Amino acid dipepetide frequency for Capnocytophaga sp. oral taxon 332 str. F0381

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.028AlaAla: 5.028 ± 0.106
0.704AlaCys: 0.704 ± 0.027
3.605AlaAsp: 3.605 ± 0.073
4.695AlaGlu: 4.695 ± 0.082
3.328AlaPhe: 3.328 ± 0.07
4.314AlaGly: 4.314 ± 0.098
1.367AlaHis: 1.367 ± 0.045
5.363AlaIle: 5.363 ± 0.09
5.036AlaLys: 5.036 ± 0.087
7.074AlaLeu: 7.074 ± 0.116
1.751AlaMet: 1.751 ± 0.05
3.815AlaAsn: 3.815 ± 0.092
2.42AlaPro: 2.42 ± 0.076
3.471AlaGln: 3.471 ± 0.073
2.256AlaArg: 2.256 ± 0.057
3.674AlaSer: 3.674 ± 0.08
4.896AlaThr: 4.896 ± 0.132
4.42AlaVal: 4.42 ± 0.083
0.582AlaTrp: 0.582 ± 0.032
3.015AlaTyr: 3.015 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.585CysAla: 0.585 ± 0.03
0.127CysCys: 0.127 ± 0.015
0.435CysAsp: 0.435 ± 0.03
0.623CysGlu: 0.623 ± 0.033
0.477CysPhe: 0.477 ± 0.025
0.613CysGly: 0.613 ± 0.037
0.203CysHis: 0.203 ± 0.021
0.609CysIle: 0.609 ± 0.028
0.57CysLys: 0.57 ± 0.031
0.718CysLeu: 0.718 ± 0.03
0.154CysMet: 0.154 ± 0.016
0.543CysAsn: 0.543 ± 0.031
0.368CysPro: 0.368 ± 0.027
0.296CysGln: 0.296 ± 0.02
0.296CysArg: 0.296 ± 0.02
0.557CysSer: 0.557 ± 0.028
0.549CysThr: 0.549 ± 0.03
0.566CysVal: 0.566 ± 0.028
0.102CysTrp: 0.102 ± 0.011
0.476CysTyr: 0.476 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.2AspAla: 3.2 ± 0.074
0.482AspCys: 0.482 ± 0.028
2.645AspAsp: 2.645 ± 0.072
3.691AspGlu: 3.691 ± 0.077
3.311AspPhe: 3.311 ± 0.064
2.943AspGly: 2.943 ± 0.086
0.668AspHis: 0.668 ± 0.028
4.055AspIle: 4.055 ± 0.064
4.434AspLys: 4.434 ± 0.085
4.27AspLeu: 4.27 ± 0.086
1.18AspMet: 1.18 ± 0.041
3.109AspAsn: 3.109 ± 0.065
1.595AspPro: 1.595 ± 0.046
0.953AspGln: 0.953 ± 0.031
1.866AspArg: 1.866 ± 0.046
2.71AspSer: 2.71 ± 0.061
3.03AspThr: 3.03 ± 0.068
3.001AspVal: 3.001 ± 0.063
0.62AspTrp: 0.62 ± 0.027
2.808AspTyr: 2.808 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
5.237GluAla: 5.237 ± 0.095
0.45GluCys: 0.45 ± 0.027
3.157GluAsp: 3.157 ± 0.07
5.509GluGlu: 5.509 ± 0.112
2.426GluPhe: 2.426 ± 0.058
4.087GluGly: 4.087 ± 0.082
1.13GluHis: 1.13 ± 0.041
4.88GluIle: 4.88 ± 0.091
6.154GluLys: 6.154 ± 0.104
6.151GluLeu: 6.151 ± 0.096
1.507GluMet: 1.507 ± 0.043
4.05GluAsn: 4.05 ± 0.08
1.666GluPro: 1.666 ± 0.047
2.803GluGln: 2.803 ± 0.062
3.303GluArg: 3.303 ± 0.075
2.731GluSer: 2.731 ± 0.056
3.274GluThr: 3.274 ± 0.065
5.073GluVal: 5.073 ± 0.092
0.72GluTrp: 0.72 ± 0.029
2.74GluTyr: 2.74 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.395PheAla: 3.395 ± 0.066
0.455PheCys: 0.455 ± 0.026
2.611PheAsp: 2.611 ± 0.054
2.997PheGlu: 2.997 ± 0.057
2.687PhePhe: 2.687 ± 0.073
3.125PheGly: 3.125 ± 0.071
0.784PheHis: 0.784 ± 0.028
3.624PheIle: 3.624 ± 0.085
3.139PheLys: 3.139 ± 0.068
4.472PheLeu: 4.472 ± 0.092
1.096PheMet: 1.096 ± 0.044
2.484PheAsn: 2.484 ± 0.056
1.67PhePro: 1.67 ± 0.048
1.506PheGln: 1.506 ± 0.044
1.791PheArg: 1.791 ± 0.05
3.614PheSer: 3.614 ± 0.071
2.95PheThr: 2.95 ± 0.071
3.097PheVal: 3.097 ± 0.066
0.533PheTrp: 0.533 ± 0.031
2.23PheTyr: 2.23 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
4.302GlyAla: 4.302 ± 0.092
0.694GlyCys: 0.694 ± 0.039
3.055GlyAsp: 3.055 ± 0.078
3.735GlyGlu: 3.735 ± 0.077
2.951GlyPhe: 2.951 ± 0.066
4.426GlyGly: 4.426 ± 0.11
1.021GlyHis: 1.021 ± 0.039
4.717GlyIle: 4.717 ± 0.102
5.354GlyLys: 5.354 ± 0.092
5.141GlyLeu: 5.141 ± 0.079
1.383GlyMet: 1.383 ± 0.048
3.577GlyAsn: 3.577 ± 0.072
0.694GlyPro: 0.694 ± 0.028
1.85GlyGln: 1.85 ± 0.048
2.319GlyArg: 2.319 ± 0.062
3.435GlySer: 3.435 ± 0.082
3.927GlyThr: 3.927 ± 0.143
4.819GlyVal: 4.819 ± 0.093
0.739GlyTrp: 0.739 ± 0.031
2.993GlyTyr: 2.993 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
0.752HisAla: 0.752 ± 0.033
0.233HisCys: 0.233 ± 0.018
0.606HisAsp: 0.606 ± 0.029
0.715HisGlu: 0.715 ± 0.033
1.178HisPhe: 1.178 ± 0.044
0.808HisGly: 0.808 ± 0.03
0.458HisHis: 0.458 ± 0.027
1.744HisIle: 1.744 ± 0.05
1.392HisLys: 1.392 ± 0.046
2.031HisLeu: 2.031 ± 0.055
0.215HisMet: 0.215 ± 0.015
1.161HisAsn: 1.161 ± 0.035
0.984HisPro: 0.984 ± 0.038
0.878HisGln: 0.878 ± 0.034
0.751HisArg: 0.751 ± 0.034
1.206HisSer: 1.206 ± 0.04
1.307HisThr: 1.307 ± 0.043
0.598HisVal: 0.598 ± 0.03
0.268HisTrp: 0.268 ± 0.019
1.116HisTyr: 1.116 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
6.283IleAla: 6.283 ± 0.091
0.634IleCys: 0.634 ± 0.027
4.567IleAsp: 4.567 ± 0.088
5.364IleGlu: 5.364 ± 0.092
3.332IlePhe: 3.332 ± 0.087
4.877IleGly: 4.877 ± 0.102
1.225IleHis: 1.225 ± 0.04
5.29IleIle: 5.29 ± 0.118
5.334IleLys: 5.334 ± 0.092
5.963IleLeu: 5.963 ± 0.112
1.198IleMet: 1.198 ± 0.037
4.032IleAsn: 4.032 ± 0.078
3.036IlePro: 3.036 ± 0.068
2.316IleGln: 2.316 ± 0.054
2.721IleArg: 2.721 ± 0.058
4.722IleSer: 4.722 ± 0.091
5.287IleThr: 5.287 ± 0.111
4.752IleVal: 4.752 ± 0.086
0.556IleTrp: 0.556 ± 0.028
2.992IleTyr: 2.992 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
5.343LysAla: 5.343 ± 0.089
0.385LysCys: 0.385 ± 0.021
4.34LysAsp: 4.34 ± 0.086
6.924LysGlu: 6.924 ± 0.139
2.385LysPhe: 2.385 ± 0.055
4.991LysGly: 4.991 ± 0.093
1.4LysHis: 1.4 ± 0.043
5.694LysIle: 5.694 ± 0.096
6.693LysLys: 6.693 ± 0.123
6.058LysLeu: 6.058 ± 0.084
1.946LysMet: 1.946 ± 0.049
4.848LysAsn: 4.848 ± 0.086
2.338LysPro: 2.338 ± 0.054
3.004LysGln: 3.004 ± 0.061
3.241LysArg: 3.241 ± 0.074
3.45LysSer: 3.45 ± 0.071
4.267LysThr: 4.267 ± 0.073
5.1LysVal: 5.1 ± 0.091
0.773LysTrp: 0.773 ± 0.031
3.351LysTyr: 3.351 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
6.38LeuAla: 6.38 ± 0.101
0.989LeuCys: 0.989 ± 0.042
4.069LeuAsp: 4.069 ± 0.08
5.308LeuGlu: 5.308 ± 0.095
4.731LeuPhe: 4.731 ± 0.111
5.274LeuGly: 5.274 ± 0.09
1.809LeuHis: 1.809 ± 0.047
6.32LeuIle: 6.32 ± 0.119
7.245LeuLys: 7.245 ± 0.113
9.942LeuLeu: 9.942 ± 0.207
1.965LeuMet: 1.965 ± 0.055
4.836LeuAsn: 4.836 ± 0.093
4.181LeuPro: 4.181 ± 0.071
4.338LeuGln: 4.338 ± 0.099
3.811LeuArg: 3.811 ± 0.071
6.741LeuSer: 6.741 ± 0.099
5.591LeuThr: 5.591 ± 0.109
5.091LeuVal: 5.091 ± 0.076
0.988LeuTrp: 0.988 ± 0.045
3.89LeuTyr: 3.89 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
1.602MetAla: 1.602 ± 0.044
0.159MetCys: 0.159 ± 0.014
0.92MetAsp: 0.92 ± 0.034
1.289MetGlu: 1.289 ± 0.039
0.745MetPhe: 0.745 ± 0.03
1.508MetGly: 1.508 ± 0.044
0.396MetHis: 0.396 ± 0.025
1.463MetIle: 1.463 ± 0.05
2.102MetLys: 2.102 ± 0.041
2.024MetLeu: 2.024 ± 0.057
0.48MetMet: 0.48 ± 0.027
1.355MetAsn: 1.355 ± 0.042
0.939MetPro: 0.939 ± 0.036
0.926MetGln: 0.926 ± 0.032
1.003MetArg: 1.003 ± 0.036
1.159MetSer: 1.159 ± 0.037
1.034MetThr: 1.034 ± 0.035
1.293MetVal: 1.293 ± 0.043
0.175MetTrp: 0.175 ± 0.014
0.692MetTyr: 0.692 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.759AsnAla: 3.759 ± 0.084
0.498AsnCys: 0.498 ± 0.03
3.067AsnAsp: 3.067 ± 0.064
3.61AsnGlu: 3.61 ± 0.069
2.663AsnPhe: 2.663 ± 0.056
3.589AsnGly: 3.589 ± 0.109
1.043AsnHis: 1.043 ± 0.038
4.397AsnIle: 4.397 ± 0.083
4.227AsnLys: 4.227 ± 0.093
4.82AsnLeu: 4.82 ± 0.095
1.103AsnMet: 1.103 ± 0.041
3.747AsnAsn: 3.747 ± 0.092
2.511AsnPro: 2.511 ± 0.064
1.831AsnGln: 1.831 ± 0.053
2.111AsnArg: 2.111 ± 0.055
3.178AsnSer: 3.178 ± 0.076
3.758AsnThr: 3.758 ± 0.077
3.249AsnVal: 3.249 ± 0.072
0.612AsnTrp: 0.612 ± 0.026
2.918AsnTyr: 2.918 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
2.51ProAla: 2.51 ± 0.086
0.259ProCys: 0.259 ± 0.019
1.912ProAsp: 1.912 ± 0.052
2.729ProGlu: 2.729 ± 0.067
2.009ProPhe: 2.009 ± 0.055
1.221ProGly: 1.221 ± 0.044
0.793ProHis: 0.793 ± 0.038
2.949ProIle: 2.949 ± 0.059
2.564ProLys: 2.564 ± 0.06
3.357ProLeu: 3.357 ± 0.07
0.814ProMet: 0.814 ± 0.032
2.322ProAsn: 2.322 ± 0.064
1.132ProPro: 1.132 ± 0.051
1.586ProGln: 1.586 ± 0.055
0.961ProArg: 0.961 ± 0.034
2.063ProSer: 2.063 ± 0.055
2.697ProThr: 2.697 ± 0.087
2.082ProVal: 2.082 ± 0.052
0.261ProTrp: 0.261 ± 0.017
1.829ProTyr: 1.829 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
2.675GlnAla: 2.675 ± 0.071
0.276GlnCys: 0.276 ± 0.018
1.389GlnAsp: 1.389 ± 0.043
2.692GlnGlu: 2.692 ± 0.069
1.481GlnPhe: 1.481 ± 0.046
2.234GlnGly: 2.234 ± 0.055
0.894GlnHis: 0.894 ± 0.039
2.583GlnIle: 2.583 ± 0.057
3.156GlnLys: 3.156 ± 0.079
4.18GlnLeu: 4.18 ± 0.079
0.916GlnMet: 0.916 ± 0.033
1.96GlnAsn: 1.96 ± 0.059
1.369GlnPro: 1.369 ± 0.051
2.478GlnGln: 2.478 ± 0.081
1.834GlnArg: 1.834 ± 0.052
1.95GlnSer: 1.95 ± 0.05
2.193GlnThr: 2.193 ± 0.055
2.342GlnVal: 2.342 ± 0.061
0.597GlnTrp: 0.597 ± 0.027
1.829GlnTyr: 1.829 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.542ArgAla: 2.542 ± 0.058
0.268ArgCys: 0.268 ± 0.017
1.813ArgAsp: 1.813 ± 0.047
2.567ArgGlu: 2.567 ± 0.061
1.919ArgPhe: 1.919 ± 0.045
2.099ArgGly: 2.099 ± 0.059
0.698ArgHis: 0.698 ± 0.031
3.186ArgIle: 3.186 ± 0.066
2.975ArgLys: 2.975 ± 0.061
3.776ArgLeu: 3.776 ± 0.075
0.976ArgMet: 0.976 ± 0.037
2.258ArgAsn: 2.258 ± 0.057
1.199ArgPro: 1.199 ± 0.038
1.39ArgGln: 1.39 ± 0.044
1.593ArgArg: 1.593 ± 0.048
1.917ArgSer: 1.917 ± 0.053
2.347ArgThr: 2.347 ± 0.059
2.463ArgVal: 2.463 ± 0.06
0.47ArgTrp: 0.47 ± 0.026
1.988ArgTyr: 1.988 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
3.848SerAla: 3.848 ± 0.102
0.561SerCys: 0.561 ± 0.03
2.759SerAsp: 2.759 ± 0.065
3.488SerGlu: 3.488 ± 0.073
3.307SerPhe: 3.307 ± 0.07
3.651SerGly: 3.651 ± 0.09
1.015SerHis: 1.015 ± 0.038
4.018SerIle: 4.018 ± 0.074
3.944SerLys: 3.944 ± 0.074
5.876SerLeu: 5.876 ± 0.1
1.093SerMet: 1.093 ± 0.038
2.998SerAsn: 2.998 ± 0.077
2.127SerPro: 2.127 ± 0.055
2.055SerGln: 2.055 ± 0.054
1.834SerArg: 1.834 ± 0.044
3.478SerSer: 3.478 ± 0.074
3.146SerThr: 3.146 ± 0.086
4.164SerVal: 4.164 ± 0.092
0.573SerTrp: 0.573 ± 0.026
2.9SerTyr: 2.9 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
4.83ThrAla: 4.83 ± 0.112
0.449ThrCys: 0.449 ± 0.036
3.484ThrAsp: 3.484 ± 0.062
3.788ThrGlu: 3.788 ± 0.076
3.176ThrPhe: 3.176 ± 0.061
3.705ThrGly: 3.705 ± 0.119
1.307ThrHis: 1.307 ± 0.042
5.041ThrIle: 5.041 ± 0.113
3.487ThrLys: 3.487 ± 0.067
6.135ThrLeu: 6.135 ± 0.1
1.122ThrMet: 1.122 ± 0.04
3.092ThrAsn: 3.092 ± 0.082
3.393ThrPro: 3.393 ± 0.099
2.41ThrGln: 2.41 ± 0.062
1.739ThrArg: 1.739 ± 0.05
3.204ThrSer: 3.204 ± 0.084
4.389ThrThr: 4.389 ± 0.162
3.712ThrVal: 3.712 ± 0.142
0.467ThrTrp: 0.467 ± 0.03
2.917ThrTyr: 2.917 ± 0.094
0.0ThrXaa: 0.0 ± 0.0
Val
5.042ValAla: 5.042 ± 0.089
0.677ValCys: 0.677 ± 0.032
3.003ValAsp: 3.003 ± 0.061
3.744ValGlu: 3.744 ± 0.089
3.145ValPhe: 3.145 ± 0.074
4.179ValGly: 4.179 ± 0.105
0.961ValHis: 0.961 ± 0.035
4.589ValIle: 4.589 ± 0.079
4.568ValLys: 4.568 ± 0.077
6.159ValLeu: 6.159 ± 0.101
1.37ValMet: 1.37 ± 0.041
3.089ValAsn: 3.089 ± 0.068
2.537ValPro: 2.537 ± 0.063
2.238ValGln: 2.238 ± 0.047
2.636ValArg: 2.636 ± 0.062
4.008ValSer: 4.008 ± 0.09
3.868ValThr: 3.868 ± 0.126
4.789ValVal: 4.789 ± 0.096
0.644ValTrp: 0.644 ± 0.028
2.483ValTyr: 2.483 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.698TrpAla: 0.698 ± 0.029
0.113TrpCys: 0.113 ± 0.011
0.557TrpAsp: 0.557 ± 0.026
0.703TrpGlu: 0.703 ± 0.031
0.535TrpPhe: 0.535 ± 0.027
0.757TrpGly: 0.757 ± 0.033
0.236TrpHis: 0.236 ± 0.019
0.655TrpIle: 0.655 ± 0.028
0.742TrpLys: 0.742 ± 0.033
1.142TrpLeu: 1.142 ± 0.039
0.213TrpMet: 0.213 ± 0.016
0.541TrpAsn: 0.541 ± 0.031
0.106TrpPro: 0.106 ± 0.012
0.617TrpGln: 0.617 ± 0.026
0.487TrpArg: 0.487 ± 0.023
0.449TrpSer: 0.449 ± 0.025
0.509TrpThr: 0.509 ± 0.026
0.717TrpVal: 0.717 ± 0.033
0.166TrpTrp: 0.166 ± 0.015
0.461TrpTyr: 0.461 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.803TyrAla: 2.803 ± 0.063
0.453TyrCys: 0.453 ± 0.025
2.579TyrAsp: 2.579 ± 0.067
2.879TyrGlu: 2.879 ± 0.063
2.473TyrPhe: 2.473 ± 0.057
2.731TyrGly: 2.731 ± 0.072
0.993TyrHis: 0.993 ± 0.036
3.305TyrIle: 3.305 ± 0.076
3.418TyrLys: 3.418 ± 0.067
4.209TyrLeu: 4.209 ± 0.09
0.779TyrMet: 0.779 ± 0.03
2.874TyrAsn: 2.874 ± 0.062
1.786TyrPro: 1.786 ± 0.041
2.081TyrGln: 2.081 ± 0.057
1.891TyrArg: 1.891 ± 0.046
2.588TyrSer: 2.588 ± 0.065
2.826TyrThr: 2.826 ± 0.071
2.404TyrVal: 2.404 ± 0.059
0.56TyrTrp: 0.56 ± 0.029
2.467TyrTyr: 2.467 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2698 proteins (810813 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski