Amino acid dipepetide frequency for Mycobacterium virus Kssjeb

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.703AlaAla: 13.703 ± 1.538
0.744AlaCys: 0.744 ± 0.242
7.068AlaAsp: 7.068 ± 0.696
6.014AlaGlu: 6.014 ± 0.574
3.596AlaPhe: 3.596 ± 0.53
7.75AlaGly: 7.75 ± 0.912
1.736AlaHis: 1.736 ± 0.395
4.526AlaIle: 4.526 ± 0.588
4.03AlaLys: 4.03 ± 0.603
9.115AlaLeu: 9.115 ± 0.801
2.852AlaMet: 2.852 ± 0.417
2.48AlaAsn: 2.48 ± 0.459
4.588AlaPro: 4.588 ± 0.682
2.976AlaGln: 2.976 ± 0.442
6.262AlaArg: 6.262 ± 0.708
5.022AlaSer: 5.022 ± 0.606
5.58AlaThr: 5.58 ± 0.613
8.805AlaVal: 8.805 ± 0.743
1.86AlaTrp: 1.86 ± 0.32
2.79AlaTyr: 2.79 ± 0.385
0.0AlaXaa: 0.0 ± 0.0
Cys
0.62CysAla: 0.62 ± 0.187
0.0CysCys: 0.0 ± 0.0
0.372CysAsp: 0.372 ± 0.158
0.682CysGlu: 0.682 ± 0.192
0.186CysPhe: 0.186 ± 0.085
0.806CysGly: 0.806 ± 0.273
0.186CysHis: 0.186 ± 0.126
0.31CysIle: 0.31 ± 0.145
0.372CysLys: 0.372 ± 0.167
0.496CysLeu: 0.496 ± 0.225
0.124CysMet: 0.124 ± 0.094
0.186CysAsn: 0.186 ± 0.113
0.248CysPro: 0.248 ± 0.121
0.186CysGln: 0.186 ± 0.114
0.434CysArg: 0.434 ± 0.147
0.372CysSer: 0.372 ± 0.139
0.31CysThr: 0.31 ± 0.125
0.496CysVal: 0.496 ± 0.211
0.248CysTrp: 0.248 ± 0.129
0.124CysTyr: 0.124 ± 0.089
0.0CysXaa: 0.0 ± 0.0
Asp
6.076AspAla: 6.076 ± 0.625
0.434AspCys: 0.434 ± 0.147
4.092AspAsp: 4.092 ± 0.513
4.03AspGlu: 4.03 ± 0.53
1.984AspPhe: 1.984 ± 0.363
6.138AspGly: 6.138 ± 0.63
1.054AspHis: 1.054 ± 0.29
2.79AspIle: 2.79 ± 0.439
2.604AspLys: 2.604 ± 0.5
7.068AspLeu: 7.068 ± 0.697
0.992AspMet: 0.992 ± 0.214
1.736AspAsn: 1.736 ± 0.364
5.456AspPro: 5.456 ± 0.695
1.674AspGln: 1.674 ± 0.398
3.72AspArg: 3.72 ± 0.403
3.41AspSer: 3.41 ± 0.526
4.154AspThr: 4.154 ± 0.449
4.588AspVal: 4.588 ± 0.49
1.86AspTrp: 1.86 ± 0.323
1.984AspTyr: 1.984 ± 0.346
0.0AspXaa: 0.0 ± 0.0
Glu
6.386GluAla: 6.386 ± 0.913
0.248GluCys: 0.248 ± 0.148
4.712GluAsp: 4.712 ± 0.565
4.898GluGlu: 4.898 ± 0.581
2.046GluPhe: 2.046 ± 0.361
3.658GluGly: 3.658 ± 0.428
1.55GluHis: 1.55 ± 0.307
3.286GluIle: 3.286 ± 0.445
2.666GluLys: 2.666 ± 0.489
7.068GluLeu: 7.068 ± 0.674
1.736GluMet: 1.736 ± 0.351
1.612GluAsn: 1.612 ± 0.367
2.356GluPro: 2.356 ± 0.422
2.294GluGln: 2.294 ± 0.367
3.658GluArg: 3.658 ± 0.523
3.596GluSer: 3.596 ± 0.438
4.03GluThr: 4.03 ± 0.521
5.084GluVal: 5.084 ± 0.569
1.736GluTrp: 1.736 ± 0.312
2.728GluTyr: 2.728 ± 0.52
0.0GluXaa: 0.0 ± 0.0
Phe
2.418PheAla: 2.418 ± 0.327
0.434PheCys: 0.434 ± 0.18
2.914PheAsp: 2.914 ± 0.448
2.294PheGlu: 2.294 ± 0.374
0.558PhePhe: 0.558 ± 0.163
3.472PheGly: 3.472 ± 0.478
0.744PheHis: 0.744 ± 0.26
1.302PheIle: 1.302 ± 0.29
1.24PheLys: 1.24 ± 0.299
2.542PheLeu: 2.542 ± 0.417
0.806PheMet: 0.806 ± 0.222
1.116PheAsn: 1.116 ± 0.264
1.488PhePro: 1.488 ± 0.345
0.93PheGln: 0.93 ± 0.24
1.736PheArg: 1.736 ± 0.348
2.294PheSer: 2.294 ± 0.581
1.984PheThr: 1.984 ± 0.385
2.108PheVal: 2.108 ± 0.371
0.682PheTrp: 0.682 ± 0.206
0.93PheTyr: 0.93 ± 0.235
0.0PheXaa: 0.0 ± 0.0
Gly
7.44GlyAla: 7.44 ± 1.017
0.868GlyCys: 0.868 ± 0.213
6.076GlyAsp: 6.076 ± 0.591
4.278GlyGlu: 4.278 ± 0.554
3.038GlyPhe: 3.038 ± 0.509
9.239GlyGly: 9.239 ± 2.1
1.86GlyHis: 1.86 ± 0.324
4.65GlyIle: 4.65 ± 0.726
3.782GlyLys: 3.782 ± 0.565
7.502GlyLeu: 7.502 ± 1.005
1.674GlyMet: 1.674 ± 0.363
3.162GlyAsn: 3.162 ± 0.443
3.782GlyPro: 3.782 ± 0.484
2.666GlyGln: 2.666 ± 0.371
4.588GlyArg: 4.588 ± 0.558
6.758GlySer: 6.758 ± 0.872
5.208GlyThr: 5.208 ± 0.635
5.146GlyVal: 5.146 ± 0.6
2.666GlyTrp: 2.666 ± 0.37
2.852GlyTyr: 2.852 ± 0.423
0.0GlyXaa: 0.0 ± 0.0
His
1.922HisAla: 1.922 ± 0.4
0.186HisCys: 0.186 ± 0.138
1.116HisAsp: 1.116 ± 0.208
1.736HisGlu: 1.736 ± 0.386
0.744HisPhe: 0.744 ± 0.202
1.612HisGly: 1.612 ± 0.396
0.744HisHis: 0.744 ± 0.203
0.744HisIle: 0.744 ± 0.226
1.116HisLys: 1.116 ± 0.292
1.302HisLeu: 1.302 ± 0.351
0.062HisMet: 0.062 ± 0.057
0.372HisAsn: 0.372 ± 0.128
1.364HisPro: 1.364 ± 0.222
0.868HisGln: 0.868 ± 0.229
1.55HisArg: 1.55 ± 0.32
0.682HisSer: 0.682 ± 0.194
1.116HisThr: 1.116 ± 0.306
1.798HisVal: 1.798 ± 0.336
0.434HisTrp: 0.434 ± 0.161
0.558HisTyr: 0.558 ± 0.185
0.0HisXaa: 0.0 ± 0.0
Ile
6.262IleAla: 6.262 ± 0.861
0.248IleCys: 0.248 ± 0.123
3.41IleAsp: 3.41 ± 0.352
3.596IleGlu: 3.596 ± 0.4
0.992IlePhe: 0.992 ± 0.268
3.782IleGly: 3.782 ± 0.487
0.93IleHis: 0.93 ± 0.241
1.736IleIle: 1.736 ± 0.274
1.86IleLys: 1.86 ± 0.304
3.596IleLeu: 3.596 ± 0.437
0.62IleMet: 0.62 ± 0.167
1.922IleAsn: 1.922 ± 0.331
3.162IlePro: 3.162 ± 0.376
1.612IleGln: 1.612 ± 0.44
3.472IleArg: 3.472 ± 0.433
3.41IleSer: 3.41 ± 0.531
3.1IleThr: 3.1 ± 0.473
2.976IleVal: 2.976 ± 0.524
0.744IleTrp: 0.744 ± 0.19
1.798IleTyr: 1.798 ± 0.289
0.0IleXaa: 0.0 ± 0.0
Lys
3.906LysAla: 3.906 ± 0.536
0.496LysCys: 0.496 ± 0.175
2.666LysAsp: 2.666 ± 0.45
1.922LysGlu: 1.922 ± 0.379
1.488LysPhe: 1.488 ± 0.299
2.48LysGly: 2.48 ± 0.402
1.302LysHis: 1.302 ± 0.287
2.356LysIle: 2.356 ± 0.494
1.922LysLys: 1.922 ± 0.396
3.286LysLeu: 3.286 ± 0.508
0.806LysMet: 0.806 ± 0.175
1.488LysAsn: 1.488 ± 0.29
2.542LysPro: 2.542 ± 0.405
1.364LysGln: 1.364 ± 0.333
3.1LysArg: 3.1 ± 0.533
2.418LysSer: 2.418 ± 0.438
2.17LysThr: 2.17 ± 0.377
3.286LysVal: 3.286 ± 0.457
0.62LysTrp: 0.62 ± 0.229
1.116LysTyr: 1.116 ± 0.299
0.0LysXaa: 0.0 ± 0.0
Leu
9.611LeuAla: 9.611 ± 0.939
0.434LeuCys: 0.434 ± 0.17
6.014LeuAsp: 6.014 ± 0.538
5.394LeuGlu: 5.394 ± 0.617
2.17LeuPhe: 2.17 ± 0.376
7.502LeuGly: 7.502 ± 0.813
1.612LeuHis: 1.612 ± 0.348
4.96LeuIle: 4.96 ± 0.647
3.782LeuLys: 3.782 ± 0.519
5.456LeuLeu: 5.456 ± 0.591
1.674LeuMet: 1.674 ± 0.322
2.666LeuAsn: 2.666 ± 0.394
5.456LeuPro: 5.456 ± 0.576
2.542LeuGln: 2.542 ± 0.401
6.262LeuArg: 6.262 ± 0.682
5.394LeuSer: 5.394 ± 0.478
6.076LeuThr: 6.076 ± 0.537
4.712LeuVal: 4.712 ± 0.603
1.178LeuTrp: 1.178 ± 0.336
2.294LeuTyr: 2.294 ± 0.435
0.0LeuXaa: 0.0 ± 0.0
Met
2.418MetAla: 2.418 ± 0.364
0.0MetCys: 0.0 ± 0.0
1.302MetAsp: 1.302 ± 0.289
1.488MetGlu: 1.488 ± 0.329
0.806MetPhe: 0.806 ± 0.225
1.55MetGly: 1.55 ± 0.316
0.372MetHis: 0.372 ± 0.133
0.434MetIle: 0.434 ± 0.163
1.054MetLys: 1.054 ± 0.261
1.426MetLeu: 1.426 ± 0.292
0.248MetMet: 0.248 ± 0.115
1.178MetAsn: 1.178 ± 0.234
1.24MetPro: 1.24 ± 0.28
0.434MetGln: 0.434 ± 0.147
1.178MetArg: 1.178 ± 0.248
1.984MetSer: 1.984 ± 0.365
2.046MetThr: 2.046 ± 0.317
1.116MetVal: 1.116 ± 0.304
0.248MetTrp: 0.248 ± 0.124
0.372MetTyr: 0.372 ± 0.157
0.0MetXaa: 0.0 ± 0.0
Asn
3.1AsnAla: 3.1 ± 0.456
0.062AsnCys: 0.062 ± 0.057
2.356AsnAsp: 2.356 ± 0.399
1.922AsnGlu: 1.922 ± 0.333
0.992AsnPhe: 0.992 ± 0.287
3.41AsnGly: 3.41 ± 0.511
0.62AsnHis: 0.62 ± 0.183
1.55AsnIle: 1.55 ± 0.432
0.496AsnLys: 0.496 ± 0.153
2.294AsnLeu: 2.294 ± 0.369
0.682AsnMet: 0.682 ± 0.179
0.868AsnAsn: 0.868 ± 0.204
2.852AsnPro: 2.852 ± 0.312
1.24AsnGln: 1.24 ± 0.261
1.798AsnArg: 1.798 ± 0.348
1.736AsnSer: 1.736 ± 0.323
1.736AsnThr: 1.736 ± 0.363
2.046AsnVal: 2.046 ± 0.378
0.62AsnTrp: 0.62 ± 0.178
1.178AsnTyr: 1.178 ± 0.308
0.0AsnXaa: 0.0 ± 0.0
Pro
5.27ProAla: 5.27 ± 0.617
0.558ProCys: 0.558 ± 0.225
4.588ProAsp: 4.588 ± 0.613
4.34ProGlu: 4.34 ± 0.588
2.294ProPhe: 2.294 ± 0.445
4.898ProGly: 4.898 ± 0.582
0.806ProHis: 0.806 ± 0.224
2.232ProIle: 2.232 ± 0.459
1.86ProLys: 1.86 ± 0.266
4.154ProLeu: 4.154 ± 0.543
0.806ProMet: 0.806 ± 0.248
1.922ProAsn: 1.922 ± 0.309
2.79ProPro: 2.79 ± 0.494
1.674ProGln: 1.674 ± 0.326
2.914ProArg: 2.914 ± 0.396
3.348ProSer: 3.348 ± 0.444
4.092ProThr: 4.092 ± 0.505
4.03ProVal: 4.03 ± 0.449
0.744ProTrp: 0.744 ± 0.25
1.674ProTyr: 1.674 ± 0.34
0.0ProXaa: 0.0 ± 0.0
Gln
3.286GlnAla: 3.286 ± 0.512
0.186GlnCys: 0.186 ± 0.116
1.24GlnAsp: 1.24 ± 0.263
1.922GlnGlu: 1.922 ± 0.344
1.054GlnPhe: 1.054 ± 0.23
2.728GlnGly: 2.728 ± 0.375
0.496GlnHis: 0.496 ± 0.18
2.914GlnIle: 2.914 ± 0.63
1.302GlnLys: 1.302 ± 0.297
3.906GlnLeu: 3.906 ± 0.499
0.868GlnMet: 0.868 ± 0.25
0.62GlnAsn: 0.62 ± 0.189
1.674GlnPro: 1.674 ± 0.353
2.108GlnGln: 2.108 ± 0.389
1.488GlnArg: 1.488 ± 0.349
1.674GlnSer: 1.674 ± 0.312
1.488GlnThr: 1.488 ± 0.297
2.356GlnVal: 2.356 ± 0.355
0.682GlnTrp: 0.682 ± 0.166
0.558GlnTyr: 0.558 ± 0.169
0.0GlnXaa: 0.0 ± 0.0
Arg
6.386ArgAla: 6.386 ± 0.776
0.558ArgCys: 0.558 ± 0.16
2.976ArgAsp: 2.976 ± 0.337
4.836ArgGlu: 4.836 ± 0.612
2.108ArgPhe: 2.108 ± 0.384
4.96ArgGly: 4.96 ± 0.478
1.364ArgHis: 1.364 ± 0.295
2.976ArgIle: 2.976 ± 0.447
3.162ArgLys: 3.162 ± 0.44
5.828ArgLeu: 5.828 ± 0.763
1.922ArgMet: 1.922 ± 0.405
2.294ArgAsn: 2.294 ± 0.438
2.48ArgPro: 2.48 ± 0.431
1.984ArgGln: 1.984 ± 0.372
5.27ArgArg: 5.27 ± 0.63
3.286ArgSer: 3.286 ± 0.46
2.914ArgThr: 2.914 ± 0.448
4.898ArgVal: 4.898 ± 0.535
1.426ArgTrp: 1.426 ± 0.345
1.798ArgTyr: 1.798 ± 0.275
0.0ArgXaa: 0.0 ± 0.0
Ser
5.642SerAla: 5.642 ± 0.687
0.372SerCys: 0.372 ± 0.159
2.914SerAsp: 2.914 ± 0.408
3.968SerGlu: 3.968 ± 0.461
1.922SerPhe: 1.922 ± 0.501
7.254SerGly: 7.254 ± 1.014
1.364SerHis: 1.364 ± 0.318
2.914SerIle: 2.914 ± 0.447
2.108SerLys: 2.108 ± 0.378
5.084SerLeu: 5.084 ± 0.649
1.736SerMet: 1.736 ± 0.348
2.17SerAsn: 2.17 ± 0.401
3.286SerPro: 3.286 ± 0.538
1.736SerGln: 1.736 ± 0.297
3.286SerArg: 3.286 ± 0.427
3.286SerSer: 3.286 ± 0.531
2.914SerThr: 2.914 ± 0.47
4.03SerVal: 4.03 ± 0.515
1.24SerTrp: 1.24 ± 0.332
1.55SerTyr: 1.55 ± 0.329
0.0SerXaa: 0.0 ± 0.0
Thr
6.262ThrAla: 6.262 ± 0.995
0.31ThrCys: 0.31 ± 0.141
3.906ThrAsp: 3.906 ± 0.49
4.03ThrGlu: 4.03 ± 0.513
1.984ThrPhe: 1.984 ± 0.371
7.13ThrGly: 7.13 ± 0.69
0.992ThrHis: 0.992 ± 0.292
3.038ThrIle: 3.038 ± 0.537
2.728ThrLys: 2.728 ± 0.425
5.456ThrLeu: 5.456 ± 0.627
0.868ThrMet: 0.868 ± 0.248
1.736ThrAsn: 1.736 ± 0.335
3.658ThrPro: 3.658 ± 0.536
1.612ThrGln: 1.612 ± 0.342
3.534ThrArg: 3.534 ± 0.519
3.472ThrSer: 3.472 ± 0.507
4.588ThrThr: 4.588 ± 0.619
4.898ThrVal: 4.898 ± 0.552
1.054ThrTrp: 1.054 ± 0.262
1.736ThrTyr: 1.736 ± 0.345
0.0ThrXaa: 0.0 ± 0.0
Val
6.82ValAla: 6.82 ± 0.699
0.248ValCys: 0.248 ± 0.102
5.518ValAsp: 5.518 ± 0.723
4.712ValGlu: 4.712 ± 0.592
2.48ValPhe: 2.48 ± 0.392
4.65ValGly: 4.65 ± 0.578
1.426ValHis: 1.426 ± 0.288
3.844ValIle: 3.844 ± 0.492
2.976ValLys: 2.976 ± 0.503
4.836ValLeu: 4.836 ± 0.586
1.302ValMet: 1.302 ± 0.352
2.356ValAsn: 2.356 ± 0.404
4.092ValPro: 4.092 ± 0.511
2.418ValGln: 2.418 ± 0.373
5.208ValArg: 5.208 ± 0.703
4.588ValSer: 4.588 ± 0.538
5.766ValThr: 5.766 ± 0.631
5.208ValVal: 5.208 ± 0.651
1.178ValTrp: 1.178 ± 0.264
1.922ValTyr: 1.922 ± 0.383
0.0ValXaa: 0.0 ± 0.0
Trp
1.674TrpAla: 1.674 ± 0.335
0.186TrpCys: 0.186 ± 0.104
1.302TrpAsp: 1.302 ± 0.281
0.992TrpGlu: 0.992 ± 0.227
0.744TrpPhe: 0.744 ± 0.195
1.55TrpGly: 1.55 ± 0.338
0.434TrpHis: 0.434 ± 0.154
1.24TrpIle: 1.24 ± 0.239
0.434TrpLys: 0.434 ± 0.192
1.984TrpLeu: 1.984 ± 0.303
0.496TrpMet: 0.496 ± 0.182
0.372TrpAsn: 0.372 ± 0.159
0.868TrpPro: 0.868 ± 0.286
1.116TrpGln: 1.116 ± 0.219
1.364TrpArg: 1.364 ± 0.386
0.868TrpSer: 0.868 ± 0.203
1.674TrpThr: 1.674 ± 0.344
1.984TrpVal: 1.984 ± 0.283
0.558TrpTrp: 0.558 ± 0.21
0.372TrpTyr: 0.372 ± 0.137
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.294TyrAla: 2.294 ± 0.424
0.186TyrCys: 0.186 ± 0.112
1.302TyrAsp: 1.302 ± 0.304
2.294TyrGlu: 2.294 ± 0.371
0.806TyrPhe: 0.806 ± 0.222
2.666TyrGly: 2.666 ± 0.452
0.434TyrHis: 0.434 ± 0.167
1.426TyrIle: 1.426 ± 0.343
1.24TyrLys: 1.24 ± 0.276
2.79TyrLeu: 2.79 ± 0.438
0.558TyrMet: 0.558 ± 0.162
1.302TyrAsn: 1.302 ± 0.309
1.612TyrPro: 1.612 ± 0.312
1.116TyrGln: 1.116 ± 0.269
2.666TyrArg: 2.666 ± 0.315
1.178TyrSer: 1.178 ± 0.276
2.046TyrThr: 2.046 ± 0.349
1.984TyrVal: 1.984 ± 0.329
0.434TyrTrp: 0.434 ± 0.198
0.806TyrTyr: 0.806 ± 0.244
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 92 proteins (16129 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski