Amino acid dipepetide frequency for Candidatus Evansia muelleri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.097AlaAla: 3.097 ± 0.196
0.718AlaCys: 0.718 ± 0.084
2.074AlaAsp: 2.074 ± 0.148
1.912AlaGlu: 1.912 ± 0.147
2.029AlaPhe: 2.029 ± 0.142
2.989AlaGly: 2.989 ± 0.21
1.176AlaHis: 1.176 ± 0.099
6.948AlaIle: 6.948 ± 0.281
3.582AlaLys: 3.582 ± 0.19
5.179AlaLeu: 5.179 ± 0.239
1.328AlaMet: 1.328 ± 0.122
3.321AlaAsn: 3.321 ± 0.183
1.311AlaPro: 1.311 ± 0.113
1.391AlaGln: 1.391 ± 0.117
2.271AlaArg: 2.271 ± 0.131
2.612AlaSer: 2.612 ± 0.164
2.029AlaThr: 2.029 ± 0.124
2.379AlaVal: 2.379 ± 0.143
0.574AlaTrp: 0.574 ± 0.068
2.181AlaTyr: 2.181 ± 0.15
0.0AlaXaa: 0.0 ± 0.0
Cys
0.628CysAla: 0.628 ± 0.083
0.162CysCys: 0.162 ± 0.031
0.619CysAsp: 0.619 ± 0.07
0.682CysGlu: 0.682 ± 0.078
0.61CysPhe: 0.61 ± 0.071
0.96CysGly: 0.96 ± 0.081
0.242CysHis: 0.242 ± 0.053
1.75CysIle: 1.75 ± 0.136
1.472CysLys: 1.472 ± 0.118
1.23CysLeu: 1.23 ± 0.097
0.233CysMet: 0.233 ± 0.049
1.14CysAsn: 1.14 ± 0.096
0.512CysPro: 0.512 ± 0.073
0.224CysGln: 0.224 ± 0.042
0.521CysArg: 0.521 ± 0.066
0.943CysSer: 0.943 ± 0.099
0.655CysThr: 0.655 ± 0.076
0.592CysVal: 0.592 ± 0.076
0.117CysTrp: 0.117 ± 0.03
0.592CysTyr: 0.592 ± 0.071
0.0CysXaa: 0.0 ± 0.0
Asp
2.154AspAla: 2.154 ± 0.16
0.583AspCys: 0.583 ± 0.067
1.49AspAsp: 1.49 ± 0.135
2.02AspGlu: 2.02 ± 0.13
2.011AspPhe: 2.011 ± 0.145
2.029AspGly: 2.029 ± 0.137
0.727AspHis: 0.727 ± 0.084
6.499AspIle: 6.499 ± 0.268
3.51AspLys: 3.51 ± 0.235
3.842AspLeu: 3.842 ± 0.195
0.853AspMet: 0.853 ± 0.092
3.034AspAsn: 3.034 ± 0.169
1.427AspPro: 1.427 ± 0.101
0.943AspGln: 0.943 ± 0.087
1.508AspArg: 1.508 ± 0.106
1.957AspSer: 1.957 ± 0.145
1.777AspThr: 1.777 ± 0.114
2.056AspVal: 2.056 ± 0.121
0.566AspTrp: 0.566 ± 0.081
2.065AspTyr: 2.065 ± 0.151
0.0AspXaa: 0.0 ± 0.0
Glu
2.828GluAla: 2.828 ± 0.191
0.736GluCys: 0.736 ± 0.085
1.607GluAsp: 1.607 ± 0.126
2.289GluGlu: 2.289 ± 0.18
2.038GluPhe: 2.038 ± 0.139
2.675GluGly: 2.675 ± 0.146
0.916GluHis: 0.916 ± 0.099
6.867GluIle: 6.867 ± 0.261
4.856GluLys: 4.856 ± 0.224
4.425GluLeu: 4.425 ± 0.193
0.907GluMet: 0.907 ± 0.084
3.644GluAsn: 3.644 ± 0.204
0.996GluPro: 0.996 ± 0.099
1.221GluGln: 1.221 ± 0.104
1.984GluArg: 1.984 ± 0.136
2.684GluSer: 2.684 ± 0.148
1.948GluThr: 1.948 ± 0.138
2.253GluVal: 2.253 ± 0.142
0.377GluTrp: 0.377 ± 0.057
2.612GluTyr: 2.612 ± 0.166
0.0GluXaa: 0.0 ± 0.0
Phe
1.714PheAla: 1.714 ± 0.126
0.772PheCys: 0.772 ± 0.078
2.477PheAsp: 2.477 ± 0.147
2.109PheGlu: 2.109 ± 0.144
2.63PhePhe: 2.63 ± 0.212
2.486PheGly: 2.486 ± 0.135
0.745PheHis: 0.745 ± 0.083
6.804PheIle: 6.804 ± 0.328
4.38PheLys: 4.38 ± 0.224
3.752PheLeu: 3.752 ± 0.212
0.817PheMet: 0.817 ± 0.095
4.452PheAsn: 4.452 ± 0.209
1.302PhePro: 1.302 ± 0.116
0.871PheGln: 0.871 ± 0.081
1.382PheArg: 1.382 ± 0.109
3.142PheSer: 3.142 ± 0.16
2.038PheThr: 2.038 ± 0.144
1.607PheVal: 1.607 ± 0.113
0.386PheTrp: 0.386 ± 0.058
2.747PheTyr: 2.747 ± 0.164
0.0PheXaa: 0.0 ± 0.0
Gly
3.384GlyAla: 3.384 ± 0.21
0.862GlyCys: 0.862 ± 0.096
2.54GlyAsp: 2.54 ± 0.181
2.63GlyGlu: 2.63 ± 0.158
2.594GlyPhe: 2.594 ± 0.171
4.452GlyGly: 4.452 ± 0.266
1.337GlyHis: 1.337 ± 0.122
8.177GlyIle: 8.177 ± 0.276
5.072GlyLys: 5.072 ± 0.205
5.179GlyLeu: 5.179 ± 0.239
1.4GlyMet: 1.4 ± 0.108
3.617GlyAsn: 3.617 ± 0.186
1.688GlyPro: 1.688 ± 0.126
1.598GlyGln: 1.598 ± 0.124
2.576GlyArg: 2.576 ± 0.161
3.052GlySer: 3.052 ± 0.169
2.98GlyThr: 2.98 ± 0.149
3.267GlyVal: 3.267 ± 0.181
0.557GlyTrp: 0.557 ± 0.066
2.765GlyTyr: 2.765 ± 0.158
0.0GlyXaa: 0.0 ± 0.0
His
1.023HisAla: 1.023 ± 0.084
0.332HisCys: 0.332 ± 0.058
0.628HisAsp: 0.628 ± 0.071
0.745HisGlu: 0.745 ± 0.074
0.727HisPhe: 0.727 ± 0.074
1.553HisGly: 1.553 ± 0.111
0.404HisHis: 0.404 ± 0.068
2.729HisIle: 2.729 ± 0.164
1.382HisLys: 1.382 ± 0.129
1.571HisLeu: 1.571 ± 0.12
0.35HisMet: 0.35 ± 0.059
1.544HisAsn: 1.544 ± 0.113
1.041HisPro: 1.041 ± 0.102
0.449HisGln: 0.449 ± 0.053
0.835HisArg: 0.835 ± 0.093
1.041HisSer: 1.041 ± 0.086
0.969HisThr: 0.969 ± 0.091
0.844HisVal: 0.844 ± 0.091
0.171HisTrp: 0.171 ± 0.036
0.727HisTyr: 0.727 ± 0.071
0.0HisXaa: 0.0 ± 0.0
Ile
7.046IleAla: 7.046 ± 0.277
1.795IleCys: 1.795 ± 0.136
7.235IleAsp: 7.235 ± 0.285
7.881IleGlu: 7.881 ± 0.256
5.996IlePhe: 5.996 ± 0.266
7.54IleGly: 7.54 ± 0.307
2.235IleHis: 2.235 ± 0.15
18.725IleIle: 18.725 ± 0.559
14.245IleLys: 14.245 ± 0.425
11.912IleLeu: 11.912 ± 0.443
2.792IleMet: 2.792 ± 0.174
13.868IleAsn: 13.868 ± 0.368
4.093IlePro: 4.093 ± 0.184
2.863IleGln: 2.863 ± 0.194
4.578IleArg: 4.578 ± 0.173
9.03IleSer: 9.03 ± 0.271
5.592IleThr: 5.592 ± 0.218
5.26IleVal: 5.26 ± 0.194
0.978IleTrp: 0.978 ± 0.113
6.66IleTyr: 6.66 ± 0.291
0.0IleXaa: 0.0 ± 0.0
Lys
3.555LysAla: 3.555 ± 0.197
1.032LysCys: 1.032 ± 0.096
2.81LysAsp: 2.81 ± 0.165
4.291LysGlu: 4.291 ± 0.182
4.425LysPhe: 4.425 ± 0.204
3.994LysGly: 3.994 ± 0.221
1.373LysHis: 1.373 ± 0.095
12.621LysIle: 12.621 ± 0.411
10.691LysLys: 10.691 ± 0.404
9.676LysLeu: 9.676 ± 0.332
1.661LysMet: 1.661 ± 0.131
9.829LysAsn: 9.829 ± 0.356
1.903LysPro: 1.903 ± 0.153
1.975LysGln: 1.975 ± 0.125
3.088LysArg: 3.088 ± 0.154
5.161LysSer: 5.161 ± 0.257
3.797LysThr: 3.797 ± 0.173
3.115LysVal: 3.115 ± 0.156
0.592LysTrp: 0.592 ± 0.078
5.655LysTyr: 5.655 ± 0.267
0.0LysXaa: 0.0 ± 0.0
Leu
4.327LeuAla: 4.327 ± 0.187
1.203LeuCys: 1.203 ± 0.103
3.617LeuAsp: 3.617 ± 0.175
4.686LeuGlu: 4.686 ± 0.225
4.336LeuPhe: 4.336 ± 0.211
5.96LeuGly: 5.96 ± 0.19
2.172LeuHis: 2.172 ± 0.127
12.477LeuIle: 12.477 ± 0.405
7.845LeuLys: 7.845 ± 0.279
8.94LeuLeu: 8.94 ± 0.365
1.777LeuMet: 1.777 ± 0.124
7.567LeuAsn: 7.567 ± 0.286
3.537LeuPro: 3.537 ± 0.195
2.37LeuGln: 2.37 ± 0.169
3.779LeuArg: 3.779 ± 0.168
6.032LeuSer: 6.032 ± 0.239
3.617LeuThr: 3.617 ± 0.161
3.474LeuVal: 3.474 ± 0.187
0.709LeuTrp: 0.709 ± 0.082
4.228LeuTyr: 4.228 ± 0.205
0.0LeuXaa: 0.0 ± 0.0
Met
0.96MetAla: 0.96 ± 0.096
0.233MetCys: 0.233 ± 0.044
0.808MetAsp: 0.808 ± 0.078
0.969MetGlu: 0.969 ± 0.107
0.96MetPhe: 0.96 ± 0.085
1.616MetGly: 1.616 ± 0.116
0.592MetHis: 0.592 ± 0.071
2.513MetIle: 2.513 ± 0.168
1.472MetLys: 1.472 ± 0.108
2.002MetLeu: 2.002 ± 0.13
0.386MetMet: 0.386 ± 0.052
1.499MetAsn: 1.499 ± 0.105
0.853MetPro: 0.853 ± 0.093
0.718MetGln: 0.718 ± 0.085
0.907MetArg: 0.907 ± 0.096
1.427MetSer: 1.427 ± 0.103
0.754MetThr: 0.754 ± 0.085
0.969MetVal: 0.969 ± 0.1
0.117MetTrp: 0.117 ± 0.034
0.853MetTyr: 0.853 ± 0.085
0.0MetXaa: 0.0 ± 0.0
Asn
3.42AsnAla: 3.42 ± 0.192
1.248AsnCys: 1.248 ± 0.106
3.07AsnAsp: 3.07 ± 0.164
3.582AsnGlu: 3.582 ± 0.175
4.425AsnPhe: 4.425 ± 0.207
3.941AsnGly: 3.941 ± 0.209
1.346AsnHis: 1.346 ± 0.112
14.111AsnIle: 14.111 ± 0.453
8.725AsnLys: 8.725 ± 0.32
7.881AsnLeu: 7.881 ± 0.297
1.93AsnMet: 1.93 ± 0.113
7.809AsnAsn: 7.809 ± 0.36
2.415AsnPro: 2.415 ± 0.141
1.661AsnGln: 1.661 ± 0.122
2.926AsnArg: 2.926 ± 0.165
4.111AsnSer: 4.111 ± 0.196
3.285AsnThr: 3.285 ± 0.173
3.196AsnVal: 3.196 ± 0.157
0.862AsnTrp: 0.862 ± 0.099
4.434AsnTyr: 4.434 ± 0.212
0.0AsnXaa: 0.0 ± 0.0
Pro
1.257ProAla: 1.257 ± 0.094
0.368ProCys: 0.368 ± 0.049
1.302ProAsp: 1.302 ± 0.095
1.661ProGlu: 1.661 ± 0.106
1.337ProPhe: 1.337 ± 0.108
2.226ProGly: 2.226 ± 0.169
0.682ProHis: 0.682 ± 0.062
4.524ProIle: 4.524 ± 0.188
2.28ProLys: 2.28 ± 0.163
2.46ProLeu: 2.46 ± 0.146
0.727ProMet: 0.727 ± 0.071
2.1ProAsn: 2.1 ± 0.134
0.96ProPro: 0.96 ± 0.109
1.059ProGln: 1.059 ± 0.123
0.826ProArg: 0.826 ± 0.087
1.759ProSer: 1.759 ± 0.134
1.427ProThr: 1.427 ± 0.125
1.688ProVal: 1.688 ± 0.138
0.332ProTrp: 0.332 ± 0.054
1.616ProTyr: 1.616 ± 0.119
0.0ProXaa: 0.0 ± 0.0
Gln
1.221GlnAla: 1.221 ± 0.115
0.377GlnCys: 0.377 ± 0.053
0.736GlnAsp: 0.736 ± 0.103
1.059GlnGlu: 1.059 ± 0.107
1.23GlnPhe: 1.23 ± 0.095
1.445GlnGly: 1.445 ± 0.129
0.539GlnHis: 0.539 ± 0.068
3.187GlnIle: 3.187 ± 0.186
1.876GlnLys: 1.876 ± 0.124
2.433GlnLeu: 2.433 ± 0.128
0.431GlnMet: 0.431 ± 0.06
1.786GlnAsn: 1.786 ± 0.122
0.79GlnPro: 0.79 ± 0.096
0.799GlnGln: 0.799 ± 0.087
0.889GlnArg: 0.889 ± 0.096
1.598GlnSer: 1.598 ± 0.11
0.96GlnThr: 0.96 ± 0.096
1.113GlnVal: 1.113 ± 0.11
0.332GlnTrp: 0.332 ± 0.054
1.328GlnTyr: 1.328 ± 0.1
0.0GlnXaa: 0.0 ± 0.0
Arg
2.011ArgAla: 2.011 ± 0.125
0.53ArgCys: 0.53 ± 0.068
1.472ArgAsp: 1.472 ± 0.115
2.011ArgGlu: 2.011 ± 0.146
1.679ArgPhe: 1.679 ± 0.112
2.091ArgGly: 2.091 ± 0.153
0.566ArgHis: 0.566 ± 0.081
5.099ArgIle: 5.099 ± 0.206
3.07ArgLys: 3.07 ± 0.172
3.411ArgLeu: 3.411 ± 0.167
0.96ArgMet: 0.96 ± 0.099
2.639ArgAsn: 2.639 ± 0.165
1.284ArgPro: 1.284 ± 0.104
1.041ArgGln: 1.041 ± 0.097
1.661ArgArg: 1.661 ± 0.117
2.199ArgSer: 2.199 ± 0.146
1.517ArgThr: 1.517 ± 0.109
1.813ArgVal: 1.813 ± 0.129
0.377ArgTrp: 0.377 ± 0.057
1.894ArgTyr: 1.894 ± 0.135
0.0ArgXaa: 0.0 ± 0.0
Ser
3.187SerAla: 3.187 ± 0.183
0.727SerCys: 0.727 ± 0.078
2.361SerAsp: 2.361 ± 0.165
2.675SerGlu: 2.675 ± 0.143
2.756SerPhe: 2.756 ± 0.197
4.219SerGly: 4.219 ± 0.209
0.96SerHis: 0.96 ± 0.111
8.519SerIle: 8.519 ± 0.32
5.036SerLys: 5.036 ± 0.187
5.565SerLeu: 5.565 ± 0.242
0.969SerMet: 0.969 ± 0.089
4.407SerAsn: 4.407 ± 0.226
1.571SerPro: 1.571 ± 0.102
1.4SerGln: 1.4 ± 0.124
2.217SerArg: 2.217 ± 0.135
3.088SerSer: 3.088 ± 0.179
2.747SerThr: 2.747 ± 0.168
2.522SerVal: 2.522 ± 0.168
0.503SerTrp: 0.503 ± 0.065
2.513SerTyr: 2.513 ± 0.161
0.0SerXaa: 0.0 ± 0.0
Thr
2.334ThrAla: 2.334 ± 0.158
0.628ThrCys: 0.628 ± 0.073
1.732ThrAsp: 1.732 ± 0.14
1.822ThrGlu: 1.822 ± 0.125
1.903ThrPhe: 1.903 ± 0.135
3.546ThrGly: 3.546 ± 0.203
1.086ThrHis: 1.086 ± 0.11
5.449ThrIle: 5.449 ± 0.2
2.72ThrLys: 2.72 ± 0.139
4.282ThrLeu: 4.282 ± 0.151
0.871ThrMet: 0.871 ± 0.085
2.962ThrAsn: 2.962 ± 0.146
1.93ThrPro: 1.93 ± 0.141
1.176ThrGln: 1.176 ± 0.1
1.759ThrArg: 1.759 ± 0.13
2.307ThrSer: 2.307 ± 0.15
2.271ThrThr: 2.271 ± 0.166
1.984ThrVal: 1.984 ± 0.137
0.422ThrTrp: 0.422 ± 0.06
1.741ThrTyr: 1.741 ± 0.145
0.0ThrXaa: 0.0 ± 0.0
Val
2.352ValAla: 2.352 ± 0.169
0.655ValCys: 0.655 ± 0.083
1.957ValAsp: 1.957 ± 0.132
2.217ValGlu: 2.217 ± 0.153
2.091ValPhe: 2.091 ± 0.143
2.594ValGly: 2.594 ± 0.184
0.79ValHis: 0.79 ± 0.086
5.673ValIle: 5.673 ± 0.239
3.052ValLys: 3.052 ± 0.159
3.644ValLeu: 3.644 ± 0.207
0.898ValMet: 0.898 ± 0.086
3.528ValAsn: 3.528 ± 0.167
1.499ValPro: 1.499 ± 0.124
0.951ValGln: 0.951 ± 0.114
1.688ValArg: 1.688 ± 0.151
2.675ValSer: 2.675 ± 0.187
2.145ValThr: 2.145 ± 0.145
2.154ValVal: 2.154 ± 0.155
0.314ValTrp: 0.314 ± 0.057
1.759ValTyr: 1.759 ± 0.125
0.0ValXaa: 0.0 ± 0.0
Trp
0.359TrpAla: 0.359 ± 0.055
0.144TrpCys: 0.144 ± 0.036
0.359TrpAsp: 0.359 ± 0.062
0.476TrpGlu: 0.476 ± 0.066
0.404TrpPhe: 0.404 ± 0.067
0.566TrpGly: 0.566 ± 0.083
0.215TrpHis: 0.215 ± 0.039
1.023TrpIle: 1.023 ± 0.104
0.817TrpLys: 0.817 ± 0.087
0.987TrpLeu: 0.987 ± 0.09
0.171TrpMet: 0.171 ± 0.037
0.628TrpAsn: 0.628 ± 0.073
0.215TrpPro: 0.215 ± 0.045
0.377TrpGln: 0.377 ± 0.06
0.341TrpArg: 0.341 ± 0.055
0.431TrpSer: 0.431 ± 0.05
0.422TrpThr: 0.422 ± 0.055
0.377TrpVal: 0.377 ± 0.054
0.054TrpTrp: 0.054 ± 0.02
0.368TrpTyr: 0.368 ± 0.055
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.244TyrAla: 2.244 ± 0.144
0.781TyrCys: 0.781 ± 0.088
2.154TyrAsp: 2.154 ± 0.132
2.154TyrGlu: 2.154 ± 0.154
2.433TyrPhe: 2.433 ± 0.194
2.845TyrGly: 2.845 ± 0.144
0.96TyrHis: 0.96 ± 0.087
6.634TyrIle: 6.634 ± 0.297
5.161TyrLys: 5.161 ± 0.255
4.282TyrLeu: 4.282 ± 0.2
1.14TyrMet: 1.14 ± 0.101
5.0TyrAsn: 5.0 ± 0.209
1.266TyrPro: 1.266 ± 0.11
1.041TyrGln: 1.041 ± 0.112
1.589TyrArg: 1.589 ± 0.123
2.693TyrSer: 2.693 ± 0.178
1.993TyrThr: 1.993 ± 0.13
1.975TyrVal: 1.975 ± 0.138
0.395TyrTrp: 0.395 ± 0.069
2.46TyrTyr: 2.46 ± 0.167
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 330 proteins (111405 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski