Amino acid dipepetide frequency for Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.545AlaAla: 5.545 ± 0.142
0.989AlaCys: 0.989 ± 0.042
3.13AlaAsp: 3.13 ± 0.076
3.941AlaGlu: 3.941 ± 0.098
2.909AlaPhe: 2.909 ± 0.09
4.976AlaGly: 4.976 ± 0.123
1.082AlaHis: 1.082 ± 0.044
5.884AlaIle: 5.884 ± 0.111
4.417AlaLys: 4.417 ± 0.11
8.354AlaLeu: 8.354 ± 0.151
1.759AlaMet: 1.759 ± 0.055
3.029AlaAsn: 3.029 ± 0.081
2.317AlaPro: 2.317 ± 0.068
2.253AlaGln: 2.253 ± 0.075
3.335AlaArg: 3.335 ± 0.076
5.121AlaSer: 5.121 ± 0.129
3.232AlaThr: 3.232 ± 0.088
4.198AlaVal: 4.198 ± 0.099
0.892AlaTrp: 0.892 ± 0.044
1.678AlaTyr: 1.678 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.65CysAla: 0.65 ± 0.041
0.203CysCys: 0.203 ± 0.02
0.6CysAsp: 0.6 ± 0.035
0.706CysGlu: 0.706 ± 0.033
0.59CysPhe: 0.59 ± 0.035
1.049CysGly: 1.049 ± 0.05
0.265CysHis: 0.265 ± 0.023
0.931CysIle: 0.931 ± 0.038
0.747CysLys: 0.747 ± 0.033
1.382CysLeu: 1.382 ± 0.052
0.186CysMet: 0.186 ± 0.019
0.596CysAsn: 0.596 ± 0.034
0.592CysPro: 0.592 ± 0.035
0.358CysGln: 0.358 ± 0.029
0.623CysArg: 0.623 ± 0.039
1.053CysSer: 1.053 ± 0.046
0.53CysThr: 0.53 ± 0.035
0.625CysVal: 0.625 ± 0.034
0.221CysTrp: 0.221 ± 0.022
0.3CysTyr: 0.3 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
2.938AspAla: 2.938 ± 0.083
0.643AspCys: 0.643 ± 0.037
2.201AspAsp: 2.201 ± 0.086
3.199AspGlu: 3.199 ± 0.098
2.294AspPhe: 2.294 ± 0.068
3.192AspGly: 3.192 ± 0.073
0.915AspHis: 0.915 ± 0.051
3.581AspIle: 3.581 ± 0.091
2.824AspLys: 2.824 ± 0.083
6.821AspLeu: 6.821 ± 0.126
0.815AspMet: 0.815 ± 0.034
2.025AspAsn: 2.025 ± 0.07
2.671AspPro: 2.671 ± 0.075
2.197AspGln: 2.197 ± 0.069
2.415AspArg: 2.415 ± 0.069
3.674AspSer: 3.674 ± 0.086
1.8AspThr: 1.8 ± 0.065
2.851AspVal: 2.851 ± 0.079
0.883AspTrp: 0.883 ± 0.046
1.459AspTyr: 1.459 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
4.976GluAla: 4.976 ± 0.108
0.602GluCys: 0.602 ± 0.032
3.031GluAsp: 3.031 ± 0.085
4.786GluGlu: 4.786 ± 0.125
2.085GluPhe: 2.085 ± 0.058
4.084GluGly: 4.084 ± 0.09
1.063GluHis: 1.063 ± 0.054
5.404GluIle: 5.404 ± 0.106
4.87GluLys: 4.87 ± 0.094
7.796GluLeu: 7.796 ± 0.153
1.316GluMet: 1.316 ± 0.057
3.066GluAsn: 3.066 ± 0.082
2.232GluPro: 2.232 ± 0.074
2.326GluGln: 2.326 ± 0.065
3.352GluArg: 3.352 ± 0.094
4.262GluSer: 4.262 ± 0.09
2.853GluThr: 2.853 ± 0.082
4.03GluVal: 4.03 ± 0.096
0.863GluTrp: 0.863 ± 0.051
1.334GluTyr: 1.334 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
2.681PheAla: 2.681 ± 0.083
0.598PheCys: 0.598 ± 0.033
2.443PheAsp: 2.443 ± 0.066
2.315PheGlu: 2.315 ± 0.07
1.854PhePhe: 1.854 ± 0.072
2.942PheGly: 2.942 ± 0.075
0.797PheHis: 0.797 ± 0.041
2.839PheIle: 2.839 ± 0.089
2.305PheLys: 2.305 ± 0.07
4.628PheLeu: 4.628 ± 0.12
0.73PheMet: 0.73 ± 0.036
2.025PheAsn: 2.025 ± 0.069
1.651PhePro: 1.651 ± 0.055
1.395PheGln: 1.395 ± 0.055
1.885PheArg: 1.885 ± 0.064
3.583PheSer: 3.583 ± 0.09
2.028PheThr: 2.028 ± 0.07
2.218PheVal: 2.218 ± 0.069
0.625PheTrp: 0.625 ± 0.039
1.136PheTyr: 1.136 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.699GlyAla: 4.699 ± 0.118
1.01GlyCys: 1.01 ± 0.041
3.176GlyAsp: 3.176 ± 0.078
4.004GlyGlu: 4.004 ± 0.089
3.31GlyPhe: 3.31 ± 0.078
5.305GlyGly: 5.305 ± 0.174
1.38GlyHis: 1.38 ± 0.061
5.911GlyIle: 5.911 ± 0.12
4.095GlyLys: 4.095 ± 0.082
8.001GlyLeu: 8.001 ± 0.135
1.56GlyMet: 1.56 ± 0.067
2.739GlyAsn: 2.739 ± 0.083
2.326GlyPro: 2.326 ± 0.072
2.251GlyGln: 2.251 ± 0.072
3.434GlyArg: 3.434 ± 0.099
4.796GlySer: 4.796 ± 0.105
3.356GlyThr: 3.356 ± 0.086
4.442GlyVal: 4.442 ± 0.09
1.123GlyTrp: 1.123 ± 0.054
1.875GlyTyr: 1.875 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
1.121HisAla: 1.121 ± 0.054
0.275HisCys: 0.275 ± 0.023
0.73HisAsp: 0.73 ± 0.044
0.89HisGlu: 0.89 ± 0.04
0.817HisPhe: 0.817 ± 0.047
1.318HisGly: 1.318 ± 0.061
0.548HisHis: 0.548 ± 0.04
1.256HisIle: 1.256 ± 0.051
1.022HisLys: 1.022 ± 0.047
2.323HisLeu: 2.323 ± 0.072
0.294HisMet: 0.294 ± 0.025
0.782HisAsn: 0.782 ± 0.048
1.107HisPro: 1.107 ± 0.047
0.755HisGln: 0.755 ± 0.041
1.037HisArg: 1.037 ± 0.046
1.388HisSer: 1.388 ± 0.046
0.77HisThr: 0.77 ± 0.042
0.842HisVal: 0.842 ± 0.041
0.387HisTrp: 0.387 ± 0.028
0.49HisTyr: 0.49 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.137IleAla: 6.137 ± 0.138
1.053IleCys: 1.053 ± 0.047
4.767IleAsp: 4.767 ± 0.109
5.551IleGlu: 5.551 ± 0.116
2.973IlePhe: 2.973 ± 0.081
5.795IleGly: 5.795 ± 0.126
1.44IleHis: 1.44 ± 0.058
5.028IleIle: 5.028 ± 0.115
5.148IleLys: 5.148 ± 0.12
7.105IleLeu: 7.105 ± 0.136
1.059IleMet: 1.059 ± 0.046
4.721IleAsn: 4.721 ± 0.104
3.699IlePro: 3.699 ± 0.084
2.681IleGln: 2.681 ± 0.073
3.507IleArg: 3.507 ± 0.09
6.693IleSer: 6.693 ± 0.117
4.024IleThr: 4.024 ± 0.094
3.954IleVal: 3.954 ± 0.086
0.941IleTrp: 0.941 ± 0.044
1.901IleTyr: 1.901 ± 0.066
0.0IleXaa: 0.0 ± 0.0
Lys
4.724LysAla: 4.724 ± 0.103
0.602LysCys: 0.602 ± 0.036
3.674LysAsp: 3.674 ± 0.087
5.495LysGlu: 5.495 ± 0.112
1.968LysPhe: 1.968 ± 0.068
4.252LysGly: 4.252 ± 0.09
1.006LysHis: 1.006 ± 0.047
4.736LysIle: 4.736 ± 0.106
5.148LysLys: 5.148 ± 0.122
6.799LysLeu: 6.799 ± 0.126
1.241LysMet: 1.241 ± 0.049
3.608LysAsn: 3.608 ± 0.093
2.508LysPro: 2.508 ± 0.085
2.354LysGln: 2.354 ± 0.069
3.381LysArg: 3.381 ± 0.082
4.812LysSer: 4.812 ± 0.102
3.333LysThr: 3.333 ± 0.081
3.821LysVal: 3.821 ± 0.093
0.838LysTrp: 0.838 ± 0.047
1.732LysTyr: 1.732 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
8.414LeuAla: 8.414 ± 0.155
1.274LeuCys: 1.274 ± 0.051
5.774LeuAsp: 5.774 ± 0.12
7.812LeuGlu: 7.812 ± 0.138
4.363LeuPhe: 4.363 ± 0.104
7.899LeuGly: 7.899 ± 0.146
1.901LeuHis: 1.901 ± 0.069
9.706LeuIle: 9.706 ± 0.167
7.668LeuLys: 7.668 ± 0.121
13.128LeuLeu: 13.128 ± 0.242
2.288LeuMet: 2.288 ± 0.072
5.768LeuAsn: 5.768 ± 0.107
5.266LeuPro: 5.266 ± 0.112
4.041LeuGln: 4.041 ± 0.098
5.69LeuArg: 5.69 ± 0.12
8.744LeuSer: 8.744 ± 0.154
5.479LeuThr: 5.479 ± 0.111
6.457LeuVal: 6.457 ± 0.138
1.39LeuTrp: 1.39 ± 0.057
2.172LeuTyr: 2.172 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
1.829MetAla: 1.829 ± 0.062
0.126MetCys: 0.126 ± 0.016
0.865MetAsp: 0.865 ± 0.04
1.113MetGlu: 1.113 ± 0.055
0.573MetPhe: 0.573 ± 0.032
1.45MetGly: 1.45 ± 0.053
0.379MetHis: 0.379 ± 0.029
1.295MetIle: 1.295 ± 0.049
1.378MetLys: 1.378 ± 0.058
1.835MetLeu: 1.835 ± 0.058
0.343MetMet: 0.343 ± 0.027
1.084MetAsn: 1.084 ± 0.044
1.076MetPro: 1.076 ± 0.046
0.768MetGln: 0.768 ± 0.045
0.983MetArg: 0.983 ± 0.042
1.541MetSer: 1.541 ± 0.053
1.25MetThr: 1.25 ± 0.051
1.188MetVal: 1.188 ± 0.047
0.126MetTrp: 0.126 ± 0.016
0.286MetTyr: 0.286 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.87AsnAla: 2.87 ± 0.084
0.677AsnCys: 0.677 ± 0.036
2.503AsnAsp: 2.503 ± 0.08
2.988AsnGlu: 2.988 ± 0.079
1.905AsnPhe: 1.905 ± 0.067
2.957AsnGly: 2.957 ± 0.071
1.016AsnHis: 1.016 ± 0.055
3.726AsnIle: 3.726 ± 0.113
3.542AsnLys: 3.542 ± 0.106
5.514AsnLeu: 5.514 ± 0.104
0.857AsnMet: 0.857 ± 0.038
2.988AsnAsn: 2.988 ± 0.093
2.431AsnPro: 2.431 ± 0.066
2.414AsnGln: 2.414 ± 0.067
2.354AsnArg: 2.354 ± 0.067
4.105AsnSer: 4.105 ± 0.104
2.261AsnThr: 2.261 ± 0.066
2.266AsnVal: 2.266 ± 0.072
0.929AsnTrp: 0.929 ± 0.047
1.457AsnTyr: 1.457 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.454ProAla: 2.454 ± 0.072
0.443ProCys: 0.443 ± 0.028
2.102ProAsp: 2.102 ± 0.07
2.965ProGlu: 2.965 ± 0.079
1.959ProPhe: 1.959 ± 0.049
2.741ProGly: 2.741 ± 0.082
0.768ProHis: 0.768 ± 0.04
3.534ProIle: 3.534 ± 0.084
2.669ProLys: 2.669 ± 0.077
4.904ProLeu: 4.904 ± 0.098
0.825ProMet: 0.825 ± 0.04
2.183ProAsn: 2.183 ± 0.071
1.595ProPro: 1.595 ± 0.068
1.479ProGln: 1.479 ± 0.051
1.717ProArg: 1.717 ± 0.054
3.67ProSer: 3.67 ± 0.099
2.007ProThr: 2.007 ± 0.062
2.594ProVal: 2.594 ± 0.076
0.716ProTrp: 0.716 ± 0.045
1.198ProTyr: 1.198 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.642GlnAla: 2.642 ± 0.069
0.372GlnCys: 0.372 ± 0.029
1.506GlnAsp: 1.506 ± 0.061
2.655GlnGlu: 2.655 ± 0.089
1.266GlnPhe: 1.266 ± 0.059
2.305GlnGly: 2.305 ± 0.066
0.552GlnHis: 0.552 ± 0.032
2.961GlnIle: 2.961 ± 0.078
2.77GlnLys: 2.77 ± 0.092
4.473GlnLeu: 4.473 ± 0.097
0.766GlnMet: 0.766 ± 0.037
1.661GlnAsn: 1.661 ± 0.061
1.415GlnPro: 1.415 ± 0.05
1.409GlnGln: 1.409 ± 0.062
2.032GlnArg: 2.032 ± 0.065
2.685GlnSer: 2.685 ± 0.073
1.637GlnThr: 1.637 ± 0.061
2.181GlnVal: 2.181 ± 0.075
0.61GlnTrp: 0.61 ± 0.035
0.765GlnTyr: 0.765 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.911ArgAla: 2.911 ± 0.074
0.571ArgCys: 0.571 ± 0.033
2.259ArgAsp: 2.259 ± 0.066
3.029ArgGlu: 3.029 ± 0.083
2.241ArgPhe: 2.241 ± 0.075
2.843ArgGly: 2.843 ± 0.085
0.956ArgHis: 0.956 ± 0.043
3.883ArgIle: 3.883 ± 0.084
3.29ArgLys: 3.29 ± 0.081
6.108ArgLeu: 6.108 ± 0.118
1.035ArgMet: 1.035 ± 0.044
2.359ArgAsn: 2.359 ± 0.067
1.947ArgPro: 1.947 ± 0.061
1.999ArgGln: 1.999 ± 0.075
3.145ArgArg: 3.145 ± 0.095
3.53ArgSer: 3.53 ± 0.082
2.03ArgThr: 2.03 ± 0.069
2.861ArgVal: 2.861 ± 0.079
0.902ArgTrp: 0.902 ± 0.041
1.399ArgTyr: 1.399 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
4.43SerAla: 4.43 ± 0.093
1.005SerCys: 1.005 ± 0.047
3.53SerAsp: 3.53 ± 0.096
4.378SerGlu: 4.378 ± 0.104
3.509SerPhe: 3.509 ± 0.097
5.119SerGly: 5.119 ± 0.099
1.401SerHis: 1.401 ± 0.051
6.437SerIle: 6.437 ± 0.121
5.439SerLys: 5.439 ± 0.115
9.217SerLeu: 9.217 ± 0.153
1.589SerMet: 1.589 ± 0.061
4.303SerAsn: 4.303 ± 0.104
3.17SerPro: 3.17 ± 0.088
2.952SerGln: 2.952 ± 0.085
3.679SerArg: 3.679 ± 0.108
6.513SerSer: 6.513 ± 0.125
3.656SerThr: 3.656 ± 0.079
3.716SerVal: 3.716 ± 0.077
1.14SerTrp: 1.14 ± 0.048
2.003SerTyr: 2.003 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
3.335ThrAla: 3.335 ± 0.089
0.6ThrCys: 0.6 ± 0.033
2.139ThrAsp: 2.139 ± 0.063
2.52ThrGlu: 2.52 ± 0.071
2.017ThrPhe: 2.017 ± 0.059
3.619ThrGly: 3.619 ± 0.115
0.834ThrHis: 0.834 ± 0.046
3.666ThrIle: 3.666 ± 0.088
2.99ThrLys: 2.99 ± 0.07
5.175ThrLeu: 5.175 ± 0.107
0.844ThrMet: 0.844 ± 0.038
2.423ThrAsn: 2.423 ± 0.076
2.381ThrPro: 2.381 ± 0.066
1.531ThrGln: 1.531 ± 0.056
2.017ThrArg: 2.017 ± 0.074
3.865ThrSer: 3.865 ± 0.088
2.506ThrThr: 2.506 ± 0.083
2.644ThrVal: 2.644 ± 0.08
0.619ThrTrp: 0.619 ± 0.041
1.223ThrTyr: 1.223 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
4.347ValAla: 4.347 ± 0.112
0.6ValCys: 0.6 ± 0.034
3.17ValAsp: 3.17 ± 0.086
3.588ValGlu: 3.588 ± 0.104
2.328ValPhe: 2.328 ± 0.076
3.975ValGly: 3.975 ± 0.086
1.082ValHis: 1.082 ± 0.041
4.626ValIle: 4.626 ± 0.095
3.134ValLys: 3.134 ± 0.086
6.735ValLeu: 6.735 ± 0.141
1.163ValMet: 1.163 ± 0.046
2.702ValAsn: 2.702 ± 0.07
2.454ValPro: 2.454 ± 0.069
1.837ValGln: 1.837 ± 0.064
2.572ValArg: 2.572 ± 0.08
4.092ValSer: 4.092 ± 0.09
2.663ValThr: 2.663 ± 0.071
4.154ValVal: 4.154 ± 0.105
0.635ValTrp: 0.635 ± 0.036
1.163ValTyr: 1.163 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.886TrpAla: 0.886 ± 0.045
0.194TrpCys: 0.194 ± 0.02
0.716TrpAsp: 0.716 ± 0.037
0.9TrpGlu: 0.9 ± 0.05
0.6TrpPhe: 0.6 ± 0.037
0.914TrpGly: 0.914 ± 0.044
0.352TrpHis: 0.352 ± 0.03
1.204TrpIle: 1.204 ± 0.054
0.886TrpLys: 0.886 ± 0.047
1.935TrpLeu: 1.935 ± 0.077
0.352TrpMet: 0.352 ± 0.031
0.71TrpAsn: 0.71 ± 0.038
0.577TrpPro: 0.577 ± 0.042
0.604TrpGln: 0.604 ± 0.036
0.743TrpArg: 0.743 ± 0.042
1.076TrpSer: 1.076 ± 0.05
0.55TrpThr: 0.55 ± 0.033
0.811TrpVal: 0.811 ± 0.041
0.288TrpTrp: 0.288 ± 0.024
0.308TrpTyr: 0.308 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.45TyrAla: 1.45 ± 0.046
0.374TyrCys: 0.374 ± 0.032
1.082TyrAsp: 1.082 ± 0.053
1.492TyrGlu: 1.492 ± 0.051
1.119TyrPhe: 1.119 ± 0.059
2.059TyrGly: 2.059 ± 0.071
0.412TyrHis: 0.412 ± 0.028
1.57TyrIle: 1.57 ± 0.061
1.69TyrLys: 1.69 ± 0.06
2.998TyrLeu: 2.998 ± 0.084
0.465TyrMet: 0.465 ± 0.029
0.991TyrAsn: 0.991 ± 0.05
1.107TyrPro: 1.107 ± 0.046
1.059TyrGln: 1.059 ± 0.046
1.397TyrArg: 1.397 ± 0.058
1.986TyrSer: 1.986 ± 0.073
0.981TyrThr: 0.981 ± 0.043
1.169TyrVal: 1.169 ± 0.044
0.48TyrTrp: 0.48 ± 0.029
0.585TyrTyr: 0.585 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1881 proteins (516670 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski