Amino acid dipepetide frequency for Eptesipox virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.959AlaAla: 1.959 ± 0.243
0.894AlaCys: 0.894 ± 0.118
1.636AlaAsp: 1.636 ± 0.173
1.37AlaGlu: 1.37 ± 0.164
1.408AlaPhe: 1.408 ± 0.161
0.989AlaGly: 0.989 ± 0.168
0.704AlaHis: 0.704 ± 0.115
4.128AlaIle: 4.128 ± 0.257
2.644AlaLys: 2.644 ± 0.203
3.633AlaLeu: 3.633 ± 0.267
0.704AlaMet: 0.704 ± 0.14
2.378AlaAsn: 2.378 ± 0.187
0.742AlaPro: 0.742 ± 0.139
0.875AlaGln: 0.875 ± 0.134
1.103AlaArg: 1.103 ± 0.156
2.53AlaSer: 2.53 ± 0.26
2.188AlaThr: 2.188 ± 0.206
1.921AlaVal: 1.921 ± 0.209
0.152AlaTrp: 0.152 ± 0.058
1.598AlaTyr: 1.598 ± 0.18
0.0AlaXaa: 0.0 ± 0.0
Cys
0.818CysAla: 0.818 ± 0.115
0.628CysCys: 0.628 ± 0.132
1.522CysAsp: 1.522 ± 0.155
1.389CysGlu: 1.389 ± 0.181
1.141CysPhe: 1.141 ± 0.142
0.742CysGly: 0.742 ± 0.117
0.247CysHis: 0.247 ± 0.064
2.226CysIle: 2.226 ± 0.213
2.264CysLys: 2.264 ± 0.224
1.446CysLeu: 1.446 ± 0.149
0.495CysMet: 0.495 ± 0.092
1.769CysAsn: 1.769 ± 0.162
0.628CysPro: 0.628 ± 0.118
0.361CysGln: 0.361 ± 0.075
0.59CysArg: 0.59 ± 0.096
1.845CysSer: 1.845 ± 0.218
1.255CysThr: 1.255 ± 0.167
1.313CysVal: 1.313 ± 0.2
0.228CysTrp: 0.228 ± 0.071
1.408CysTyr: 1.408 ± 0.166
0.0CysXaa: 0.0 ± 0.0
Asp
2.226AspAla: 2.226 ± 0.17
0.799AspCys: 0.799 ± 0.136
3.88AspAsp: 3.88 ± 0.321
3.766AspGlu: 3.766 ± 0.28
2.91AspPhe: 2.91 ± 0.236
1.826AspGly: 1.826 ± 0.219
0.514AspHis: 0.514 ± 0.091
7.323AspIle: 7.323 ± 0.336
5.193AspLys: 5.193 ± 0.374
4.375AspLeu: 4.375 ± 0.288
1.617AspMet: 1.617 ± 0.176
4.565AspAsn: 4.565 ± 0.332
1.046AspPro: 1.046 ± 0.126
0.97AspGln: 0.97 ± 0.126
1.274AspArg: 1.274 ± 0.136
3.253AspSer: 3.253 ± 0.312
3.215AspThr: 3.215 ± 0.209
3.919AspVal: 3.919 ± 0.29
0.361AspTrp: 0.361 ± 0.09
3.063AspTyr: 3.063 ± 0.258
0.0AspXaa: 0.0 ± 0.0
Glu
1.503GluAla: 1.503 ± 0.156
1.274GluCys: 1.274 ± 0.14
3.005GluAsp: 3.005 ± 0.257
3.215GluGlu: 3.215 ± 0.262
2.416GluPhe: 2.416 ± 0.265
1.332GluGly: 1.332 ± 0.173
1.332GluHis: 1.332 ± 0.142
5.383GluIle: 5.383 ± 0.328
4.755GluLys: 4.755 ± 0.313
5.65GluLeu: 5.65 ± 0.472
1.236GluMet: 1.236 ± 0.162
4.394GluAsn: 4.394 ± 0.31
1.465GluPro: 1.465 ± 0.149
1.598GluGln: 1.598 ± 0.175
1.807GluArg: 1.807 ± 0.383
3.481GluSer: 3.481 ± 0.244
3.519GluThr: 3.519 ± 0.242
2.321GluVal: 2.321 ± 0.224
0.438GluTrp: 0.438 ± 0.089
3.31GluTyr: 3.31 ± 0.256
0.0GluXaa: 0.0 ± 0.0
Phe
1.37PheAla: 1.37 ± 0.174
1.255PheCys: 1.255 ± 0.197
3.005PheAsp: 3.005 ± 0.233
2.168PheGlu: 2.168 ± 0.22
2.321PhePhe: 2.321 ± 0.254
2.149PheGly: 2.149 ± 0.236
0.761PheHis: 0.761 ± 0.117
6.563PheIle: 6.563 ± 0.369
4.432PheLys: 4.432 ± 0.291
4.755PheLeu: 4.755 ± 0.319
1.56PheMet: 1.56 ± 0.184
5.022PheAsn: 5.022 ± 0.268
1.293PhePro: 1.293 ± 0.143
0.932PheGln: 0.932 ± 0.129
1.255PheArg: 1.255 ± 0.137
3.919PheSer: 3.919 ± 0.271
3.652PheThr: 3.652 ± 0.249
2.758PheVal: 2.758 ± 0.233
0.418PheTrp: 0.418 ± 0.093
2.473PheTyr: 2.473 ± 0.207
0.0PheXaa: 0.0 ± 0.0
Gly
1.274GlyAla: 1.274 ± 0.168
0.685GlyCys: 0.685 ± 0.126
1.921GlyAsp: 1.921 ± 0.164
1.769GlyGlu: 1.769 ± 0.195
1.788GlyPhe: 1.788 ± 0.223
1.807GlyGly: 1.807 ± 0.222
0.552GlyHis: 0.552 ± 0.099
3.633GlyIle: 3.633 ± 0.251
2.663GlyLys: 2.663 ± 0.238
2.568GlyLeu: 2.568 ± 0.221
0.609GlyMet: 0.609 ± 0.097
2.606GlyAsn: 2.606 ± 0.236
0.647GlyPro: 0.647 ± 0.118
0.647GlyGln: 0.647 ± 0.112
1.084GlyArg: 1.084 ± 0.142
2.13GlySer: 2.13 ± 0.231
2.035GlyThr: 2.035 ± 0.187
1.788GlyVal: 1.788 ± 0.197
0.247GlyTrp: 0.247 ± 0.064
1.579GlyTyr: 1.579 ± 0.219
0.0GlyXaa: 0.0 ± 0.0
His
0.742HisAla: 0.742 ± 0.1
0.59HisCys: 0.59 ± 0.124
0.647HisAsp: 0.647 ± 0.095
0.894HisGlu: 0.894 ± 0.111
0.818HisPhe: 0.818 ± 0.118
0.818HisGly: 0.818 ± 0.13
0.38HisHis: 0.38 ± 0.099
2.283HisIle: 2.283 ± 0.202
1.826HisLys: 1.826 ± 0.173
1.579HisLeu: 1.579 ± 0.157
0.628HisMet: 0.628 ± 0.104
1.636HisAsn: 1.636 ± 0.198
0.59HisPro: 0.59 ± 0.115
0.342HisGln: 0.342 ± 0.077
0.418HisArg: 0.418 ± 0.086
1.141HisSer: 1.141 ± 0.156
0.932HisThr: 0.932 ± 0.135
1.313HisVal: 1.313 ± 0.17
0.266HisTrp: 0.266 ± 0.087
0.799HisTyr: 0.799 ± 0.132
0.0HisXaa: 0.0 ± 0.0
Ile
3.462IleAla: 3.462 ± 0.269
2.188IleCys: 2.188 ± 0.228
6.525IleAsp: 6.525 ± 0.332
5.402IleGlu: 5.402 ± 0.344
5.44IlePhe: 5.44 ± 0.344
3.481IleGly: 3.481 ± 0.285
2.111IleHis: 2.111 ± 0.204
11.185IleIle: 11.185 ± 0.499
9.948IleLys: 9.948 ± 0.449
9.948IleLeu: 9.948 ± 0.485
1.902IleMet: 1.902 ± 0.192
11.014IleAsn: 11.014 ± 0.612
2.948IlePro: 2.948 ± 0.245
2.188IleGln: 2.188 ± 0.233
2.454IleArg: 2.454 ± 0.19
8.541IleSer: 8.541 ± 0.385
7.19IleThr: 7.19 ± 0.404
6.201IleVal: 6.201 ± 0.337
0.628IleTrp: 0.628 ± 0.096
5.402IleTyr: 5.402 ± 0.32
0.0IleXaa: 0.0 ± 0.0
Lys
2.226LysAla: 2.226 ± 0.198
2.149LysCys: 2.149 ± 0.243
4.318LysAsp: 4.318 ± 0.281
5.326LysGlu: 5.326 ± 0.301
4.204LysPhe: 4.204 ± 0.286
2.13LysGly: 2.13 ± 0.184
2.245LysHis: 2.245 ± 0.195
9.283LysIle: 9.283 ± 0.528
7.78LysLys: 7.78 ± 0.426
8.655LysLeu: 8.655 ± 0.382
2.073LysMet: 2.073 ± 0.164
8.408LysAsn: 8.408 ± 0.507
2.416LysPro: 2.416 ± 0.268
3.158LysGln: 3.158 ± 0.252
3.024LysArg: 3.024 ± 0.236
6.372LysSer: 6.372 ± 0.378
5.973LysThr: 5.973 ± 0.351
4.299LysVal: 4.299 ± 0.28
0.78LysTrp: 0.78 ± 0.148
6.429LysTyr: 6.429 ± 0.421
0.0LysXaa: 0.0 ± 0.0
Leu
2.891LeuAla: 2.891 ± 0.274
2.016LeuCys: 2.016 ± 0.179
5.041LeuAsp: 5.041 ± 0.325
5.478LeuGlu: 5.478 ± 0.439
5.592LeuPhe: 5.592 ± 0.333
2.245LeuGly: 2.245 ± 0.264
2.149LeuHis: 2.149 ± 0.28
7.856LeuIle: 7.856 ± 0.414
8.294LeuLys: 8.294 ± 0.453
8.56LeuLeu: 8.56 ± 0.479
2.302LeuMet: 2.302 ± 0.226
6.753LeuAsn: 6.753 ± 0.378
3.348LeuPro: 3.348 ± 0.27
2.435LeuGln: 2.435 ± 0.199
2.359LeuArg: 2.359 ± 0.241
7.076LeuSer: 7.076 ± 0.328
5.611LeuThr: 5.611 ± 0.318
4.337LeuVal: 4.337 ± 0.342
0.514LeuTrp: 0.514 ± 0.111
5.155LeuTyr: 5.155 ± 0.318
0.0LeuXaa: 0.0 ± 0.0
Met
1.293MetAla: 1.293 ± 0.133
0.533MetCys: 0.533 ± 0.103
1.807MetAsp: 1.807 ± 0.174
1.332MetGlu: 1.332 ± 0.17
1.864MetPhe: 1.864 ± 0.224
0.913MetGly: 0.913 ± 0.13
0.438MetHis: 0.438 ± 0.094
2.016MetIle: 2.016 ± 0.204
1.674MetLys: 1.674 ± 0.152
2.454MetLeu: 2.454 ± 0.214
0.647MetMet: 0.647 ± 0.123
1.198MetAsn: 1.198 ± 0.133
0.818MetPro: 0.818 ± 0.115
0.457MetGln: 0.457 ± 0.083
0.723MetArg: 0.723 ± 0.122
1.921MetSer: 1.921 ± 0.179
1.065MetThr: 1.065 ± 0.129
0.856MetVal: 0.856 ± 0.117
0.228MetTrp: 0.228 ± 0.062
1.617MetTyr: 1.617 ± 0.163
0.0MetXaa: 0.0 ± 0.0
Asn
2.587AsnAla: 2.587 ± 0.247
1.217AsnCys: 1.217 ± 0.161
4.641AsnAsp: 4.641 ± 0.34
4.394AsnGlu: 4.394 ± 0.281
4.242AsnPhe: 4.242 ± 0.271
2.739AsnGly: 2.739 ± 0.271
1.122AsnHis: 1.122 ± 0.139
11.775AsnIle: 11.775 ± 0.687
8.997AsnLys: 8.997 ± 0.496
6.258AsnLeu: 6.258 ± 0.357
2.168AsnMet: 2.168 ± 0.173
10.785AsnAsn: 10.785 ± 0.912
2.073AsnPro: 2.073 ± 0.204
1.522AsnGln: 1.522 ± 0.166
1.693AsnArg: 1.693 ± 0.186
5.174AsnSer: 5.174 ± 0.309
4.927AsnThr: 4.927 ± 0.331
5.421AsnVal: 5.421 ± 0.323
0.418AsnTrp: 0.418 ± 0.081
5.44AsnTyr: 5.44 ± 0.334
0.0AsnXaa: 0.0 ± 0.0
Pro
0.818ProAla: 0.818 ± 0.121
0.552ProCys: 0.552 ± 0.081
1.37ProAsp: 1.37 ± 0.153
1.351ProGlu: 1.351 ± 0.165
1.617ProPhe: 1.617 ± 0.184
0.951ProGly: 0.951 ± 0.136
0.628ProHis: 0.628 ± 0.145
3.291ProIle: 3.291 ± 0.229
2.72ProLys: 2.72 ± 0.254
2.72ProLeu: 2.72 ± 0.237
0.685ProMet: 0.685 ± 0.113
2.492ProAsn: 2.492 ± 0.278
1.122ProPro: 1.122 ± 0.19
0.913ProGln: 0.913 ± 0.118
0.837ProArg: 0.837 ± 0.14
2.188ProSer: 2.188 ± 0.18
1.807ProThr: 1.807 ± 0.211
1.179ProVal: 1.179 ± 0.145
0.209ProTrp: 0.209 ± 0.057
1.389ProTyr: 1.389 ± 0.153
0.0ProXaa: 0.0 ± 0.0
Gln
0.609GlnAla: 0.609 ± 0.111
0.704GlnCys: 0.704 ± 0.117
1.008GlnAsp: 1.008 ± 0.149
1.16GlnGlu: 1.16 ± 0.141
0.856GlnPhe: 0.856 ± 0.125
0.514GlnGly: 0.514 ± 0.114
0.666GlnHis: 0.666 ± 0.105
2.302GlnIle: 2.302 ± 0.235
2.111GlnLys: 2.111 ± 0.219
2.53GlnLeu: 2.53 ± 0.234
0.552GlnMet: 0.552 ± 0.107
1.655GlnAsn: 1.655 ± 0.189
0.742GlnPro: 0.742 ± 0.11
0.856GlnGln: 0.856 ± 0.149
1.008GlnArg: 1.008 ± 0.156
1.617GlnSer: 1.617 ± 0.197
1.826GlnThr: 1.826 ± 0.196
0.989GlnVal: 0.989 ± 0.131
0.285GlnTrp: 0.285 ± 0.07
1.598GlnTyr: 1.598 ± 0.189
0.0GlnXaa: 0.0 ± 0.0
Arg
0.951ArgAla: 0.951 ± 0.152
0.685ArgCys: 0.685 ± 0.131
1.446ArgAsp: 1.446 ± 0.17
1.484ArgGlu: 1.484 ± 0.284
1.408ArgPhe: 1.408 ± 0.146
1.027ArgGly: 1.027 ± 0.157
0.647ArgHis: 0.647 ± 0.112
2.777ArgIle: 2.777 ± 0.223
2.264ArgLys: 2.264 ± 0.202
2.378ArgLeu: 2.378 ± 0.251
0.571ArgMet: 0.571 ± 0.104
1.313ArgAsn: 1.313 ± 0.157
0.894ArgPro: 0.894 ± 0.134
1.141ArgGln: 1.141 ± 0.134
1.465ArgArg: 1.465 ± 0.179
2.035ArgSer: 2.035 ± 0.184
1.313ArgThr: 1.313 ± 0.166
1.921ArgVal: 1.921 ± 0.195
0.114ArgTrp: 0.114 ± 0.05
1.427ArgTyr: 1.427 ± 0.197
0.0ArgXaa: 0.0 ± 0.0
Ser
2.321SerAla: 2.321 ± 0.176
1.56SerCys: 1.56 ± 0.169
4.128SerAsp: 4.128 ± 0.322
3.614SerGlu: 3.614 ± 0.242
4.09SerPhe: 4.09 ± 0.232
2.454SerGly: 2.454 ± 0.257
1.198SerHis: 1.198 ± 0.166
7.761SerIle: 7.761 ± 0.413
7.114SerLys: 7.114 ± 0.361
6.829SerLeu: 6.829 ± 0.409
1.769SerMet: 1.769 ± 0.182
5.44SerAsn: 5.44 ± 0.274
1.826SerPro: 1.826 ± 0.201
1.769SerGln: 1.769 ± 0.198
1.902SerArg: 1.902 ± 0.187
5.764SerSer: 5.764 ± 0.45
4.527SerThr: 4.527 ± 0.326
4.071SerVal: 4.071 ± 0.373
0.418SerTrp: 0.418 ± 0.091
3.576SerTyr: 3.576 ± 0.249
0.0SerXaa: 0.0 ± 0.0
Thr
2.302ThrAla: 2.302 ± 0.209
1.56ThrCys: 1.56 ± 0.197
3.329ThrAsp: 3.329 ± 0.252
3.405ThrGlu: 3.405 ± 0.266
3.633ThrPhe: 3.633 ± 0.27
2.016ThrGly: 2.016 ± 0.196
1.122ThrHis: 1.122 ± 0.163
6.049ThrIle: 6.049 ± 0.393
5.383ThrLys: 5.383 ± 0.314
5.611ThrLeu: 5.611 ± 0.28
1.522ThrMet: 1.522 ± 0.154
4.984ThrAsn: 4.984 ± 0.298
2.663ThrPro: 2.663 ± 0.235
1.198ThrGln: 1.198 ± 0.155
1.389ThrArg: 1.389 ± 0.195
4.736ThrSer: 4.736 ± 0.299
4.261ThrThr: 4.261 ± 0.309
3.785ThrVal: 3.785 ± 0.271
0.476ThrTrp: 0.476 ± 0.095
3.215ThrTyr: 3.215 ± 0.266
0.0ThrXaa: 0.0 ± 0.0
Val
1.807ValAla: 1.807 ± 0.188
1.541ValCys: 1.541 ± 0.232
3.272ValAsp: 3.272 ± 0.263
3.196ValGlu: 3.196 ± 0.231
2.834ValPhe: 2.834 ± 0.226
1.446ValGly: 1.446 ± 0.174
0.837ValHis: 0.837 ± 0.131
4.813ValIle: 4.813 ± 0.276
5.288ValLys: 5.288 ± 0.316
4.565ValLeu: 4.565 ± 0.357
1.274ValMet: 1.274 ± 0.164
5.212ValAsn: 5.212 ± 0.317
1.56ValPro: 1.56 ± 0.172
1.217ValGln: 1.217 ± 0.162
1.408ValArg: 1.408 ± 0.182
4.451ValSer: 4.451 ± 0.25
3.272ValThr: 3.272 ± 0.292
2.511ValVal: 2.511 ± 0.243
0.171ValTrp: 0.171 ± 0.065
3.101ValTyr: 3.101 ± 0.274
0.0ValXaa: 0.0 ± 0.0
Trp
0.209TrpAla: 0.209 ± 0.06
0.228TrpCys: 0.228 ± 0.067
0.266TrpAsp: 0.266 ± 0.067
0.38TrpGlu: 0.38 ± 0.082
0.571TrpPhe: 0.571 ± 0.111
0.171TrpGly: 0.171 ± 0.065
0.057TrpHis: 0.057 ± 0.031
0.685TrpIle: 0.685 ± 0.113
0.59TrpLys: 0.59 ± 0.091
0.761TrpLeu: 0.761 ± 0.14
0.247TrpMet: 0.247 ± 0.067
0.457TrpAsn: 0.457 ± 0.088
0.171TrpPro: 0.171 ± 0.06
0.152TrpGln: 0.152 ± 0.061
0.285TrpArg: 0.285 ± 0.085
0.399TrpSer: 0.399 ± 0.102
0.38TrpThr: 0.38 ± 0.08
0.285TrpVal: 0.285 ± 0.071
0.019TrpTrp: 0.019 ± 0.017
0.38TrpTyr: 0.38 ± 0.086
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.188TyrAla: 2.188 ± 0.201
1.255TyrCys: 1.255 ± 0.139
3.329TyrAsp: 3.329 ± 0.258
2.34TyrGlu: 2.34 ± 0.208
2.91TyrPhe: 2.91 ± 0.202
2.283TyrGly: 2.283 ± 0.207
0.932TyrHis: 0.932 ± 0.13
6.829TyrIle: 6.829 ± 0.461
5.326TyrLys: 5.326 ± 0.293
4.736TyrLeu: 4.736 ± 0.31
1.274TyrMet: 1.274 ± 0.136
5.516TyrAsn: 5.516 ± 0.32
1.845TyrPro: 1.845 ± 0.17
0.856TyrGln: 0.856 ± 0.106
1.179TyrArg: 1.179 ± 0.155
3.557TyrSer: 3.557 ± 0.273
3.69TyrThr: 3.69 ± 0.283
2.587TyrVal: 2.587 ± 0.256
0.323TyrTrp: 0.323 ± 0.079
3.12TyrTyr: 3.12 ± 0.243
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 179 proteins (52572 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski