Amino acid dipepetide frequency for Erwinia gerundensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.08AlaAla: 12.08 ± 0.155	1.085AlaCys: 1.085 ± 0.028	5.577AlaAsp: 5.577 ± 0.073	6.215AlaGlu: 6.215 ± 0.081	3.649AlaPhe: 3.649 ± 0.056	8.214AlaGly: 8.214 ± 0.08	2.017AlaHis: 2.017 ± 0.043	6.119AlaIle: 6.119 ± 0.075	3.479AlaLys: 3.479 ± 0.065	12.997AlaLeu: 12.997 ± 0.149	3.226AlaMet: 3.226 ± 0.05	2.992AlaAsn: 2.992 ± 0.059	4.017AlaPro: 4.017 ± 0.071	5.036AlaGln: 5.036 ± 0.071	5.99AlaArg: 5.99 ± 0.066	6.22AlaSer: 6.22 ± 0.081	5.24AlaThr: 5.24 ± 0.069	7.225AlaVal: 7.225 ± 0.078	1.75AlaTrp: 1.75 ± 0.041	1.929AlaTyr: 1.929 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.943CysAla: 0.943 ± 0.029	0.197CysCys: 0.197 ± 0.012	0.564CysAsp: 0.564 ± 0.019	0.538CysGlu: 0.538 ± 0.019	0.414CysPhe: 0.414 ± 0.018	0.993CysGly: 0.993 ± 0.029	0.319CysHis: 0.319 ± 0.015	0.501CysIle: 0.501 ± 0.023	0.253CysLys: 0.253 ± 0.014	0.999CysLeu: 0.999 ± 0.029	0.214CysMet: 0.214 ± 0.013	0.297CysAsn: 0.297 ± 0.016	0.436CysPro: 0.436 ± 0.022	0.469CysGln: 0.469 ± 0.019	0.616CysArg: 0.616 ± 0.025	0.625CysSer: 0.625 ± 0.023	0.421CysThr: 0.421 ± 0.02	0.694CysVal: 0.694 ± 0.023	0.181CysTrp: 0.181 ± 0.011	0.308CysTyr: 0.308 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.718AspAla: 5.718 ± 0.074	0.466AspCys: 0.466 ± 0.02	3.075AspAsp: 3.075 ± 0.058	3.402AspGlu: 3.402 ± 0.056	2.146AspPhe: 2.146 ± 0.039	3.82AspGly: 3.82 ± 0.08	1.075AspHis: 1.075 ± 0.031	3.267AspIle: 3.267 ± 0.057	2.201AspLys: 2.201 ± 0.043	4.723AspLeu: 4.723 ± 0.066	1.309AspMet: 1.309 ± 0.029	2.184AspAsn: 2.184 ± 0.048	2.151AspPro: 2.151 ± 0.047	1.757AspGln: 1.757 ± 0.039	3.247AspArg: 3.247 ± 0.053	2.833AspSer: 2.833 ± 0.041	2.394AspThr: 2.394 ± 0.047	3.744AspVal: 3.744 ± 0.058	0.761AspTrp: 0.761 ± 0.025	1.843AspTyr: 1.843 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.532GluAla: 5.532 ± 0.071	0.375GluCys: 0.375 ± 0.016	2.142GluAsp: 2.142 ± 0.045	3.192GluGlu: 3.192 ± 0.055	1.701GluPhe: 1.701 ± 0.042	3.358GluGly: 3.358 ± 0.051	1.345GluHis: 1.345 ± 0.033	3.193GluIle: 3.193 ± 0.057	2.964GluLys: 2.964 ± 0.057	5.614GluLeu: 5.614 ± 0.073	1.713GluMet: 1.713 ± 0.037	2.251GluAsn: 2.251 ± 0.043	2.144GluPro: 2.144 ± 0.052	3.583GluGln: 3.583 ± 0.057	3.506GluArg: 3.506 ± 0.061	2.824GluSer: 2.824 ± 0.045	2.844GluThr: 2.844 ± 0.047	3.572GluVal: 3.572 ± 0.059	0.8GluTrp: 0.8 ± 0.024	1.251GluTyr: 1.251 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.815PheAla: 3.815 ± 0.057	0.55PheCys: 0.55 ± 0.024	2.299PheAsp: 2.299 ± 0.052	1.597PheGlu: 1.597 ± 0.036	1.585PhePhe: 1.585 ± 0.045	3.058PheGly: 3.058 ± 0.062	0.86PheHis: 0.86 ± 0.028	2.396PheIle: 2.396 ± 0.049	1.153PheLys: 1.153 ± 0.035	3.259PheLeu: 3.259 ± 0.054	1.006PheMet: 1.006 ± 0.029	1.668PheAsn: 1.668 ± 0.04	1.537PhePro: 1.537 ± 0.035	1.223PheGln: 1.223 ± 0.031	1.924PheArg: 1.924 ± 0.04	3.175PheSer: 3.175 ± 0.052	2.351PheThr: 2.351 ± 0.045	2.405PheVal: 2.405 ± 0.052	0.641PheTrp: 0.641 ± 0.027	1.205PheTyr: 1.205 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.488GlyAla: 6.488 ± 0.078	0.967GlyCys: 0.967 ± 0.031	3.849GlyAsp: 3.849 ± 0.067	4.69GlyGlu: 4.69 ± 0.065	3.231GlyPhe: 3.231 ± 0.057	5.345GlyGly: 5.345 ± 0.078	1.602GlyHis: 1.602 ± 0.04	4.826GlyIle: 4.826 ± 0.066	3.68GlyLys: 3.68 ± 0.064	7.418GlyLeu: 7.418 ± 0.097	2.36GlyMet: 2.36 ± 0.053	2.779GlyAsn: 2.779 ± 0.062	2.047GlyPro: 2.047 ± 0.039	2.956GlyGln: 2.956 ± 0.052	3.911GlyArg: 3.911 ± 0.06	4.488GlySer: 4.488 ± 0.07	3.777GlyThr: 3.777 ± 0.077	5.48GlyVal: 5.48 ± 0.067	1.364GlyTrp: 1.364 ± 0.036	2.518GlyTyr: 2.518 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.187HisAla: 2.187 ± 0.04	0.343HisCys: 0.343 ± 0.019	1.221HisAsp: 1.221 ± 0.031	1.091HisGlu: 1.091 ± 0.032	1.118HisPhe: 1.118 ± 0.026	1.801HisGly: 1.801 ± 0.039	0.83HisHis: 0.83 ± 0.028	1.225HisIle: 1.225 ± 0.032	0.7HisLys: 0.7 ± 0.024	2.324HisLeu: 2.324 ± 0.044	0.519HisMet: 0.519 ± 0.019	0.838HisAsn: 0.838 ± 0.024	1.351HisPro: 1.351 ± 0.036	1.366HisGln: 1.366 ± 0.035	1.362HisArg: 1.362 ± 0.031	1.342HisSer: 1.342 ± 0.033	1.052HisThr: 1.052 ± 0.03	1.215HisVal: 1.215 ± 0.033	0.459HisTrp: 0.459 ± 0.018	0.921HisTyr: 0.921 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.685IleAla: 6.685 ± 0.068	0.645IleCys: 0.645 ± 0.024	3.605IleAsp: 3.605 ± 0.05	3.107IleGlu: 3.107 ± 0.053	1.976IlePhe: 1.976 ± 0.045	4.633IleGly: 4.633 ± 0.069	1.125IleHis: 1.125 ± 0.03	3.206IleIle: 3.206 ± 0.065	2.122IleLys: 2.122 ± 0.044	4.642IleLeu: 4.642 ± 0.07	1.296IleMet: 1.296 ± 0.037	2.53IleAsn: 2.53 ± 0.052	2.412IlePro: 2.412 ± 0.043	1.684IleGln: 1.684 ± 0.04	2.895IleArg: 2.895 ± 0.046	3.715IleSer: 3.715 ± 0.057	3.46IleThr: 3.46 ± 0.06	3.825IleVal: 3.825 ± 0.058	0.721IleTrp: 0.721 ± 0.025	1.439IleTyr: 1.439 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.931LysAla: 3.931 ± 0.071	0.221LysCys: 0.221 ± 0.012	1.633LysAsp: 1.633 ± 0.04	2.031LysGlu: 2.031 ± 0.045	0.987LysPhe: 0.987 ± 0.032	2.601LysGly: 2.601 ± 0.053	0.751LysHis: 0.751 ± 0.022	2.118LysIle: 2.118 ± 0.047	1.983LysLys: 1.983 ± 0.045	3.797LysLeu: 3.797 ± 0.059	1.17LysMet: 1.17 ± 0.034	1.509LysAsn: 1.509 ± 0.033	2.003LysPro: 2.003 ± 0.048	1.929LysGln: 1.929 ± 0.042	2.318LysArg: 2.318 ± 0.051	2.203LysSer: 2.203 ± 0.046	2.289LysThr: 2.289 ± 0.048	2.683LysVal: 2.683 ± 0.051	0.431LysTrp: 0.431 ± 0.02	0.91LysTyr: 0.91 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.414LeuAla: 12.414 ± 0.124	1.232LeuCys: 1.232 ± 0.028	5.488LeuAsp: 5.488 ± 0.073	5.184LeuGlu: 5.184 ± 0.071	4.406LeuPhe: 4.406 ± 0.071	7.094LeuGly: 7.094 ± 0.088	2.455LeuHis: 2.455 ± 0.045	6.08LeuIle: 6.08 ± 0.079	4.032LeuLys: 4.032 ± 0.066	12.972LeuLeu: 12.972 ± 0.171	3.132LeuMet: 3.132 ± 0.053	4.15LeuAsn: 4.15 ± 0.062	6.013LeuPro: 6.013 ± 0.079	4.93LeuGln: 4.93 ± 0.071	6.559LeuArg: 6.559 ± 0.094	7.607LeuSer: 7.607 ± 0.098	6.616LeuThr: 6.616 ± 0.093	6.907LeuVal: 6.907 ± 0.08	1.493LeuTrp: 1.493 ± 0.039	2.493LeuTyr: 2.493 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.078MetAla: 3.078 ± 0.054	0.179MetCys: 0.179 ± 0.011	1.062MetAsp: 1.062 ± 0.031	1.171MetGlu: 1.171 ± 0.031	0.821MetPhe: 0.821 ± 0.024	1.757MetGly: 1.757 ± 0.039	0.562MetHis: 0.562 ± 0.02	1.482MetIle: 1.482 ± 0.037	1.313MetLys: 1.313 ± 0.031	3.333MetLeu: 3.333 ± 0.051	0.935MetMet: 0.935 ± 0.03	1.117MetAsn: 1.117 ± 0.029	1.406MetPro: 1.406 ± 0.036	1.371MetGln: 1.371 ± 0.035	1.569MetArg: 1.569 ± 0.037	1.869MetSer: 1.869 ± 0.039	1.757MetThr: 1.757 ± 0.036	1.844MetVal: 1.844 ± 0.042	0.241MetTrp: 0.241 ± 0.014	0.443MetTyr: 0.443 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.742AsnAla: 3.742 ± 0.062	0.294AsnCys: 0.294 ± 0.015	1.996AsnAsp: 1.996 ± 0.039	1.747AsnGlu: 1.747 ± 0.041	1.302AsnPhe: 1.302 ± 0.034	3.037AsnGly: 3.037 ± 0.067	0.81AsnHis: 0.81 ± 0.026	2.064AsnIle: 2.064 ± 0.039	1.346AsnLys: 1.346 ± 0.037	3.418AsnLeu: 3.418 ± 0.057	0.875AsnMet: 0.875 ± 0.026	1.522AsnAsn: 1.522 ± 0.039	1.949AsnPro: 1.949 ± 0.047	1.642AsnGln: 1.642 ± 0.039	2.08AsnArg: 2.08 ± 0.042	2.119AsnSer: 2.119 ± 0.051	1.757AsnThr: 1.757 ± 0.04	2.495AsnVal: 2.495 ± 0.052	0.609AsnTrp: 0.609 ± 0.022	1.028AsnTyr: 1.028 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.295ProAla: 5.295 ± 0.069	0.369ProCys: 0.369 ± 0.017	2.774ProAsp: 2.774 ± 0.053	3.102ProGlu: 3.102 ± 0.052	1.81ProPhe: 1.81 ± 0.038	3.603ProGly: 3.603 ± 0.056	1.126ProHis: 1.126 ± 0.027	1.816ProIle: 1.816 ± 0.037	1.275ProLys: 1.275 ± 0.038	5.526ProLeu: 5.526 ± 0.076	1.089ProMet: 1.089 ± 0.031	1.205ProAsn: 1.205 ± 0.033	1.881ProPro: 1.881 ± 0.051	2.523ProGln: 2.523 ± 0.049	2.137ProArg: 2.137 ± 0.05	2.062ProSer: 2.062 ± 0.036	2.112ProThr: 2.112 ± 0.043	4.026ProVal: 4.026 ± 0.075	0.758ProTrp: 0.758 ± 0.022	1.099ProTyr: 1.099 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	5.329GlnAla: 5.329 ± 0.086	0.357GlnCys: 0.357 ± 0.017	1.967GlnAsp: 1.967 ± 0.043	2.035GlnGlu: 2.035 ± 0.048	1.466GlnPhe: 1.466 ± 0.032	3.317GlnGly: 3.317 ± 0.055	1.539GlnHis: 1.539 ± 0.037	2.204GlnIle: 2.204 ± 0.044	1.677GlnLys: 1.677 ± 0.037	5.776GlnLeu: 5.776 ± 0.088	1.23GlnMet: 1.23 ± 0.031	1.387GlnAsn: 1.387 ± 0.03	2.879GlnPro: 2.879 ± 0.054	4.503GlnGln: 4.503 ± 0.125	3.691GlnArg: 3.691 ± 0.056	2.414GlnSer: 2.414 ± 0.049	2.197GlnThr: 2.197 ± 0.044	3.111GlnVal: 3.111 ± 0.049	0.666GlnTrp: 0.666 ± 0.023	1.068GlnTyr: 1.068 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	5.197ArgAla: 5.197 ± 0.069	0.604ArgCys: 0.604 ± 0.023	3.26ArgAsp: 3.26 ± 0.054	3.707ArgGlu: 3.707 ± 0.062	2.703ArgPhe: 2.703 ± 0.048	3.572ArgGly: 3.572 ± 0.064	1.668ArgHis: 1.668 ± 0.038	3.372ArgIle: 3.372 ± 0.054	2.098ArgLys: 2.098 ± 0.046	6.981ArgLeu: 6.981 ± 0.088	1.594ArgMet: 1.594 ± 0.034	1.989ArgAsn: 1.989 ± 0.04	2.347ArgPro: 2.347 ± 0.042	3.375ArgGln: 3.375 ± 0.057	3.772ArgArg: 3.772 ± 0.066	2.999ArgSer: 2.999 ± 0.045	2.556ArgThr: 2.556 ± 0.042	3.915ArgVal: 3.915 ± 0.066	1.106ArgTrp: 1.106 ± 0.026	2.237ArgTyr: 2.237 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.373SerAla: 6.373 ± 0.079	0.531SerCys: 0.531 ± 0.02	3.193SerAsp: 3.193 ± 0.048	3.223SerGlu: 3.223 ± 0.051	2.306SerPhe: 2.306 ± 0.045	5.544SerGly: 5.544 ± 0.079	1.455SerHis: 1.455 ± 0.034	2.694SerIle: 2.694 ± 0.053	1.894SerLys: 1.894 ± 0.04	7.024SerLeu: 7.024 ± 0.089	1.496SerMet: 1.496 ± 0.033	1.901SerAsn: 1.901 ± 0.042	2.634SerPro: 2.634 ± 0.044	2.662SerGln: 2.662 ± 0.049	3.587SerArg: 3.587 ± 0.052	3.612SerSer: 3.612 ± 0.061	2.986SerThr: 2.986 ± 0.05	4.264SerVal: 4.264 ± 0.058	1.176SerTrp: 1.176 ± 0.038	1.523SerTyr: 1.523 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.372ThrAla: 5.372 ± 0.074	0.416ThrCys: 0.416 ± 0.019	2.66ThrAsp: 2.66 ± 0.064	2.455ThrGlu: 2.455 ± 0.046	1.978ThrPhe: 1.978 ± 0.045	4.387ThrGly: 4.387 ± 0.07	1.273ThrHis: 1.273 ± 0.034	2.671ThrIle: 2.671 ± 0.046	1.285ThrLys: 1.285 ± 0.032	7.844ThrLeu: 7.844 ± 0.092	1.078ThrMet: 1.078 ± 0.032	1.423ThrAsn: 1.423 ± 0.04	3.279ThrPro: 3.279 ± 0.08	2.266ThrGln: 2.266 ± 0.047	3.163ThrArg: 3.163 ± 0.051	2.836ThrSer: 2.836 ± 0.045	2.819ThrThr: 2.819 ± 0.059	3.729ThrVal: 3.729 ± 0.06	0.725ThrTrp: 0.725 ± 0.022	1.034ThrTyr: 1.034 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.385ValAla: 7.385 ± 0.082	0.631ValCys: 0.631 ± 0.024	3.612ValAsp: 3.612 ± 0.056	3.753ValGlu: 3.753 ± 0.065	2.338ValPhe: 2.338 ± 0.041	4.682ValGly: 4.682 ± 0.076	1.25ValHis: 1.25 ± 0.031	4.501ValIle: 4.501 ± 0.068	2.796ValLys: 2.796 ± 0.05	7.232ValLeu: 7.232 ± 0.086	2.131ValMet: 2.131 ± 0.041	2.707ValAsn: 2.707 ± 0.048	3.058ValPro: 3.058 ± 0.043	2.468ValGln: 2.468 ± 0.041	3.73ValArg: 3.73 ± 0.06	4.649ValSer: 4.649 ± 0.077	4.221ValThr: 4.221 ± 0.061	5.346ValVal: 5.346 ± 0.073	0.932ValTrp: 0.932 ± 0.029	1.509ValTyr: 1.509 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.009TrpAla: 1.009 ± 0.031	0.189TrpCys: 0.189 ± 0.014	0.634TrpAsp: 0.634 ± 0.021	0.566TrpGlu: 0.566 ± 0.024	0.718TrpPhe: 0.718 ± 0.024	0.859TrpGly: 0.859 ± 0.028	0.528TrpHis: 0.528 ± 0.021	0.785TrpIle: 0.785 ± 0.027	0.441TrpLys: 0.441 ± 0.02	2.494TrpLeu: 2.494 ± 0.05	0.398TrpMet: 0.398 ± 0.019	0.484TrpAsn: 0.484 ± 0.018	0.705TrpPro: 0.705 ± 0.026	1.441TrpGln: 1.441 ± 0.04	1.165TrpArg: 1.165 ± 0.032	0.935TrpSer: 0.935 ± 0.038	0.593TrpThr: 0.593 ± 0.023	0.848TrpVal: 0.848 ± 0.028	0.224TrpTrp: 0.224 ± 0.014	0.426TrpTyr: 0.426 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.488TyrAla: 2.488 ± 0.045	0.327TyrCys: 0.327 ± 0.015	1.503TyrAsp: 1.503 ± 0.034	1.097TyrGlu: 1.097 ± 0.033	1.051TyrPhe: 1.051 ± 0.031	2.101TyrGly: 2.101 ± 0.042	0.674TyrHis: 0.674 ± 0.027	1.2TyrIle: 1.2 ± 0.027	0.808TyrLys: 0.808 ± 0.027	2.885TyrLeu: 2.885 ± 0.049	0.535TyrMet: 0.535 ± 0.021	0.9TyrAsn: 0.9 ± 0.03	1.34TyrPro: 1.34 ± 0.034	1.633TyrGln: 1.633 ± 0.043	1.832TyrArg: 1.832 ± 0.036	1.55TyrSer: 1.55 ± 0.039	1.25TyrThr: 1.25 ± 0.034	1.605TyrVal: 1.605 ± 0.037	0.405TyrTrp: 0.405 ± 0.019	0.799TyrTyr: 0.799 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4160 proteins (1290596 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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