Amino acid dipepetide frequency for Hebeloma cylindrosporum h7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.308AlaAla: 7.308 ± 0.049	1.007AlaCys: 1.007 ± 0.013	3.651AlaAsp: 3.651 ± 0.024	4.306AlaGlu: 4.306 ± 0.029	3.303AlaPhe: 3.303 ± 0.027	4.876AlaGly: 4.876 ± 0.032	1.898AlaHis: 1.898 ± 0.019	4.133AlaIle: 4.133 ± 0.031	3.729AlaLys: 3.729 ± 0.035	7.763AlaLeu: 7.763 ± 0.042	1.737AlaMet: 1.737 ± 0.017	2.79AlaAsn: 2.79 ± 0.023	4.708AlaPro: 4.708 ± 0.04	2.977AlaGln: 2.977 ± 0.024	4.553AlaArg: 4.553 ± 0.03	7.154AlaSer: 7.154 ± 0.038	4.817AlaThr: 4.817 ± 0.031	4.795AlaVal: 4.795 ± 0.036	1.057AlaTrp: 1.057 ± 0.015	1.993AlaTyr: 1.993 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.917CysAla: 0.917 ± 0.013	0.239CysCys: 0.239 ± 0.007	0.64CysAsp: 0.64 ± 0.011	0.589CysGlu: 0.589 ± 0.011	0.555CysPhe: 0.555 ± 0.01	0.89CysGly: 0.89 ± 0.014	0.364CysHis: 0.364 ± 0.008	0.739CysIle: 0.739 ± 0.013	0.53CysLys: 0.53 ± 0.01	1.321CysLeu: 1.321 ± 0.017	0.278CysMet: 0.278 ± 0.006	0.439CysAsn: 0.439 ± 0.009	0.775CysPro: 0.775 ± 0.012	0.451CysGln: 0.451 ± 0.01	0.803CysArg: 0.803 ± 0.014	1.052CysSer: 1.052 ± 0.015	0.71CysThr: 0.71 ± 0.012	0.788CysVal: 0.788 ± 0.012	0.203CysTrp: 0.203 ± 0.006	0.332CysTyr: 0.332 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.307AspAla: 4.307 ± 0.029	0.593AspCys: 0.593 ± 0.01	4.174AspAsp: 4.174 ± 0.038	4.151AspGlu: 4.151 ± 0.037	2.255AspPhe: 2.255 ± 0.021	3.668AspGly: 3.668 ± 0.025	1.288AspHis: 1.288 ± 0.016	3.285AspIle: 3.285 ± 0.025	2.167AspLys: 2.167 ± 0.021	5.14AspLeu: 5.14 ± 0.033	1.126AspMet: 1.126 ± 0.014	1.853AspAsn: 1.853 ± 0.02	3.488AspPro: 3.488 ± 0.03	1.593AspGln: 1.593 ± 0.017	2.789AspArg: 2.789 ± 0.028	4.165AspSer: 4.165 ± 0.032	2.696AspThr: 2.696 ± 0.023	3.708AspVal: 3.708 ± 0.024	0.862AspTrp: 0.862 ± 0.012	1.432AspTyr: 1.432 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	4.551GluAla: 4.551 ± 0.032	0.653GluCys: 0.653 ± 0.012	4.027GluAsp: 4.027 ± 0.033	5.331GluGlu: 5.331 ± 0.049	2.021GluPhe: 2.021 ± 0.018	3.611GluGly: 3.611 ± 0.027	1.346GluHis: 1.346 ± 0.013	3.201GluIle: 3.201 ± 0.027	3.295GluLys: 3.295 ± 0.03	5.229GluLeu: 5.229 ± 0.036	1.362GluMet: 1.362 ± 0.016	2.17GluAsn: 2.17 ± 0.021	2.671GluPro: 2.671 ± 0.022	2.021GluGln: 2.021 ± 0.02	3.902GluArg: 3.902 ± 0.034	4.071GluSer: 4.071 ± 0.027	3.041GluThr: 3.041 ± 0.025	3.491GluVal: 3.491 ± 0.026	0.879GluTrp: 0.879 ± 0.013	1.557GluTyr: 1.557 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.007PheAla: 3.007 ± 0.022	0.604PheCys: 0.604 ± 0.011	2.363PheAsp: 2.363 ± 0.023	2.121PheGlu: 2.121 ± 0.023	1.853PhePhe: 1.853 ± 0.022	2.726PheGly: 2.726 ± 0.03	1.085PheHis: 1.085 ± 0.012	2.113PheIle: 2.113 ± 0.021	1.667PheLys: 1.667 ± 0.016	4.04PheLeu: 4.04 ± 0.029	0.824PheMet: 0.824 ± 0.013	1.541PheAsn: 1.541 ± 0.017	2.435PhePro: 2.435 ± 0.022	1.425PheGln: 1.425 ± 0.017	2.142PheArg: 2.142 ± 0.024	3.608PheSer: 3.608 ± 0.027	2.228PheThr: 2.228 ± 0.02	2.521PheVal: 2.521 ± 0.024	0.601PheTrp: 0.601 ± 0.011	1.119PheTyr: 1.119 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	4.528GlyAla: 4.528 ± 0.032	0.82GlyCys: 0.82 ± 0.013	3.313GlyAsp: 3.313 ± 0.027	3.278GlyGlu: 3.278 ± 0.025	2.663GlyPhe: 2.663 ± 0.024	5.376GlyGly: 5.376 ± 0.06	1.626GlyHis: 1.626 ± 0.019	3.373GlyIle: 3.373 ± 0.025	3.343GlyLys: 3.343 ± 0.026	5.498GlyLeu: 5.498 ± 0.033	1.478GlyMet: 1.478 ± 0.018	2.439GlyAsn: 2.439 ± 0.024	3.309GlyPro: 3.309 ± 0.029	2.149GlyGln: 2.149 ± 0.019	3.89GlyArg: 3.89 ± 0.033	5.492GlySer: 5.492 ± 0.038	3.669GlyThr: 3.669 ± 0.028	4.126GlyVal: 4.126 ± 0.031	1.102GlyTrp: 1.102 ± 0.013	1.837GlyTyr: 1.837 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.915HisAla: 1.915 ± 0.021	0.371HisCys: 0.371 ± 0.008	1.34HisAsp: 1.34 ± 0.017	1.313HisGlu: 1.313 ± 0.015	1.096HisPhe: 1.096 ± 0.015	1.621HisGly: 1.621 ± 0.017	1.005HisHis: 1.005 ± 0.02	1.48HisIle: 1.48 ± 0.018	0.967HisLys: 0.967 ± 0.017	2.729HisLeu: 2.729 ± 0.025	0.477HisMet: 0.477 ± 0.009	0.883HisAsn: 0.883 ± 0.012	2.068HisPro: 2.068 ± 0.023	0.99HisGln: 0.99 ± 0.015	1.745HisArg: 1.745 ± 0.019	2.243HisSer: 2.243 ± 0.022	1.421HisThr: 1.421 ± 0.017	1.536HisVal: 1.536 ± 0.016	0.354HisTrp: 0.354 ± 0.007	0.707HisTyr: 0.707 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.123IleAla: 4.123 ± 0.028	0.802IleCys: 0.802 ± 0.013	2.905IleAsp: 2.905 ± 0.024	2.727IleGlu: 2.727 ± 0.023	2.28IlePhe: 2.28 ± 0.021	3.027IleGly: 3.027 ± 0.026	1.473IleHis: 1.473 ± 0.016	2.798IleIle: 2.798 ± 0.023	2.189IleLys: 2.189 ± 0.024	5.166IleLeu: 5.166 ± 0.031	1.009IleMet: 1.009 ± 0.015	1.828IleAsn: 1.828 ± 0.02	3.766IlePro: 3.766 ± 0.025	1.977IleGln: 1.977 ± 0.02	2.999IleArg: 2.999 ± 0.025	4.573IleSer: 4.573 ± 0.029	2.96IleThr: 2.96 ± 0.021	3.256IleVal: 3.256 ± 0.028	0.784IleTrp: 0.784 ± 0.013	1.489IleTyr: 1.489 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.03LysAla: 4.03 ± 0.036	0.538LysCys: 0.538 ± 0.01	2.572LysAsp: 2.572 ± 0.025	3.24LysGlu: 3.24 ± 0.03	1.598LysPhe: 1.598 ± 0.018	2.862LysGly: 2.862 ± 0.024	1.157LysHis: 1.157 ± 0.018	2.334LysIle: 2.334 ± 0.019	3.234LysLys: 3.234 ± 0.039	4.138LysLeu: 4.138 ± 0.028	0.957LysMet: 0.957 ± 0.015	1.708LysAsn: 1.708 ± 0.019	2.762LysPro: 2.762 ± 0.025	1.626LysGln: 1.626 ± 0.017	3.482LysArg: 3.482 ± 0.029	3.522LysSer: 3.522 ± 0.028	2.659LysThr: 2.659 ± 0.026	2.877LysVal: 2.877 ± 0.024	0.664LysTrp: 0.664 ± 0.011	1.311LysTyr: 1.311 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.6LeuAla: 7.6 ± 0.04	1.31LeuCys: 1.31 ± 0.017	5.307LeuAsp: 5.307 ± 0.027	5.844LeuGlu: 5.844 ± 0.04	3.688LeuPhe: 3.688 ± 0.025	5.625LeuGly: 5.625 ± 0.033	2.646LeuHis: 2.646 ± 0.023	4.194LeuIle: 4.194 ± 0.028	4.455LeuLys: 4.455 ± 0.03	8.822LeuLeu: 8.822 ± 0.055	1.748LeuMet: 1.748 ± 0.018	3.301LeuAsn: 3.301 ± 0.025	6.458LeuPro: 6.458 ± 0.037	3.773LeuGln: 3.773 ± 0.029	6.074LeuArg: 6.074 ± 0.035	8.325LeuSer: 8.325 ± 0.045	5.289LeuThr: 5.289 ± 0.034	5.69LeuVal: 5.69 ± 0.04	1.239LeuTrp: 1.239 ± 0.015	2.414LeuTyr: 2.414 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	1.799MetAla: 1.799 ± 0.02	0.233MetCys: 0.233 ± 0.006	1.304MetAsp: 1.304 ± 0.016	1.305MetGlu: 1.305 ± 0.014	0.759MetPhe: 0.759 ± 0.01	1.306MetGly: 1.306 ± 0.019	0.511MetHis: 0.511 ± 0.009	0.959MetIle: 0.959 ± 0.013	1.052MetLys: 1.052 ± 0.015	1.793MetLeu: 1.793 ± 0.018	0.502MetMet: 0.502 ± 0.011	0.808MetAsn: 0.808 ± 0.011	1.217MetPro: 1.217 ± 0.017	0.778MetGln: 0.778 ± 0.012	1.235MetArg: 1.235 ± 0.013	1.864MetSer: 1.864 ± 0.016	1.208MetThr: 1.208 ± 0.015	1.227MetVal: 1.227 ± 0.012	0.252MetTrp: 0.252 ± 0.007	0.52MetTyr: 0.52 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.104AsnAla: 3.104 ± 0.023	0.417AsnCys: 0.417 ± 0.009	1.914AsnAsp: 1.914 ± 0.02	1.899AsnGlu: 1.899 ± 0.019	1.459AsnPhe: 1.459 ± 0.016	2.604AsnGly: 2.604 ± 0.025	0.956AsnHis: 0.956 ± 0.014	2.14AsnIle: 2.14 ± 0.02	1.519AsnLys: 1.519 ± 0.016	3.609AsnLeu: 3.609 ± 0.029	0.753AsnMet: 0.753 ± 0.012	1.487AsnAsn: 1.487 ± 0.02	2.753AsnPro: 2.753 ± 0.025	1.241AsnGln: 1.241 ± 0.017	1.907AsnArg: 1.907 ± 0.022	2.966AsnSer: 2.966 ± 0.026	2.109AsnThr: 2.109 ± 0.019	2.462AsnVal: 2.462 ± 0.022	0.509AsnTrp: 0.509 ± 0.01	0.938AsnTyr: 0.938 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	5.017ProAla: 5.017 ± 0.039	0.584ProCys: 0.584 ± 0.01	3.128ProAsp: 3.128 ± 0.025	3.628ProGlu: 3.628 ± 0.027	2.46ProPhe: 2.46 ± 0.023	3.78ProGly: 3.78 ± 0.033	1.712ProHis: 1.712 ± 0.018	3.11ProIle: 3.11 ± 0.026	2.739ProLys: 2.739 ± 0.028	5.603ProLeu: 5.603 ± 0.036	1.15ProMet: 1.15 ± 0.014	2.51ProAsn: 2.51 ± 0.026	6.906ProPro: 6.906 ± 0.077	2.51ProGln: 2.51 ± 0.021	3.759ProArg: 3.759 ± 0.026	7.457ProSer: 7.457 ± 0.05	4.73ProThr: 4.73 ± 0.035	3.712ProVal: 3.712 ± 0.028	0.734ProTrp: 0.734 ± 0.012	1.577ProTyr: 1.577 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	2.967GlnAla: 2.967 ± 0.026	0.458GlnCys: 0.458 ± 0.01	1.842GlnAsp: 1.842 ± 0.02	2.188GlnGlu: 2.188 ± 0.019	1.313GlnPhe: 1.313 ± 0.017	2.187GlnGly: 2.187 ± 0.02	1.066GlnHis: 1.066 ± 0.014	1.875GlnIle: 1.875 ± 0.015	1.735GlnLys: 1.735 ± 0.02	3.363GlnLeu: 3.363 ± 0.025	0.76GlnMet: 0.76 ± 0.011	1.381GlnAsn: 1.381 ± 0.016	2.462GlnPro: 2.462 ± 0.025	2.133GlnGln: 2.133 ± 0.062	2.492GlnArg: 2.492 ± 0.023	2.909GlnSer: 2.909 ± 0.027	2.212GlnThr: 2.212 ± 0.022	2.096GlnVal: 2.096 ± 0.021	0.511GlnTrp: 0.511 ± 0.01	1.025GlnTyr: 1.025 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	4.414ArgAla: 4.414 ± 0.032	0.811ArgCys: 0.811 ± 0.013	3.183ArgAsp: 3.183 ± 0.027	3.701ArgGlu: 3.701 ± 0.034	2.317ArgPhe: 2.317 ± 0.021	3.555ArgGly: 3.555 ± 0.03	1.634ArgHis: 1.634 ± 0.017	3.241ArgIle: 3.241 ± 0.025	3.547ArgLys: 3.547 ± 0.029	5.676ArgLeu: 5.676 ± 0.033	1.355ArgMet: 1.355 ± 0.014	2.324ArgAsn: 2.324 ± 0.02	3.663ArgPro: 3.663 ± 0.03	2.307ArgGln: 2.307 ± 0.025	5.059ArgArg: 5.059 ± 0.042	5.188ArgSer: 5.188 ± 0.044	3.493ArgThr: 3.493 ± 0.025	3.504ArgVal: 3.504 ± 0.025	0.951ArgTrp: 0.951 ± 0.013	1.677ArgTyr: 1.677 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.559SerAla: 6.559 ± 0.038	0.999SerCys: 0.999 ± 0.015	4.244SerAsp: 4.244 ± 0.032	4.102SerGlu: 4.102 ± 0.029	3.552SerPhe: 3.552 ± 0.027	5.478SerGly: 5.478 ± 0.037	2.253SerHis: 2.253 ± 0.023	4.476SerIle: 4.476 ± 0.03	3.825SerLys: 3.825 ± 0.034	8.291SerLeu: 8.291 ± 0.048	1.798SerMet: 1.798 ± 0.02	3.252SerAsn: 3.252 ± 0.027	6.506SerPro: 6.506 ± 0.053	3.241SerGln: 3.241 ± 0.027	5.434SerArg: 5.434 ± 0.037	10.616SerSer: 10.616 ± 0.082	6.18SerThr: 6.18 ± 0.04	4.865SerVal: 4.865 ± 0.031	1.104SerTrp: 1.104 ± 0.012	2.099SerTyr: 2.099 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	4.578ThrAla: 4.578 ± 0.027	0.741ThrCys: 0.741 ± 0.013	2.581ThrAsp: 2.581 ± 0.022	2.721ThrGlu: 2.721 ± 0.021	2.553ThrPhe: 2.553 ± 0.022	3.679ThrGly: 3.679 ± 0.033	1.535ThrHis: 1.535 ± 0.017	3.247ThrIle: 3.247 ± 0.024	2.524ThrLys: 2.524 ± 0.024	5.791ThrLeu: 5.791 ± 0.035	1.187ThrMet: 1.187 ± 0.016	2.11ThrAsn: 2.11 ± 0.02	4.697ThrPro: 4.697 ± 0.039	2.034ThrGln: 2.034 ± 0.02	3.358ThrArg: 3.358 ± 0.028	5.827ThrSer: 5.827 ± 0.038	4.42ThrThr: 4.42 ± 0.039	3.572ThrVal: 3.572 ± 0.027	0.807ThrTrp: 0.807 ± 0.012	1.58ThrTyr: 1.58 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	4.839ValAla: 4.839 ± 0.034	0.84ValCys: 0.84 ± 0.014	3.78ValAsp: 3.78 ± 0.024	3.725ValGlu: 3.725 ± 0.027	2.5ValPhe: 2.5 ± 0.021	3.799ValGly: 3.799 ± 0.027	1.599ValHis: 1.599 ± 0.018	3.177ValIle: 3.177 ± 0.024	2.851ValLys: 2.851 ± 0.026	5.887ValLeu: 5.887 ± 0.039	1.237ValMet: 1.237 ± 0.016	2.236ValAsn: 2.236 ± 0.022	3.888ValPro: 3.888 ± 0.029	2.307ValGln: 2.307 ± 0.022	3.412ValArg: 3.412 ± 0.026	4.669ValSer: 4.669 ± 0.026	3.282ValThr: 3.282 ± 0.028	4.37ValVal: 4.37 ± 0.031	0.889ValTrp: 0.889 ± 0.014	1.7ValTyr: 1.7 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.028TrpAla: 1.028 ± 0.014	0.219TrpCys: 0.219 ± 0.007	0.898TrpAsp: 0.898 ± 0.013	0.843TrpGlu: 0.843 ± 0.013	0.58TrpPhe: 0.58 ± 0.009	0.861TrpGly: 0.861 ± 0.014	0.328TrpHis: 0.328 ± 0.007	0.798TrpIle: 0.798 ± 0.011	0.846TrpLys: 0.846 ± 0.013	1.246TrpLeu: 1.246 ± 0.015	0.349TrpMet: 0.349 ± 0.008	0.655TrpAsn: 0.655 ± 0.011	0.606TrpPro: 0.606 ± 0.01	0.445TrpGln: 0.445 ± 0.009	0.973TrpArg: 0.973 ± 0.014	1.078TrpSer: 1.078 ± 0.013	0.875TrpThr: 0.875 ± 0.013	0.843TrpVal: 0.843 ± 0.012	0.268TrpTrp: 0.268 ± 0.007	0.4TrpTyr: 0.4 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.965TyrAla: 1.965 ± 0.018	0.376TyrCys: 0.376 ± 0.007	1.576TyrAsp: 1.576 ± 0.019	1.42TyrGlu: 1.42 ± 0.016	1.218TyrPhe: 1.218 ± 0.016	1.778TyrGly: 1.778 ± 0.023	0.781TyrHis: 0.781 ± 0.013	1.46TyrIle: 1.46 ± 0.017	1.058TyrLys: 1.058 ± 0.013	2.694TyrLeu: 2.694 ± 0.022	0.545TyrMet: 0.545 ± 0.009	1.03TyrAsn: 1.03 ± 0.014	1.669TyrPro: 1.669 ± 0.019	0.996TyrGln: 0.996 ± 0.012	1.589TyrArg: 1.589 ± 0.018	2.095TyrSer: 2.095 ± 0.02	1.544TyrThr: 1.544 ± 0.017	1.547TyrVal: 1.547 ± 0.017	0.367TyrTrp: 0.367 ± 0.007	0.855TyrTyr: 0.855 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 15327 proteins (5907033 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---