Amino acid dipepetide frequency for Actinomadura mexicana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.497AlaAla: 22.497 ± 0.15	1.146AlaCys: 1.146 ± 0.022	8.014AlaAsp: 8.014 ± 0.058	8.917AlaGlu: 8.917 ± 0.08	3.783AlaPhe: 3.783 ± 0.038	14.383AlaGly: 14.383 ± 0.102	2.663AlaHis: 2.663 ± 0.033	3.899AlaIle: 3.899 ± 0.04	2.53AlaLys: 2.53 ± 0.037	14.531AlaLeu: 14.531 ± 0.089	2.682AlaMet: 2.682 ± 0.035	1.805AlaAsn: 1.805 ± 0.028	7.276AlaPro: 7.276 ± 0.074	3.406AlaGln: 3.406 ± 0.043	11.496AlaArg: 11.496 ± 0.078	5.919AlaSer: 5.919 ± 0.049	6.294AlaThr: 6.294 ± 0.056	12.184AlaVal: 12.184 ± 0.082	1.953AlaTrp: 1.953 ± 0.028	2.592AlaTyr: 2.592 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.033CysAla: 1.033 ± 0.021	0.098CysCys: 0.098 ± 0.007	0.518CysAsp: 0.518 ± 0.014	0.435CysGlu: 0.435 ± 0.013	0.207CysPhe: 0.207 ± 0.009	1.003CysGly: 1.003 ± 0.021	0.204CysHis: 0.204 ± 0.009	0.143CysIle: 0.143 ± 0.007	0.113CysLys: 0.113 ± 0.007	0.703CysLeu: 0.703 ± 0.016	0.14CysMet: 0.14 ± 0.008	0.125CysAsn: 0.125 ± 0.007	0.497CysPro: 0.497 ± 0.015	0.168CysGln: 0.168 ± 0.009	0.641CysArg: 0.641 ± 0.016	0.399CysSer: 0.399 ± 0.013	0.461CysThr: 0.461 ± 0.014	0.679CysVal: 0.679 ± 0.015	0.123CysTrp: 0.123 ± 0.007	0.174CysTyr: 0.174 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.715AspAla: 7.715 ± 0.056	0.395AspCys: 0.395 ± 0.013	3.763AspAsp: 3.763 ± 0.042	4.003AspGlu: 4.003 ± 0.052	1.536AspPhe: 1.536 ± 0.023	6.401AspGly: 6.401 ± 0.055	1.391AspHis: 1.391 ± 0.02	1.743AspIle: 1.743 ± 0.026	1.0AspLys: 1.0 ± 0.024	6.701AspLeu: 6.701 ± 0.057	0.929AspMet: 0.929 ± 0.02	0.811AspAsn: 0.811 ± 0.02	4.73AspPro: 4.73 ± 0.052	1.5AspGln: 1.5 ± 0.023	5.488AspArg: 5.488 ± 0.045	2.049AspSer: 2.049 ± 0.032	2.574AspThr: 2.574 ± 0.033	5.149AspVal: 5.149 ± 0.047	0.929AspTrp: 0.929 ± 0.019	1.102AspTyr: 1.102 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.462GluAla: 7.462 ± 0.071	0.374GluCys: 0.374 ± 0.013	2.92GluAsp: 2.92 ± 0.038	3.453GluGlu: 3.453 ± 0.048	1.487GluPhe: 1.487 ± 0.024	4.285GluGly: 4.285 ± 0.041	1.599GluHis: 1.599 ± 0.027	2.433GluIle: 2.433 ± 0.034	1.208GluLys: 1.208 ± 0.024	6.455GluLeu: 6.455 ± 0.057	1.037GluMet: 1.037 ± 0.022	0.971GluAsn: 0.971 ± 0.018	3.687GluPro: 3.687 ± 0.045	2.0GluGln: 2.0 ± 0.031	6.115GluArg: 6.115 ± 0.057	2.451GluSer: 2.451 ± 0.035	2.895GluThr: 2.895 ± 0.039	4.516GluVal: 4.516 ± 0.048	0.779GluTrp: 0.779 ± 0.017	1.087GluTyr: 1.087 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.835PheAla: 3.835 ± 0.037	0.287PheCys: 0.287 ± 0.011	1.965PheAsp: 1.965 ± 0.029	1.514PheGlu: 1.514 ± 0.03	0.87PhePhe: 0.87 ± 0.02	3.174PheGly: 3.174 ± 0.036	0.61PheHis: 0.61 ± 0.016	0.705PheIle: 0.705 ± 0.014	0.451PheLys: 0.451 ± 0.015	2.583PheLeu: 2.583 ± 0.037	0.43PheMet: 0.43 ± 0.014	0.538PheAsn: 0.538 ± 0.016	1.42PhePro: 1.42 ± 0.025	0.71PheGln: 0.71 ± 0.019	1.95PheArg: 1.95 ± 0.025	1.352PheSer: 1.352 ± 0.026	1.907PheThr: 1.907 ± 0.031	2.326PheVal: 2.326 ± 0.028	0.43PheTrp: 0.43 ± 0.013	0.573PheTyr: 0.573 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	11.734GlyAla: 11.734 ± 0.076	0.842GlyCys: 0.842 ± 0.016	5.708GlyAsp: 5.708 ± 0.049	5.45GlyGlu: 5.45 ± 0.054	2.896GlyPhe: 2.896 ± 0.034	9.699GlyGly: 9.699 ± 0.085	2.291GlyHis: 2.291 ± 0.036	3.221GlyIle: 3.221 ± 0.04	2.246GlyLys: 2.246 ± 0.033	9.969GlyLeu: 9.969 ± 0.067	2.138GlyMet: 2.138 ± 0.026	1.614GlyAsn: 1.614 ± 0.027	5.713GlyPro: 5.713 ± 0.05	2.474GlyGln: 2.474 ± 0.04	9.023GlyArg: 9.023 ± 0.07	4.919GlySer: 4.919 ± 0.047	5.891GlyThr: 5.891 ± 0.057	7.762GlyVal: 7.762 ± 0.057	1.739GlyTrp: 1.739 ± 0.026	2.21GlyTyr: 2.21 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.657HisAla: 2.657 ± 0.033	0.212HisCys: 0.212 ± 0.009	1.34HisAsp: 1.34 ± 0.023	1.159HisGlu: 1.159 ± 0.021	0.574HisPhe: 0.574 ± 0.018	2.384HisGly: 2.384 ± 0.034	0.637HisHis: 0.637 ± 0.016	0.637HisIle: 0.637 ± 0.015	0.289HisLys: 0.289 ± 0.01	2.368HisLeu: 2.368 ± 0.03	0.374HisMet: 0.374 ± 0.011	0.332HisAsn: 0.332 ± 0.011	1.697HisPro: 1.697 ± 0.027	0.552HisGln: 0.552 ± 0.015	2.115HisArg: 2.115 ± 0.03	0.876HisSer: 0.876 ± 0.017	1.03HisThr: 1.03 ± 0.022	1.771HisVal: 1.771 ± 0.029	0.354HisTrp: 0.354 ± 0.013	0.479HisTyr: 0.479 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.989IleAla: 4.989 ± 0.044	0.286IleCys: 0.286 ± 0.01	2.267IleAsp: 2.267 ± 0.026	2.115IleGlu: 2.115 ± 0.027	0.764IlePhe: 0.764 ± 0.02	3.66IleGly: 3.66 ± 0.043	0.564IleHis: 0.564 ± 0.016	0.978IleIle: 0.978 ± 0.022	0.647IleLys: 0.647 ± 0.018	2.527IleLeu: 2.527 ± 0.036	0.52IleMet: 0.52 ± 0.016	0.648IleAsn: 0.648 ± 0.019	1.761IlePro: 1.761 ± 0.026	0.702IleGln: 0.702 ± 0.017	2.371IleArg: 2.371 ± 0.035	1.598IleSer: 1.598 ± 0.028	2.169IleThr: 2.169 ± 0.031	3.113IleVal: 3.113 ± 0.038	0.374IleTrp: 0.374 ± 0.013	0.517IleTyr: 0.517 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.71LysAla: 2.71 ± 0.039	0.106LysCys: 0.106 ± 0.006	1.126LysAsp: 1.126 ± 0.025	0.975LysGlu: 0.975 ± 0.024	0.4LysPhe: 0.4 ± 0.012	1.697LysGly: 1.697 ± 0.029	0.376LysHis: 0.376 ± 0.011	0.919LysIle: 0.919 ± 0.019	0.667LysLys: 0.667 ± 0.017	1.662LysLeu: 1.662 ± 0.025	0.366LysMet: 0.366 ± 0.011	0.424LysAsn: 0.424 ± 0.015	1.234LysPro: 1.234 ± 0.024	0.57LysGln: 0.57 ± 0.018	1.42LysArg: 1.42 ± 0.025	0.987LysSer: 0.987 ± 0.018	1.117LysThr: 1.117 ± 0.024	1.78LysVal: 1.78 ± 0.026	0.244LysTrp: 0.244 ± 0.01	0.379LysTyr: 0.379 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.782LeuAla: 15.782 ± 0.106	0.791LeuCys: 0.791 ± 0.016	6.932LeuAsp: 6.932 ± 0.058	4.978LeuGlu: 4.978 ± 0.05	2.618LeuPhe: 2.618 ± 0.034	9.454LeuGly: 9.454 ± 0.071	2.133LeuHis: 2.133 ± 0.029	3.26LeuIle: 3.26 ± 0.04	1.793LeuLys: 1.793 ± 0.032	10.984LeuLeu: 10.984 ± 0.087	1.658LeuMet: 1.658 ± 0.026	1.719LeuAsn: 1.719 ± 0.028	6.386LeuPro: 6.386 ± 0.051	2.075LeuGln: 2.075 ± 0.029	9.323LeuArg: 9.323 ± 0.066	5.072LeuSer: 5.072 ± 0.039	6.277LeuThr: 6.277 ± 0.049	8.994LeuVal: 8.994 ± 0.063	1.258LeuTrp: 1.258 ± 0.024	1.805LeuTyr: 1.805 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.482MetAla: 2.482 ± 0.035	0.136MetCys: 0.136 ± 0.007	0.972MetAsp: 0.972 ± 0.019	0.809MetGlu: 0.809 ± 0.021	0.52MetPhe: 0.52 ± 0.015	1.376MetGly: 1.376 ± 0.026	0.37MetHis: 0.37 ± 0.012	0.774MetIle: 0.774 ± 0.018	0.418MetLys: 0.418 ± 0.014	1.901MetLeu: 1.901 ± 0.029	0.325MetMet: 0.325 ± 0.012	0.426MetAsn: 0.426 ± 0.014	1.245MetPro: 1.245 ± 0.022	0.416MetGln: 0.416 ± 0.013	1.694MetArg: 1.694 ± 0.026	1.345MetSer: 1.345 ± 0.024	1.586MetThr: 1.586 ± 0.022	1.411MetVal: 1.411 ± 0.023	0.231MetTrp: 0.231 ± 0.01	0.295MetTyr: 0.295 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.179AsnAla: 2.179 ± 0.035	0.152AsnCys: 0.152 ± 0.007	0.904AsnAsp: 0.904 ± 0.021	0.835AsnGlu: 0.835 ± 0.021	0.436AsnPhe: 0.436 ± 0.014	1.805AsnGly: 1.805 ± 0.031	0.336AsnHis: 0.336 ± 0.013	0.581AsnIle: 0.581 ± 0.015	0.347AsnLys: 0.347 ± 0.013	1.654AsnLeu: 1.654 ± 0.027	0.298AsnMet: 0.298 ± 0.011	0.316AsnAsn: 0.316 ± 0.013	1.268AsnPro: 1.268 ± 0.024	0.458AsnGln: 0.458 ± 0.014	1.268AsnArg: 1.268 ± 0.019	0.714AsnSer: 0.714 ± 0.018	0.947AsnThr: 0.947 ± 0.025	1.438AsnVal: 1.438 ± 0.023	0.273AsnTrp: 0.273 ± 0.01	0.382AsnTyr: 0.382 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	8.935ProAla: 8.935 ± 0.065	0.369ProCys: 0.369 ± 0.013	4.601ProAsp: 4.601 ± 0.044	4.331ProGlu: 4.331 ± 0.048	1.623ProPhe: 1.623 ± 0.025	7.426ProGly: 7.426 ± 0.059	1.319ProHis: 1.319 ± 0.022	1.532ProIle: 1.532 ± 0.023	1.18ProLys: 1.18 ± 0.024	5.331ProLeu: 5.331 ± 0.048	1.128ProMet: 1.128 ± 0.024	0.922ProAsn: 0.922 ± 0.018	4.549ProPro: 4.549 ± 0.076	1.593ProGln: 1.593 ± 0.031	4.432ProArg: 4.432 ± 0.043	3.449ProSer: 3.449 ± 0.042	2.729ProThr: 2.729 ± 0.036	5.467ProVal: 5.467 ± 0.046	0.918ProTrp: 0.918 ± 0.017	1.312ProTyr: 1.312 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.512GlnAla: 3.512 ± 0.044	0.164GlnCys: 0.164 ± 0.008	1.298GlnAsp: 1.298 ± 0.025	1.352GlnGlu: 1.352 ± 0.023	0.65GlnPhe: 0.65 ± 0.016	2.2GlnGly: 2.2 ± 0.032	0.532GlnHis: 0.532 ± 0.016	1.19GlnIle: 1.19 ± 0.022	0.54GlnLys: 0.54 ± 0.015	2.376GlnLeu: 2.376 ± 0.033	0.516GlnMet: 0.516 ± 0.015	0.505GlnAsn: 0.505 ± 0.016	1.488GlnPro: 1.488 ± 0.03	0.991GlnGln: 0.991 ± 0.031	2.295GlnArg: 2.295 ± 0.032	1.102GlnSer: 1.102 ± 0.023	1.273GlnThr: 1.273 ± 0.025	2.374GlnVal: 2.374 ± 0.029	0.392GlnTrp: 0.392 ± 0.013	0.498GlnTyr: 0.498 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.907ArgAla: 10.907 ± 0.081	0.621ArgCys: 0.621 ± 0.019	5.048ArgAsp: 5.048 ± 0.045	5.098ArgGlu: 5.098 ± 0.051	2.594ArgPhe: 2.594 ± 0.033	6.5ArgGly: 6.5 ± 0.057	2.226ArgHis: 2.226 ± 0.029	3.277ArgIle: 3.277 ± 0.033	1.547ArgLys: 1.547 ± 0.026	10.053ArgLeu: 10.053 ± 0.077	1.959ArgMet: 1.959 ± 0.032	1.384ArgAsn: 1.384 ± 0.02	5.886ArgPro: 5.886 ± 0.052	2.292ArgGln: 2.292 ± 0.032	9.26ArgArg: 9.26 ± 0.078	4.185ArgSer: 4.185 ± 0.045	5.169ArgThr: 5.169 ± 0.05	6.474ArgVal: 6.474 ± 0.053	1.494ArgTrp: 1.494 ± 0.026	1.947ArgTyr: 1.947 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.26SerAla: 6.26 ± 0.048	0.38SerCys: 0.38 ± 0.011	2.522SerAsp: 2.522 ± 0.031	2.315SerGlu: 2.315 ± 0.035	1.461SerPhe: 1.461 ± 0.026	5.854SerGly: 5.854 ± 0.052	0.901SerHis: 0.901 ± 0.021	1.485SerIle: 1.485 ± 0.023	0.922SerLys: 0.922 ± 0.021	4.577SerLeu: 4.577 ± 0.043	1.096SerMet: 1.096 ± 0.019	0.777SerAsn: 0.777 ± 0.018	3.234SerPro: 3.234 ± 0.043	1.135SerGln: 1.135 ± 0.02	3.874SerArg: 3.874 ± 0.042	2.556SerSer: 2.556 ± 0.036	2.589SerThr: 2.589 ± 0.034	3.924SerVal: 3.924 ± 0.037	0.839SerTrp: 0.839 ± 0.019	1.067SerTyr: 1.067 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	7.9ThrAla: 7.9 ± 0.061	0.434ThrCys: 0.434 ± 0.012	2.93ThrAsp: 2.93 ± 0.03	2.834ThrGlu: 2.834 ± 0.032	1.613ThrPhe: 1.613 ± 0.026	6.518ThrGly: 6.518 ± 0.051	0.978ThrHis: 0.978 ± 0.018	1.804ThrIle: 1.804 ± 0.023	0.947ThrLys: 0.947 ± 0.021	5.372ThrLeu: 5.372 ± 0.045	1.049ThrMet: 1.049 ± 0.021	0.875ThrAsn: 0.875 ± 0.018	3.611ThrPro: 3.611 ± 0.043	1.115ThrGln: 1.115 ± 0.021	4.06ThrArg: 4.06 ± 0.032	2.846ThrSer: 2.846 ± 0.037	3.098ThrThr: 3.098 ± 0.045	5.42ThrVal: 5.42 ± 0.046	0.869ThrTrp: 0.869 ± 0.018	1.127ThrTyr: 1.127 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	11.184ValAla: 11.184 ± 0.071	0.745ValCys: 0.745 ± 0.018	4.886ValAsp: 4.886 ± 0.05	4.779ValGlu: 4.779 ± 0.049	2.503ValPhe: 2.503 ± 0.03	6.47ValGly: 6.47 ± 0.049	1.953ValHis: 1.953 ± 0.026	2.95ValIle: 2.95 ± 0.038	1.619ValLys: 1.619 ± 0.025	9.697ValLeu: 9.697 ± 0.075	1.508ValMet: 1.508 ± 0.026	1.647ValAsn: 1.647 ± 0.03	5.588ValPro: 5.588 ± 0.05	2.049ValGln: 2.049 ± 0.026	7.639ValArg: 7.639 ± 0.058	4.174ValSer: 4.174 ± 0.035	5.276ValThr: 5.276 ± 0.046	7.997ValVal: 7.997 ± 0.068	1.111ValTrp: 1.111 ± 0.022	1.552ValTyr: 1.552 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.675TrpAla: 1.675 ± 0.026	0.141TrpCys: 0.141 ± 0.007	0.85TrpAsp: 0.85 ± 0.02	0.714TrpGlu: 0.714 ± 0.018	0.483TrpPhe: 0.483 ± 0.014	1.061TrpGly: 1.061 ± 0.019	0.38TrpHis: 0.38 ± 0.012	0.552TrpIle: 0.552 ± 0.016	0.337TrpLys: 0.337 ± 0.012	1.712TrpLeu: 1.712 ± 0.028	0.287TrpMet: 0.287 ± 0.009	0.381TrpAsn: 0.381 ± 0.012	0.864TrpPro: 0.864 ± 0.021	0.493TrpGln: 0.493 ± 0.015	1.533TrpArg: 1.533 ± 0.027	0.85TrpSer: 0.85 ± 0.018	1.062TrpThr: 1.062 ± 0.018	0.925TrpVal: 0.925 ± 0.02	0.345TrpTrp: 0.345 ± 0.012	0.338TrpTyr: 0.338 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.519TyrAla: 2.519 ± 0.033	0.185TyrCys: 0.185 ± 0.009	1.344TyrAsp: 1.344 ± 0.023	1.151TyrGlu: 1.151 ± 0.019	0.609TyrPhe: 0.609 ± 0.016	2.192TyrGly: 2.192 ± 0.03	0.374TyrHis: 0.374 ± 0.013	0.485TyrIle: 0.485 ± 0.016	0.357TyrLys: 0.357 ± 0.011	2.139TyrLeu: 2.139 ± 0.033	0.29TyrMet: 0.29 ± 0.011	0.372TyrAsn: 0.372 ± 0.012	1.011TyrPro: 1.011 ± 0.021	0.549TyrGln: 0.549 ± 0.016	1.925TyrArg: 1.925 ± 0.026	0.924TyrSer: 0.924 ± 0.02	1.056TyrThr: 1.056 ± 0.021	1.624TyrVal: 1.624 ± 0.024	0.33TyrTrp: 0.33 ± 0.012	0.46TyrTyr: 0.46 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8033 proteins (2593954 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---