 0.165 ± 0.012	0.508TrpAsp: 0.508 ± 0.023	0.482TrpGlu: 0.482 ± 0.023	0.552TrpPhe: 0.552 ± 0.028	0.769TrpGly: 0.769 ± 0.027	0.384TrpHis: 0.384 ± 0.02	0.647TrpIle: 0.647 ± 0.027	0.391TrpLys: 0.391 ± 0.017	2.017TrpLeu: 2.017 ± 0.051	0.325TrpMet: 0.325 ± 0.016	0.363TrpAsn: 0.363 ± 0.02	0.558TrpPro: 0.558 ± 0.022	1.151TrpGln: 1.151 ± 0.036	0.709TrpArg: 0.709 ± 0.027	0.771TrpSer: 0.771 ± 0.03	0.445TrpThr: 0.445 ± 0.021	0.842TrpVal: 0.842 ± 0.029	0.169TrpTrp: 0.169 ± 0.015	0.321TrpTyr: 0.321 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.281TyrAla: 2.281 ± 0.049	0.341TyrCys: 0.341 ± 0.019	1.45TyrAsp: 1.45 ± 0.039	1.475TyrGlu: 1.475 ± 0.036	1.247TyrPhe: 1.247 ± 0.035	2.017TyrGly: 2.017 ± 0.049	0.667TyrHis: 0.667 ± 0.023	1.382TyrIle: 1.382 ± 0.043	1.179TyrLys: 1.179 ± 0.038	3.264TyrLeu: 3.264 ± 0.053	0.574TyrMet: 0.574 ± 0.024	0.942TyrAsn: 0.942 ± 0.034	1.363TyrPro: 1.363 ± 0.042	2.081TyrGln: 2.081 ± 0.045	1.755TyrArg: 1.755 ± 0.043	1.893TyrSer: 1.893 ± 0.044	1.318TyrThr: 1.318 ± 0.038	1.557TyrVal: 1.557 ± 0.035	0.459TyrTrp: 0.459 ± 0.017	0.88TyrTyr: 0.88 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3411 proteins (1060053 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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