Amino acid dipepetide frequency for Gordonia phage Samba

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.704AlaAla: 16.704 ± 1.224
0.597AlaCys: 0.597 ± 0.213
7.636AlaAsp: 7.636 ± 0.946
6.682AlaGlu: 6.682 ± 0.627
3.162AlaPhe: 3.162 ± 0.607
8.829AlaGly: 8.829 ± 0.934
2.028AlaHis: 2.028 ± 0.375
5.847AlaIle: 5.847 ± 0.536
3.699AlaLys: 3.699 ± 0.609
9.724AlaLeu: 9.724 ± 0.956
2.923AlaMet: 2.923 ± 0.506
3.162AlaAsn: 3.162 ± 0.467
5.31AlaPro: 5.31 ± 0.655
4.295AlaGln: 4.295 ± 0.515
8.591AlaArg: 8.591 ± 0.846
5.847AlaSer: 5.847 ± 0.801
8.173AlaThr: 8.173 ± 0.872
7.994AlaVal: 7.994 ± 0.948
1.849AlaTrp: 1.849 ± 0.294
1.969AlaTyr: 1.969 ± 0.357
0.0AlaXaa: 0.0 ± 0.0
Cys
0.716CysAla: 0.716 ± 0.2
0.119CysCys: 0.119 ± 0.126
1.134CysAsp: 1.134 ± 0.3
0.298CysGlu: 0.298 ± 0.123
0.0CysPhe: 0.0 ± 0.0
0.895CysGly: 0.895 ± 0.269
0.358CysHis: 0.358 ± 0.159
0.418CysIle: 0.418 ± 0.148
0.179CysLys: 0.179 ± 0.094
0.477CysLeu: 0.477 ± 0.198
0.298CysMet: 0.298 ± 0.129
0.418CysAsn: 0.418 ± 0.148
0.776CysPro: 0.776 ± 0.24
0.597CysGln: 0.597 ± 0.151
0.716CysArg: 0.716 ± 0.258
0.537CysSer: 0.537 ± 0.173
0.597CysThr: 0.597 ± 0.201
0.298CysVal: 0.298 ± 0.131
0.179CysTrp: 0.179 ± 0.131
0.06CysTyr: 0.06 ± 0.05
0.0CysXaa: 0.0 ± 0.0
Asp
6.92AspAla: 6.92 ± 0.66
0.358AspCys: 0.358 ± 0.156
5.489AspAsp: 5.489 ± 0.748
4.653AspGlu: 4.653 ± 0.633
1.969AspPhe: 1.969 ± 0.43
7.219AspGly: 7.219 ± 0.96
1.79AspHis: 1.79 ± 0.386
3.102AspIle: 3.102 ± 0.458
1.611AspLys: 1.611 ± 0.301
6.145AspLeu: 6.145 ± 0.785
1.312AspMet: 1.312 ± 0.269
2.207AspAsn: 2.207 ± 0.394
3.818AspPro: 3.818 ± 0.471
2.744AspGln: 2.744 ± 0.342
4.713AspArg: 4.713 ± 0.804
3.401AspSer: 3.401 ± 0.361
4.355AspThr: 4.355 ± 0.512
6.085AspVal: 6.085 ± 0.661
0.955AspTrp: 0.955 ± 0.221
1.73AspTyr: 1.73 ± 0.347
0.0AspXaa: 0.0 ± 0.0
Glu
5.608GluAla: 5.608 ± 0.651
0.418GluCys: 0.418 ± 0.149
2.744GluAsp: 2.744 ± 0.455
2.267GluGlu: 2.267 ± 0.434
2.207GluPhe: 2.207 ± 0.349
3.937GluGly: 3.937 ± 0.437
1.551GluHis: 1.551 ± 0.262
2.804GluIle: 2.804 ± 0.465
2.148GluLys: 2.148 ± 0.292
5.011GluLeu: 5.011 ± 0.762
1.491GluMet: 1.491 ± 0.313
1.73GluAsn: 1.73 ± 0.376
3.401GluPro: 3.401 ± 0.552
3.043GluGln: 3.043 ± 0.456
4.952GluArg: 4.952 ± 0.582
3.162GluSer: 3.162 ± 0.388
2.625GluThr: 2.625 ± 0.351
4.713GluVal: 4.713 ± 0.662
1.193GluTrp: 1.193 ± 0.302
1.551GluTyr: 1.551 ± 0.336
0.0GluXaa: 0.0 ± 0.0
Phe
2.923PheAla: 2.923 ± 0.376
0.298PheCys: 0.298 ± 0.139
2.207PheAsp: 2.207 ± 0.278
1.909PheGlu: 1.909 ± 0.302
0.835PhePhe: 0.835 ± 0.235
2.565PheGly: 2.565 ± 0.452
0.418PheHis: 0.418 ± 0.157
0.716PheIle: 0.716 ± 0.221
0.955PheLys: 0.955 ± 0.313
1.551PheLeu: 1.551 ± 0.372
0.418PheMet: 0.418 ± 0.129
0.716PheAsn: 0.716 ± 0.239
1.193PhePro: 1.193 ± 0.261
0.597PheGln: 0.597 ± 0.19
1.909PheArg: 1.909 ± 0.283
1.67PheSer: 1.67 ± 0.393
2.446PheThr: 2.446 ± 0.322
2.685PheVal: 2.685 ± 0.403
0.119PheTrp: 0.119 ± 0.081
0.537PheTyr: 0.537 ± 0.181
0.0PheXaa: 0.0 ± 0.0
Gly
8.531GlyAla: 8.531 ± 1.084
0.537GlyCys: 0.537 ± 0.18
5.787GlyAsp: 5.787 ± 0.591
4.892GlyGlu: 4.892 ± 0.75
2.565GlyPhe: 2.565 ± 0.458
6.801GlyGly: 6.801 ± 0.941
1.79GlyHis: 1.79 ± 0.289
3.937GlyIle: 3.937 ± 0.628
3.401GlyLys: 3.401 ± 0.484
8.472GlyLeu: 8.472 ± 1.125
1.611GlyMet: 1.611 ± 0.306
2.625GlyAsn: 2.625 ± 0.494
3.759GlyPro: 3.759 ± 0.57
3.102GlyGln: 3.102 ± 0.374
5.847GlyArg: 5.847 ± 0.566
4.295GlySer: 4.295 ± 0.498
4.474GlyThr: 4.474 ± 0.546
5.906GlyVal: 5.906 ± 0.525
2.506GlyTrp: 2.506 ± 0.422
2.565GlyTyr: 2.565 ± 0.417
0.0GlyXaa: 0.0 ± 0.0
His
2.267HisAla: 2.267 ± 0.351
0.239HisCys: 0.239 ± 0.116
1.611HisAsp: 1.611 ± 0.281
0.776HisGlu: 0.776 ± 0.169
0.477HisPhe: 0.477 ± 0.179
1.849HisGly: 1.849 ± 0.347
0.537HisHis: 0.537 ± 0.207
1.312HisIle: 1.312 ± 0.308
0.477HisLys: 0.477 ± 0.155
1.611HisLeu: 1.611 ± 0.311
0.239HisMet: 0.239 ± 0.109
0.537HisAsn: 0.537 ± 0.167
1.969HisPro: 1.969 ± 0.432
0.537HisGln: 0.537 ± 0.169
1.909HisArg: 1.909 ± 0.383
1.134HisSer: 1.134 ± 0.304
1.253HisThr: 1.253 ± 0.279
1.67HisVal: 1.67 ± 0.355
0.418HisTrp: 0.418 ± 0.149
0.537HisTyr: 0.537 ± 0.161
0.0HisXaa: 0.0 ± 0.0
Ile
5.906IleAla: 5.906 ± 0.585
0.358IleCys: 0.358 ± 0.157
4.236IleAsp: 4.236 ± 0.533
2.923IleGlu: 2.923 ± 0.429
1.134IlePhe: 1.134 ± 0.253
4.474IleGly: 4.474 ± 0.653
0.895IleHis: 0.895 ± 0.244
1.551IleIle: 1.551 ± 0.385
1.909IleLys: 1.909 ± 0.515
2.267IleLeu: 2.267 ± 0.425
0.358IleMet: 0.358 ± 0.146
0.955IleAsn: 0.955 ± 0.234
2.923IlePro: 2.923 ± 0.435
1.253IleGln: 1.253 ± 0.265
4.057IleArg: 4.057 ± 0.552
2.386IleSer: 2.386 ± 0.408
3.222IleThr: 3.222 ± 0.373
4.355IleVal: 4.355 ± 0.486
0.179IleTrp: 0.179 ± 0.125
0.835IleTyr: 0.835 ± 0.251
0.0IleXaa: 0.0 ± 0.0
Lys
3.52LysAla: 3.52 ± 0.531
0.239LysCys: 0.239 ± 0.115
1.909LysAsp: 1.909 ± 0.432
1.432LysGlu: 1.432 ± 0.289
1.253LysPhe: 1.253 ± 0.28
2.625LysGly: 2.625 ± 0.515
0.776LysHis: 0.776 ± 0.26
1.909LysIle: 1.909 ± 0.329
1.909LysLys: 1.909 ± 0.35
2.923LysLeu: 2.923 ± 0.482
0.537LysMet: 0.537 ± 0.184
0.955LysAsn: 0.955 ± 0.286
2.565LysPro: 2.565 ± 0.37
0.955LysGln: 0.955 ± 0.321
1.432LysArg: 1.432 ± 0.291
1.611LysSer: 1.611 ± 0.31
2.446LysThr: 2.446 ± 0.386
2.983LysVal: 2.983 ± 0.433
0.656LysTrp: 0.656 ± 0.146
0.895LysTyr: 0.895 ± 0.271
0.0LysXaa: 0.0 ± 0.0
Leu
11.276LeuAla: 11.276 ± 0.905
0.776LeuCys: 0.776 ± 0.226
6.622LeuAsp: 6.622 ± 0.812
3.818LeuGlu: 3.818 ± 0.535
1.551LeuPhe: 1.551 ± 0.286
5.787LeuGly: 5.787 ± 0.798
0.955LeuHis: 0.955 ± 0.236
3.043LeuIle: 3.043 ± 0.357
1.849LeuLys: 1.849 ± 0.281
4.415LeuLeu: 4.415 ± 0.539
1.969LeuMet: 1.969 ± 0.382
2.148LeuAsn: 2.148 ± 0.367
4.653LeuPro: 4.653 ± 0.509
2.207LeuGln: 2.207 ± 0.353
4.892LeuArg: 4.892 ± 0.544
4.355LeuSer: 4.355 ± 0.662
6.264LeuThr: 6.264 ± 0.654
6.741LeuVal: 6.741 ± 0.75
2.386LeuTrp: 2.386 ± 0.368
1.253LeuTyr: 1.253 ± 0.246
0.0LeuXaa: 0.0 ± 0.0
Met
3.222MetAla: 3.222 ± 0.735
0.239MetCys: 0.239 ± 0.125
0.597MetAsp: 0.597 ± 0.188
0.716MetGlu: 0.716 ± 0.199
0.477MetPhe: 0.477 ± 0.188
1.432MetGly: 1.432 ± 0.28
0.358MetHis: 0.358 ± 0.149
0.776MetIle: 0.776 ± 0.19
0.537MetLys: 0.537 ± 0.16
1.551MetLeu: 1.551 ± 0.301
0.119MetMet: 0.119 ± 0.107
0.239MetAsn: 0.239 ± 0.101
1.909MetPro: 1.909 ± 0.323
0.597MetGln: 0.597 ± 0.233
2.267MetArg: 2.267 ± 0.604
1.491MetSer: 1.491 ± 0.261
2.625MetThr: 2.625 ± 0.454
0.955MetVal: 0.955 ± 0.31
0.597MetTrp: 0.597 ± 0.208
0.358MetTyr: 0.358 ± 0.13
0.0MetXaa: 0.0 ± 0.0
Asn
2.506AsnAla: 2.506 ± 0.36
0.298AsnCys: 0.298 ± 0.133
2.028AsnAsp: 2.028 ± 0.327
1.432AsnGlu: 1.432 ± 0.277
0.477AsnPhe: 0.477 ± 0.176
3.58AsnGly: 3.58 ± 0.532
0.716AsnHis: 0.716 ± 0.196
0.955AsnIle: 0.955 ± 0.233
0.895AsnLys: 0.895 ± 0.226
2.148AsnLeu: 2.148 ± 0.377
0.418AsnMet: 0.418 ± 0.16
0.835AsnAsn: 0.835 ± 0.292
3.341AsnPro: 3.341 ± 0.385
1.074AsnGln: 1.074 ± 0.228
1.79AsnArg: 1.79 ± 0.398
1.73AsnSer: 1.73 ± 0.333
2.267AsnThr: 2.267 ± 0.457
1.67AsnVal: 1.67 ± 0.329
0.477AsnTrp: 0.477 ± 0.155
0.955AsnTyr: 0.955 ± 0.257
0.0AsnXaa: 0.0 ± 0.0
Pro
6.443ProAla: 6.443 ± 0.878
0.835ProCys: 0.835 ± 0.296
4.594ProAsp: 4.594 ± 0.639
4.176ProGlu: 4.176 ± 0.566
1.551ProPhe: 1.551 ± 0.262
5.071ProGly: 5.071 ± 0.603
1.193ProHis: 1.193 ± 0.322
2.685ProIle: 2.685 ± 0.408
2.983ProLys: 2.983 ± 0.405
2.565ProLeu: 2.565 ± 0.448
1.73ProMet: 1.73 ± 0.483
1.849ProAsn: 1.849 ± 0.341
3.281ProPro: 3.281 ± 0.686
2.028ProGln: 2.028 ± 0.3
2.864ProArg: 2.864 ± 0.462
3.222ProSer: 3.222 ± 0.358
4.176ProThr: 4.176 ± 0.638
4.355ProVal: 4.355 ± 0.532
1.253ProTrp: 1.253 ± 0.264
1.074ProTyr: 1.074 ± 0.23
0.0ProXaa: 0.0 ± 0.0
Gln
3.639GlnAla: 3.639 ± 0.493
0.239GlnCys: 0.239 ± 0.115
1.253GlnAsp: 1.253 ± 0.223
1.372GlnGlu: 1.372 ± 0.29
1.014GlnPhe: 1.014 ± 0.246
1.969GlnGly: 1.969 ± 0.375
1.014GlnHis: 1.014 ± 0.271
1.67GlnIle: 1.67 ± 0.284
1.074GlnLys: 1.074 ± 0.197
3.46GlnLeu: 3.46 ± 0.379
0.716GlnMet: 0.716 ± 0.243
0.955GlnAsn: 0.955 ± 0.219
2.267GlnPro: 2.267 ± 0.461
1.551GlnGln: 1.551 ± 0.333
3.043GlnArg: 3.043 ± 0.377
1.969GlnSer: 1.969 ± 0.337
2.088GlnThr: 2.088 ± 0.327
2.864GlnVal: 2.864 ± 0.507
0.955GlnTrp: 0.955 ± 0.256
0.955GlnTyr: 0.955 ± 0.238
0.0GlnXaa: 0.0 ± 0.0
Arg
8.054ArgAla: 8.054 ± 0.892
1.134ArgCys: 1.134 ± 0.274
5.906ArgAsp: 5.906 ± 0.67
4.713ArgGlu: 4.713 ± 0.544
1.909ArgPhe: 1.909 ± 0.412
6.383ArgGly: 6.383 ± 0.612
1.73ArgHis: 1.73 ± 0.358
4.057ArgIle: 4.057 ± 0.526
2.148ArgLys: 2.148 ± 0.267
5.668ArgLeu: 5.668 ± 0.492
1.79ArgMet: 1.79 ± 0.349
2.386ArgAsn: 2.386 ± 0.341
2.983ArgPro: 2.983 ± 0.441
2.386ArgGln: 2.386 ± 0.379
6.98ArgArg: 6.98 ± 0.913
3.878ArgSer: 3.878 ± 0.465
4.176ArgThr: 4.176 ± 0.439
5.608ArgVal: 5.608 ± 0.584
1.372ArgTrp: 1.372 ± 0.326
1.312ArgTyr: 1.312 ± 0.291
0.0ArgXaa: 0.0 ± 0.0
Ser
6.205SerAla: 6.205 ± 0.696
0.239SerCys: 0.239 ± 0.112
2.923SerAsp: 2.923 ± 0.404
3.759SerGlu: 3.759 ± 0.573
1.253SerPhe: 1.253 ± 0.21
5.489SerGly: 5.489 ± 0.725
0.776SerHis: 0.776 ± 0.192
2.506SerIle: 2.506 ± 0.437
1.372SerLys: 1.372 ± 0.311
3.937SerLeu: 3.937 ± 0.451
1.372SerMet: 1.372 ± 0.245
1.73SerAsn: 1.73 ± 0.341
2.983SerPro: 2.983 ± 0.509
1.253SerGln: 1.253 ± 0.333
4.176SerArg: 4.176 ± 0.594
2.446SerSer: 2.446 ± 0.536
3.759SerThr: 3.759 ± 0.467
4.176SerVal: 4.176 ± 0.523
1.312SerTrp: 1.312 ± 0.242
0.716SerTyr: 0.716 ± 0.184
0.0SerXaa: 0.0 ± 0.0
Thr
8.352ThrAla: 8.352 ± 0.837
0.477ThrCys: 0.477 ± 0.184
5.071ThrAsp: 5.071 ± 0.737
3.699ThrGlu: 3.699 ± 0.426
2.506ThrPhe: 2.506 ± 0.497
5.727ThrGly: 5.727 ± 0.647
1.551ThrHis: 1.551 ± 0.271
3.281ThrIle: 3.281 ± 0.472
2.685ThrLys: 2.685 ± 0.377
5.787ThrLeu: 5.787 ± 0.595
1.134ThrMet: 1.134 ± 0.25
2.327ThrAsn: 2.327 ± 0.401
4.534ThrPro: 4.534 ± 0.601
2.028ThrGln: 2.028 ± 0.39
4.415ThrArg: 4.415 ± 0.503
2.923ThrSer: 2.923 ± 0.461
4.773ThrThr: 4.773 ± 0.649
5.787ThrVal: 5.787 ± 0.486
1.312ThrTrp: 1.312 ± 0.32
1.491ThrTyr: 1.491 ± 0.337
0.0ThrXaa: 0.0 ± 0.0
Val
8.829ValAla: 8.829 ± 0.67
1.134ValCys: 1.134 ± 0.327
6.443ValAsp: 6.443 ± 0.669
4.773ValGlu: 4.773 ± 0.688
1.432ValPhe: 1.432 ± 0.331
5.847ValGly: 5.847 ± 0.72
1.67ValHis: 1.67 ± 0.312
3.937ValIle: 3.937 ± 0.426
2.207ValLys: 2.207 ± 0.337
5.668ValLeu: 5.668 ± 0.66
1.551ValMet: 1.551 ± 0.47
2.028ValAsn: 2.028 ± 0.353
3.878ValPro: 3.878 ± 0.604
2.565ValGln: 2.565 ± 0.451
6.205ValArg: 6.205 ± 0.629
3.759ValSer: 3.759 ± 0.574
6.801ValThr: 6.801 ± 0.734
7.04ValVal: 7.04 ± 0.689
1.372ValTrp: 1.372 ± 0.297
2.028ValTyr: 2.028 ± 0.235
0.0ValXaa: 0.0 ± 0.0
Trp
1.253TrpAla: 1.253 ± 0.323
0.179TrpCys: 0.179 ± 0.112
1.491TrpAsp: 1.491 ± 0.351
0.716TrpGlu: 0.716 ± 0.199
0.537TrpPhe: 0.537 ± 0.211
0.656TrpGly: 0.656 ± 0.278
0.477TrpHis: 0.477 ± 0.202
0.895TrpIle: 0.895 ± 0.249
0.656TrpLys: 0.656 ± 0.169
2.148TrpLeu: 2.148 ± 0.346
0.418TrpMet: 0.418 ± 0.174
1.074TrpAsn: 1.074 ± 0.388
1.312TrpPro: 1.312 ± 0.251
0.597TrpGln: 0.597 ± 0.191
1.909TrpArg: 1.909 ± 0.317
1.432TrpSer: 1.432 ± 0.344
1.67TrpThr: 1.67 ± 0.295
1.67TrpVal: 1.67 ± 0.266
0.418TrpTrp: 0.418 ± 0.147
0.537TrpTyr: 0.537 ± 0.171
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.148TyrAla: 2.148 ± 0.322
0.358TyrCys: 0.358 ± 0.152
0.895TyrAsp: 0.895 ± 0.208
1.551TyrGlu: 1.551 ± 0.32
0.358TyrPhe: 0.358 ± 0.157
2.267TyrGly: 2.267 ± 0.36
0.776TyrHis: 0.776 ± 0.24
0.776TyrIle: 0.776 ± 0.264
0.835TyrLys: 0.835 ± 0.194
1.432TyrLeu: 1.432 ± 0.277
0.597TyrMet: 0.597 ± 0.19
0.716TyrAsn: 0.716 ± 0.234
1.074TyrPro: 1.074 ± 0.259
0.656TyrGln: 0.656 ± 0.23
1.909TyrArg: 1.909 ± 0.365
1.193TyrSer: 1.193 ± 0.237
1.67TyrThr: 1.67 ± 0.333
1.611TyrVal: 1.611 ± 0.265
0.537TyrTrp: 0.537 ± 0.189
0.656TyrTyr: 0.656 ± 0.185
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (16763 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski