Amino acid dipepetide frequency for Peptoniphilus indolicus ATCC 29427

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.85AlaAla: 3.85 ± 0.103
0.642AlaCys: 0.642 ± 0.034
2.905AlaAsp: 2.905 ± 0.065
4.033AlaGlu: 4.033 ± 0.093
2.509AlaPhe: 2.509 ± 0.069
3.888AlaGly: 3.888 ± 0.104
0.901AlaHis: 0.901 ± 0.044
5.886AlaIle: 5.886 ± 0.106
5.186AlaLys: 5.186 ± 0.115
5.563AlaLeu: 5.563 ± 0.102
1.846AlaMet: 1.846 ± 0.056
2.811AlaAsn: 2.811 ± 0.062
1.529AlaPro: 1.529 ± 0.055
1.566AlaGln: 1.566 ± 0.051
2.236AlaArg: 2.236 ± 0.077
3.295AlaSer: 3.295 ± 0.075
3.07AlaThr: 3.07 ± 0.073
4.069AlaVal: 4.069 ± 0.094
0.315AlaTrp: 0.315 ± 0.024
2.036AlaTyr: 2.036 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.497CysAla: 0.497 ± 0.029
0.113CysCys: 0.113 ± 0.014
0.51CysAsp: 0.51 ± 0.033
0.58CysGlu: 0.58 ± 0.032
0.339CysPhe: 0.339 ± 0.029
0.906CysGly: 0.906 ± 0.042
0.19CysHis: 0.19 ± 0.019
0.746CysIle: 0.746 ± 0.033
0.639CysLys: 0.639 ± 0.032
0.746CysLeu: 0.746 ± 0.039
0.238CysMet: 0.238 ± 0.02
0.407CysAsn: 0.407 ± 0.022
0.398CysPro: 0.398 ± 0.026
0.19CysGln: 0.19 ± 0.018
0.286CysArg: 0.286 ± 0.02
0.634CysSer: 0.634 ± 0.036
0.444CysThr: 0.444 ± 0.03
0.596CysVal: 0.596 ± 0.036
0.042CysTrp: 0.042 ± 0.008
0.377CysTyr: 0.377 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
2.654AspAla: 2.654 ± 0.073
0.438AspCys: 0.438 ± 0.028
2.629AspAsp: 2.629 ± 0.076
5.216AspGlu: 5.216 ± 0.1
3.014AspPhe: 3.014 ± 0.065
3.763AspGly: 3.763 ± 0.077
0.614AspHis: 0.614 ± 0.034
5.419AspIle: 5.419 ± 0.086
5.083AspLys: 5.083 ± 0.107
5.406AspLeu: 5.406 ± 0.102
1.392AspMet: 1.392 ± 0.043
2.737AspAsn: 2.737 ± 0.077
1.393AspPro: 1.393 ± 0.047
0.932AspGln: 0.932 ± 0.044
2.354AspArg: 2.354 ± 0.061
3.373AspSer: 3.373 ± 0.069
2.541AspThr: 2.541 ± 0.067
3.842AspVal: 3.842 ± 0.083
0.348AspTrp: 0.348 ± 0.025
2.693AspTyr: 2.693 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
4.375GluAla: 4.375 ± 0.111
0.51GluCys: 0.51 ± 0.032
4.769GluAsp: 4.769 ± 0.096
7.287GluGlu: 7.287 ± 0.141
3.495GluPhe: 3.495 ± 0.084
3.808GluGly: 3.808 ± 0.084
1.055GluHis: 1.055 ± 0.039
7.96GluIle: 7.96 ± 0.116
8.045GluLys: 8.045 ± 0.134
7.353GluLeu: 7.353 ± 0.131
2.175GluMet: 2.175 ± 0.065
5.814GluAsn: 5.814 ± 0.12
1.572GluPro: 1.572 ± 0.065
1.922GluGln: 1.922 ± 0.07
2.881GluArg: 2.881 ± 0.067
4.256GluSer: 4.256 ± 0.084
3.26GluThr: 3.26 ± 0.074
5.697GluVal: 5.697 ± 0.098
0.439GluTrp: 0.439 ± 0.026
3.461GluTyr: 3.461 ± 0.084
0.0GluXaa: 0.0 ± 0.0
Phe
2.592PheAla: 2.592 ± 0.077
0.441PheCys: 0.441 ± 0.027
2.725PheAsp: 2.725 ± 0.072
3.695PheGlu: 3.695 ± 0.079
1.937PhePhe: 1.937 ± 0.061
3.083PheGly: 3.083 ± 0.08
0.586PheHis: 0.586 ± 0.03
4.251PheIle: 4.251 ± 0.103
3.914PheLys: 3.914 ± 0.084
4.169PheLeu: 4.169 ± 0.098
1.234PheMet: 1.234 ± 0.051
2.627PheAsn: 2.627 ± 0.068
1.096PhePro: 1.096 ± 0.047
0.97PheGln: 0.97 ± 0.04
1.469PheArg: 1.469 ± 0.048
3.274PheSer: 3.274 ± 0.08
2.411PheThr: 2.411 ± 0.059
2.86PheVal: 2.86 ± 0.079
0.31PheTrp: 0.31 ± 0.02
1.926PheTyr: 1.926 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.34GlyAla: 4.34 ± 0.099
0.676GlyCys: 0.676 ± 0.039
3.22GlyAsp: 3.22 ± 0.078
4.553GlyGlu: 4.553 ± 0.079
3.075GlyPhe: 3.075 ± 0.079
4.492GlyGly: 4.492 ± 0.114
1.075GlyHis: 1.075 ± 0.044
6.522GlyIle: 6.522 ± 0.128
5.468GlyLys: 5.468 ± 0.094
5.623GlyLeu: 5.623 ± 0.113
1.954GlyMet: 1.954 ± 0.058
3.311GlyAsn: 3.311 ± 0.08
1.171GlyPro: 1.171 ± 0.048
1.533GlyGln: 1.533 ± 0.057
2.376GlyArg: 2.376 ± 0.06
3.815GlySer: 3.815 ± 0.076
3.351GlyThr: 3.351 ± 0.073
4.765GlyVal: 4.765 ± 0.101
0.422GlyTrp: 0.422 ± 0.029
3.15GlyTyr: 3.15 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
0.727HisAla: 0.727 ± 0.035
0.169HisCys: 0.169 ± 0.017
0.694HisAsp: 0.694 ± 0.039
0.882HisGlu: 0.882 ± 0.044
0.663HisPhe: 0.663 ± 0.03
0.956HisGly: 0.956 ± 0.044
0.32HisHis: 0.32 ± 0.029
1.192HisIle: 1.192 ± 0.04
0.965HisLys: 0.965 ± 0.039
1.25HisLeu: 1.25 ± 0.042
0.34HisMet: 0.34 ± 0.026
0.729HisAsn: 0.729 ± 0.039
0.598HisPro: 0.598 ± 0.036
0.371HisGln: 0.371 ± 0.024
0.585HisArg: 0.585 ± 0.028
0.881HisSer: 0.881 ± 0.037
0.759HisThr: 0.759 ± 0.032
0.767HisVal: 0.767 ± 0.035
0.101HisTrp: 0.101 ± 0.013
0.551HisTyr: 0.551 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.926IleAla: 5.926 ± 0.116
0.927IleCys: 0.927 ± 0.042
5.623IleAsp: 5.623 ± 0.106
7.6IleGlu: 7.6 ± 0.11
4.351IlePhe: 4.351 ± 0.114
6.068IleGly: 6.068 ± 0.107
1.173IleHis: 1.173 ± 0.043
7.621IleIle: 7.621 ± 0.143
7.53IleLys: 7.53 ± 0.105
9.115IleLeu: 9.115 ± 0.151
2.371IleMet: 2.371 ± 0.061
4.919IleAsn: 4.919 ± 0.101
3.113IlePro: 3.113 ± 0.068
2.014IleGln: 2.014 ± 0.059
3.051IleArg: 3.051 ± 0.074
6.824IleSer: 6.824 ± 0.114
4.305IleThr: 4.305 ± 0.082
6.464IleVal: 6.464 ± 0.103
0.47IleTrp: 0.47 ± 0.027
3.465IleTyr: 3.465 ± 0.076
0.0IleXaa: 0.0 ± 0.0
Lys
4.693LysAla: 4.693 ± 0.093
0.593LysCys: 0.593 ± 0.036
5.569LysAsp: 5.569 ± 0.118
7.85LysGlu: 7.85 ± 0.162
3.733LysPhe: 3.733 ± 0.071
4.682LysGly: 4.682 ± 0.099
0.972LysHis: 0.972 ± 0.036
8.526LysIle: 8.526 ± 0.127
7.784LysLys: 7.784 ± 0.128
7.827LysLeu: 7.827 ± 0.127
2.384LysMet: 2.384 ± 0.063
6.368LysAsn: 6.368 ± 0.114
2.017LysPro: 2.017 ± 0.066
1.975LysGln: 1.975 ± 0.054
3.111LysArg: 3.111 ± 0.074
5.256LysSer: 5.256 ± 0.09
4.187LysThr: 4.187 ± 0.087
5.862LysVal: 5.862 ± 0.093
0.524LysTrp: 0.524 ± 0.029
3.92LysTyr: 3.92 ± 0.084
0.0LysXaa: 0.0 ± 0.0
Leu
5.042LeuAla: 5.042 ± 0.096
0.713LeuCys: 0.713 ± 0.033
5.123LeuAsp: 5.123 ± 0.092
7.084LeuGlu: 7.084 ± 0.123
3.891LeuPhe: 3.891 ± 0.11
6.221LeuGly: 6.221 ± 0.129
1.091LeuHis: 1.091 ± 0.041
8.195LeuIle: 8.195 ± 0.145
9.353LeuLys: 9.353 ± 0.134
7.936LeuLeu: 7.936 ± 0.146
2.542LeuMet: 2.542 ± 0.063
6.127LeuAsn: 6.127 ± 0.102
2.865LeuPro: 2.865 ± 0.082
2.06LeuGln: 2.06 ± 0.056
3.25LeuArg: 3.25 ± 0.076
6.828LeuSer: 6.828 ± 0.121
4.443LeuThr: 4.443 ± 0.086
5.716LeuVal: 5.716 ± 0.111
0.492LeuTrp: 0.492 ± 0.03
3.161LeuTyr: 3.161 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
1.897MetAla: 1.897 ± 0.058
0.249MetCys: 0.249 ± 0.019
1.616MetAsp: 1.616 ± 0.044
1.994MetGlu: 1.994 ± 0.057
1.036MetPhe: 1.036 ± 0.044
1.929MetGly: 1.929 ± 0.059
0.328MetHis: 0.328 ± 0.024
2.207MetIle: 2.207 ± 0.059
2.399MetLys: 2.399 ± 0.064
2.427MetLeu: 2.427 ± 0.061
0.762MetMet: 0.762 ± 0.036
1.672MetAsn: 1.672 ± 0.054
0.893MetPro: 0.893 ± 0.039
0.668MetGln: 0.668 ± 0.031
1.109MetArg: 1.109 ± 0.044
1.89MetSer: 1.89 ± 0.048
1.339MetThr: 1.339 ± 0.048
1.799MetVal: 1.799 ± 0.053
0.147MetTrp: 0.147 ± 0.014
0.917MetTyr: 0.917 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
2.888AsnAla: 2.888 ± 0.077
0.586AsnCys: 0.586 ± 0.034
2.41AsnAsp: 2.41 ± 0.064
3.88AsnGlu: 3.88 ± 0.082
2.94AsnPhe: 2.94 ± 0.073
3.575AsnGly: 3.575 ± 0.082
0.751AsnHis: 0.751 ± 0.038
5.895AsnIle: 5.895 ± 0.093
5.007AsnLys: 5.007 ± 0.091
6.355AsnLeu: 6.355 ± 0.105
1.572AsnMet: 1.572 ± 0.056
3.033AsnAsn: 3.033 ± 0.101
2.069AsnPro: 2.069 ± 0.066
1.39AsnGln: 1.39 ± 0.054
2.263AsnArg: 2.263 ± 0.065
4.029AsnSer: 4.029 ± 0.102
2.851AsnThr: 2.851 ± 0.072
3.463AsnVal: 3.463 ± 0.069
0.406AsnTrp: 0.406 ± 0.027
2.632AsnTyr: 2.632 ± 0.076
0.0AsnXaa: 0.0 ± 0.0
Pro
1.496ProAla: 1.496 ± 0.053
0.221ProCys: 0.221 ± 0.02
1.403ProAsp: 1.403 ± 0.046
2.367ProGlu: 2.367 ± 0.064
1.322ProPhe: 1.322 ± 0.048
1.632ProGly: 1.632 ± 0.059
0.489ProHis: 0.489 ± 0.029
2.725ProIle: 2.725 ± 0.069
2.378ProLys: 2.378 ± 0.065
2.389ProLeu: 2.389 ± 0.068
0.801ProMet: 0.801 ± 0.034
1.536ProAsn: 1.536 ± 0.054
0.524ProPro: 0.524 ± 0.031
0.794ProGln: 0.794 ± 0.035
0.849ProArg: 0.849 ± 0.031
1.697ProSer: 1.697 ± 0.048
1.683ProThr: 1.683 ± 0.051
2.034ProVal: 2.034 ± 0.056
0.184ProTrp: 0.184 ± 0.016
1.157ProTyr: 1.157 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
1.504GlnAla: 1.504 ± 0.058
0.171GlnCys: 0.171 ± 0.017
1.283GlnAsp: 1.283 ± 0.042
1.83GlnGlu: 1.83 ± 0.065
0.903GlnPhe: 0.903 ± 0.042
1.477GlnGly: 1.477 ± 0.055
0.292GlnHis: 0.292 ± 0.023
2.301GlnIle: 2.301 ± 0.069
2.197GlnLys: 2.197 ± 0.064
1.969GlnLeu: 1.969 ± 0.056
0.716GlnMet: 0.716 ± 0.035
1.534GlnAsn: 1.534 ± 0.048
0.601GlnPro: 0.601 ± 0.034
0.558GlnGln: 0.558 ± 0.031
1.066GlnArg: 1.066 ± 0.04
1.347GlnSer: 1.347 ± 0.048
1.205GlnThr: 1.205 ± 0.047
1.568GlnVal: 1.568 ± 0.06
0.161GlnTrp: 0.161 ± 0.015
0.796GlnTyr: 0.796 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.322ArgAla: 2.322 ± 0.065
0.334ArgCys: 0.334 ± 0.021
2.343ArgAsp: 2.343 ± 0.066
3.837ArgGlu: 3.837 ± 0.1
1.59ArgPhe: 1.59 ± 0.049
2.298ArgGly: 2.298 ± 0.064
0.463ArgHis: 0.463 ± 0.027
3.217ArgIle: 3.217 ± 0.079
2.945ArgLys: 2.945 ± 0.074
3.03ArgLeu: 3.03 ± 0.074
1.098ArgMet: 1.098 ± 0.039
2.132ArgAsn: 2.132 ± 0.066
0.997ArgPro: 0.997 ± 0.045
1.083ArgGln: 1.083 ± 0.041
1.651ArgArg: 1.651 ± 0.083
1.686ArgSer: 1.686 ± 0.056
1.675ArgThr: 1.675 ± 0.062
2.4ArgVal: 2.4 ± 0.061
0.19ArgTrp: 0.19 ± 0.019
1.478ArgTyr: 1.478 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
3.645SerAla: 3.645 ± 0.089
0.535SerCys: 0.535 ± 0.03
3.445SerAsp: 3.445 ± 0.083
5.01SerGlu: 5.01 ± 0.098
3.107SerPhe: 3.107 ± 0.072
4.682SerGly: 4.682 ± 0.093
0.916SerHis: 0.916 ± 0.038
6.039SerIle: 6.039 ± 0.12
5.959SerLys: 5.959 ± 0.108
5.858SerLeu: 5.858 ± 0.11
1.7SerMet: 1.7 ± 0.047
3.562SerAsn: 3.562 ± 0.077
1.544SerPro: 1.544 ± 0.053
1.55SerGln: 1.55 ± 0.049
2.266SerArg: 2.266 ± 0.062
4.123SerSer: 4.123 ± 0.094
3.038SerThr: 3.038 ± 0.069
4.26SerVal: 4.26 ± 0.093
0.395SerTrp: 0.395 ± 0.027
2.579SerTyr: 2.579 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
2.995ThrAla: 2.995 ± 0.072
0.409ThrCys: 0.409 ± 0.026
2.723ThrAsp: 2.723 ± 0.065
3.394ThrGlu: 3.394 ± 0.077
2.309ThrPhe: 2.309 ± 0.066
3.573ThrGly: 3.573 ± 0.073
0.788ThrHis: 0.788 ± 0.035
4.425ThrIle: 4.425 ± 0.092
3.73ThrLys: 3.73 ± 0.086
4.599ThrLeu: 4.599 ± 0.079
1.191ThrMet: 1.191 ± 0.038
2.526ThrAsn: 2.526 ± 0.071
1.849ThrPro: 1.849 ± 0.058
1.216ThrGln: 1.216 ± 0.042
1.606ThrArg: 1.606 ± 0.051
3.033ThrSer: 3.033 ± 0.062
2.63ThrThr: 2.63 ± 0.081
3.695ThrVal: 3.695 ± 0.087
0.304ThrTrp: 0.304 ± 0.023
1.726ThrTyr: 1.726 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
4.232ValAla: 4.232 ± 0.096
0.729ValCys: 0.729 ± 0.04
4.129ValAsp: 4.129 ± 0.077
5.577ValGlu: 5.577 ± 0.103
3.067ValPhe: 3.067 ± 0.08
4.804ValGly: 4.804 ± 0.099
0.869ValHis: 0.869 ± 0.033
5.679ValIle: 5.679 ± 0.108
5.341ValLys: 5.341 ± 0.085
6.247ValLeu: 6.247 ± 0.11
1.732ValMet: 1.732 ± 0.056
3.404ValAsn: 3.404 ± 0.074
2.092ValPro: 2.092 ± 0.055
1.491ValGln: 1.491 ± 0.047
2.341ValArg: 2.341 ± 0.068
4.708ValSer: 4.708 ± 0.088
3.188ValThr: 3.188 ± 0.075
5.072ValVal: 5.072 ± 0.105
0.374ValTrp: 0.374 ± 0.026
2.507ValTyr: 2.507 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.42TrpAla: 0.42 ± 0.026
0.053TrpCys: 0.053 ± 0.009
0.366TrpAsp: 0.366 ± 0.024
0.403TrpGlu: 0.403 ± 0.025
0.221TrpPhe: 0.221 ± 0.017
0.459TrpGly: 0.459 ± 0.029
0.113TrpHis: 0.113 ± 0.013
0.55TrpIle: 0.55 ± 0.034
0.479TrpLys: 0.479 ± 0.029
0.451TrpLeu: 0.451 ± 0.027
0.205TrpMet: 0.205 ± 0.02
0.352TrpAsn: 0.352 ± 0.026
0.145TrpPro: 0.145 ± 0.017
0.168TrpGln: 0.168 ± 0.015
0.244TrpArg: 0.244 ± 0.019
0.355TrpSer: 0.355 ± 0.026
0.308TrpThr: 0.308 ± 0.025
0.34TrpVal: 0.34 ± 0.022
0.061TrpTrp: 0.061 ± 0.008
0.244TrpTyr: 0.244 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.041TyrAla: 2.041 ± 0.068
0.371TyrCys: 0.371 ± 0.025
2.357TyrAsp: 2.357 ± 0.061
3.063TyrGlu: 3.063 ± 0.068
2.069TyrPhe: 2.069 ± 0.058
2.598TyrGly: 2.598 ± 0.066
0.511TyrHis: 0.511 ± 0.029
3.575TyrIle: 3.575 ± 0.078
3.431TyrLys: 3.431 ± 0.088
3.821TyrLeu: 3.821 ± 0.089
1.023TyrMet: 1.023 ± 0.044
2.395TyrAsn: 2.395 ± 0.063
1.21TyrPro: 1.21 ± 0.041
1.028TyrGln: 1.028 ± 0.04
1.775TyrArg: 1.775 ± 0.055
2.91TyrSer: 2.91 ± 0.071
2.033TyrThr: 2.033 ± 0.067
2.312TyrVal: 2.312 ± 0.061
0.252TyrTrp: 0.252 ± 0.02
1.719TyrTyr: 1.719 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2269 proteins (625768 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski