Amino acid dipepetide frequency for Tropicimonas sediminicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.258AlaAla: 17.258 ± 0.166	1.174AlaCys: 1.174 ± 0.028	6.743AlaAsp: 6.743 ± 0.078	9.05AlaGlu: 9.05 ± 0.11	4.547AlaPhe: 4.547 ± 0.065	11.193AlaGly: 11.193 ± 0.09	2.19AlaHis: 2.19 ± 0.04	6.018AlaIle: 6.018 ± 0.067	3.008AlaLys: 3.008 ± 0.047	13.848AlaLeu: 13.848 ± 0.12	3.804AlaMet: 3.804 ± 0.054	2.648AlaAsn: 2.648 ± 0.047	6.11AlaPro: 6.11 ± 0.082	3.784AlaGln: 3.784 ± 0.048	9.143AlaArg: 9.143 ± 0.107	5.911AlaSer: 5.911 ± 0.067	6.033AlaThr: 6.033 ± 0.065	8.475AlaVal: 8.475 ± 0.097	1.589AlaTrp: 1.589 ± 0.04	2.467AlaTyr: 2.467 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.035CysAla: 1.035 ± 0.027	0.108CysCys: 0.108 ± 0.009	0.566CysAsp: 0.566 ± 0.021	0.491CysGlu: 0.491 ± 0.022	0.33CysPhe: 0.33 ± 0.015	0.972CysGly: 0.972 ± 0.028	0.278CysHis: 0.278 ± 0.017	0.396CysIle: 0.396 ± 0.016	0.194CysLys: 0.194 ± 0.011	0.885CysLeu: 0.885 ± 0.023	0.165CysMet: 0.165 ± 0.01	0.226CysAsn: 0.226 ± 0.011	0.51CysPro: 0.51 ± 0.022	0.216CysGln: 0.216 ± 0.011	0.624CysArg: 0.624 ± 0.019	0.436CysSer: 0.436 ± 0.018	0.437CysThr: 0.437 ± 0.017	0.619CysVal: 0.619 ± 0.021	0.125CysTrp: 0.125 ± 0.009	0.211CysTyr: 0.211 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.28AspAla: 7.28 ± 0.078	0.505AspCys: 0.505 ± 0.019	3.28AspAsp: 3.28 ± 0.078	3.453AspGlu: 3.453 ± 0.057	2.366AspPhe: 2.366 ± 0.042	5.942AspGly: 5.942 ± 0.086	1.32AspHis: 1.32 ± 0.029	2.873AspIle: 2.873 ± 0.04	1.473AspLys: 1.473 ± 0.037	6.358AspLeu: 6.358 ± 0.068	1.602AspMet: 1.602 ± 0.034	1.196AspAsn: 1.196 ± 0.031	3.737AspPro: 3.737 ± 0.053	1.496AspGln: 1.496 ± 0.033	4.515AspArg: 4.515 ± 0.059	2.315AspSer: 2.315 ± 0.038	3.046AspThr: 3.046 ± 0.051	4.122AspVal: 4.122 ± 0.056	1.193AspTrp: 1.193 ± 0.028	1.523AspTyr: 1.523 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	9.128GluAla: 9.128 ± 0.102	0.361GluCys: 0.361 ± 0.016	3.492GluAsp: 3.492 ± 0.05	3.959GluGlu: 3.959 ± 0.064	1.95GluPhe: 1.95 ± 0.031	5.08GluGly: 5.08 ± 0.071	1.204GluHis: 1.204 ± 0.031	3.995GluIle: 3.995 ± 0.052	1.928GluLys: 1.928 ± 0.042	5.478GluLeu: 5.478 ± 0.072	1.918GluMet: 1.918 ± 0.035	1.597GluAsn: 1.597 ± 0.033	2.936GluPro: 2.936 ± 0.053	1.995GluGln: 1.995 ± 0.04	4.826GluArg: 4.826 ± 0.066	2.403GluSer: 2.403 ± 0.044	4.183GluThr: 4.183 ± 0.053	4.588GluVal: 4.588 ± 0.061	0.73GluTrp: 0.73 ± 0.02	1.049GluTyr: 1.049 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.479PheAla: 4.479 ± 0.06	0.399PheCys: 0.399 ± 0.017	2.926PheAsp: 2.926 ± 0.047	2.332PheGlu: 2.332 ± 0.04	1.441PhePhe: 1.441 ± 0.034	3.855PheGly: 3.855 ± 0.053	0.781PheHis: 0.781 ± 0.025	1.604PheIle: 1.604 ± 0.036	0.798PheLys: 0.798 ± 0.026	3.765PheLeu: 3.765 ± 0.059	0.83PheMet: 0.83 ± 0.025	0.979PheAsn: 0.979 ± 0.025	1.646PhePro: 1.646 ± 0.033	0.989PheGln: 0.989 ± 0.027	2.361PheArg: 2.361 ± 0.041	2.149PheSer: 2.149 ± 0.039	2.091PheThr: 2.091 ± 0.042	2.734PheVal: 2.734 ± 0.045	0.573PheTrp: 0.573 ± 0.022	0.901PheTyr: 0.901 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.286GlyAla: 10.286 ± 0.087	0.915GlyCys: 0.915 ± 0.026	4.865GlyAsp: 4.865 ± 0.09	5.121GlyGlu: 5.121 ± 0.063	3.718GlyPhe: 3.718 ± 0.06	7.966GlyGly: 7.966 ± 0.13	1.897GlyHis: 1.897 ± 0.033	4.642GlyIle: 4.642 ± 0.06	2.942GlyLys: 2.942 ± 0.047	9.463GlyLeu: 9.463 ± 0.097	2.652GlyMet: 2.652 ± 0.046	2.308GlyAsn: 2.308 ± 0.053	3.979GlyPro: 3.979 ± 0.055	2.942GlyGln: 2.942 ± 0.048	6.178GlyArg: 6.178 ± 0.064	4.49GlySer: 4.49 ± 0.058	4.878GlyThr: 4.878 ± 0.062	6.515GlyVal: 6.515 ± 0.068	1.63GlyTrp: 1.63 ± 0.036	2.325GlyTyr: 2.325 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.348HisAla: 2.348 ± 0.04	0.235HisCys: 0.235 ± 0.012	1.236HisAsp: 1.236 ± 0.031	1.06HisGlu: 1.06 ± 0.024	0.84HisPhe: 0.84 ± 0.023	1.964HisGly: 1.964 ± 0.038	0.551HisHis: 0.551 ± 0.021	0.88HisIle: 0.88 ± 0.024	0.439HisLys: 0.439 ± 0.017	2.068HisLeu: 2.068 ± 0.043	0.528HisMet: 0.528 ± 0.017	0.422HisAsn: 0.422 ± 0.017	1.404HisPro: 1.404 ± 0.032	0.515HisGln: 0.515 ± 0.021	1.405HisArg: 1.405 ± 0.03	0.983HisSer: 0.983 ± 0.027	0.813HisThr: 0.813 ± 0.028	1.527HisVal: 1.527 ± 0.036	0.37HisTrp: 0.37 ± 0.017	0.534HisTyr: 0.534 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.88IleAla: 6.88 ± 0.088	0.601IleCys: 0.601 ± 0.023	3.51IleAsp: 3.51 ± 0.047	3.428IleGlu: 3.428 ± 0.047	1.755IlePhe: 1.755 ± 0.041	4.962IleGly: 4.962 ± 0.066	0.941IleHis: 0.941 ± 0.024	1.906IleIle: 1.906 ± 0.042	1.099IleLys: 1.099 ± 0.03	4.866IleLeu: 4.866 ± 0.067	0.97IleMet: 0.97 ± 0.027	1.226IleAsn: 1.226 ± 0.03	2.326IlePro: 2.326 ± 0.044	1.065IleGln: 1.065 ± 0.027	3.24IleArg: 3.24 ± 0.046	2.841IleSer: 2.841 ± 0.045	2.576IleThr: 2.576 ± 0.046	3.92IleVal: 3.92 ± 0.064	0.698IleTrp: 0.698 ± 0.024	1.108IleTyr: 1.108 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.45LysAla: 3.45 ± 0.048	0.156LysCys: 0.156 ± 0.01	1.495LysAsp: 1.495 ± 0.035	1.437LysGlu: 1.437 ± 0.036	0.83LysPhe: 0.83 ± 0.024	2.384LysGly: 2.384 ± 0.047	0.512LysHis: 0.512 ± 0.013	1.376LysIle: 1.376 ± 0.035	0.928LysLys: 0.928 ± 0.027	2.672LysLeu: 2.672 ± 0.043	0.708LysMet: 0.708 ± 0.022	0.676LysAsn: 0.676 ± 0.026	1.545LysPro: 1.545 ± 0.034	0.774LysGln: 0.774 ± 0.023	1.915LysArg: 1.915 ± 0.042	1.484LysSer: 1.484 ± 0.032	1.526LysThr: 1.526 ± 0.032	2.147LysVal: 2.147 ± 0.042	0.321LysTrp: 0.321 ± 0.018	0.558LysTyr: 0.558 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.687LeuAla: 13.687 ± 0.122	0.96LeuCys: 0.96 ± 0.028	6.137LeuAsp: 6.137 ± 0.074	6.004LeuGlu: 6.004 ± 0.06	3.662LeuPhe: 3.662 ± 0.066	8.895LeuGly: 8.895 ± 0.09	1.893LeuHis: 1.893 ± 0.034	4.786LeuIle: 4.786 ± 0.061	2.855LeuLys: 2.855 ± 0.051	9.731LeuLeu: 9.731 ± 0.122	2.519LeuMet: 2.519 ± 0.046	2.433LeuAsn: 2.433 ± 0.04	5.783LeuPro: 5.783 ± 0.076	2.707LeuGln: 2.707 ± 0.046	7.25LeuArg: 7.25 ± 0.075	6.481LeuSer: 6.481 ± 0.074	5.649LeuThr: 5.649 ± 0.062	7.491LeuVal: 7.491 ± 0.086	1.344LeuTrp: 1.344 ± 0.03	1.979LeuTyr: 1.979 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	3.365MetAla: 3.365 ± 0.052	0.169MetCys: 0.169 ± 0.011	1.328MetAsp: 1.328 ± 0.034	1.442MetGlu: 1.442 ± 0.031	0.796MetPhe: 0.796 ± 0.027	2.098MetGly: 2.098 ± 0.042	0.461MetHis: 0.461 ± 0.02	1.502MetIle: 1.502 ± 0.032	1.008MetLys: 1.008 ± 0.027	2.614MetLeu: 2.614 ± 0.04	0.725MetMet: 0.725 ± 0.024	0.817MetAsn: 0.817 ± 0.021	1.561MetPro: 1.561 ± 0.029	0.898MetGln: 0.898 ± 0.023	1.875MetArg: 1.875 ± 0.037	1.711MetSer: 1.711 ± 0.032	1.983MetThr: 1.983 ± 0.039	1.948MetVal: 1.948 ± 0.043	0.22MetTrp: 0.22 ± 0.01	0.313MetTyr: 0.313 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.948AsnAla: 2.948 ± 0.05	0.236AsnCys: 0.236 ± 0.013	1.466AsnAsp: 1.466 ± 0.05	1.135AsnGlu: 1.135 ± 0.03	0.918AsnPhe: 0.918 ± 0.024	2.396AsnGly: 2.396 ± 0.057	0.482AsnHis: 0.482 ± 0.02	1.186AsnIle: 1.186 ± 0.027	0.536AsnLys: 0.536 ± 0.019	2.373AsnLeu: 2.373 ± 0.039	0.667AsnMet: 0.667 ± 0.021	0.599AsnAsn: 0.599 ± 0.025	1.796AsnPro: 1.796 ± 0.038	0.632AsnGln: 0.632 ± 0.025	1.697AsnArg: 1.697 ± 0.037	1.12AsnSer: 1.12 ± 0.024	1.232AsnThr: 1.232 ± 0.033	1.829AsnVal: 1.829 ± 0.035	0.441AsnTrp: 0.441 ± 0.018	0.642AsnTyr: 0.642 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.227ProAla: 6.227 ± 0.077	0.375ProCys: 0.375 ± 0.018	3.992ProAsp: 3.992 ± 0.061	4.853ProGlu: 4.853 ± 0.064	2.029ProPhe: 2.029 ± 0.039	4.876ProGly: 4.876 ± 0.066	1.035ProHis: 1.035 ± 0.03	2.216ProIle: 2.216 ± 0.043	1.372ProLys: 1.372 ± 0.034	4.824ProLeu: 4.824 ± 0.059	1.358ProMet: 1.358 ± 0.029	1.239ProAsn: 1.239 ± 0.029	2.48ProPro: 2.48 ± 0.043	1.509ProGln: 1.509 ± 0.033	3.004ProArg: 3.004 ± 0.046	2.655ProSer: 2.655 ± 0.045	2.489ProThr: 2.489 ± 0.042	4.397ProVal: 4.397 ± 0.057	0.704ProTrp: 0.704 ± 0.025	1.127ProTyr: 1.127 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.666GlnAla: 3.666 ± 0.051	0.2GlnCys: 0.2 ± 0.013	1.513GlnAsp: 1.513 ± 0.032	1.606GlnGlu: 1.606 ± 0.033	0.984GlnPhe: 0.984 ± 0.026	2.343GlnGly: 2.343 ± 0.045	0.532GlnHis: 0.532 ± 0.017	1.767GlnIle: 1.767 ± 0.033	0.9GlnLys: 0.9 ± 0.026	2.587GlnLeu: 2.587 ± 0.041	0.967GlnMet: 0.967 ± 0.026	0.738GlnAsn: 0.738 ± 0.024	1.606GlnPro: 1.606 ± 0.036	1.015GlnGln: 1.015 ± 0.03	2.053GlnArg: 2.053 ± 0.036	1.624GlnSer: 1.624 ± 0.039	1.576GlnThr: 1.576 ± 0.031	2.246GlnVal: 2.246 ± 0.038	0.394GlnTrp: 0.394 ± 0.015	0.543GlnTyr: 0.543 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.05ArgAla: 8.05 ± 0.089	0.532ArgCys: 0.532 ± 0.02	4.196ArgAsp: 4.196 ± 0.05	4.231ArgGlu: 4.231 ± 0.058	2.751ArgPhe: 2.751 ± 0.039	4.985ArgGly: 4.985 ± 0.065	1.677ArgHis: 1.677 ± 0.038	3.965ArgIle: 3.965 ± 0.047	2.168ArgLys: 2.168 ± 0.038	7.816ArgLeu: 7.816 ± 0.076	2.07ArgMet: 2.07 ± 0.04	1.806ArgAsn: 1.806 ± 0.033	3.619ArgPro: 3.619 ± 0.058	2.364ArgGln: 2.364 ± 0.042	5.447ArgArg: 5.447 ± 0.075	3.587ArgSer: 3.587 ± 0.063	3.177ArgThr: 3.177 ± 0.051	4.691ArgVal: 4.691 ± 0.06	0.908ArgTrp: 0.908 ± 0.025	1.563ArgTyr: 1.563 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	5.858SerAla: 5.858 ± 0.062	0.402SerCys: 0.402 ± 0.016	3.286SerAsp: 3.286 ± 0.05	3.145SerGlu: 3.145 ± 0.05	2.256SerPhe: 2.256 ± 0.04	5.575SerGly: 5.575 ± 0.072	1.143SerHis: 1.143 ± 0.025	2.459SerIle: 2.459 ± 0.043	1.29SerLys: 1.29 ± 0.03	5.14SerLeu: 5.14 ± 0.063	1.331SerMet: 1.331 ± 0.026	1.308SerAsn: 1.308 ± 0.033	2.631SerPro: 2.631 ± 0.053	1.481SerGln: 1.481 ± 0.034	3.463SerArg: 3.463 ± 0.053	2.641SerSer: 2.641 ± 0.057	2.572SerThr: 2.572 ± 0.046	3.952SerVal: 3.952 ± 0.049	0.72SerTrp: 0.72 ± 0.023	1.287SerTyr: 1.287 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.147ThrAla: 6.147 ± 0.066	0.465ThrCys: 0.465 ± 0.017	3.155ThrAsp: 3.155 ± 0.05	3.151ThrGlu: 3.151 ± 0.049	2.083ThrPhe: 2.083 ± 0.039	5.477ThrGly: 5.477 ± 0.064	1.057ThrHis: 1.057 ± 0.026	2.725ThrIle: 2.725 ± 0.046	1.128ThrLys: 1.128 ± 0.029	6.052ThrLeu: 6.052 ± 0.068	1.22ThrMet: 1.22 ± 0.025	1.224ThrAsn: 1.224 ± 0.026	3.423ThrPro: 3.423 ± 0.051	1.312ThrGln: 1.312 ± 0.029	3.402ThrArg: 3.402 ± 0.046	2.753ThrSer: 2.753 ± 0.049	2.746ThrThr: 2.746 ± 0.045	4.098ThrVal: 4.098 ± 0.054	0.715ThrTrp: 0.715 ± 0.023	1.226ThrTyr: 1.226 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.128ValAla: 9.128 ± 0.081	0.65ValCys: 0.65 ± 0.021	4.114ValAsp: 4.114 ± 0.058	4.854ValGlu: 4.854 ± 0.058	2.955ValPhe: 2.955 ± 0.052	5.606ValGly: 5.606 ± 0.07	1.368ValHis: 1.368 ± 0.03	4.042ValIle: 4.042 ± 0.054	1.861ValLys: 1.861 ± 0.038	7.78ValLeu: 7.78 ± 0.085	1.915ValMet: 1.915 ± 0.043	1.859ValAsn: 1.859 ± 0.038	3.87ValPro: 3.87 ± 0.048	1.958ValGln: 1.958 ± 0.033	4.455ValArg: 4.455 ± 0.063	4.369ValSer: 4.369 ± 0.055	4.615ValThr: 4.615 ± 0.054	5.778ValVal: 5.778 ± 0.074	0.888ValTrp: 0.888 ± 0.024	1.457ValTyr: 1.457 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.389TrpAla: 1.389 ± 0.038	0.137TrpCys: 0.137 ± 0.009	0.761TrpAsp: 0.761 ± 0.023	0.76TrpGlu: 0.76 ± 0.022	0.534TrpPhe: 0.534 ± 0.019	1.013TrpGly: 1.013 ± 0.028	0.341TrpHis: 0.341 ± 0.013	0.706TrpIle: 0.706 ± 0.021	0.476TrpLys: 0.476 ± 0.021	1.701TrpLeu: 1.701 ± 0.04	0.423TrpMet: 0.423 ± 0.016	0.439TrpAsn: 0.439 ± 0.016	0.706TrpPro: 0.706 ± 0.022	0.587TrpGln: 0.587 ± 0.022	1.081TrpArg: 1.081 ± 0.03	0.847TrpSer: 0.847 ± 0.024	0.825TrpThr: 0.825 ± 0.022	0.914TrpVal: 0.914 ± 0.028	0.226TrpTrp: 0.226 ± 0.013	0.298TrpTyr: 0.298 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.383TyrAla: 2.383 ± 0.048	0.242TyrCys: 0.242 ± 0.014	1.536TyrAsp: 1.536 ± 0.037	1.29TyrGlu: 1.29 ± 0.029	0.89TyrPhe: 0.89 ± 0.025	2.131TyrGly: 2.131 ± 0.047	0.458TyrHis: 0.458 ± 0.018	0.877TyrIle: 0.877 ± 0.027	0.489TyrLys: 0.489 ± 0.018	2.222TyrLeu: 2.222 ± 0.04	0.462TyrMet: 0.462 ± 0.018	0.59TyrAsn: 0.59 ± 0.018	1.092TyrPro: 1.092 ± 0.026	0.624TyrGln: 0.624 ± 0.022	1.668TyrArg: 1.668 ± 0.032	1.14TyrSer: 1.14 ± 0.029	1.112TyrThr: 1.112 ± 0.027	1.531TyrVal: 1.531 ± 0.031	0.377TyrTrp: 0.377 ± 0.018	0.581TyrTyr: 0.581 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4801 proteins (1534549 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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