Amino acid dipepetide frequency for Streptococcus phage Javan645

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.39AlaAla: 4.39 ± 1.489
0.09AlaCys: 0.09 ± 0.097
3.763AlaAsp: 3.763 ± 0.556
5.107AlaGlu: 5.107 ± 0.969
3.404AlaPhe: 3.404 ± 1.092
5.644AlaGly: 5.644 ± 1.873
0.448AlaHis: 0.448 ± 0.211
5.196AlaIle: 5.196 ± 0.536
6.092AlaLys: 6.092 ± 0.825
7.346AlaLeu: 7.346 ± 1.449
2.509AlaMet: 2.509 ± 0.738
4.121AlaAsn: 4.121 ± 0.543
1.792AlaPro: 1.792 ± 0.325
3.136AlaGln: 3.136 ± 0.909
2.419AlaArg: 2.419 ± 0.705
5.375AlaSer: 5.375 ± 1.257
5.017AlaThr: 5.017 ± 1.36
5.107AlaVal: 5.107 ± 1.208
0.448AlaTrp: 0.448 ± 0.217
2.061AlaTyr: 2.061 ± 0.508
0.0AlaXaa: 0.0 ± 0.0
Cys
0.269CysAla: 0.269 ± 0.142
0.09CysCys: 0.09 ± 0.094
0.448CysAsp: 0.448 ± 0.176
0.269CysGlu: 0.269 ± 0.166
0.0CysPhe: 0.0 ± 0.0
0.179CysGly: 0.179 ± 0.138
0.358CysHis: 0.358 ± 0.197
0.269CysIle: 0.269 ± 0.245
0.179CysLys: 0.179 ± 0.157
0.448CysLeu: 0.448 ± 0.156
0.269CysMet: 0.269 ± 0.15
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.09CysGln: 0.09 ± 0.073
0.179CysArg: 0.179 ± 0.129
0.09CysSer: 0.09 ± 0.094
0.358CysThr: 0.358 ± 0.192
0.269CysVal: 0.269 ± 0.138
0.0CysTrp: 0.0 ± 0.0
0.448CysTyr: 0.448 ± 0.192
0.0CysXaa: 0.0 ± 0.0
Asp
3.584AspAla: 3.584 ± 0.542
0.627AspCys: 0.627 ± 0.271
4.211AspAsp: 4.211 ± 0.886
5.375AspGlu: 5.375 ± 0.92
3.852AspPhe: 3.852 ± 0.605
5.644AspGly: 5.644 ± 1.037
1.075AspHis: 1.075 ± 0.348
4.479AspIle: 4.479 ± 0.921
5.107AspLys: 5.107 ± 0.691
5.107AspLeu: 5.107 ± 0.583
1.792AspMet: 1.792 ± 0.416
4.838AspAsn: 4.838 ± 0.662
1.613AspPro: 1.613 ± 0.509
1.702AspGln: 1.702 ± 0.35
1.792AspArg: 1.792 ± 0.487
2.956AspSer: 2.956 ± 0.65
4.748AspThr: 4.748 ± 0.84
3.404AspVal: 3.404 ± 0.693
0.627AspTrp: 0.627 ± 0.229
2.688AspTyr: 2.688 ± 0.488
0.0AspXaa: 0.0 ± 0.0
Glu
3.494GluAla: 3.494 ± 0.901
0.269GluCys: 0.269 ± 0.146
2.956GluAsp: 2.956 ± 0.636
4.479GluGlu: 4.479 ± 0.829
3.494GluPhe: 3.494 ± 0.571
2.777GluGly: 2.777 ± 0.459
0.717GluHis: 0.717 ± 0.218
5.107GluIle: 5.107 ± 0.63
4.748GluLys: 4.748 ± 0.6
7.526GluLeu: 7.526 ± 1.121
2.509GluMet: 2.509 ± 0.401
4.121GluAsn: 4.121 ± 0.595
1.165GluPro: 1.165 ± 0.354
2.509GluGln: 2.509 ± 0.546
3.136GluArg: 3.136 ± 0.855
3.404GluSer: 3.404 ± 0.513
3.494GluThr: 3.494 ± 0.721
5.017GluVal: 5.017 ± 0.951
1.344GluTrp: 1.344 ± 0.318
3.046GluTyr: 3.046 ± 0.727
0.0GluXaa: 0.0 ± 0.0
Phe
2.509PheAla: 2.509 ± 0.55
0.0PheCys: 0.0 ± 0.0
4.39PheAsp: 4.39 ± 0.555
4.479PheGlu: 4.479 ± 0.768
1.075PhePhe: 1.075 ± 0.334
2.329PheGly: 2.329 ± 0.715
0.448PheHis: 0.448 ± 0.197
2.419PheIle: 2.419 ± 0.454
3.494PheLys: 3.494 ± 0.535
2.688PheLeu: 2.688 ± 0.46
0.896PheMet: 0.896 ± 0.333
2.15PheAsn: 2.15 ± 0.494
0.448PhePro: 0.448 ± 0.187
0.627PheGln: 0.627 ± 0.226
1.613PheArg: 1.613 ± 0.391
3.046PheSer: 3.046 ± 0.592
3.046PheThr: 3.046 ± 0.561
2.598PheVal: 2.598 ± 0.702
0.358PheTrp: 0.358 ± 0.225
2.509PheTyr: 2.509 ± 0.433
0.0PheXaa: 0.0 ± 0.0
Gly
4.838GlyAla: 4.838 ± 1.652
0.179GlyCys: 0.179 ± 0.126
2.867GlyAsp: 2.867 ± 0.53
3.225GlyGlu: 3.225 ± 0.467
2.688GlyPhe: 2.688 ± 0.527
3.763GlyGly: 3.763 ± 0.673
0.806GlyHis: 0.806 ± 0.276
5.107GlyIle: 5.107 ± 1.015
5.823GlyLys: 5.823 ± 0.664
5.465GlyLeu: 5.465 ± 0.928
2.509GlyMet: 2.509 ± 0.604
2.956GlyAsn: 2.956 ± 0.584
0.627GlyPro: 0.627 ± 0.207
3.046GlyGln: 3.046 ± 0.588
3.136GlyArg: 3.136 ± 0.667
3.673GlySer: 3.673 ± 0.852
4.569GlyThr: 4.569 ± 0.819
4.39GlyVal: 4.39 ± 0.869
0.448GlyTrp: 0.448 ± 0.187
2.688GlyTyr: 2.688 ± 0.594
0.0GlyXaa: 0.0 ± 0.0
His
0.269HisAla: 0.269 ± 0.133
0.0HisCys: 0.0 ± 0.0
1.075HisAsp: 1.075 ± 0.37
1.523HisGlu: 1.523 ± 0.453
0.269HisPhe: 0.269 ± 0.177
0.179HisGly: 0.179 ± 0.126
0.269HisHis: 0.269 ± 0.156
0.985HisIle: 0.985 ± 0.219
0.985HisLys: 0.985 ± 0.354
0.717HisLeu: 0.717 ± 0.296
0.179HisMet: 0.179 ± 0.136
0.627HisAsn: 0.627 ± 0.195
0.806HisPro: 0.806 ± 0.321
0.806HisGln: 0.806 ± 0.263
0.358HisArg: 0.358 ± 0.204
0.896HisSer: 0.896 ± 0.228
0.538HisThr: 0.538 ± 0.174
0.896HisVal: 0.896 ± 0.314
0.179HisTrp: 0.179 ± 0.127
0.358HisTyr: 0.358 ± 0.194
0.0HisXaa: 0.0 ± 0.0
Ile
5.375IleAla: 5.375 ± 1.167
0.538IleCys: 0.538 ± 0.271
6.092IleAsp: 6.092 ± 0.8
5.465IleGlu: 5.465 ± 0.647
2.061IlePhe: 2.061 ± 0.401
4.39IleGly: 4.39 ± 0.608
1.165IleHis: 1.165 ± 0.357
2.598IleIle: 2.598 ± 0.417
7.615IleLys: 7.615 ± 0.681
4.479IleLeu: 4.479 ± 0.654
1.613IleMet: 1.613 ± 0.488
5.913IleAsn: 5.913 ± 0.975
1.881IlePro: 1.881 ± 0.316
2.061IleGln: 2.061 ± 0.427
2.329IleArg: 2.329 ± 0.42
5.465IleSer: 5.465 ± 0.94
4.659IleThr: 4.659 ± 0.686
4.748IleVal: 4.748 ± 0.628
0.358IleTrp: 0.358 ± 0.155
2.419IleTyr: 2.419 ± 0.376
0.0IleXaa: 0.0 ± 0.0
Lys
6.271LysAla: 6.271 ± 0.891
0.179LysCys: 0.179 ± 0.14
5.107LysAsp: 5.107 ± 0.887
7.257LysGlu: 7.257 ± 0.805
2.777LysPhe: 2.777 ± 0.461
3.942LysGly: 3.942 ± 0.484
0.985LysHis: 0.985 ± 0.311
6.361LysIle: 6.361 ± 0.761
8.78LysLys: 8.78 ± 1.368
6.898LysLeu: 6.898 ± 0.994
2.688LysMet: 2.688 ± 0.451
4.121LysAsn: 4.121 ± 0.615
2.061LysPro: 2.061 ± 0.529
4.39LysGln: 4.39 ± 0.721
2.867LysArg: 2.867 ± 0.652
6.361LysSer: 6.361 ± 0.728
5.555LysThr: 5.555 ± 0.661
5.555LysVal: 5.555 ± 0.782
0.896LysTrp: 0.896 ± 0.278
3.315LysTyr: 3.315 ± 0.599
0.0LysXaa: 0.0 ± 0.0
Leu
6.988LeuAla: 6.988 ± 1.245
0.09LeuCys: 0.09 ± 0.108
6.361LeuAsp: 6.361 ± 0.876
4.838LeuGlu: 4.838 ± 0.639
2.598LeuPhe: 2.598 ± 0.45
4.659LeuGly: 4.659 ± 0.471
0.985LeuHis: 0.985 ± 0.3
5.644LeuIle: 5.644 ± 0.716
6.988LeuLys: 6.988 ± 0.901
5.734LeuLeu: 5.734 ± 0.811
1.165LeuMet: 1.165 ± 0.542
5.823LeuAsn: 5.823 ± 0.85
2.956LeuPro: 2.956 ± 0.504
2.956LeuGln: 2.956 ± 0.476
3.136LeuArg: 3.136 ± 0.529
7.257LeuSer: 7.257 ± 0.73
5.913LeuThr: 5.913 ± 0.896
4.748LeuVal: 4.748 ± 0.582
0.717LeuTrp: 0.717 ± 0.261
1.613LeuTyr: 1.613 ± 0.434
0.0LeuXaa: 0.0 ± 0.0
Met
2.777MetAla: 2.777 ± 0.732
0.09MetCys: 0.09 ± 0.084
1.075MetAsp: 1.075 ± 0.269
0.896MetGlu: 0.896 ± 0.255
0.806MetPhe: 0.806 ± 0.25
1.613MetGly: 1.613 ± 0.43
0.0MetHis: 0.0 ± 0.0
2.061MetIle: 2.061 ± 0.509
2.777MetLys: 2.777 ± 0.504
1.702MetLeu: 1.702 ± 0.359
0.269MetMet: 0.269 ± 0.144
1.254MetAsn: 1.254 ± 0.323
0.717MetPro: 0.717 ± 0.256
1.344MetGln: 1.344 ± 0.427
0.806MetArg: 0.806 ± 0.273
2.419MetSer: 2.419 ± 0.5
2.15MetThr: 2.15 ± 0.548
1.792MetVal: 1.792 ± 0.409
0.269MetTrp: 0.269 ± 0.147
0.806MetTyr: 0.806 ± 0.275
0.0MetXaa: 0.0 ± 0.0
Asn
3.673AsnAla: 3.673 ± 0.571
0.717AsnCys: 0.717 ± 0.248
4.569AsnAsp: 4.569 ± 0.517
3.315AsnGlu: 3.315 ± 0.601
1.971AsnPhe: 1.971 ± 0.381
5.107AsnGly: 5.107 ± 0.608
0.896AsnHis: 0.896 ± 0.307
4.39AsnIle: 4.39 ± 0.708
5.465AsnLys: 5.465 ± 0.639
4.838AsnLeu: 4.838 ± 0.862
1.075AsnMet: 1.075 ± 0.335
4.3AsnAsn: 4.3 ± 0.716
2.509AsnPro: 2.509 ± 0.438
3.584AsnGln: 3.584 ± 0.818
2.061AsnArg: 2.061 ± 0.452
3.225AsnSer: 3.225 ± 0.448
3.763AsnThr: 3.763 ± 0.617
2.777AsnVal: 2.777 ± 0.438
0.627AsnTrp: 0.627 ± 0.21
2.688AsnTyr: 2.688 ± 0.803
0.0AsnXaa: 0.0 ± 0.0
Pro
2.329ProAla: 2.329 ± 0.429
0.0ProCys: 0.0 ± 0.0
1.433ProAsp: 1.433 ± 0.416
1.613ProGlu: 1.613 ± 0.327
1.971ProPhe: 1.971 ± 0.508
1.344ProGly: 1.344 ± 0.414
0.09ProHis: 0.09 ± 0.092
1.433ProIle: 1.433 ± 0.342
2.688ProLys: 2.688 ± 0.573
1.792ProLeu: 1.792 ± 0.545
0.448ProMet: 0.448 ± 0.183
1.702ProAsn: 1.702 ± 0.424
0.358ProPro: 0.358 ± 0.167
0.448ProGln: 0.448 ± 0.232
0.448ProArg: 0.448 ± 0.198
1.613ProSer: 1.613 ± 0.353
1.433ProThr: 1.433 ± 0.382
1.702ProVal: 1.702 ± 0.457
0.179ProTrp: 0.179 ± 0.132
1.433ProTyr: 1.433 ± 0.35
0.0ProXaa: 0.0 ± 0.0
Gln
4.121GlnAla: 4.121 ± 1.103
0.269GlnCys: 0.269 ± 0.192
2.15GlnAsp: 2.15 ± 0.375
1.344GlnGlu: 1.344 ± 0.351
1.433GlnPhe: 1.433 ± 0.31
2.598GlnGly: 2.598 ± 0.513
0.627GlnHis: 0.627 ± 0.275
4.39GlnIle: 4.39 ± 0.699
2.777GlnLys: 2.777 ± 0.389
3.404GlnLeu: 3.404 ± 0.671
1.075GlnMet: 1.075 ± 0.283
3.404GlnAsn: 3.404 ± 0.625
0.627GlnPro: 0.627 ± 0.242
2.061GlnGln: 2.061 ± 0.541
1.344GlnArg: 1.344 ± 0.334
2.777GlnSer: 2.777 ± 0.5
2.329GlnThr: 2.329 ± 0.531
2.329GlnVal: 2.329 ± 0.42
0.269GlnTrp: 0.269 ± 0.176
1.165GlnTyr: 1.165 ± 0.313
0.0GlnXaa: 0.0 ± 0.0
Arg
2.24ArgAla: 2.24 ± 0.522
0.448ArgCys: 0.448 ± 0.243
1.792ArgAsp: 1.792 ± 0.391
1.971ArgGlu: 1.971 ± 0.508
1.433ArgPhe: 1.433 ± 0.311
1.881ArgGly: 1.881 ± 0.371
0.717ArgHis: 0.717 ± 0.38
2.061ArgIle: 2.061 ± 0.388
2.867ArgLys: 2.867 ± 0.813
3.225ArgLeu: 3.225 ± 0.555
1.075ArgMet: 1.075 ± 0.314
2.598ArgAsn: 2.598 ± 0.525
0.806ArgPro: 0.806 ± 0.293
2.15ArgGln: 2.15 ± 0.569
1.523ArgArg: 1.523 ± 0.503
1.613ArgSer: 1.613 ± 0.41
1.881ArgThr: 1.881 ± 0.378
1.881ArgVal: 1.881 ± 0.505
0.985ArgTrp: 0.985 ± 0.361
2.329ArgTyr: 2.329 ± 0.509
0.0ArgXaa: 0.0 ± 0.0
Ser
6.54SerAla: 6.54 ± 2.145
0.269SerCys: 0.269 ± 0.132
4.569SerAsp: 4.569 ± 0.667
4.121SerGlu: 4.121 ± 0.809
2.688SerPhe: 2.688 ± 0.599
4.569SerGly: 4.569 ± 0.75
0.627SerHis: 0.627 ± 0.215
4.659SerIle: 4.659 ± 0.851
5.286SerLys: 5.286 ± 0.744
5.017SerLeu: 5.017 ± 0.607
1.254SerMet: 1.254 ± 0.349
3.763SerAsn: 3.763 ± 0.659
1.792SerPro: 1.792 ± 0.429
3.136SerGln: 3.136 ± 0.482
2.867SerArg: 2.867 ± 0.549
4.927SerSer: 4.927 ± 1.019
3.494SerThr: 3.494 ± 0.674
5.375SerVal: 5.375 ± 1.027
0.985SerTrp: 0.985 ± 0.341
2.419SerTyr: 2.419 ± 0.55
0.0SerXaa: 0.0 ± 0.0
Thr
6.003ThrAla: 6.003 ± 1.08
0.179ThrCys: 0.179 ± 0.115
4.479ThrAsp: 4.479 ± 0.693
3.225ThrGlu: 3.225 ± 0.677
3.763ThrPhe: 3.763 ± 0.64
5.196ThrGly: 5.196 ± 0.725
0.985ThrHis: 0.985 ± 0.33
5.465ThrIle: 5.465 ± 0.686
3.852ThrLys: 3.852 ± 0.619
4.748ThrLeu: 4.748 ± 0.585
1.075ThrMet: 1.075 ± 0.272
3.315ThrAsn: 3.315 ± 0.595
1.613ThrPro: 1.613 ± 0.35
2.598ThrGln: 2.598 ± 0.736
0.985ThrArg: 0.985 ± 0.235
4.748ThrSer: 4.748 ± 1.084
5.017ThrThr: 5.017 ± 0.723
5.017ThrVal: 5.017 ± 0.804
0.179ThrTrp: 0.179 ± 0.102
3.046ThrTyr: 3.046 ± 0.448
0.0ThrXaa: 0.0 ± 0.0
Val
4.659ValAla: 4.659 ± 0.949
0.09ValCys: 0.09 ± 0.108
5.017ValAsp: 5.017 ± 0.758
4.032ValGlu: 4.032 ± 0.63
2.598ValPhe: 2.598 ± 0.567
4.211ValGly: 4.211 ± 1.238
0.358ValHis: 0.358 ± 0.168
5.286ValIle: 5.286 ± 0.76
6.092ValLys: 6.092 ± 0.824
5.465ValLeu: 5.465 ± 0.998
1.881ValMet: 1.881 ± 0.417
3.852ValAsn: 3.852 ± 0.57
1.433ValPro: 1.433 ± 0.346
2.329ValGln: 2.329 ± 0.475
1.165ValArg: 1.165 ± 0.403
5.196ValSer: 5.196 ± 0.887
4.39ValThr: 4.39 ± 0.777
4.838ValVal: 4.838 ± 0.822
0.627ValTrp: 0.627 ± 0.194
2.15ValTyr: 2.15 ± 0.544
0.0ValXaa: 0.0 ± 0.0
Trp
0.627TrpAla: 0.627 ± 0.179
0.0TrpCys: 0.0 ± 0.0
0.627TrpAsp: 0.627 ± 0.246
0.627TrpGlu: 0.627 ± 0.243
0.448TrpPhe: 0.448 ± 0.189
0.269TrpGly: 0.269 ± 0.13
0.09TrpHis: 0.09 ± 0.097
1.075TrpIle: 1.075 ± 0.205
0.985TrpLys: 0.985 ± 0.267
0.717TrpLeu: 0.717 ± 0.263
0.358TrpMet: 0.358 ± 0.144
0.358TrpAsn: 0.358 ± 0.191
0.179TrpPro: 0.179 ± 0.131
0.448TrpGln: 0.448 ± 0.201
0.538TrpArg: 0.538 ± 0.162
0.806TrpSer: 0.806 ± 0.327
0.806TrpThr: 0.806 ± 0.307
0.269TrpVal: 0.269 ± 0.146
0.179TrpTrp: 0.179 ± 0.118
0.806TrpTyr: 0.806 ± 0.277
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.509TyrAla: 2.509 ± 0.67
0.09TyrCys: 0.09 ± 0.094
2.24TyrAsp: 2.24 ± 0.485
2.24TyrGlu: 2.24 ± 0.438
1.792TyrPhe: 1.792 ± 0.607
2.509TyrGly: 2.509 ± 0.441
0.269TyrHis: 0.269 ± 0.175
2.24TyrIle: 2.24 ± 0.437
3.763TyrLys: 3.763 ± 0.635
3.852TyrLeu: 3.852 ± 0.784
0.896TyrMet: 0.896 ± 0.242
2.329TyrAsn: 2.329 ± 0.332
1.075TyrPro: 1.075 ± 0.309
1.075TyrGln: 1.075 ± 0.32
2.777TyrArg: 2.777 ± 0.733
2.509TyrSer: 2.509 ± 0.487
2.329TyrThr: 2.329 ± 0.465
2.956TyrVal: 2.956 ± 0.382
0.538TyrTrp: 0.538 ± 0.21
1.881TyrTyr: 1.881 ± 0.527
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (11163 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski