Amino acid dipepetide frequency for Fluviicoccus keumensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.759AlaAla: 13.759 ± 0.168
1.236AlaCys: 1.236 ± 0.034
6.283AlaAsp: 6.283 ± 0.082
6.651AlaGlu: 6.651 ± 0.105
3.885AlaPhe: 3.885 ± 0.072
9.274AlaGly: 9.274 ± 0.135
2.134AlaHis: 2.134 ± 0.054
5.288AlaIle: 5.288 ± 0.069
3.856AlaLys: 3.856 ± 0.071
12.469AlaLeu: 12.469 ± 0.129
3.086AlaMet: 3.086 ± 0.057
3.124AlaAsn: 3.124 ± 0.063
4.647AlaPro: 4.647 ± 0.081
3.961AlaGln: 3.961 ± 0.068
7.09AlaArg: 7.09 ± 0.084
5.455AlaSer: 5.455 ± 0.076
5.085AlaThr: 5.085 ± 0.092
8.056AlaVal: 8.056 ± 0.084
1.674AlaTrp: 1.674 ± 0.041
2.442AlaTyr: 2.442 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.927CysAla: 0.927 ± 0.026
0.133CysCys: 0.133 ± 0.011
0.522CysAsp: 0.522 ± 0.023
0.543CysGlu: 0.543 ± 0.023
0.374CysPhe: 0.374 ± 0.019
0.954CysGly: 0.954 ± 0.031
0.302CysHis: 0.302 ± 0.018
0.406CysIle: 0.406 ± 0.017
0.266CysLys: 0.266 ± 0.016
1.122CysLeu: 1.122 ± 0.032
0.208CysMet: 0.208 ± 0.014
0.296CysAsn: 0.296 ± 0.016
0.544CysPro: 0.544 ± 0.024
0.372CysGln: 0.372 ± 0.021
0.72CysArg: 0.72 ± 0.027
0.543CysSer: 0.543 ± 0.023
0.506CysThr: 0.506 ± 0.042
0.647CysVal: 0.647 ± 0.027
0.134CysTrp: 0.134 ± 0.012
0.251CysTyr: 0.251 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
5.854AspAla: 5.854 ± 0.098
0.564AspCys: 0.564 ± 0.024
2.949AspAsp: 2.949 ± 0.056
3.232AspGlu: 3.232 ± 0.057
2.353AspPhe: 2.353 ± 0.049
4.462AspGly: 4.462 ± 0.084
1.183AspHis: 1.183 ± 0.035
3.181AspIle: 3.181 ± 0.057
2.133AspLys: 2.133 ± 0.053
5.53AspLeu: 5.53 ± 0.071
1.376AspMet: 1.376 ± 0.034
1.849AspAsn: 1.849 ± 0.049
2.74AspPro: 2.74 ± 0.058
1.715AspGln: 1.715 ± 0.041
3.603AspArg: 3.603 ± 0.068
2.923AspSer: 2.923 ± 0.054
2.744AspThr: 2.744 ± 0.079
3.635AspVal: 3.635 ± 0.059
1.061AspTrp: 1.061 ± 0.036
1.8AspTyr: 1.8 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
6.812GluAla: 6.812 ± 0.089
0.46GluCys: 0.46 ± 0.021
2.618GluAsp: 2.618 ± 0.056
3.198GluGlu: 3.198 ± 0.073
2.002GluPhe: 2.002 ± 0.047
3.899GluGly: 3.899 ± 0.069
1.453GluHis: 1.453 ± 0.038
3.03GluIle: 3.03 ± 0.063
2.543GluLys: 2.543 ± 0.065
6.165GluLeu: 6.165 ± 0.092
1.464GluMet: 1.464 ± 0.042
1.812GluAsn: 1.812 ± 0.042
2.373GluPro: 2.373 ± 0.05
2.72GluGln: 2.72 ± 0.061
4.034GluArg: 4.034 ± 0.076
2.985GluSer: 2.985 ± 0.055
2.974GluThr: 2.974 ± 0.05
3.97GluVal: 3.97 ± 0.064
0.817GluTrp: 0.817 ± 0.028
1.344GluTyr: 1.344 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.741PheAla: 3.741 ± 0.068
0.453PheCys: 0.453 ± 0.018
2.263PheAsp: 2.263 ± 0.047
1.91PheGlu: 1.91 ± 0.046
1.474PhePhe: 1.474 ± 0.049
3.115PheGly: 3.115 ± 0.054
0.825PheHis: 0.825 ± 0.03
1.74PheIle: 1.74 ± 0.046
1.222PheLys: 1.222 ± 0.034
3.613PheLeu: 3.613 ± 0.064
0.909PheMet: 0.909 ± 0.03
1.379PheAsn: 1.379 ± 0.038
1.752PhePro: 1.752 ± 0.045
1.166PheGln: 1.166 ± 0.037
2.389PheArg: 2.389 ± 0.055
2.406PheSer: 2.406 ± 0.05
2.19PheThr: 2.19 ± 0.055
2.428PheVal: 2.428 ± 0.056
0.564PheTrp: 0.564 ± 0.027
1.079PheTyr: 1.079 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
6.847GlyAla: 6.847 ± 0.108
0.944GlyCys: 0.944 ± 0.032
4.114GlyAsp: 4.114 ± 0.082
4.734GlyGlu: 4.734 ± 0.068
3.29GlyPhe: 3.29 ± 0.067
6.4GlyGly: 6.4 ± 0.135
1.832GlyHis: 1.832 ± 0.041
4.346GlyIle: 4.346 ± 0.071
3.789GlyLys: 3.789 ± 0.064
9.012GlyLeu: 9.012 ± 0.111
2.438GlyMet: 2.438 ± 0.052
2.68GlyAsn: 2.68 ± 0.112
2.39GlyPro: 2.39 ± 0.052
3.204GlyGln: 3.204 ± 0.055
4.91GlyArg: 4.91 ± 0.091
4.382GlySer: 4.382 ± 0.089
3.63GlyThr: 3.63 ± 0.099
6.019GlyVal: 6.019 ± 0.094
1.289GlyTrp: 1.289 ± 0.039
2.513GlyTyr: 2.513 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
2.421HisAla: 2.421 ± 0.045
0.262HisCys: 0.262 ± 0.015
1.339HisAsp: 1.339 ± 0.04
1.214HisGlu: 1.214 ± 0.035
0.993HisPhe: 0.993 ± 0.03
1.987HisGly: 1.987 ± 0.042
0.759HisHis: 0.759 ± 0.031
1.1HisIle: 1.1 ± 0.032
0.638HisLys: 0.638 ± 0.027
2.448HisLeu: 2.448 ± 0.049
0.493HisMet: 0.493 ± 0.025
0.591HisAsn: 0.591 ± 0.022
1.554HisPro: 1.554 ± 0.041
0.841HisGln: 0.841 ± 0.026
1.5HisArg: 1.5 ± 0.04
1.073HisSer: 1.073 ± 0.033
1.055HisThr: 1.055 ± 0.027
1.429HisVal: 1.429 ± 0.037
0.394HisTrp: 0.394 ± 0.019
0.797HisTyr: 0.797 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.375IleAla: 5.375 ± 0.076
0.49IleCys: 0.49 ± 0.023
3.004IleAsp: 3.004 ± 0.056
2.758IleGlu: 2.758 ± 0.065
1.53IlePhe: 1.53 ± 0.039
4.058IleGly: 4.058 ± 0.065
1.128IleHis: 1.128 ± 0.034
2.253IleIle: 2.253 ± 0.056
1.684IleLys: 1.684 ± 0.04
4.4IleLeu: 4.4 ± 0.082
0.963IleMet: 0.963 ± 0.034
1.974IleAsn: 1.974 ± 0.041
2.687IlePro: 2.687 ± 0.054
1.567IleGln: 1.567 ± 0.035
3.688IleArg: 3.688 ± 0.054
3.049IleSer: 3.049 ± 0.057
2.779IleThr: 2.779 ± 0.059
3.249IleVal: 3.249 ± 0.053
0.477IleTrp: 0.477 ± 0.021
1.17IleTyr: 1.17 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.376LysAla: 4.376 ± 0.083
0.224LysCys: 0.224 ± 0.016
1.898LysAsp: 1.898 ± 0.048
1.927LysGlu: 1.927 ± 0.048
1.007LysPhe: 1.007 ± 0.032
2.636LysGly: 2.636 ± 0.058
0.818LysHis: 0.818 ± 0.025
1.802LysIle: 1.802 ± 0.043
1.651LysLys: 1.651 ± 0.051
3.885LysLeu: 3.885 ± 0.071
0.926LysMet: 0.926 ± 0.031
1.195LysAsn: 1.195 ± 0.035
2.414LysPro: 2.414 ± 0.054
1.588LysGln: 1.588 ± 0.042
2.255LysArg: 2.255 ± 0.047
2.033LysSer: 2.033 ± 0.047
2.243LysThr: 2.243 ± 0.053
2.808LysVal: 2.808 ± 0.057
0.41LysTrp: 0.41 ± 0.019
0.894LysTyr: 0.894 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
13.428LeuAla: 13.428 ± 0.164
1.051LeuCys: 1.051 ± 0.032
6.292LeuAsp: 6.292 ± 0.087
6.035LeuGlu: 6.035 ± 0.104
3.687LeuPhe: 3.687 ± 0.063
8.179LeuGly: 8.179 ± 0.106
2.405LeuHis: 2.405 ± 0.06
4.685LeuIle: 4.685 ± 0.079
4.534LeuLys: 4.534 ± 0.068
12.045LeuLeu: 12.045 ± 0.162
2.783LeuMet: 2.783 ± 0.06
3.572LeuAsn: 3.572 ± 0.063
6.5LeuPro: 6.5 ± 0.093
4.614LeuGln: 4.614 ± 0.076
6.926LeuArg: 6.926 ± 0.077
6.986LeuSer: 6.986 ± 0.091
6.419LeuThr: 6.419 ± 0.107
7.324LeuVal: 7.324 ± 0.102
1.392LeuTrp: 1.392 ± 0.04
2.393LeuTyr: 2.393 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
2.862MetAla: 2.862 ± 0.053
0.186MetCys: 0.186 ± 0.014
1.258MetAsp: 1.258 ± 0.037
1.201MetGlu: 1.201 ± 0.036
0.702MetPhe: 0.702 ± 0.028
1.792MetGly: 1.792 ± 0.048
0.52MetHis: 0.52 ± 0.023
1.15MetIle: 1.15 ± 0.034
1.159MetLys: 1.159 ± 0.034
2.641MetLeu: 2.641 ± 0.06
0.71MetMet: 0.71 ± 0.029
0.993MetAsn: 0.993 ± 0.029
1.531MetPro: 1.531 ± 0.033
1.176MetGln: 1.176 ± 0.034
1.549MetArg: 1.549 ± 0.038
1.704MetSer: 1.704 ± 0.043
1.847MetThr: 1.847 ± 0.044
1.79MetVal: 1.79 ± 0.039
0.199MetTrp: 0.199 ± 0.013
0.387MetTyr: 0.387 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.362AsnAla: 3.362 ± 0.081
0.306AsnCys: 0.306 ± 0.016
1.695AsnAsp: 1.695 ± 0.061
1.45AsnGlu: 1.45 ± 0.04
1.071AsnPhe: 1.071 ± 0.037
2.82AsnGly: 2.82 ± 0.076
0.729AsnHis: 0.729 ± 0.024
1.699AsnIle: 1.699 ± 0.045
1.013AsnLys: 1.013 ± 0.032
3.257AsnLeu: 3.257 ± 0.054
0.645AsnMet: 0.645 ± 0.024
1.121AsnAsn: 1.121 ± 0.037
2.306AsnPro: 2.306 ± 0.053
1.133AsnGln: 1.133 ± 0.034
2.24AsnArg: 2.24 ± 0.05
1.7AsnSer: 1.7 ± 0.044
1.771AsnThr: 1.771 ± 0.054
2.003AsnVal: 2.003 ± 0.051
0.429AsnTrp: 0.429 ± 0.019
0.894AsnTyr: 0.894 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
6.153ProAla: 6.153 ± 0.097
0.375ProCys: 0.375 ± 0.02
3.563ProAsp: 3.563 ± 0.065
4.053ProGlu: 4.053 ± 0.071
1.8ProPhe: 1.8 ± 0.045
4.162ProGly: 4.162 ± 0.069
1.106ProHis: 1.106 ± 0.036
1.778ProIle: 1.778 ± 0.037
1.638ProLys: 1.638 ± 0.044
5.266ProLeu: 5.266 ± 0.085
1.23ProMet: 1.23 ± 0.035
1.313ProAsn: 1.313 ± 0.035
2.396ProPro: 2.396 ± 0.057
1.824ProGln: 1.824 ± 0.037
2.499ProArg: 2.499 ± 0.061
2.602ProSer: 2.602 ± 0.055
2.182ProThr: 2.182 ± 0.051
4.946ProVal: 4.946 ± 0.073
0.725ProTrp: 0.725 ± 0.028
1.205ProTyr: 1.205 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.929GlnAla: 4.929 ± 0.076
0.325GlnCys: 0.325 ± 0.018
1.859GlnAsp: 1.859 ± 0.045
2.041GlnGlu: 2.041 ± 0.052
1.257GlnPhe: 1.257 ± 0.037
3.033GlnGly: 3.033 ± 0.053
0.959GlnHis: 0.959 ± 0.032
1.841GlnIle: 1.841 ± 0.043
1.528GlnLys: 1.528 ± 0.045
4.34GlnLeu: 4.34 ± 0.07
0.967GlnMet: 0.967 ± 0.029
1.048GlnAsn: 1.048 ± 0.03
2.137GlnPro: 2.137 ± 0.052
2.217GlnGln: 2.217 ± 0.062
2.849GlnArg: 2.849 ± 0.053
2.097GlnSer: 2.097 ± 0.05
2.131GlnThr: 2.131 ± 0.051
3.06GlnVal: 3.06 ± 0.05
0.572GlnTrp: 0.572 ± 0.024
0.886GlnTyr: 0.886 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
5.769ArgAla: 5.769 ± 0.075
0.561ArgCys: 0.561 ± 0.024
3.68ArgAsp: 3.68 ± 0.067
4.336ArgGlu: 4.336 ± 0.072
2.997ArgPhe: 2.997 ± 0.056
3.728ArgGly: 3.728 ± 0.06
1.966ArgHis: 1.966 ± 0.043
3.657ArgIle: 3.657 ± 0.062
2.366ArgLys: 2.366 ± 0.051
8.467ArgLeu: 8.467 ± 0.114
1.726ArgMet: 1.726 ± 0.043
2.047ArgAsn: 2.047 ± 0.045
2.932ArgPro: 2.932 ± 0.071
3.597ArgGln: 3.597 ± 0.071
4.52ArgArg: 4.52 ± 0.075
3.033ArgSer: 3.033 ± 0.05
2.91ArgThr: 2.91 ± 0.055
4.571ArgVal: 4.571 ± 0.082
1.048ArgTrp: 1.048 ± 0.031
2.078ArgTyr: 2.078 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
5.859SerAla: 5.859 ± 0.085
0.552SerCys: 0.552 ± 0.031
2.705SerAsp: 2.705 ± 0.046
2.674SerGlu: 2.674 ± 0.06
2.12SerPhe: 2.12 ± 0.052
5.365SerGly: 5.365 ± 0.106
1.251SerHis: 1.251 ± 0.037
2.429SerIle: 2.429 ± 0.051
1.727SerLys: 1.727 ± 0.045
6.84SerLeu: 6.84 ± 0.087
1.357SerMet: 1.357 ± 0.04
1.607SerAsn: 1.607 ± 0.044
3.135SerPro: 3.135 ± 0.058
1.973SerGln: 1.973 ± 0.043
3.823SerArg: 3.823 ± 0.062
3.052SerSer: 3.052 ± 0.066
2.795SerThr: 2.795 ± 0.076
3.891SerVal: 3.891 ± 0.068
0.8SerTrp: 0.8 ± 0.028
1.417SerTyr: 1.417 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
5.931ThrAla: 5.931 ± 0.111
0.457ThrCys: 0.457 ± 0.022
2.758ThrAsp: 2.758 ± 0.058
2.484ThrGlu: 2.484 ± 0.049
1.719ThrPhe: 1.719 ± 0.043
5.188ThrGly: 5.188 ± 0.11
1.079ThrHis: 1.079 ± 0.033
2.296ThrIle: 2.296 ± 0.055
1.271ThrLys: 1.271 ± 0.039
6.66ThrLeu: 6.66 ± 0.107
1.018ThrMet: 1.018 ± 0.034
1.284ThrAsn: 1.284 ± 0.051
3.602ThrPro: 3.602 ± 0.063
1.782ThrGln: 1.782 ± 0.044
3.282ThrArg: 3.282 ± 0.068
2.568ThrSer: 2.568 ± 0.078
2.93ThrThr: 2.93 ± 0.127
4.346ThrVal: 4.346 ± 0.088
0.622ThrTrp: 0.622 ± 0.025
1.236ThrTyr: 1.236 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
7.469ValAla: 7.469 ± 0.09
0.755ValCys: 0.755 ± 0.028
3.872ValAsp: 3.872 ± 0.074
4.21ValGlu: 4.21 ± 0.072
2.719ValPhe: 2.719 ± 0.05
4.776ValGly: 4.776 ± 0.081
1.465ValHis: 1.465 ± 0.04
3.983ValIle: 3.983 ± 0.062
2.676ValLys: 2.676 ± 0.061
7.926ValLeu: 7.926 ± 0.098
2.121ValMet: 2.121 ± 0.048
2.505ValAsn: 2.505 ± 0.048
3.273ValPro: 3.273 ± 0.065
2.592ValGln: 2.592 ± 0.045
4.846ValArg: 4.846 ± 0.068
4.61ValSer: 4.61 ± 0.078
4.286ValThr: 4.286 ± 0.093
5.534ValVal: 5.534 ± 0.09
1.038ValTrp: 1.038 ± 0.032
1.825ValTyr: 1.825 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
1.089TrpAla: 1.089 ± 0.034
0.154TrpCys: 0.154 ± 0.012
0.624TrpAsp: 0.624 ± 0.025
0.658TrpGlu: 0.658 ± 0.028
0.57TrpPhe: 0.57 ± 0.022
0.905TrpGly: 0.905 ± 0.031
0.365TrpHis: 0.365 ± 0.019
0.607TrpIle: 0.607 ± 0.026
0.546TrpLys: 0.546 ± 0.022
2.213TrpLeu: 2.213 ± 0.06
0.436TrpMet: 0.436 ± 0.023
0.465TrpAsn: 0.465 ± 0.021
0.631TrpPro: 0.631 ± 0.025
0.873TrpGln: 0.873 ± 0.031
1.176TrpArg: 1.176 ± 0.039
0.768TrpSer: 0.768 ± 0.029
0.662TrpThr: 0.662 ± 0.025
0.976TrpVal: 0.976 ± 0.029
0.25TrpTrp: 0.25 ± 0.013
0.385TrpTyr: 0.385 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.495TyrAla: 2.495 ± 0.055
0.28TyrCys: 0.28 ± 0.016
1.59TyrAsp: 1.59 ± 0.093
1.367TyrGlu: 1.367 ± 0.046
1.068TyrPhe: 1.068 ± 0.033
2.032TyrGly: 2.032 ± 0.045
0.609TyrHis: 0.609 ± 0.025
1.011TyrIle: 1.011 ± 0.025
0.748TyrLys: 0.748 ± 0.027
2.95TyrLeu: 2.95 ± 0.049
0.5TyrMet: 0.5 ± 0.021
0.789TyrAsn: 0.789 ± 0.03
1.273TyrPro: 1.273 ± 0.033
1.159TyrGln: 1.159 ± 0.033
2.09TyrArg: 2.09 ± 0.042
1.404TyrSer: 1.404 ± 0.042
1.374TyrThr: 1.374 ± 0.046
1.8TyrVal: 1.8 ± 0.048
0.455TyrTrp: 0.455 ± 0.021
0.829TyrTyr: 0.829 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3271 proteins (1113237 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski