Amino acid dipepetide frequency for Streptococcus satellite phage Javan194

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.65AlaAla: 0.65 ± 0.377
0.325AlaCys: 0.325 ± 0.329
6.82AlaAsp: 6.82 ± 2.139
6.496AlaGlu: 6.496 ± 1.496
3.248AlaPhe: 3.248 ± 0.978
2.923AlaGly: 2.923 ± 1.059
0.974AlaHis: 0.974 ± 0.56
4.222AlaIle: 4.222 ± 0.884
4.547AlaLys: 4.547 ± 1.489
7.795AlaLeu: 7.795 ± 1.24
2.923AlaMet: 2.923 ± 0.885
2.923AlaAsn: 2.923 ± 0.551
1.299AlaPro: 1.299 ± 0.557
2.923AlaGln: 2.923 ± 0.816
3.248AlaArg: 3.248 ± 0.825
2.598AlaSer: 2.598 ± 0.746
3.248AlaThr: 3.248 ± 1.073
2.923AlaVal: 2.923 ± 1.008
0.325AlaTrp: 0.325 ± 0.306
2.273AlaTyr: 2.273 ± 0.895
0.0AlaXaa: 0.0 ± 0.0
Cys
0.65CysAla: 0.65 ± 0.445
0.0CysCys: 0.0 ± 0.0
0.325CysAsp: 0.325 ± 0.329
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.65CysGly: 0.65 ± 0.62
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.325CysLeu: 0.325 ± 0.318
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.325CysPro: 0.325 ± 0.31
0.974CysGln: 0.974 ± 0.67
0.65CysArg: 0.65 ± 0.367
0.65CysSer: 0.65 ± 0.458
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.325CysTyr: 0.325 ± 0.329
0.0CysXaa: 0.0 ± 0.0
Asp
1.949AspAla: 1.949 ± 0.848
0.65AspCys: 0.65 ± 0.62
3.248AspAsp: 3.248 ± 1.14
2.273AspGlu: 2.273 ± 0.726
3.573AspPhe: 3.573 ± 1.081
2.273AspGly: 2.273 ± 0.861
0.325AspHis: 0.325 ± 0.314
6.496AspIle: 6.496 ± 1.606
6.171AspLys: 6.171 ± 1.298
5.846AspLeu: 5.846 ± 1.059
2.273AspMet: 2.273 ± 0.888
3.573AspAsn: 3.573 ± 1.338
0.65AspPro: 0.65 ± 0.382
0.974AspGln: 0.974 ± 0.549
2.273AspArg: 2.273 ± 0.698
3.573AspSer: 3.573 ± 0.893
3.573AspThr: 3.573 ± 1.175
1.299AspVal: 1.299 ± 0.495
1.299AspTrp: 1.299 ± 0.576
3.248AspTyr: 3.248 ± 1.027
0.0AspXaa: 0.0 ± 0.0
Glu
5.846GluAla: 5.846 ± 1.742
0.65GluCys: 0.65 ± 0.443
3.573GluAsp: 3.573 ± 0.73
5.521GluGlu: 5.521 ± 1.764
2.598GluPhe: 2.598 ± 0.946
2.273GluGly: 2.273 ± 1.287
0.325GluHis: 0.325 ± 0.306
4.872GluIle: 4.872 ± 1.301
7.47GluLys: 7.47 ± 1.826
12.342GluLeu: 12.342 ± 1.767
1.299GluMet: 1.299 ± 0.57
3.897GluAsn: 3.897 ± 0.941
2.273GluPro: 2.273 ± 0.774
7.47GluGln: 7.47 ± 1.982
2.923GluArg: 2.923 ± 1.248
3.573GluSer: 3.573 ± 0.921
4.222GluThr: 4.222 ± 1.048
3.248GluVal: 3.248 ± 1.391
0.65GluTrp: 0.65 ± 0.441
2.273GluTyr: 2.273 ± 0.773
0.0GluXaa: 0.0 ± 0.0
Phe
1.299PheAla: 1.299 ± 0.616
0.325PheCys: 0.325 ± 0.329
1.624PheAsp: 1.624 ± 0.824
3.573PheGlu: 3.573 ± 1.155
2.273PhePhe: 2.273 ± 0.702
2.598PheGly: 2.598 ± 0.916
1.624PheHis: 1.624 ± 0.859
4.547PheIle: 4.547 ± 1.519
2.923PheLys: 2.923 ± 1.017
2.598PheLeu: 2.598 ± 1.01
0.65PheMet: 0.65 ± 0.393
1.299PheAsn: 1.299 ± 0.522
1.949PhePro: 1.949 ± 0.978
0.325PheGln: 0.325 ± 0.305
1.624PheArg: 1.624 ± 0.63
2.923PheSer: 2.923 ± 0.892
1.624PheThr: 1.624 ± 0.736
1.299PheVal: 1.299 ± 0.685
0.0PheTrp: 0.0 ± 0.0
1.949PheTyr: 1.949 ± 0.743
0.0PheXaa: 0.0 ± 0.0
Gly
4.222GlyAla: 4.222 ± 1.433
0.974GlyCys: 0.974 ± 0.467
1.949GlyAsp: 1.949 ± 0.769
3.248GlyGlu: 3.248 ± 1.026
1.624GlyPhe: 1.624 ± 0.946
1.624GlyGly: 1.624 ± 0.792
1.299GlyHis: 1.299 ± 0.721
4.222GlyIle: 4.222 ± 0.804
2.923GlyLys: 2.923 ± 0.754
4.222GlyLeu: 4.222 ± 1.267
1.624GlyMet: 1.624 ± 0.614
1.949GlyAsn: 1.949 ± 1.206
0.325GlyPro: 0.325 ± 0.314
1.949GlyGln: 1.949 ± 0.617
2.598GlyArg: 2.598 ± 1.005
1.624GlySer: 1.624 ± 0.667
2.273GlyThr: 2.273 ± 1.038
4.222GlyVal: 4.222 ± 0.996
1.299GlyTrp: 1.299 ± 0.752
2.598GlyTyr: 2.598 ± 1.026
0.0GlyXaa: 0.0 ± 0.0
His
1.949HisAla: 1.949 ± 1.08
0.0HisCys: 0.0 ± 0.0
0.325HisAsp: 0.325 ± 0.306
0.974HisGlu: 0.974 ± 0.668
0.0HisPhe: 0.0 ± 0.0
0.974HisGly: 0.974 ± 0.786
0.325HisHis: 0.325 ± 0.306
0.65HisIle: 0.65 ± 0.42
1.949HisLys: 1.949 ± 0.863
1.624HisLeu: 1.624 ± 0.661
0.0HisMet: 0.0 ± 0.0
0.325HisAsn: 0.325 ± 0.306
1.624HisPro: 1.624 ± 0.773
0.974HisGln: 0.974 ± 0.672
1.624HisArg: 1.624 ± 0.912
0.325HisSer: 0.325 ± 0.266
0.974HisThr: 0.974 ± 0.427
0.65HisVal: 0.65 ± 0.448
0.0HisTrp: 0.0 ± 0.0
0.65HisTyr: 0.65 ± 0.367
0.0HisXaa: 0.0 ± 0.0
Ile
4.872IleAla: 4.872 ± 1.052
0.0IleCys: 0.0 ± 0.0
3.897IleAsp: 3.897 ± 1.247
5.846IleGlu: 5.846 ± 1.097
1.624IlePhe: 1.624 ± 0.67
1.949IleGly: 1.949 ± 0.842
2.273IleHis: 2.273 ± 0.832
5.196IleIle: 5.196 ± 1.659
7.145IleLys: 7.145 ± 1.672
3.897IleLeu: 3.897 ± 0.863
0.65IleMet: 0.65 ± 0.363
6.171IleAsn: 6.171 ± 1.624
4.222IlePro: 4.222 ± 0.82
1.949IleGln: 1.949 ± 0.527
2.273IleArg: 2.273 ± 0.803
6.171IleSer: 6.171 ± 0.947
6.496IleThr: 6.496 ± 1.36
1.624IleVal: 1.624 ± 0.528
0.325IleTrp: 0.325 ± 0.337
2.923IleTyr: 2.923 ± 0.935
0.0IleXaa: 0.0 ± 0.0
Lys
7.145LysAla: 7.145 ± 1.382
0.0LysCys: 0.0 ± 0.0
3.897LysAsp: 3.897 ± 1.073
12.017LysGlu: 12.017 ± 1.544
1.299LysPhe: 1.299 ± 0.636
5.521LysGly: 5.521 ± 1.511
2.923LysHis: 2.923 ± 1.017
3.897LysIle: 3.897 ± 0.818
8.769LysLys: 8.769 ± 1.575
9.094LysLeu: 9.094 ± 1.568
2.598LysMet: 2.598 ± 1.197
5.846LysAsn: 5.846 ± 1.168
4.547LysPro: 4.547 ± 1.051
5.196LysGln: 5.196 ± 1.184
4.222LysArg: 4.222 ± 1.3
3.897LysSer: 3.897 ± 1.29
6.496LysThr: 6.496 ± 1.339
5.846LysVal: 5.846 ± 1.318
0.325LysTrp: 0.325 ± 0.337
1.624LysTyr: 1.624 ± 0.653
0.0LysXaa: 0.0 ± 0.0
Leu
6.82LeuAla: 6.82 ± 1.279
0.974LeuCys: 0.974 ± 0.504
5.196LeuAsp: 5.196 ± 1.277
8.12LeuGlu: 8.12 ± 2.002
2.598LeuPhe: 2.598 ± 0.794
7.47LeuGly: 7.47 ± 1.312
0.65LeuHis: 0.65 ± 0.445
5.846LeuIle: 5.846 ± 1.383
12.342LeuLys: 12.342 ± 2.155
12.991LeuLeu: 12.991 ± 1.716
2.598LeuMet: 2.598 ± 0.764
7.795LeuAsn: 7.795 ± 1.6
3.573LeuPro: 3.573 ± 0.897
4.222LeuGln: 4.222 ± 0.889
3.248LeuArg: 3.248 ± 0.763
7.47LeuSer: 7.47 ± 1.804
6.171LeuThr: 6.171 ± 1.616
2.923LeuVal: 2.923 ± 0.914
1.299LeuTrp: 1.299 ± 0.495
3.573LeuTyr: 3.573 ± 0.99
0.0LeuXaa: 0.0 ± 0.0
Met
6.171MetAla: 6.171 ± 1.15
0.325MetCys: 0.325 ± 0.31
1.299MetAsp: 1.299 ± 0.602
0.974MetGlu: 0.974 ± 0.411
0.974MetPhe: 0.974 ± 0.485
0.974MetGly: 0.974 ± 0.516
0.0MetHis: 0.0 ± 0.0
1.624MetIle: 1.624 ± 0.738
0.974MetLys: 0.974 ± 0.417
2.598MetLeu: 2.598 ± 0.654
0.0MetMet: 0.0 ± 0.0
1.299MetAsn: 1.299 ± 0.527
0.325MetPro: 0.325 ± 0.347
0.325MetGln: 0.325 ± 0.343
1.624MetArg: 1.624 ± 0.667
2.273MetSer: 2.273 ± 1.098
3.248MetThr: 3.248 ± 0.775
2.598MetVal: 2.598 ± 0.842
0.325MetTrp: 0.325 ± 0.314
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.923AsnAla: 2.923 ± 0.835
0.0AsnCys: 0.0 ± 0.0
2.923AsnAsp: 2.923 ± 0.83
2.598AsnGlu: 2.598 ± 0.98
2.273AsnPhe: 2.273 ± 0.819
2.923AsnGly: 2.923 ± 0.875
0.65AsnHis: 0.65 ± 0.363
3.897AsnIle: 3.897 ± 1.256
3.897AsnLys: 3.897 ± 0.893
6.82AsnLeu: 6.82 ± 1.24
1.949AsnMet: 1.949 ± 0.821
4.222AsnAsn: 4.222 ± 0.977
2.923AsnPro: 2.923 ± 0.799
4.222AsnGln: 4.222 ± 1.603
3.897AsnArg: 3.897 ± 1.141
3.897AsnSer: 3.897 ± 0.848
2.273AsnThr: 2.273 ± 0.86
1.624AsnVal: 1.624 ± 0.553
0.325AsnTrp: 0.325 ± 0.343
1.624AsnTyr: 1.624 ± 0.616
0.0AsnXaa: 0.0 ± 0.0
Pro
2.273ProAla: 2.273 ± 0.724
0.0ProCys: 0.0 ± 0.0
2.598ProAsp: 2.598 ± 0.778
1.949ProGlu: 1.949 ± 0.644
1.949ProPhe: 1.949 ± 0.746
0.65ProGly: 0.65 ± 0.447
0.325ProHis: 0.325 ± 0.347
2.598ProIle: 2.598 ± 0.822
6.496ProLys: 6.496 ± 1.434
2.598ProLeu: 2.598 ± 0.968
0.65ProMet: 0.65 ± 0.437
0.974ProAsn: 0.974 ± 0.672
1.949ProPro: 1.949 ± 0.706
1.299ProGln: 1.299 ± 0.556
1.624ProArg: 1.624 ± 0.656
2.273ProSer: 2.273 ± 0.906
2.273ProThr: 2.273 ± 0.803
2.273ProVal: 2.273 ± 0.588
0.0ProTrp: 0.0 ± 0.0
1.624ProTyr: 1.624 ± 0.575
0.0ProXaa: 0.0 ± 0.0
Gln
5.846GlnAla: 5.846 ± 1.765
0.0GlnCys: 0.0 ± 0.0
3.248GlnAsp: 3.248 ± 0.973
4.547GlnGlu: 4.547 ± 0.915
1.299GlnPhe: 1.299 ± 0.57
1.624GlnGly: 1.624 ± 0.832
0.974GlnHis: 0.974 ± 0.509
3.248GlnIle: 3.248 ± 0.957
5.521GlnLys: 5.521 ± 1.344
4.547GlnLeu: 4.547 ± 1.528
1.624GlnMet: 1.624 ± 0.694
2.598GlnAsn: 2.598 ± 1.23
1.624GlnPro: 1.624 ± 0.749
3.573GlnGln: 3.573 ± 1.183
3.573GlnArg: 3.573 ± 0.999
1.624GlnSer: 1.624 ± 0.655
2.273GlnThr: 2.273 ± 0.642
1.949GlnVal: 1.949 ± 0.635
0.0GlnTrp: 0.0 ± 0.0
2.923GlnTyr: 2.923 ± 0.877
0.0GlnXaa: 0.0 ± 0.0
Arg
2.273ArgAla: 2.273 ± 0.528
0.325ArgCys: 0.325 ± 0.31
3.248ArgAsp: 3.248 ± 0.955
4.547ArgGlu: 4.547 ± 1.175
1.949ArgPhe: 1.949 ± 0.61
3.248ArgGly: 3.248 ± 1.03
0.65ArgHis: 0.65 ± 0.369
1.949ArgIle: 1.949 ± 0.694
4.872ArgLys: 4.872 ± 1.077
7.145ArgLeu: 7.145 ± 1.422
1.624ArgMet: 1.624 ± 0.784
1.299ArgAsn: 1.299 ± 0.688
0.65ArgPro: 0.65 ± 0.447
3.573ArgGln: 3.573 ± 1.013
2.273ArgArg: 2.273 ± 0.776
0.325ArgSer: 0.325 ± 0.31
2.598ArgThr: 2.598 ± 0.702
2.273ArgVal: 2.273 ± 0.899
0.974ArgTrp: 0.974 ± 0.521
1.949ArgTyr: 1.949 ± 0.833
0.0ArgXaa: 0.0 ± 0.0
Ser
2.273SerAla: 2.273 ± 0.731
0.325SerCys: 0.325 ± 0.309
3.248SerAsp: 3.248 ± 0.785
3.248SerGlu: 3.248 ± 1.07
0.974SerPhe: 0.974 ± 0.437
1.624SerGly: 1.624 ± 0.637
0.65SerHis: 0.65 ± 0.456
3.897SerIle: 3.897 ± 0.843
6.171SerLys: 6.171 ± 1.249
7.47SerLeu: 7.47 ± 1.547
2.273SerMet: 2.273 ± 0.777
3.573SerAsn: 3.573 ± 1.018
1.949SerPro: 1.949 ± 0.918
3.573SerGln: 3.573 ± 0.832
1.949SerArg: 1.949 ± 0.704
1.624SerSer: 1.624 ± 0.649
2.273SerThr: 2.273 ± 0.656
2.923SerVal: 2.923 ± 1.304
0.0SerTrp: 0.0 ± 0.0
3.897SerTyr: 3.897 ± 1.583
0.0SerXaa: 0.0 ± 0.0
Thr
1.949ThrAla: 1.949 ± 0.965
0.0ThrCys: 0.0 ± 0.0
3.573ThrAsp: 3.573 ± 0.915
5.196ThrGlu: 5.196 ± 1.262
1.949ThrPhe: 1.949 ± 0.8
4.222ThrGly: 4.222 ± 1.108
0.974ThrHis: 0.974 ± 0.533
6.496ThrIle: 6.496 ± 1.191
4.547ThrLys: 4.547 ± 1.39
4.872ThrLeu: 4.872 ± 1.19
1.299ThrMet: 1.299 ± 0.636
2.598ThrAsn: 2.598 ± 1.081
3.248ThrPro: 3.248 ± 0.959
2.923ThrGln: 2.923 ± 0.943
1.949ThrArg: 1.949 ± 0.816
3.248ThrSer: 3.248 ± 0.853
2.273ThrThr: 2.273 ± 0.601
4.547ThrVal: 4.547 ± 0.855
0.65ThrTrp: 0.65 ± 0.628
2.598ThrTyr: 2.598 ± 0.849
0.0ThrXaa: 0.0 ± 0.0
Val
2.273ValAla: 2.273 ± 0.637
0.0ValCys: 0.0 ± 0.0
2.598ValAsp: 2.598 ± 0.917
3.573ValGlu: 3.573 ± 1.053
2.273ValPhe: 2.273 ± 0.823
1.299ValGly: 1.299 ± 0.495
0.65ValHis: 0.65 ± 0.533
2.923ValIle: 2.923 ± 1.031
3.897ValLys: 3.897 ± 0.928
3.897ValLeu: 3.897 ± 1.14
1.624ValMet: 1.624 ± 0.599
1.624ValAsn: 1.624 ± 0.779
1.624ValPro: 1.624 ± 0.677
1.624ValGln: 1.624 ± 0.794
3.573ValArg: 3.573 ± 0.972
3.573ValSer: 3.573 ± 0.996
3.897ValThr: 3.897 ± 1.107
2.923ValVal: 2.923 ± 1.076
0.0ValTrp: 0.0 ± 0.0
2.273ValTyr: 2.273 ± 0.642
0.0ValXaa: 0.0 ± 0.0
Trp
1.299TrpAla: 1.299 ± 0.581
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.299TrpGlu: 1.299 ± 0.549
0.325TrpPhe: 0.325 ± 0.314
0.0TrpGly: 0.0 ± 0.0
0.325TrpHis: 0.325 ± 0.343
0.325TrpIle: 0.325 ± 0.347
0.65TrpLys: 0.65 ± 0.433
0.974TrpLeu: 0.974 ± 0.416
0.0TrpMet: 0.0 ± 0.0
0.65TrpAsn: 0.65 ± 0.396
0.0TrpPro: 0.0 ± 0.0
0.65TrpGln: 0.65 ± 0.399
0.65TrpArg: 0.65 ± 0.628
0.65TrpSer: 0.65 ± 0.357
0.325TrpThr: 0.325 ± 0.337
0.0TrpVal: 0.0 ± 0.0
0.325TrpTrp: 0.325 ± 0.314
0.65TrpTyr: 0.65 ± 0.44
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.0TyrCys: 0.0 ± 0.0
1.949TyrAsp: 1.949 ± 0.84
1.299TyrGlu: 1.299 ± 0.718
4.222TyrPhe: 4.222 ± 1.064
1.949TyrGly: 1.949 ± 0.672
0.0TyrHis: 0.0 ± 0.0
2.598TyrIle: 2.598 ± 0.61
3.897TyrLys: 3.897 ± 1.139
4.222TyrLeu: 4.222 ± 1.121
1.949TyrMet: 1.949 ± 0.762
3.248TyrAsn: 3.248 ± 0.734
1.299TyrPro: 1.299 ± 0.493
4.222TyrGln: 4.222 ± 1.074
1.949TyrArg: 1.949 ± 0.773
1.624TyrSer: 1.624 ± 0.857
2.598TyrThr: 2.598 ± 0.739
0.974TyrVal: 0.974 ± 0.451
0.974TyrTrp: 0.974 ± 0.678
1.624TyrTyr: 1.624 ± 0.689
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 21 proteins (3080 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski