Amino acid dipepetide frequency for Piscibacillus halophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.417AlaAla: 4.417 ± 0.086	0.495AlaCys: 0.495 ± 0.025	3.099AlaAsp: 3.099 ± 0.067	4.08AlaGlu: 4.08 ± 0.087	3.093AlaPhe: 3.093 ± 0.061	4.589AlaGly: 4.589 ± 0.083	1.261AlaHis: 1.261 ± 0.043	5.457AlaIle: 5.457 ± 0.077	4.095AlaLys: 4.095 ± 0.08	6.646AlaLeu: 6.646 ± 0.089	1.817AlaMet: 1.817 ± 0.053	2.665AlaAsn: 2.665 ± 0.059	1.884AlaPro: 1.884 ± 0.054	2.166AlaGln: 2.166 ± 0.05	2.286AlaArg: 2.286 ± 0.06	3.756AlaSer: 3.756 ± 0.072	3.344AlaThr: 3.344 ± 0.063	4.696AlaVal: 4.696 ± 0.078	0.574AlaTrp: 0.574 ± 0.024	2.204AlaTyr: 2.204 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.311CysAla: 0.311 ± 0.019	0.067CysCys: 0.067 ± 0.011	0.373CysAsp: 0.373 ± 0.022	0.373CysGlu: 0.373 ± 0.021	0.242CysPhe: 0.242 ± 0.017	0.586CysGly: 0.586 ± 0.027	0.192CysHis: 0.192 ± 0.014	0.381CysIle: 0.381 ± 0.023	0.29CysLys: 0.29 ± 0.019	0.547CysLeu: 0.547 ± 0.029	0.148CysMet: 0.148 ± 0.014	0.23CysAsn: 0.23 ± 0.019	0.322CysPro: 0.322 ± 0.022	0.25CysGln: 0.25 ± 0.017	0.256CysArg: 0.256 ± 0.018	0.347CysSer: 0.347 ± 0.019	0.297CysThr: 0.297 ± 0.016	0.356CysVal: 0.356 ± 0.02	0.056CysTrp: 0.056 ± 0.008	0.204CysTyr: 0.204 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.12AspAla: 3.12 ± 0.063	0.309AspCys: 0.309 ± 0.021	3.232AspAsp: 3.232 ± 0.074	5.765AspGlu: 5.765 ± 0.08	2.578AspPhe: 2.578 ± 0.06	3.655AspGly: 3.655 ± 0.08	1.621AspHis: 1.621 ± 0.046	4.27AspIle: 4.27 ± 0.062	2.454AspLys: 2.454 ± 0.059	5.861AspLeu: 5.861 ± 0.086	1.495AspMet: 1.495 ± 0.044	1.695AspAsn: 1.695 ± 0.05	2.266AspPro: 2.266 ± 0.045	3.297AspGln: 3.297 ± 0.068	2.525AspArg: 2.525 ± 0.054	2.835AspSer: 2.835 ± 0.062	2.485AspThr: 2.485 ± 0.052	4.379AspVal: 4.379 ± 0.072	0.702AspTrp: 0.702 ± 0.032	2.553AspTyr: 2.553 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	5.293GluAla: 5.293 ± 0.099	0.324GluCys: 0.324 ± 0.021	4.736GluAsp: 4.736 ± 0.083	8.403GluGlu: 8.403 ± 0.156	2.74GluPhe: 2.74 ± 0.048	4.787GluGly: 4.787 ± 0.094	1.943GluHis: 1.943 ± 0.045	5.561GluIle: 5.561 ± 0.086	6.076GluLys: 6.076 ± 0.082	7.564GluLeu: 7.564 ± 0.105	2.134GluMet: 2.134 ± 0.049	3.828GluAsn: 3.828 ± 0.075	2.327GluPro: 2.327 ± 0.059	3.968GluGln: 3.968 ± 0.075	3.716GluArg: 3.716 ± 0.073	4.011GluSer: 4.011 ± 0.062	4.0GluThr: 4.0 ± 0.076	5.704GluVal: 5.704 ± 0.088	0.969GluTrp: 0.969 ± 0.032	2.525GluTyr: 2.525 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	2.731PheAla: 2.731 ± 0.063	0.268PheCys: 0.268 ± 0.018	2.615PheAsp: 2.615 ± 0.059	3.106PheGlu: 3.106 ± 0.062	2.255PhePhe: 2.255 ± 0.065	3.258PheGly: 3.258 ± 0.075	0.973PheHis: 0.973 ± 0.038	3.967PheIle: 3.967 ± 0.082	2.562PheLys: 2.562 ± 0.05	4.284PheLeu: 4.284 ± 0.086	1.217PheMet: 1.217 ± 0.039	2.287PheAsn: 2.287 ± 0.055	1.599PhePro: 1.599 ± 0.04	1.569PheGln: 1.569 ± 0.047	1.448PheArg: 1.448 ± 0.037	2.896PheSer: 2.896 ± 0.068	2.515PheThr: 2.515 ± 0.06	3.188PheVal: 3.188 ± 0.049	0.477PheTrp: 0.477 ± 0.025	1.782PheTyr: 1.782 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	4.475GlyAla: 4.475 ± 0.078	0.512GlyCys: 0.512 ± 0.025	3.461GlyAsp: 3.461 ± 0.066	4.975GlyGlu: 4.975 ± 0.096	3.438GlyPhe: 3.438 ± 0.065	4.572GlyGly: 4.572 ± 0.09	1.536GlyHis: 1.536 ± 0.047	5.486GlyIle: 5.486 ± 0.086	4.283GlyLys: 4.283 ± 0.068	6.491GlyLeu: 6.491 ± 0.104	2.048GlyMet: 2.048 ± 0.057	2.506GlyAsn: 2.506 ± 0.061	1.838GlyPro: 1.838 ± 0.047	2.484GlyGln: 2.484 ± 0.056	2.522GlyArg: 2.522 ± 0.061	3.955GlySer: 3.955 ± 0.072	3.806GlyThr: 3.806 ± 0.073	5.288GlyVal: 5.288 ± 0.088	0.744GlyTrp: 0.744 ± 0.031	2.938GlyTyr: 2.938 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.33HisAla: 1.33 ± 0.043	0.19HisCys: 0.19 ± 0.016	1.387HisAsp: 1.387 ± 0.042	1.745HisGlu: 1.745 ± 0.049	1.072HisPhe: 1.072 ± 0.035	1.463HisGly: 1.463 ± 0.044	0.82HisHis: 0.82 ± 0.035	1.695HisIle: 1.695 ± 0.042	1.125HisLys: 1.125 ± 0.04	2.293HisLeu: 2.293 ± 0.061	0.584HisMet: 0.584 ± 0.023	0.895HisAsn: 0.895 ± 0.03	1.138HisPro: 1.138 ± 0.037	1.153HisGln: 1.153 ± 0.04	0.892HisArg: 0.892 ± 0.039	1.308HisSer: 1.308 ± 0.033	1.051HisThr: 1.051 ± 0.037	1.576HisVal: 1.576 ± 0.048	0.245HisTrp: 0.245 ± 0.018	0.958HisTyr: 0.958 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.376IleAla: 5.376 ± 0.088	0.497IleCys: 0.497 ± 0.026	4.873IleAsp: 4.873 ± 0.078	6.122IleGlu: 6.122 ± 0.086	3.482IlePhe: 3.482 ± 0.067	5.797IleGly: 5.797 ± 0.108	1.765IleHis: 1.765 ± 0.05	6.093IleIle: 6.093 ± 0.102	4.666IleLys: 4.666 ± 0.076	7.142IleLeu: 7.142 ± 0.127	1.954IleMet: 1.954 ± 0.054	3.568IleAsn: 3.568 ± 0.067	3.265IlePro: 3.265 ± 0.067	3.182IleGln: 3.182 ± 0.06	2.976IleArg: 2.976 ± 0.058	4.84IleSer: 4.84 ± 0.091	4.143IleThr: 4.143 ± 0.073	5.597IleVal: 5.597 ± 0.09	0.669IleTrp: 0.669 ± 0.031	2.627IleTyr: 2.627 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	3.912LysAla: 3.912 ± 0.084	0.265LysCys: 0.265 ± 0.018	3.859LysAsp: 3.859 ± 0.065	6.27LysGlu: 6.27 ± 0.09	1.798LysPhe: 1.798 ± 0.052	4.088LysGly: 4.088 ± 0.069	1.463LysHis: 1.463 ± 0.043	4.08LysIle: 4.08 ± 0.065	4.984LysLys: 4.984 ± 0.078	5.247LysLeu: 5.247 ± 0.068	1.905LysMet: 1.905 ± 0.042	3.004LysAsn: 3.004 ± 0.066	2.089LysPro: 2.089 ± 0.043	3.14LysGln: 3.14 ± 0.065	3.241LysArg: 3.241 ± 0.066	3.335LysSer: 3.335 ± 0.068	3.146LysThr: 3.146 ± 0.06	4.693LysVal: 4.693 ± 0.078	0.749LysTrp: 0.749 ± 0.026	2.054LysTyr: 2.054 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	6.3LeuAla: 6.3 ± 0.098	0.521LeuCys: 0.521 ± 0.026	5.536LeuAsp: 5.536 ± 0.08	7.008LeuGlu: 7.008 ± 0.108	4.58LeuPhe: 4.58 ± 0.084	6.3LeuGly: 6.3 ± 0.096	1.833LeuHis: 1.833 ± 0.043	7.982LeuIle: 7.982 ± 0.13	6.548LeuLys: 6.548 ± 0.081	9.436LeuLeu: 9.436 ± 0.146	2.644LeuMet: 2.644 ± 0.062	5.073LeuAsn: 5.073 ± 0.076	3.714LeuPro: 3.714 ± 0.074	3.166LeuGln: 3.166 ± 0.065	3.246LeuArg: 3.246 ± 0.061	6.488LeuSer: 6.488 ± 0.097	5.563LeuThr: 5.563 ± 0.082	6.401LeuVal: 6.401 ± 0.095	0.793LeuTrp: 0.793 ± 0.033	3.114LeuTyr: 3.114 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	1.954MetAla: 1.954 ± 0.045	0.116MetCys: 0.116 ± 0.01	1.611MetAsp: 1.611 ± 0.042	1.864MetGlu: 1.864 ± 0.052	1.181MetPhe: 1.181 ± 0.039	1.824MetGly: 1.824 ± 0.051	0.425MetHis: 0.425 ± 0.02	2.173MetIle: 2.173 ± 0.05	2.233MetLys: 2.233 ± 0.055	2.468MetLeu: 2.468 ± 0.057	0.93MetMet: 0.93 ± 0.033	1.656MetAsn: 1.656 ± 0.04	0.875MetPro: 0.875 ± 0.031	0.879MetGln: 0.879 ± 0.033	1.094MetArg: 1.094 ± 0.036	1.803MetSer: 1.803 ± 0.051	1.682MetThr: 1.682 ± 0.047	2.0MetVal: 2.0 ± 0.056	0.18MetTrp: 0.18 ± 0.016	0.7MetTyr: 0.7 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.564AsnAla: 2.564 ± 0.057	0.279AsnCys: 0.279 ± 0.017	2.59AsnAsp: 2.59 ± 0.06	4.126AsnGlu: 4.126 ± 0.071	1.722AsnPhe: 1.722 ± 0.04	3.329AsnGly: 3.329 ± 0.067	1.304AsnHis: 1.304 ± 0.041	3.495AsnIle: 3.495 ± 0.062	2.702AsnLys: 2.702 ± 0.057	3.941AsnLeu: 3.941 ± 0.065	1.273AsnMet: 1.273 ± 0.04	1.99AsnAsn: 1.99 ± 0.059	2.067AsnPro: 2.067 ± 0.049	2.7AsnGln: 2.7 ± 0.064	2.177AsnArg: 2.177 ± 0.046	2.322AsnSer: 2.322 ± 0.056	2.06AsnThr: 2.06 ± 0.047	3.172AsnVal: 3.172 ± 0.051	0.59AsnTrp: 0.59 ± 0.027	1.629AsnTyr: 1.629 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	1.822ProAla: 1.822 ± 0.048	0.182ProCys: 0.182 ± 0.015	2.148ProAsp: 2.148 ± 0.063	3.124ProGlu: 3.124 ± 0.062	1.977ProPhe: 1.977 ± 0.054	2.253ProGly: 2.253 ± 0.054	0.842ProHis: 0.842 ± 0.03	2.985ProIle: 2.985 ± 0.057	2.184ProLys: 2.184 ± 0.051	3.28ProLeu: 3.28 ± 0.067	0.814ProMet: 0.814 ± 0.029	2.046ProAsn: 2.046 ± 0.047	0.961ProPro: 0.961 ± 0.033	1.09ProGln: 1.09 ± 0.037	1.108ProArg: 1.108 ± 0.037	2.197ProSer: 2.197 ± 0.05	1.973ProThr: 1.973 ± 0.048	2.753ProVal: 2.753 ± 0.06	0.368ProTrp: 0.368 ± 0.023	1.53ProTyr: 1.53 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.801GlnAla: 2.801 ± 0.056	0.181GlnCys: 0.181 ± 0.014	2.29GlnAsp: 2.29 ± 0.053	3.322GlnGlu: 3.322 ± 0.073	1.743GlnPhe: 1.743 ± 0.048	2.376GlnGly: 2.376 ± 0.055	1.011GlnHis: 1.011 ± 0.035	2.995GlnIle: 2.995 ± 0.072	2.737GlnLys: 2.737 ± 0.066	4.45GlnLeu: 4.45 ± 0.083	1.218GlnMet: 1.218 ± 0.039	2.018GlnAsn: 2.018 ± 0.049	1.448GlnPro: 1.448 ± 0.046	2.145GlnGln: 2.145 ± 0.073	1.571GlnArg: 1.571 ± 0.046	2.524GlnSer: 2.524 ± 0.054	2.128GlnThr: 2.128 ± 0.048	2.732GlnVal: 2.732 ± 0.066	0.456GlnTrp: 0.456 ± 0.026	1.612GlnTyr: 1.612 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.251ArgAla: 2.251 ± 0.059	0.218ArgCys: 0.218 ± 0.017	2.299ArgAsp: 2.299 ± 0.048	3.273ArgGlu: 3.273 ± 0.069	1.848ArgPhe: 1.848 ± 0.044	2.384ArgGly: 2.384 ± 0.053	0.898ArgHis: 0.898 ± 0.04	2.928ArgIle: 2.928 ± 0.059	2.744ArgLys: 2.744 ± 0.055	3.939ArgLeu: 3.939 ± 0.072	1.17ArgMet: 1.17 ± 0.034	1.815ArgAsn: 1.815 ± 0.047	1.263ArgPro: 1.263 ± 0.045	1.719ArgGln: 1.719 ± 0.049	1.754ArgArg: 1.754 ± 0.051	2.131ArgSer: 2.131 ± 0.052	1.936ArgThr: 1.936 ± 0.047	2.835ArgVal: 2.835 ± 0.061	0.39ArgTrp: 0.39 ± 0.023	1.498ArgTyr: 1.498 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.242SerAla: 3.242 ± 0.063	0.295SerCys: 0.295 ± 0.02	3.12SerAsp: 3.12 ± 0.057	4.287SerGlu: 4.287 ± 0.08	3.129SerPhe: 3.129 ± 0.061	4.155SerGly: 4.155 ± 0.072	1.303SerHis: 1.303 ± 0.041	5.145SerIle: 5.145 ± 0.088	3.557SerLys: 3.557 ± 0.071	5.804SerLeu: 5.804 ± 0.083	1.777SerMet: 1.777 ± 0.045	2.747SerAsn: 2.747 ± 0.057	2.054SerPro: 2.054 ± 0.053	2.274SerGln: 2.274 ± 0.051	2.221SerArg: 2.221 ± 0.055	3.726SerSer: 3.726 ± 0.076	2.941SerThr: 2.941 ± 0.058	4.15SerVal: 4.15 ± 0.061	0.613SerTrp: 0.613 ± 0.026	2.2SerTyr: 2.2 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	3.288ThrAla: 3.288 ± 0.069	0.321ThrCys: 0.321 ± 0.018	2.778ThrAsp: 2.778 ± 0.061	3.584ThrGlu: 3.584 ± 0.074	2.565ThrPhe: 2.565 ± 0.058	3.88ThrGly: 3.88 ± 0.07	1.1ThrHis: 1.1 ± 0.04	4.643ThrIle: 4.643 ± 0.079	3.037ThrLys: 3.037 ± 0.06	5.149ThrLeu: 5.149 ± 0.077	1.274ThrMet: 1.274 ± 0.038	2.478ThrAsn: 2.478 ± 0.052	2.181ThrPro: 2.181 ± 0.057	1.663ThrGln: 1.663 ± 0.052	1.654ThrArg: 1.654 ± 0.04	3.164ThrSer: 3.164 ± 0.057	2.924ThrThr: 2.924 ± 0.057	4.144ThrVal: 4.144 ± 0.076	0.479ThrTrp: 0.479 ± 0.025	2.091ThrTyr: 2.091 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.841ValAla: 4.841 ± 0.084	0.483ValCys: 0.483 ± 0.027	4.239ValAsp: 4.239 ± 0.083	5.612ValGlu: 5.612 ± 0.103	3.095ValPhe: 3.095 ± 0.062	4.952ValGly: 4.952 ± 0.08	1.454ValHis: 1.454 ± 0.043	5.891ValIle: 5.891 ± 0.088	4.442ValLys: 4.442 ± 0.076	6.895ValLeu: 6.895 ± 0.086	1.984ValMet: 1.984 ± 0.047	3.346ValAsn: 3.346 ± 0.059	2.652ValPro: 2.652 ± 0.055	2.668ValGln: 2.668 ± 0.051	2.609ValArg: 2.609 ± 0.054	4.421ValSer: 4.421 ± 0.074	4.093ValThr: 4.093 ± 0.065	5.25ValVal: 5.25 ± 0.087	0.648ValTrp: 0.648 ± 0.03	2.415ValTyr: 2.415 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.594TrpAla: 0.594 ± 0.029	0.065TrpCys: 0.065 ± 0.009	0.525TrpAsp: 0.525 ± 0.027	0.708TrpGlu: 0.708 ± 0.03	0.586TrpPhe: 0.586 ± 0.026	0.606TrpGly: 0.606 ± 0.032	0.178TrpHis: 0.178 ± 0.014	0.87TrpIle: 0.87 ± 0.029	0.668TrpLys: 0.668 ± 0.034	1.241TrpLeu: 1.241 ± 0.041	0.356TrpMet: 0.356 ± 0.021	0.521TrpAsn: 0.521 ± 0.025	0.262TrpPro: 0.262 ± 0.019	0.384TrpGln: 0.384 ± 0.02	0.358TrpArg: 0.358 ± 0.019	0.591TrpSer: 0.591 ± 0.028	0.554TrpThr: 0.554 ± 0.026	0.696TrpVal: 0.696 ± 0.028	0.148TrpTrp: 0.148 ± 0.014	0.381TrpTyr: 0.381 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.004TyrAla: 2.004 ± 0.051	0.239TyrCys: 0.239 ± 0.016	2.325TyrAsp: 2.325 ± 0.059	2.86TyrGlu: 2.86 ± 0.06	1.873TyrPhe: 1.873 ± 0.049	2.501TyrGly: 2.501 ± 0.06	1.0TyrHis: 1.0 ± 0.033	2.535TyrIle: 2.535 ± 0.057	1.936TyrLys: 1.936 ± 0.049	3.572TyrLeu: 3.572 ± 0.076	0.907TyrMet: 0.907 ± 0.033	1.663TyrAsn: 1.663 ± 0.042	1.433TyrPro: 1.433 ± 0.046	1.862TyrGln: 1.862 ± 0.048	1.638TyrArg: 1.638 ± 0.042	2.092TyrSer: 2.092 ± 0.049	1.757TyrThr: 1.757 ± 0.049	2.378TyrVal: 2.378 ± 0.052	0.441TyrTrp: 0.441 ± 0.024	1.563TyrTyr: 1.563 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3140 proteins (874420 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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