Amino acid dipepetide frequency for Aurantibacter aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.709AlaAla: 3.709 ± 0.089
0.538AlaCys: 0.538 ± 0.03
3.069AlaAsp: 3.069 ± 0.06
3.997AlaGlu: 3.997 ± 0.071
3.422AlaPhe: 3.422 ± 0.066
3.973AlaGly: 3.973 ± 0.092
1.055AlaHis: 1.055 ± 0.038
5.326AlaIle: 5.326 ± 0.088
4.783AlaLys: 4.783 ± 0.091
6.482AlaLeu: 6.482 ± 0.096
1.358AlaMet: 1.358 ± 0.044
3.775AlaAsn: 3.775 ± 0.076
1.823AlaPro: 1.823 ± 0.049
2.542AlaGln: 2.542 ± 0.051
1.792AlaArg: 1.792 ± 0.045
4.132AlaSer: 4.132 ± 0.079
3.832AlaThr: 3.832 ± 0.107
3.955AlaVal: 3.955 ± 0.083
0.505AlaTrp: 0.505 ± 0.026
2.637AlaTyr: 2.637 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.493CysAla: 0.493 ± 0.027
0.091CysCys: 0.091 ± 0.011
0.467CysAsp: 0.467 ± 0.044
0.482CysGlu: 0.482 ± 0.027
0.477CysPhe: 0.477 ± 0.025
0.568CysGly: 0.568 ± 0.026
0.169CysHis: 0.169 ± 0.015
0.592CysIle: 0.592 ± 0.026
0.507CysLys: 0.507 ± 0.022
0.668CysLeu: 0.668 ± 0.03
0.149CysMet: 0.149 ± 0.013
0.432CysAsn: 0.432 ± 0.024
0.323CysPro: 0.323 ± 0.024
0.21CysGln: 0.21 ± 0.015
0.172CysArg: 0.172 ± 0.015
0.578CysSer: 0.578 ± 0.028
0.41CysThr: 0.41 ± 0.024
0.457CysVal: 0.457 ± 0.023
0.064CysTrp: 0.064 ± 0.009
0.296CysTyr: 0.296 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.956AspAla: 3.956 ± 0.083
0.41AspCys: 0.41 ± 0.029
2.938AspAsp: 2.938 ± 0.07
3.428AspGlu: 3.428 ± 0.07
3.701AspPhe: 3.701 ± 0.062
3.533AspGly: 3.533 ± 0.109
0.842AspHis: 0.842 ± 0.038
4.481AspIle: 4.481 ± 0.075
4.07AspLys: 4.07 ± 0.08
5.561AspLeu: 5.561 ± 0.083
1.069AspMet: 1.069 ± 0.039
3.259AspAsn: 3.259 ± 0.079
1.495AspPro: 1.495 ± 0.065
1.548AspGln: 1.548 ± 0.045
1.604AspArg: 1.604 ± 0.047
3.173AspSer: 3.173 ± 0.075
2.911AspThr: 2.911 ± 0.068
3.897AspVal: 3.897 ± 0.062
0.709AspTrp: 0.709 ± 0.029
2.968AspTyr: 2.968 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
4.779GluAla: 4.779 ± 0.086
0.295GluCys: 0.295 ± 0.02
3.84GluAsp: 3.84 ± 0.079
4.503GluGlu: 4.503 ± 0.096
3.274GluPhe: 3.274 ± 0.064
3.111GluGly: 3.111 ± 0.066
1.241GluHis: 1.241 ± 0.041
5.004GluIle: 5.004 ± 0.079
5.181GluLys: 5.181 ± 0.11
6.173GluLeu: 6.173 ± 0.11
1.285GluMet: 1.285 ± 0.036
4.653GluAsn: 4.653 ± 0.079
1.563GluPro: 1.563 ± 0.04
2.386GluGln: 2.386 ± 0.059
2.246GluArg: 2.246 ± 0.058
3.408GluSer: 3.408 ± 0.062
4.078GluThr: 4.078 ± 0.07
4.167GluVal: 4.167 ± 0.085
0.518GluTrp: 0.518 ± 0.026
2.142GluTyr: 2.142 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
2.92PheAla: 2.92 ± 0.064
0.485PheCys: 0.485 ± 0.024
3.284PheAsp: 3.284 ± 0.071
3.448PheGlu: 3.448 ± 0.064
2.848PhePhe: 2.848 ± 0.075
3.634PheGly: 3.634 ± 0.074
0.848PheHis: 0.848 ± 0.034
4.184PheIle: 4.184 ± 0.079
4.669PheLys: 4.669 ± 0.099
4.757PheLeu: 4.757 ± 0.086
1.065PheMet: 1.065 ± 0.04
4.154PheAsn: 4.154 ± 0.101
1.69PhePro: 1.69 ± 0.048
1.53PheGln: 1.53 ± 0.038
1.49PheArg: 1.49 ± 0.039
4.256PheSer: 4.256 ± 0.074
3.457PheThr: 3.457 ± 0.076
3.029PheVal: 3.029 ± 0.062
0.515PheTrp: 0.515 ± 0.026
2.346PheTyr: 2.346 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
4.016GlyAla: 4.016 ± 0.087
0.594GlyCys: 0.594 ± 0.034
3.307GlyAsp: 3.307 ± 0.076
3.4GlyGlu: 3.4 ± 0.063
3.895GlyPhe: 3.895 ± 0.071
4.158GlyGly: 4.158 ± 0.091
1.121GlyHis: 1.121 ± 0.036
4.842GlyIle: 4.842 ± 0.083
4.301GlyLys: 4.301 ± 0.092
5.808GlyLeu: 5.808 ± 0.086
1.265GlyMet: 1.265 ± 0.041
3.652GlyAsn: 3.652 ± 0.092
1.249GlyPro: 1.249 ± 0.05
1.897GlyGln: 1.897 ± 0.053
1.883GlyArg: 1.883 ± 0.052
3.754GlySer: 3.754 ± 0.089
4.147GlyThr: 4.147 ± 0.127
4.122GlyVal: 4.122 ± 0.079
0.645GlyTrp: 0.645 ± 0.031
2.534GlyTyr: 2.534 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
0.901HisAla: 0.901 ± 0.031
0.159HisCys: 0.159 ± 0.013
0.78HisAsp: 0.78 ± 0.035
0.9HisGlu: 0.9 ± 0.032
1.181HisPhe: 1.181 ± 0.043
0.928HisGly: 0.928 ± 0.031
0.479HisHis: 0.479 ± 0.028
1.621HisIle: 1.621 ± 0.046
1.324HisLys: 1.324 ± 0.039
1.914HisLeu: 1.914 ± 0.048
0.318HisMet: 0.318 ± 0.021
0.98HisAsn: 0.98 ± 0.035
0.774HisPro: 0.774 ± 0.035
0.695HisGln: 0.695 ± 0.029
0.565HisArg: 0.565 ± 0.024
0.968HisSer: 0.968 ± 0.034
0.92HisThr: 0.92 ± 0.032
0.951HisVal: 0.951 ± 0.036
0.18HisTrp: 0.18 ± 0.015
0.857HisTyr: 0.857 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.308IleAla: 5.308 ± 0.086
0.631IleCys: 0.631 ± 0.033
4.762IleAsp: 4.762 ± 0.075
5.354IleGlu: 5.354 ± 0.083
3.586IlePhe: 3.586 ± 0.074
4.991IleGly: 4.991 ± 0.091
1.218IleHis: 1.218 ± 0.039
6.306IleIle: 6.306 ± 0.108
6.222IleLys: 6.222 ± 0.093
7.159IleLeu: 7.159 ± 0.113
1.257IleMet: 1.257 ± 0.038
5.271IleAsn: 5.271 ± 0.103
3.031IlePro: 3.031 ± 0.063
2.385IleGln: 2.385 ± 0.052
2.188IleArg: 2.188 ± 0.054
5.94IleSer: 5.94 ± 0.099
5.101IleThr: 5.101 ± 0.088
4.564IleVal: 4.564 ± 0.076
0.639IleTrp: 0.639 ± 0.026
3.091IleTyr: 3.091 ± 0.075
0.0IleXaa: 0.0 ± 0.0
Lys
5.389LysAla: 5.389 ± 0.106
0.372LysCys: 0.372 ± 0.021
4.707LysAsp: 4.707 ± 0.095
5.757LysGlu: 5.757 ± 0.13
2.97LysPhe: 2.97 ± 0.072
4.171LysGly: 4.171 ± 0.073
1.648LysHis: 1.648 ± 0.051
5.981LysIle: 5.981 ± 0.095
6.756LysLys: 6.756 ± 0.118
6.819LysLeu: 6.819 ± 0.098
1.837LysMet: 1.837 ± 0.048
5.742LysAsn: 5.742 ± 0.108
2.562LysPro: 2.562 ± 0.062
3.078LysGln: 3.078 ± 0.068
2.87LysArg: 2.87 ± 0.069
5.014LysSer: 5.014 ± 0.087
5.491LysThr: 5.491 ± 0.09
4.525LysVal: 4.525 ± 0.08
0.747LysTrp: 0.747 ± 0.03
2.915LysTyr: 2.915 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
5.599LeuAla: 5.599 ± 0.093
0.734LeuCys: 0.734 ± 0.029
5.494LeuAsp: 5.494 ± 0.079
6.396LeuGlu: 6.396 ± 0.104
5.021LeuPhe: 5.021 ± 0.099
5.643LeuGly: 5.643 ± 0.091
1.51LeuHis: 1.51 ± 0.042
7.389LeuIle: 7.389 ± 0.113
8.66LeuLys: 8.66 ± 0.139
8.536LeuLeu: 8.536 ± 0.125
1.944LeuMet: 1.944 ± 0.051
6.761LeuAsn: 6.761 ± 0.106
3.406LeuPro: 3.406 ± 0.061
3.233LeuGln: 3.233 ± 0.061
2.905LeuArg: 2.905 ± 0.054
6.62LeuSer: 6.62 ± 0.091
5.216LeuThr: 5.216 ± 0.069
5.54LeuVal: 5.54 ± 0.087
0.793LeuTrp: 0.793 ± 0.033
3.131LeuTyr: 3.131 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
1.391MetAla: 1.391 ± 0.043
0.142MetCys: 0.142 ± 0.012
0.986MetAsp: 0.986 ± 0.036
1.065MetGlu: 1.065 ± 0.032
0.869MetPhe: 0.869 ± 0.038
1.112MetGly: 1.112 ± 0.045
0.334MetHis: 0.334 ± 0.019
1.342MetIle: 1.342 ± 0.039
1.994MetLys: 1.994 ± 0.04
1.748MetLeu: 1.748 ± 0.044
0.489MetMet: 0.489 ± 0.028
1.083MetAsn: 1.083 ± 0.037
0.773MetPro: 0.773 ± 0.028
0.754MetGln: 0.754 ± 0.03
0.758MetArg: 0.758 ± 0.032
1.451MetSer: 1.451 ± 0.043
1.124MetThr: 1.124 ± 0.038
1.253MetVal: 1.253 ± 0.042
0.122MetTrp: 0.122 ± 0.011
0.681MetTyr: 0.681 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
4.334AsnAla: 4.334 ± 0.085
0.563AsnCys: 0.563 ± 0.03
3.652AsnAsp: 3.652 ± 0.07
4.108AsnGlu: 4.108 ± 0.078
3.506AsnPhe: 3.506 ± 0.083
4.395AsnGly: 4.395 ± 0.102
1.146AsnHis: 1.146 ± 0.036
4.869AsnIle: 4.869 ± 0.081
4.775AsnLys: 4.775 ± 0.107
6.089AsnLeu: 6.089 ± 0.096
1.22AsnMet: 1.22 ± 0.04
4.78AsnAsn: 4.78 ± 0.111
2.997AsnPro: 2.997 ± 0.084
2.439AsnGln: 2.439 ± 0.064
2.137AsnArg: 2.137 ± 0.057
4.491AsnSer: 4.491 ± 0.088
4.598AsnThr: 4.598 ± 0.099
3.821AsnVal: 3.821 ± 0.078
0.762AsnTrp: 0.762 ± 0.04
3.308AsnTyr: 3.308 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
1.736ProAla: 1.736 ± 0.057
0.246ProCys: 0.246 ± 0.02
1.878ProAsp: 1.878 ± 0.045
2.752ProGlu: 2.752 ± 0.058
1.875ProPhe: 1.875 ± 0.048
1.686ProGly: 1.686 ± 0.048
0.542ProHis: 0.542 ± 0.025
2.576ProIle: 2.576 ± 0.049
2.642ProLys: 2.642 ± 0.061
2.956ProLeu: 2.956 ± 0.061
0.604ProMet: 0.604 ± 0.025
2.499ProAsn: 2.499 ± 0.072
0.635ProPro: 0.635 ± 0.034
1.137ProGln: 1.137 ± 0.036
0.792ProArg: 0.792 ± 0.034
1.908ProSer: 1.908 ± 0.05
2.031ProThr: 2.031 ± 0.07
2.24ProVal: 2.24 ± 0.051
0.259ProTrp: 0.259 ± 0.017
1.373ProTyr: 1.373 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
1.94GlnAla: 1.94 ± 0.047
0.17GlnCys: 0.17 ± 0.015
1.782GlnAsp: 1.782 ± 0.048
2.114GlnGlu: 2.114 ± 0.055
1.979GlnPhe: 1.979 ± 0.047
1.591GlnGly: 1.591 ± 0.048
0.648GlnHis: 0.648 ± 0.029
2.839GlnIle: 2.839 ± 0.057
2.639GlnLys: 2.639 ± 0.06
3.807GlnLeu: 3.807 ± 0.064
0.747GlnMet: 0.747 ± 0.03
2.528GlnAsn: 2.528 ± 0.058
1.184GlnPro: 1.184 ± 0.041
1.437GlnGln: 1.437 ± 0.046
1.088GlnArg: 1.088 ± 0.033
1.937GlnSer: 1.937 ± 0.049
2.317GlnThr: 2.317 ± 0.052
2.03GlnVal: 2.03 ± 0.046
0.312GlnTrp: 0.312 ± 0.024
1.207GlnTyr: 1.207 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
1.922ArgAla: 1.922 ± 0.049
0.167ArgCys: 0.167 ± 0.014
1.691ArgAsp: 1.691 ± 0.041
1.922ArgGlu: 1.922 ± 0.054
1.863ArgPhe: 1.863 ± 0.055
1.671ArgGly: 1.671 ± 0.048
0.528ArgHis: 0.528 ± 0.026
2.616ArgIle: 2.616 ± 0.049
2.403ArgLys: 2.403 ± 0.051
3.071ArgLeu: 3.071 ± 0.065
0.719ArgMet: 0.719 ± 0.03
1.83ArgAsn: 1.83 ± 0.046
0.959ArgPro: 0.959 ± 0.035
1.086ArgGln: 1.086 ± 0.031
1.145ArgArg: 1.145 ± 0.039
1.616ArgSer: 1.616 ± 0.048
1.738ArgThr: 1.738 ± 0.043
2.034ArgVal: 2.034 ± 0.045
0.303ArgTrp: 0.303 ± 0.019
1.375ArgTyr: 1.375 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
3.717SerAla: 3.717 ± 0.068
0.604SerCys: 0.604 ± 0.027
3.395SerAsp: 3.395 ± 0.061
3.923SerGlu: 3.923 ± 0.076
3.911SerPhe: 3.911 ± 0.077
4.659SerGly: 4.659 ± 0.104
1.125SerHis: 1.125 ± 0.038
5.199SerIle: 5.199 ± 0.078
5.378SerLys: 5.378 ± 0.101
5.971SerLeu: 5.971 ± 0.102
1.122SerMet: 1.122 ± 0.035
4.485SerAsn: 4.485 ± 0.087
1.937SerPro: 1.937 ± 0.05
2.274SerGln: 2.274 ± 0.056
1.941SerArg: 1.941 ± 0.048
4.332SerSer: 4.332 ± 0.082
3.932SerThr: 3.932 ± 0.078
4.003SerVal: 4.003 ± 0.079
0.649SerTrp: 0.649 ± 0.027
2.858SerTyr: 2.858 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
3.764ThrAla: 3.764 ± 0.095
0.424ThrCys: 0.424 ± 0.03
3.31ThrAsp: 3.31 ± 0.08
3.647ThrGlu: 3.647 ± 0.073
3.393ThrPhe: 3.393 ± 0.068
4.15ThrGly: 4.15 ± 0.115
1.091ThrHis: 1.091 ± 0.034
5.227ThrIle: 5.227 ± 0.082
4.361ThrLys: 4.361 ± 0.08
5.882ThrLeu: 5.882 ± 0.074
0.896ThrMet: 0.896 ± 0.036
4.291ThrAsn: 4.291 ± 0.093
2.534ThrPro: 2.534 ± 0.067
2.167ThrGln: 2.167 ± 0.064
1.557ThrArg: 1.557 ± 0.045
4.171ThrSer: 4.171 ± 0.089
4.206ThrThr: 4.206 ± 0.127
4.033ThrVal: 4.033 ± 0.096
0.55ThrTrp: 0.55 ± 0.026
2.809ThrTyr: 2.809 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
3.903ValAla: 3.903 ± 0.076
0.559ValCys: 0.559 ± 0.025
3.406ValAsp: 3.406 ± 0.071
3.888ValGlu: 3.888 ± 0.07
3.638ValPhe: 3.638 ± 0.068
3.694ValGly: 3.694 ± 0.071
0.876ValHis: 0.876 ± 0.032
4.946ValIle: 4.946 ± 0.083
4.546ValLys: 4.546 ± 0.083
6.313ValLeu: 6.313 ± 0.09
1.206ValMet: 1.206 ± 0.039
3.977ValAsn: 3.977 ± 0.086
1.879ValPro: 1.879 ± 0.047
1.592ValGln: 1.592 ± 0.047
1.785ValArg: 1.785 ± 0.052
4.434ValSer: 4.434 ± 0.083
3.798ValThr: 3.798 ± 0.1
4.108ValVal: 4.108 ± 0.075
0.524ValTrp: 0.524 ± 0.028
2.45ValTyr: 2.45 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.529TrpAla: 0.529 ± 0.028
0.105TrpCys: 0.105 ± 0.012
0.561TrpAsp: 0.561 ± 0.03
0.568TrpGlu: 0.568 ± 0.028
0.597TrpPhe: 0.597 ± 0.028
0.495TrpGly: 0.495 ± 0.025
0.204TrpHis: 0.204 ± 0.015
0.676TrpIle: 0.676 ± 0.03
0.657TrpLys: 0.657 ± 0.03
0.944TrpLeu: 0.944 ± 0.037
0.254TrpMet: 0.254 ± 0.015
0.689TrpAsn: 0.689 ± 0.031
0.169TrpPro: 0.169 ± 0.014
0.394TrpGln: 0.394 ± 0.023
0.334TrpArg: 0.334 ± 0.018
0.59TrpSer: 0.59 ± 0.029
0.536TrpThr: 0.536 ± 0.028
0.532TrpVal: 0.532 ± 0.025
0.117TrpTrp: 0.117 ± 0.011
0.39TrpTyr: 0.39 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.399TyrAla: 2.399 ± 0.056
0.317TyrCys: 0.317 ± 0.024
2.245TyrAsp: 2.245 ± 0.05
2.194TyrGlu: 2.194 ± 0.051
2.601TyrPhe: 2.601 ± 0.052
2.428TyrGly: 2.428 ± 0.05
0.77TyrHis: 0.77 ± 0.032
2.987TyrIle: 2.987 ± 0.061
3.487TyrLys: 3.487 ± 0.078
3.874TyrLeu: 3.874 ± 0.077
0.666TyrMet: 0.666 ± 0.028
3.147TyrAsn: 3.147 ± 0.076
1.387TyrPro: 1.387 ± 0.034
1.51TyrGln: 1.51 ± 0.05
1.404TyrArg: 1.404 ± 0.044
2.641TyrSer: 2.641 ± 0.061
2.621TyrThr: 2.621 ± 0.066
2.263TyrVal: 2.263 ± 0.056
0.429TyrTrp: 0.429 ± 0.023
1.926TyrTyr: 1.926 ± 0.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2594 proteins (888837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski