Amino acid dipepetide frequency for Corynebacterium bovis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.99AlaAla: 20.99 ± 0.313
0.968AlaCys: 0.968 ± 0.039
9.377AlaAsp: 9.377 ± 0.163
7.353AlaGlu: 7.353 ± 0.127
3.032AlaPhe: 3.032 ± 0.064
15.081AlaGly: 15.081 ± 0.213
2.336AlaHis: 2.336 ± 0.058
2.749AlaIle: 2.749 ± 0.077
2.158AlaLys: 2.158 ± 0.087
11.433AlaLeu: 11.433 ± 0.147
2.282AlaMet: 2.282 ± 0.049
1.87AlaAsn: 1.87 ± 0.051
7.238AlaPro: 7.238 ± 0.193
3.029AlaGln: 3.029 ± 0.065
9.455AlaArg: 9.455 ± 0.145
5.7AlaSer: 5.7 ± 0.109
8.4AlaThr: 8.4 ± 0.131
13.923AlaVal: 13.923 ± 0.2
1.657AlaTrp: 1.657 ± 0.052
1.974AlaTyr: 1.974 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.918CysAla: 0.918 ± 0.042
0.074CysCys: 0.074 ± 0.011
0.504CysAsp: 0.504 ± 0.029
0.326CysGlu: 0.326 ± 0.022
0.178CysPhe: 0.178 ± 0.018
0.863CysGly: 0.863 ± 0.037
0.169CysHis: 0.169 ± 0.016
0.231CysIle: 0.231 ± 0.017
0.076CysLys: 0.076 ± 0.012
0.631CysLeu: 0.631 ± 0.03
0.106CysMet: 0.106 ± 0.012
0.122CysAsn: 0.122 ± 0.013
0.454CysPro: 0.454 ± 0.025
0.153CysGln: 0.153 ± 0.014
0.603CysArg: 0.603 ± 0.03
0.411CysSer: 0.411 ± 0.023
0.475CysThr: 0.475 ± 0.023
0.65CysVal: 0.65 ± 0.031
0.089CysTrp: 0.089 ± 0.012
0.121CysTyr: 0.121 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
9.641AspAla: 9.641 ± 0.163
0.421AspCys: 0.421 ± 0.023
5.324AspAsp: 5.324 ± 0.117
3.614AspGlu: 3.614 ± 0.076
1.454AspPhe: 1.454 ± 0.042
8.177AspGly: 8.177 ± 0.133
1.645AspHis: 1.645 ± 0.053
2.625AspIle: 2.625 ± 0.063
0.967AspLys: 0.967 ± 0.047
6.37AspLeu: 6.37 ± 0.103
1.104AspMet: 1.104 ± 0.04
1.167AspAsn: 1.167 ± 0.045
5.129AspPro: 5.129 ± 0.11
1.486AspGln: 1.486 ± 0.047
6.373AspArg: 6.373 ± 0.116
2.797AspSer: 2.797 ± 0.067
4.024AspThr: 4.024 ± 0.081
6.056AspVal: 6.056 ± 0.103
0.824AspTrp: 0.824 ± 0.04
1.132AspTyr: 1.132 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
6.432GluAla: 6.432 ± 0.122
0.321GluCys: 0.321 ± 0.02
3.261GluAsp: 3.261 ± 0.076
3.208GluGlu: 3.208 ± 0.093
1.578GluPhe: 1.578 ± 0.05
4.279GluGly: 4.279 ± 0.078
1.195GluHis: 1.195 ± 0.035
2.421GluIle: 2.421 ± 0.073
1.482GluLys: 1.482 ± 0.058
5.263GluLeu: 5.263 ± 0.101
0.961GluMet: 0.961 ± 0.033
1.196GluAsn: 1.196 ± 0.046
2.765GluPro: 2.765 ± 0.075
1.783GluGln: 1.783 ± 0.064
4.146GluArg: 4.146 ± 0.097
2.352GluSer: 2.352 ± 0.06
3.096GluThr: 3.096 ± 0.073
4.643GluVal: 4.643 ± 0.088
0.719GluTrp: 0.719 ± 0.035
1.042GluTyr: 1.042 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.079PheAla: 3.079 ± 0.071
0.231PheCys: 0.231 ± 0.017
1.882PheAsp: 1.882 ± 0.051
1.136PheGlu: 1.136 ± 0.05
0.851PhePhe: 0.851 ± 0.035
2.865PheGly: 2.865 ± 0.074
0.631PheHis: 0.631 ± 0.03
1.2PheIle: 1.2 ± 0.04
0.306PheLys: 0.306 ± 0.019
2.331PheLeu: 2.331 ± 0.062
0.485PheMet: 0.485 ± 0.025
0.551PheAsn: 0.551 ± 0.027
1.272PhePro: 1.272 ± 0.04
0.518PheGln: 0.518 ± 0.028
1.899PheArg: 1.899 ± 0.057
1.631PheSer: 1.631 ± 0.053
2.133PheThr: 2.133 ± 0.055
2.143PheVal: 2.143 ± 0.054
0.361PheTrp: 0.361 ± 0.021
0.567PheTyr: 0.567 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
12.396GlyAla: 12.396 ± 0.177
0.692GlyCys: 0.692 ± 0.033
7.211GlyAsp: 7.211 ± 0.112
5.42GlyGlu: 5.42 ± 0.089
2.692GlyPhe: 2.692 ± 0.068
10.127GlyGly: 10.127 ± 0.207
2.339GlyHis: 2.339 ± 0.069
3.56GlyIle: 3.56 ± 0.082
1.85GlyLys: 1.85 ± 0.061
8.537GlyLeu: 8.537 ± 0.115
2.117GlyMet: 2.117 ± 0.053
1.645GlyAsn: 1.645 ± 0.062
5.511GlyPro: 5.511 ± 0.114
2.535GlyGln: 2.535 ± 0.072
8.313GlyArg: 8.313 ± 0.125
5.732GlySer: 5.732 ± 0.108
7.843GlyThr: 7.843 ± 0.129
9.352GlyVal: 9.352 ± 0.136
1.489GlyTrp: 1.489 ± 0.055
2.043GlyTyr: 2.043 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
2.333HisAla: 2.333 ± 0.058
0.182HisCys: 0.182 ± 0.015
1.454HisAsp: 1.454 ± 0.044
0.979HisGlu: 0.979 ± 0.047
0.464HisPhe: 0.464 ± 0.026
2.339HisGly: 2.339 ± 0.06
0.615HisHis: 0.615 ± 0.036
0.715HisIle: 0.715 ± 0.033
0.239HisLys: 0.239 ± 0.021
1.932HisLeu: 1.932 ± 0.052
0.4HisMet: 0.4 ± 0.026
0.354HisAsn: 0.354 ± 0.023
1.713HisPro: 1.713 ± 0.051
0.514HisGln: 0.514 ± 0.025
2.12HisArg: 2.12 ± 0.062
0.976HisSer: 0.976 ± 0.043
1.163HisThr: 1.163 ± 0.04
1.736HisVal: 1.736 ± 0.046
0.267HisTrp: 0.267 ± 0.019
0.418HisTyr: 0.418 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
4.499IleAla: 4.499 ± 0.08
0.247IleCys: 0.247 ± 0.017
2.572IleAsp: 2.572 ± 0.066
1.742IleGlu: 1.742 ± 0.058
0.89IlePhe: 0.89 ± 0.035
3.328IleGly: 3.328 ± 0.083
0.749IleHis: 0.749 ± 0.033
1.585IleIle: 1.585 ± 0.055
0.594IleLys: 0.594 ± 0.034
3.104IleLeu: 3.104 ± 0.08
0.633IleMet: 0.633 ± 0.027
0.863IleAsn: 0.863 ± 0.036
1.95IlePro: 1.95 ± 0.061
0.75IleGln: 0.75 ± 0.033
2.531IleArg: 2.531 ± 0.057
1.761IleSer: 1.761 ± 0.05
2.257IleThr: 2.257 ± 0.063
3.407IleVal: 3.407 ± 0.071
0.321IleTrp: 0.321 ± 0.022
0.657IleTyr: 0.657 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
2.097LysAla: 2.097 ± 0.093
0.075LysCys: 0.075 ± 0.011
1.268LysAsp: 1.268 ± 0.049
1.035LysGlu: 1.035 ± 0.043
0.419LysPhe: 0.419 ± 0.025
1.497LysGly: 1.497 ± 0.063
0.269LysHis: 0.269 ± 0.017
0.857LysIle: 0.857 ± 0.039
0.793LysLys: 0.793 ± 0.065
1.476LysLeu: 1.476 ± 0.06
0.396LysMet: 0.396 ± 0.024
0.499LysAsn: 0.499 ± 0.032
0.938LysPro: 0.938 ± 0.067
0.535LysGln: 0.535 ± 0.031
1.099LysArg: 1.099 ± 0.05
0.949LysSer: 0.949 ± 0.044
1.14LysThr: 1.14 ± 0.052
1.539LysVal: 1.539 ± 0.06
0.175LysTrp: 0.175 ± 0.017
0.363LysTyr: 0.363 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
12.191LeuAla: 12.191 ± 0.173
0.688LeuCys: 0.688 ± 0.031
6.542LeuAsp: 6.542 ± 0.113
3.917LeuGlu: 3.917 ± 0.073
2.283LeuPhe: 2.283 ± 0.063
8.388LeuGly: 8.388 ± 0.122
1.965LeuHis: 1.965 ± 0.06
3.239LeuIle: 3.239 ± 0.076
1.375LeuLys: 1.375 ± 0.059
8.139LeuLeu: 8.139 ± 0.138
1.597LeuMet: 1.597 ± 0.054
1.579LeuAsn: 1.579 ± 0.046
5.364LeuPro: 5.364 ± 0.103
1.79LeuGln: 1.79 ± 0.057
7.642LeuArg: 7.642 ± 0.12
5.053LeuSer: 5.053 ± 0.093
6.46LeuThr: 6.46 ± 0.096
8.534LeuVal: 8.534 ± 0.135
1.076LeuTrp: 1.076 ± 0.045
1.446LeuTyr: 1.446 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.181MetAla: 2.181 ± 0.052
0.156MetCys: 0.156 ± 0.014
1.124MetAsp: 1.124 ± 0.042
0.821MetGlu: 0.821 ± 0.033
0.558MetPhe: 0.558 ± 0.027
1.401MetGly: 1.401 ± 0.047
0.367MetHis: 0.367 ± 0.024
0.854MetIle: 0.854 ± 0.037
0.421MetLys: 0.421 ± 0.025
1.836MetLeu: 1.836 ± 0.055
0.413MetMet: 0.413 ± 0.025
0.483MetAsn: 0.483 ± 0.027
1.067MetPro: 1.067 ± 0.041
0.451MetGln: 0.451 ± 0.025
1.258MetArg: 1.258 ± 0.041
1.511MetSer: 1.511 ± 0.046
1.8MetThr: 1.8 ± 0.049
1.504MetVal: 1.504 ± 0.047
0.211MetTrp: 0.211 ± 0.018
0.335MetTyr: 0.335 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
2.065AsnAla: 2.065 ± 0.06
0.135AsnCys: 0.135 ± 0.014
1.108AsnAsp: 1.108 ± 0.042
0.851AsnGlu: 0.851 ± 0.04
0.508AsnPhe: 0.508 ± 0.027
1.689AsnGly: 1.689 ± 0.06
0.392AsnHis: 0.392 ± 0.021
0.844AsnIle: 0.844 ± 0.038
0.403AsnLys: 0.403 ± 0.027
1.653AsnLeu: 1.653 ± 0.05
0.358AsnMet: 0.358 ± 0.023
0.467AsnAsn: 0.467 ± 0.03
1.504AsnPro: 1.504 ± 0.049
0.525AsnGln: 0.525 ± 0.034
1.421AsnArg: 1.421 ± 0.051
0.968AsnSer: 0.968 ± 0.039
1.051AsnThr: 1.051 ± 0.038
1.431AsnVal: 1.431 ± 0.044
0.258AsnTrp: 0.258 ± 0.021
0.467AsnTyr: 0.467 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
8.699ProAla: 8.699 ± 0.161
0.279ProCys: 0.279 ± 0.021
4.956ProAsp: 4.956 ± 0.096
4.086ProGlu: 4.086 ± 0.086
1.388ProPhe: 1.388 ± 0.048
7.688ProGly: 7.688 ± 0.16
1.086ProHis: 1.086 ± 0.042
1.031ProIle: 1.031 ± 0.04
0.925ProLys: 0.925 ± 0.041
4.522ProLeu: 4.522 ± 0.091
0.886ProMet: 0.886 ± 0.037
0.89ProAsn: 0.89 ± 0.043
2.722ProPro: 2.722 ± 0.082
1.465ProGln: 1.465 ± 0.043
4.082ProArg: 4.082 ± 0.08
3.227ProSer: 3.227 ± 0.093
3.954ProThr: 3.954 ± 0.089
6.339ProVal: 6.339 ± 0.116
0.76ProTrp: 0.76 ± 0.037
0.96ProTyr: 0.96 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
2.874GlnAla: 2.874 ± 0.072
0.153GlnCys: 0.153 ± 0.015
1.253GlnAsp: 1.253 ± 0.043
1.195GlnGlu: 1.195 ± 0.044
0.715GlnPhe: 0.715 ± 0.037
2.038GlnGly: 2.038 ± 0.064
0.467GlnHis: 0.467 ± 0.027
1.132GlnIle: 1.132 ± 0.039
0.564GlnLys: 0.564 ± 0.034
2.425GlnLeu: 2.425 ± 0.056
0.549GlnMet: 0.549 ± 0.027
0.513GlnAsn: 0.513 ± 0.029
1.314GlnPro: 1.314 ± 0.055
0.882GlnGln: 0.882 ± 0.042
1.986GlnArg: 1.986 ± 0.058
1.121GlnSer: 1.121 ± 0.046
1.253GlnThr: 1.253 ± 0.043
2.396GlnVal: 2.396 ± 0.06
0.408GlnTrp: 0.408 ± 0.024
0.428GlnTyr: 0.428 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
8.967ArgAla: 8.967 ± 0.155
0.554ArgCys: 0.554 ± 0.029
5.75ArgAsp: 5.75 ± 0.109
4.857ArgGlu: 4.857 ± 0.087
2.235ArgPhe: 2.235 ± 0.059
6.478ArgGly: 6.478 ± 0.093
1.931ArgHis: 1.931 ± 0.058
3.088ArgIle: 3.088 ± 0.072
1.413ArgLys: 1.413 ± 0.061
6.614ArgLeu: 6.614 ± 0.11
1.883ArgMet: 1.883 ± 0.046
1.365ArgAsn: 1.365 ± 0.048
4.846ArgPro: 4.846 ± 0.09
2.172ArgGln: 2.172 ± 0.055
8.755ArgArg: 8.755 ± 0.145
4.356ArgSer: 4.356 ± 0.08
5.318ArgThr: 5.318 ± 0.091
6.285ArgVal: 6.285 ± 0.084
1.45ArgTrp: 1.45 ± 0.044
1.66ArgTyr: 1.66 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
6.489SerAla: 6.489 ± 0.091
0.338SerCys: 0.338 ± 0.023
3.017SerAsp: 3.017 ± 0.068
2.174SerGlu: 2.174 ± 0.084
1.564SerPhe: 1.564 ± 0.052
6.089SerGly: 6.089 ± 0.121
0.967SerHis: 0.967 ± 0.039
1.456SerIle: 1.456 ± 0.045
0.799SerLys: 0.799 ± 0.039
4.734SerLeu: 4.734 ± 0.093
1.124SerMet: 1.124 ± 0.039
0.868SerAsn: 0.868 ± 0.038
3.407SerPro: 3.407 ± 0.07
1.196SerGln: 1.196 ± 0.042
4.089SerArg: 4.089 ± 0.078
3.195SerSer: 3.195 ± 0.102
3.765SerThr: 3.765 ± 0.071
4.91SerVal: 4.91 ± 0.092
0.772SerTrp: 0.772 ± 0.028
0.968SerTyr: 0.968 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
9.375ThrAla: 9.375 ± 0.159
0.475ThrCys: 0.475 ± 0.027
4.595ThrAsp: 4.595 ± 0.088
2.927ThrGlu: 2.927 ± 0.072
1.711ThrPhe: 1.711 ± 0.049
8.289ThrGly: 8.289 ± 0.135
1.215ThrHis: 1.215 ± 0.043
1.833ThrIle: 1.833 ± 0.054
1.047ThrLys: 1.047 ± 0.051
5.761ThrLeu: 5.761 ± 0.1
1.133ThrMet: 1.133 ± 0.037
1.047ThrAsn: 1.047 ± 0.046
5.26ThrPro: 5.26 ± 0.095
1.24ThrGln: 1.24 ± 0.042
4.354ThrArg: 4.354 ± 0.087
3.509ThrSer: 3.509 ± 0.089
5.196ThrThr: 5.196 ± 0.111
8.291ThrVal: 8.291 ± 0.126
0.957ThrTrp: 0.957 ± 0.036
1.246ThrTyr: 1.246 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
12.265ValAla: 12.265 ± 0.178
0.854ValCys: 0.854 ± 0.035
7.207ValAsp: 7.207 ± 0.118
4.929ValGlu: 4.929 ± 0.103
2.424ValPhe: 2.424 ± 0.067
7.975ValGly: 7.975 ± 0.124
1.978ValHis: 1.978 ± 0.06
3.657ValIle: 3.657 ± 0.074
1.495ValLys: 1.495 ± 0.062
9.314ValLeu: 9.314 ± 0.138
1.711ValMet: 1.711 ± 0.048
1.918ValAsn: 1.918 ± 0.058
5.802ValPro: 5.802 ± 0.092
1.813ValGln: 1.813 ± 0.051
6.961ValArg: 6.961 ± 0.102
4.813ValSer: 4.813 ± 0.083
8.005ValThr: 8.005 ± 0.128
10.745ValVal: 10.745 ± 0.172
1.204ValTrp: 1.204 ± 0.046
1.447ValTyr: 1.447 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
1.482TrpAla: 1.482 ± 0.044
0.143TrpCys: 0.143 ± 0.014
0.747TrpAsp: 0.747 ± 0.033
0.689TrpGlu: 0.689 ± 0.031
0.561TrpPhe: 0.561 ± 0.031
1.038TrpGly: 1.038 ± 0.037
0.258TrpHis: 0.258 ± 0.019
0.632TrpIle: 0.632 ± 0.032
0.235TrpLys: 0.235 ± 0.02
1.31TrpLeu: 1.31 ± 0.049
0.317TrpMet: 0.317 ± 0.02
0.332TrpAsn: 0.332 ± 0.02
0.661TrpPro: 0.661 ± 0.035
0.411TrpGln: 0.411 ± 0.026
1.243TrpArg: 1.243 ± 0.046
0.851TrpSer: 0.851 ± 0.035
0.954TrpThr: 0.954 ± 0.039
1.103TrpVal: 1.103 ± 0.045
0.318TrpTrp: 0.318 ± 0.02
0.279TrpTyr: 0.279 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.031TyrAla: 2.031 ± 0.055
0.169TyrCys: 0.169 ± 0.016
1.175TyrAsp: 1.175 ± 0.043
0.885TyrGlu: 0.885 ± 0.036
0.565TyrPhe: 0.565 ± 0.027
1.774TyrGly: 1.774 ± 0.052
0.34TyrHis: 0.34 ± 0.026
0.732TyrIle: 0.732 ± 0.03
0.278TyrLys: 0.278 ± 0.022
1.885TyrLeu: 1.885 ± 0.065
0.296TyrMet: 0.296 ± 0.022
0.371TyrAsn: 0.371 ± 0.023
1.028TyrPro: 1.028 ± 0.035
0.414TyrGln: 0.414 ± 0.026
1.65TyrArg: 1.65 ± 0.053
1.007TyrSer: 1.007 ± 0.041
1.174TyrThr: 1.174 ± 0.04
1.531TyrVal: 1.531 ± 0.05
0.247TyrTrp: 0.247 ± 0.019
0.396TyrTyr: 0.396 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2067 proteins (719965 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski