Amino acid dipepetide frequency for Staphylococcus warneri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.498AlaAla: 0.498 ± 0.34
0.0AlaCys: 0.0 ± 0.0
2.239AlaAsp: 2.239 ± 0.694
1.244AlaGlu: 1.244 ± 0.468
1.244AlaPhe: 1.244 ± 0.454
1.742AlaGly: 1.742 ± 0.774
0.746AlaHis: 0.746 ± 0.434
3.483AlaIle: 3.483 ± 0.932
3.981AlaLys: 3.981 ± 0.96
2.986AlaLeu: 2.986 ± 0.865
1.991AlaMet: 1.991 ± 0.96
3.235AlaAsn: 3.235 ± 0.719
0.746AlaPro: 0.746 ± 0.492
1.742AlaGln: 1.742 ± 0.674
1.493AlaArg: 1.493 ± 0.651
3.981AlaSer: 3.981 ± 0.702
2.488AlaThr: 2.488 ± 0.802
2.488AlaVal: 2.488 ± 0.608
0.249AlaTrp: 0.249 ± 0.284
2.737AlaTyr: 2.737 ± 0.704
0.0AlaXaa: 0.0 ± 0.0
Cys
0.249CysAla: 0.249 ± 0.226
0.0CysCys: 0.0 ± 0.0
0.249CysAsp: 0.249 ± 0.277
0.746CysGlu: 0.746 ± 0.534
0.746CysPhe: 0.746 ± 0.483
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.995CysIle: 0.995 ± 0.498
0.498CysLys: 0.498 ± 0.311
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.498CysAsn: 0.498 ± 0.366
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.249CysThr: 0.249 ± 0.245
0.498CysVal: 0.498 ± 0.275
0.0CysTrp: 0.0 ± 0.0
0.498CysTyr: 0.498 ± 0.29
0.0CysXaa: 0.0 ± 0.0
Asp
1.991AspAla: 1.991 ± 0.927
0.746AspCys: 0.746 ± 0.457
4.23AspAsp: 4.23 ± 0.84
7.713AspGlu: 7.713 ± 1.493
3.732AspPhe: 3.732 ± 0.901
2.239AspGly: 2.239 ± 0.888
0.498AspHis: 0.498 ± 0.271
7.962AspIle: 7.962 ± 1.051
5.474AspLys: 5.474 ± 1.323
5.723AspLeu: 5.723 ± 1.691
1.244AspMet: 1.244 ± 0.528
4.976AspAsn: 4.976 ± 1.185
0.498AspPro: 0.498 ± 0.489
0.746AspGln: 0.746 ± 0.568
1.493AspArg: 1.493 ± 0.537
2.737AspSer: 2.737 ± 0.82
2.239AspThr: 2.239 ± 0.949
4.479AspVal: 4.479 ± 0.996
0.746AspTrp: 0.746 ± 0.34
3.235AspTyr: 3.235 ± 1.129
0.0AspXaa: 0.0 ± 0.0
Glu
3.235GluAla: 3.235 ± 1.162
0.249GluCys: 0.249 ± 0.287
3.483GluAsp: 3.483 ± 0.914
4.479GluGlu: 4.479 ± 0.935
4.728GluPhe: 4.728 ± 1.401
2.488GluGly: 2.488 ± 0.997
1.493GluHis: 1.493 ± 0.531
6.967GluIle: 6.967 ± 1.26
6.967GluLys: 6.967 ± 0.91
10.45GluLeu: 10.45 ± 1.351
1.991GluMet: 1.991 ± 0.626
5.723GluAsn: 5.723 ± 1.445
1.244GluPro: 1.244 ± 0.523
4.728GluGln: 4.728 ± 1.147
2.986GluArg: 2.986 ± 0.776
3.235GluSer: 3.235 ± 0.893
3.732GluThr: 3.732 ± 1.145
3.235GluVal: 3.235 ± 0.701
1.991GluTrp: 1.991 ± 0.841
4.976GluTyr: 4.976 ± 1.076
0.0GluXaa: 0.0 ± 0.0
Phe
0.995PheAla: 0.995 ± 0.378
0.249PheCys: 0.249 ± 0.196
2.737PheAsp: 2.737 ± 0.943
5.474PheGlu: 5.474 ± 1.291
1.742PhePhe: 1.742 ± 0.693
1.742PheGly: 1.742 ± 0.447
0.249PheHis: 0.249 ± 0.22
3.732PheIle: 3.732 ± 0.77
7.216PheLys: 7.216 ± 1.255
2.986PheLeu: 2.986 ± 0.794
1.742PheMet: 1.742 ± 0.649
5.972PheAsn: 5.972 ± 1.325
0.498PhePro: 0.498 ± 0.3
0.746PheGln: 0.746 ± 0.449
1.493PheArg: 1.493 ± 0.509
3.235PheSer: 3.235 ± 0.738
0.995PheThr: 0.995 ± 0.504
3.483PheVal: 3.483 ± 0.632
0.0PheTrp: 0.0 ± 0.0
1.493PheTyr: 1.493 ± 0.474
0.0PheXaa: 0.0 ± 0.0
Gly
0.995GlyAla: 0.995 ± 0.458
0.0GlyCys: 0.0 ± 0.0
2.488GlyAsp: 2.488 ± 0.822
2.986GlyGlu: 2.986 ± 0.817
2.239GlyPhe: 2.239 ± 0.49
0.746GlyGly: 0.746 ± 0.701
0.995GlyHis: 0.995 ± 0.567
2.488GlyIle: 2.488 ± 0.622
2.986GlyLys: 2.986 ± 1.052
3.483GlyLeu: 3.483 ± 0.9
0.995GlyMet: 0.995 ± 0.465
2.986GlyAsn: 2.986 ± 0.755
0.0GlyPro: 0.0 ± 0.0
1.244GlyGln: 1.244 ± 0.662
1.991GlyArg: 1.991 ± 0.835
1.742GlySer: 1.742 ± 0.668
0.746GlyThr: 0.746 ± 0.35
1.991GlyVal: 1.991 ± 0.727
0.249GlyTrp: 0.249 ± 0.236
2.737GlyTyr: 2.737 ± 0.755
0.0GlyXaa: 0.0 ± 0.0
His
1.493HisAla: 1.493 ± 0.785
0.249HisCys: 0.249 ± 0.226
1.244HisAsp: 1.244 ± 0.546
0.746HisGlu: 0.746 ± 0.534
1.244HisPhe: 1.244 ± 0.494
0.249HisGly: 0.249 ± 0.244
1.493HisHis: 1.493 ± 0.708
1.742HisIle: 1.742 ± 0.633
1.991HisLys: 1.991 ± 0.705
0.995HisLeu: 0.995 ± 0.454
0.498HisMet: 0.498 ± 0.396
1.742HisAsn: 1.742 ± 0.781
0.249HisPro: 0.249 ± 0.232
1.244HisGln: 1.244 ± 0.771
0.498HisArg: 0.498 ± 0.286
1.244HisSer: 1.244 ± 0.485
0.746HisThr: 0.746 ± 0.359
1.244HisVal: 1.244 ± 0.639
0.0HisTrp: 0.0 ± 0.0
1.244HisTyr: 1.244 ± 0.587
0.0HisXaa: 0.0 ± 0.0
Ile
4.728IleAla: 4.728 ± 1.032
0.746IleCys: 0.746 ± 0.36
5.474IleAsp: 5.474 ± 0.856
8.957IleGlu: 8.957 ± 1.951
3.981IlePhe: 3.981 ± 1.109
2.986IleGly: 2.986 ± 1.041
0.746IleHis: 0.746 ± 0.426
6.469IleIle: 6.469 ± 2.339
11.197IleLys: 11.197 ± 2.056
5.723IleLeu: 5.723 ± 1.231
2.239IleMet: 2.239 ± 0.791
8.46IleAsn: 8.46 ± 1.538
1.244IlePro: 1.244 ± 0.659
3.981IleGln: 3.981 ± 1.19
2.239IleArg: 2.239 ± 0.743
7.713IleSer: 7.713 ± 1.316
5.474IleThr: 5.474 ± 0.856
4.479IleVal: 4.479 ± 1.2
0.746IleTrp: 0.746 ± 0.459
4.23IleTyr: 4.23 ± 0.907
0.0IleXaa: 0.0 ± 0.0
Lys
3.732LysAla: 3.732 ± 1.158
0.249LysCys: 0.249 ± 0.277
6.967LysAsp: 6.967 ± 1.004
8.957LysGlu: 8.957 ± 1.49
2.737LysPhe: 2.737 ± 0.643
4.23LysGly: 4.23 ± 0.959
3.483LysHis: 3.483 ± 0.917
6.718LysIle: 6.718 ± 1.212
9.455LysLys: 9.455 ± 1.596
5.225LysLeu: 5.225 ± 0.786
3.981LysMet: 3.981 ± 0.852
11.694LysAsn: 11.694 ± 1.575
2.239LysPro: 2.239 ± 0.579
5.225LysGln: 5.225 ± 1.282
5.225LysArg: 5.225 ± 1.219
5.225LysSer: 5.225 ± 0.761
4.728LysThr: 4.728 ± 0.959
5.225LysVal: 5.225 ± 1.189
1.244LysTrp: 1.244 ± 0.42
4.23LysTyr: 4.23 ± 0.856
0.0LysXaa: 0.0 ± 0.0
Leu
3.235LeuAla: 3.235 ± 0.845
0.498LeuCys: 0.498 ± 0.329
4.728LeuAsp: 4.728 ± 1.369
6.22LeuGlu: 6.22 ± 1.07
3.732LeuPhe: 3.732 ± 0.875
2.986LeuGly: 2.986 ± 0.93
0.498LeuHis: 0.498 ± 0.303
9.206LeuIle: 9.206 ± 1.414
8.211LeuLys: 8.211 ± 1.218
6.718LeuLeu: 6.718 ± 1.469
1.244LeuMet: 1.244 ± 0.531
7.216LeuAsn: 7.216 ± 1.819
1.991LeuPro: 1.991 ± 0.761
1.991LeuGln: 1.991 ± 0.803
2.737LeuArg: 2.737 ± 0.796
9.455LeuSer: 9.455 ± 1.888
5.723LeuThr: 5.723 ± 1.217
4.728LeuVal: 4.728 ± 1.083
0.249LeuTrp: 0.249 ± 0.234
3.483LeuTyr: 3.483 ± 0.802
0.0LeuXaa: 0.0 ± 0.0
Met
1.493MetAla: 1.493 ± 0.629
0.0MetCys: 0.0 ± 0.0
1.493MetAsp: 1.493 ± 0.564
0.995MetGlu: 0.995 ± 0.494
1.244MetPhe: 1.244 ± 0.605
0.746MetGly: 0.746 ± 0.479
0.0MetHis: 0.0 ± 0.0
1.742MetIle: 1.742 ± 0.614
1.991MetLys: 1.991 ± 0.546
2.986MetLeu: 2.986 ± 0.859
0.249MetMet: 0.249 ± 0.22
3.235MetAsn: 3.235 ± 0.93
0.249MetPro: 0.249 ± 0.236
0.249MetGln: 0.249 ± 0.284
1.742MetArg: 1.742 ± 0.555
1.742MetSer: 1.742 ± 0.543
2.239MetThr: 2.239 ± 0.911
0.746MetVal: 0.746 ± 0.365
0.249MetTrp: 0.249 ± 0.226
1.493MetTyr: 1.493 ± 0.605
0.0MetXaa: 0.0 ± 0.0
Asn
3.235AsnAla: 3.235 ± 0.826
0.0AsnCys: 0.0 ± 0.0
7.465AsnAsp: 7.465 ± 1.332
6.718AsnGlu: 6.718 ± 1.511
4.23AsnPhe: 4.23 ± 1.168
3.235AsnGly: 3.235 ± 0.666
1.742AsnHis: 1.742 ± 0.633
8.46AsnIle: 8.46 ± 1.582
9.206AsnLys: 9.206 ± 1.551
5.972AsnLeu: 5.972 ± 1.384
1.742AsnMet: 1.742 ± 0.491
6.967AsnAsn: 6.967 ± 1.282
1.742AsnPro: 1.742 ± 0.635
2.737AsnGln: 2.737 ± 1.066
2.488AsnArg: 2.488 ± 0.802
3.235AsnSer: 3.235 ± 0.82
4.728AsnThr: 4.728 ± 1.105
4.976AsnVal: 4.976 ± 1.239
1.244AsnTrp: 1.244 ± 0.452
4.479AsnTyr: 4.479 ± 1.15
0.0AsnXaa: 0.0 ± 0.0
Pro
0.0ProAla: 0.0 ± 0.0
0.0ProCys: 0.0 ± 0.0
0.249ProAsp: 0.249 ± 0.245
0.995ProGlu: 0.995 ± 0.401
0.249ProPhe: 0.249 ± 0.245
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
2.239ProIle: 2.239 ± 0.808
3.235ProLys: 3.235 ± 0.799
2.737ProLeu: 2.737 ± 0.91
0.249ProMet: 0.249 ± 0.236
1.742ProAsn: 1.742 ± 0.572
0.249ProPro: 0.249 ± 0.25
0.498ProGln: 0.498 ± 0.3
0.249ProArg: 0.249 ± 0.25
2.488ProSer: 2.488 ± 0.682
1.742ProThr: 1.742 ± 0.538
0.995ProVal: 0.995 ± 0.502
0.0ProTrp: 0.0 ± 0.0
1.244ProTyr: 1.244 ± 0.512
0.0ProXaa: 0.0 ± 0.0
Gln
2.488GlnAla: 2.488 ± 0.987
0.498GlnCys: 0.498 ± 0.323
1.742GlnAsp: 1.742 ± 0.648
1.991GlnGlu: 1.991 ± 0.722
1.742GlnPhe: 1.742 ± 0.767
0.995GlnGly: 0.995 ± 0.405
1.244GlnHis: 1.244 ± 0.708
4.23GlnIle: 4.23 ± 0.889
2.239GlnLys: 2.239 ± 0.762
3.732GlnLeu: 3.732 ± 1.007
1.244GlnMet: 1.244 ± 0.827
0.995GlnAsn: 0.995 ± 0.453
1.244GlnPro: 1.244 ± 0.433
1.493GlnGln: 1.493 ± 0.673
1.493GlnArg: 1.493 ± 0.482
3.235GlnSer: 3.235 ± 0.635
1.742GlnThr: 1.742 ± 0.639
2.239GlnVal: 2.239 ± 0.598
0.498GlnTrp: 0.498 ± 0.34
1.991GlnTyr: 1.991 ± 0.563
0.0GlnXaa: 0.0 ± 0.0
Arg
0.995ArgAla: 0.995 ± 0.612
0.0ArgCys: 0.0 ± 0.0
1.991ArgAsp: 1.991 ± 0.677
2.488ArgGlu: 2.488 ± 0.761
2.239ArgPhe: 2.239 ± 0.767
1.742ArgGly: 1.742 ± 0.677
0.249ArgHis: 0.249 ± 0.226
2.986ArgIle: 2.986 ± 0.741
3.732ArgLys: 3.732 ± 1.026
2.239ArgLeu: 2.239 ± 0.561
0.995ArgMet: 0.995 ± 0.611
2.488ArgAsn: 2.488 ± 0.708
1.742ArgPro: 1.742 ± 0.663
1.991ArgGln: 1.991 ± 0.832
1.742ArgArg: 1.742 ± 0.601
1.991ArgSer: 1.991 ± 0.593
2.488ArgThr: 2.488 ± 0.869
1.493ArgVal: 1.493 ± 0.848
0.0ArgTrp: 0.0 ± 0.0
2.239ArgTyr: 2.239 ± 0.604
0.0ArgXaa: 0.0 ± 0.0
Ser
1.493SerAla: 1.493 ± 0.461
0.0SerCys: 0.0 ± 0.0
4.479SerAsp: 4.479 ± 0.807
4.479SerGlu: 4.479 ± 0.944
2.488SerPhe: 2.488 ± 0.805
2.737SerGly: 2.737 ± 0.651
1.991SerHis: 1.991 ± 0.876
7.962SerIle: 7.962 ± 1.481
6.718SerLys: 6.718 ± 1.394
6.967SerLeu: 6.967 ± 1.629
0.995SerMet: 0.995 ± 0.382
5.723SerAsn: 5.723 ± 1.444
1.244SerPro: 1.244 ± 0.487
2.737SerGln: 2.737 ± 0.903
1.991SerArg: 1.991 ± 0.542
3.235SerSer: 3.235 ± 0.867
3.235SerThr: 3.235 ± 0.948
5.225SerVal: 5.225 ± 0.873
0.0SerTrp: 0.0 ± 0.0
3.483SerTyr: 3.483 ± 0.881
0.0SerXaa: 0.0 ± 0.0
Thr
1.991ThrAla: 1.991 ± 0.517
0.249ThrCys: 0.249 ± 0.277
2.488ThrAsp: 2.488 ± 0.612
3.235ThrGlu: 3.235 ± 0.704
1.742ThrPhe: 1.742 ± 0.535
2.986ThrGly: 2.986 ± 0.826
0.995ThrHis: 0.995 ± 0.511
3.483ThrIle: 3.483 ± 0.871
3.981ThrLys: 3.981 ± 1.246
4.728ThrLeu: 4.728 ± 1.194
1.742ThrMet: 1.742 ± 0.563
4.23ThrAsn: 4.23 ± 0.897
0.746ThrPro: 0.746 ± 0.382
1.991ThrGln: 1.991 ± 0.585
1.244ThrArg: 1.244 ± 0.409
4.479ThrSer: 4.479 ± 1.067
2.239ThrThr: 2.239 ± 0.709
4.23ThrVal: 4.23 ± 0.852
0.249ThrTrp: 0.249 ± 0.226
3.483ThrTyr: 3.483 ± 0.806
0.0ThrXaa: 0.0 ± 0.0
Val
3.732ValAla: 3.732 ± 0.887
0.249ValCys: 0.249 ± 0.245
5.474ValAsp: 5.474 ± 1.164
4.976ValGlu: 4.976 ± 1.18
1.991ValPhe: 1.991 ± 0.726
0.746ValGly: 0.746 ± 0.377
0.746ValHis: 0.746 ± 0.366
5.723ValIle: 5.723 ± 0.967
5.474ValLys: 5.474 ± 1.045
5.474ValLeu: 5.474 ± 1.169
0.0ValMet: 0.0 ± 0.0
4.479ValAsn: 4.479 ± 1.137
1.742ValPro: 1.742 ± 0.72
2.239ValGln: 2.239 ± 0.609
1.493ValArg: 1.493 ± 0.618
4.479ValSer: 4.479 ± 0.797
2.737ValThr: 2.737 ± 0.625
1.493ValVal: 1.493 ± 0.467
0.249ValTrp: 0.249 ± 0.234
2.239ValTyr: 2.239 ± 0.587
0.0ValXaa: 0.0 ± 0.0
Trp
0.746TrpAla: 0.746 ± 0.412
0.249TrpCys: 0.249 ± 0.234
0.498TrpAsp: 0.498 ± 0.314
0.995TrpGlu: 0.995 ± 0.497
0.746TrpPhe: 0.746 ± 0.374
0.0TrpGly: 0.0 ± 0.0
0.249TrpHis: 0.249 ± 0.311
0.746TrpIle: 0.746 ± 0.361
0.498TrpLys: 0.498 ± 0.326
0.746TrpLeu: 0.746 ± 0.389
0.498TrpMet: 0.498 ± 0.301
0.249TrpAsn: 0.249 ± 0.238
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.746TrpArg: 0.746 ± 0.411
0.498TrpSer: 0.498 ± 0.262
0.249TrpThr: 0.249 ± 0.301
0.746TrpVal: 0.746 ± 0.385
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.991TyrAla: 1.991 ± 0.888
0.995TyrCys: 0.995 ± 0.359
2.986TyrAsp: 2.986 ± 0.726
3.981TyrGlu: 3.981 ± 0.733
3.981TyrPhe: 3.981 ± 1.137
1.493TyrGly: 1.493 ± 0.632
2.737TyrHis: 2.737 ± 0.968
4.479TyrIle: 4.479 ± 1.274
5.723TyrLys: 5.723 ± 1.282
4.976TyrLeu: 4.976 ± 1.674
0.995TyrMet: 0.995 ± 0.469
1.991TyrAsn: 1.991 ± 0.564
1.493TyrPro: 1.493 ± 0.723
1.493TyrGln: 1.493 ± 0.507
2.737TyrArg: 2.737 ± 0.491
3.235TyrSer: 3.235 ± 1.223
1.991TyrThr: 1.991 ± 0.635
1.742TyrVal: 1.742 ± 0.592
0.498TyrTrp: 0.498 ± 0.311
2.986TyrTyr: 2.986 ± 0.934
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 24 proteins (4020 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski