Amino acid dipepetide frequency for Streptomyces caeruleatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.219AlaAla: 20.219 ± 0.134	1.074AlaCys: 1.074 ± 0.024	8.366AlaAsp: 8.366 ± 0.061	8.807AlaGlu: 8.807 ± 0.073	3.44AlaPhe: 3.44 ± 0.035	12.413AlaGly: 12.413 ± 0.071	2.934AlaHis: 2.934 ± 0.036	3.357AlaIle: 3.357 ± 0.039	2.892AlaLys: 2.892 ± 0.047	14.271AlaLeu: 14.271 ± 0.104	2.414AlaMet: 2.414 ± 0.032	1.991AlaAsn: 1.991 ± 0.031	6.912AlaPro: 6.912 ± 0.066	3.868AlaGln: 3.868 ± 0.041	10.067AlaArg: 10.067 ± 0.077	5.987AlaSer: 5.987 ± 0.056	7.088AlaThr: 7.088 ± 0.053	12.091AlaVal: 12.091 ± 0.099	1.884AlaTrp: 1.884 ± 0.027	2.858AlaTyr: 2.858 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.073CysAla: 1.073 ± 0.026	0.097CysCys: 0.097 ± 0.006	0.487CysAsp: 0.487 ± 0.015	0.427CysGlu: 0.427 ± 0.013	0.219CysPhe: 0.219 ± 0.01	0.949CysGly: 0.949 ± 0.018	0.185CysHis: 0.185 ± 0.009	0.159CysIle: 0.159 ± 0.008	0.118CysLys: 0.118 ± 0.006	0.791CysLeu: 0.791 ± 0.018	0.127CysMet: 0.127 ± 0.007	0.13CysAsn: 0.13 ± 0.007	0.496CysPro: 0.496 ± 0.016	0.178CysGln: 0.178 ± 0.008	0.61CysArg: 0.61 ± 0.018	0.425CysSer: 0.425 ± 0.013	0.506CysThr: 0.506 ± 0.015	0.674CysVal: 0.674 ± 0.02	0.131CysTrp: 0.131 ± 0.007	0.158CysTyr: 0.158 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.596AspAla: 7.596 ± 0.053	0.458AspCys: 0.458 ± 0.013	3.906AspAsp: 3.906 ± 0.04	4.056AspGlu: 4.056 ± 0.043	1.722AspPhe: 1.722 ± 0.03	6.539AspGly: 6.539 ± 0.058	1.503AspHis: 1.503 ± 0.021	1.968AspIle: 1.968 ± 0.027	1.307AspLys: 1.307 ± 0.028	6.31AspLeu: 6.31 ± 0.046	0.832AspMet: 0.832 ± 0.016	1.011AspAsn: 1.011 ± 0.023	4.551AspPro: 4.551 ± 0.043	1.635AspGln: 1.635 ± 0.026	4.924AspArg: 4.924 ± 0.049	2.71AspSer: 2.71 ± 0.036	3.301AspThr: 3.301 ± 0.034	4.929AspVal: 4.929 ± 0.042	1.089AspTrp: 1.089 ± 0.021	1.176AspTyr: 1.176 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.454GluAla: 7.454 ± 0.078	0.373GluCys: 0.373 ± 0.012	2.957GluAsp: 2.957 ± 0.036	3.615GluGlu: 3.615 ± 0.049	1.516GluPhe: 1.516 ± 0.024	4.39GluGly: 4.39 ± 0.041	1.554GluHis: 1.554 ± 0.024	2.233GluIle: 2.233 ± 0.034	1.515GluLys: 1.515 ± 0.028	6.928GluLeu: 6.928 ± 0.06	0.894GluMet: 0.894 ± 0.018	1.066GluAsn: 1.066 ± 0.024	3.491GluPro: 3.491 ± 0.044	2.388GluGln: 2.388 ± 0.035	5.421GluArg: 5.421 ± 0.052	2.645GluSer: 2.645 ± 0.034	2.979GluThr: 2.979 ± 0.032	4.537GluVal: 4.537 ± 0.048	0.817GluTrp: 0.817 ± 0.018	1.163GluTyr: 1.163 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.611PheAla: 3.611 ± 0.035	0.256PheCys: 0.256 ± 0.01	2.003PheAsp: 2.003 ± 0.027	1.51PheGlu: 1.51 ± 0.026	0.894PhePhe: 0.894 ± 0.017	2.953PheGly: 2.953 ± 0.033	0.616PheHis: 0.616 ± 0.014	0.69PheIle: 0.69 ± 0.015	0.56PheLys: 0.56 ± 0.014	2.6PheLeu: 2.6 ± 0.031	0.413PheMet: 0.413 ± 0.012	0.555PheAsn: 0.555 ± 0.015	1.387PhePro: 1.387 ± 0.025	0.707PheGln: 0.707 ± 0.014	1.82PheArg: 1.82 ± 0.026	1.462PheSer: 1.462 ± 0.022	1.992PheThr: 1.992 ± 0.026	2.257PheVal: 2.257 ± 0.027	0.444PheTrp: 0.444 ± 0.014	0.584PheTyr: 0.584 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.779GlyAla: 10.779 ± 0.062	0.812GlyCys: 0.812 ± 0.02	5.297GlyAsp: 5.297 ± 0.052	5.191GlyGlu: 5.191 ± 0.05	2.865GlyPhe: 2.865 ± 0.033	8.502GlyGly: 8.502 ± 0.08	2.319GlyHis: 2.319 ± 0.031	3.386GlyIle: 3.386 ± 0.035	2.501GlyLys: 2.501 ± 0.039	9.21GlyLeu: 9.21 ± 0.067	1.942GlyMet: 1.942 ± 0.027	1.723GlyAsn: 1.723 ± 0.029	4.991GlyPro: 4.991 ± 0.054	2.727GlyGln: 2.727 ± 0.035	7.481GlyArg: 7.481 ± 0.06	5.281GlySer: 5.281 ± 0.048	6.382GlyThr: 6.382 ± 0.049	7.48GlyVal: 7.48 ± 0.055	1.737GlyTrp: 1.737 ± 0.028	2.284GlyTyr: 2.284 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.721HisAla: 2.721 ± 0.034	0.222HisCys: 0.222 ± 0.01	1.387HisAsp: 1.387 ± 0.021	1.265HisGlu: 1.265 ± 0.024	0.666HisPhe: 0.666 ± 0.015	2.371HisGly: 2.371 ± 0.03	0.689HisHis: 0.689 ± 0.016	0.712HisIle: 0.712 ± 0.017	0.381HisLys: 0.381 ± 0.012	2.475HisLeu: 2.475 ± 0.03	0.331HisMet: 0.331 ± 0.011	0.411HisAsn: 0.411 ± 0.012	1.842HisPro: 1.842 ± 0.027	0.669HisGln: 0.669 ± 0.015	2.102HisArg: 2.102 ± 0.029	1.028HisSer: 1.028 ± 0.02	1.379HisThr: 1.379 ± 0.024	1.707HisVal: 1.707 ± 0.025	0.392HisTrp: 0.392 ± 0.011	0.499HisTyr: 0.499 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.599IleAla: 4.599 ± 0.043	0.276IleCys: 0.276 ± 0.009	2.245IleAsp: 2.245 ± 0.031	1.942IleGlu: 1.942 ± 0.025	0.694IlePhe: 0.694 ± 0.016	3.438IleGly: 3.438 ± 0.038	0.639IleHis: 0.639 ± 0.016	0.87IleIle: 0.87 ± 0.017	0.761IleLys: 0.761 ± 0.018	2.455IleLeu: 2.455 ± 0.031	0.436IleMet: 0.436 ± 0.014	0.698IleAsn: 0.698 ± 0.018	1.819IlePro: 1.819 ± 0.029	0.733IleGln: 0.733 ± 0.018	2.289IleArg: 2.289 ± 0.03	1.669IleSer: 1.669 ± 0.028	2.216IleThr: 2.216 ± 0.028	2.661IleVal: 2.661 ± 0.029	0.382IleTrp: 0.382 ± 0.012	0.528IleTyr: 0.528 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.074LysAla: 3.074 ± 0.05	0.117LysCys: 0.117 ± 0.006	1.462LysAsp: 1.462 ± 0.031	1.264LysGlu: 1.264 ± 0.026	0.479LysPhe: 0.479 ± 0.015	1.94LysGly: 1.94 ± 0.033	0.428LysHis: 0.428 ± 0.011	0.871LysIle: 0.871 ± 0.019	0.894LysLys: 0.894 ± 0.026	2.094LysLeu: 2.094 ± 0.032	0.386LysMet: 0.386 ± 0.013	0.521LysAsn: 0.521 ± 0.014	1.402LysPro: 1.402 ± 0.029	0.746LysGln: 0.746 ± 0.018	1.469LysArg: 1.469 ± 0.026	1.229LysSer: 1.229 ± 0.023	1.31LysThr: 1.31 ± 0.029	1.979LysVal: 1.979 ± 0.031	0.295LysTrp: 0.295 ± 0.011	0.505LysTyr: 0.505 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	14.902LeuAla: 14.902 ± 0.097	0.842LeuCys: 0.842 ± 0.023	6.764LeuAsp: 6.764 ± 0.054	4.715LeuGlu: 4.715 ± 0.048	2.623LeuPhe: 2.623 ± 0.039	9.148LeuGly: 9.148 ± 0.067	2.305LeuHis: 2.305 ± 0.031	3.224LeuIle: 3.224 ± 0.034	2.178LeuLys: 2.178 ± 0.036	11.263LeuLeu: 11.263 ± 0.1	1.636LeuMet: 1.636 ± 0.024	1.752LeuAsn: 1.752 ± 0.028	6.503LeuPro: 6.503 ± 0.063	2.266LeuGln: 2.266 ± 0.03	8.619LeuArg: 8.619 ± 0.069	5.326LeuSer: 5.326 ± 0.047	6.994LeuThr: 6.994 ± 0.06	8.721LeuVal: 8.721 ± 0.083	1.385LeuTrp: 1.385 ± 0.025	1.95LeuTyr: 1.95 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.225MetAla: 2.225 ± 0.029	0.139MetCys: 0.139 ± 0.007	0.859MetAsp: 0.859 ± 0.017	0.751MetGlu: 0.751 ± 0.016	0.433MetPhe: 0.433 ± 0.013	1.298MetGly: 1.298 ± 0.022	0.357MetHis: 0.357 ± 0.01	0.626MetIle: 0.626 ± 0.015	0.413MetLys: 0.413 ± 0.012	1.642MetLeu: 1.642 ± 0.026	0.301MetMet: 0.301 ± 0.01	0.434MetAsn: 0.434 ± 0.014	1.115MetPro: 1.115 ± 0.019	0.439MetGln: 0.439 ± 0.013	1.419MetArg: 1.419 ± 0.024	1.29MetSer: 1.29 ± 0.02	1.558MetThr: 1.558 ± 0.023	1.263MetVal: 1.263 ± 0.022	0.221MetTrp: 0.221 ± 0.009	0.327MetTyr: 0.327 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.212AsnAla: 2.212 ± 0.028	0.182AsnCys: 0.182 ± 0.009	1.043AsnAsp: 1.043 ± 0.022	0.827AsnGlu: 0.827 ± 0.017	0.496AsnPhe: 0.496 ± 0.015	1.899AsnGly: 1.899 ± 0.029	0.406AsnHis: 0.406 ± 0.012	0.656AsnIle: 0.656 ± 0.016	0.433AsnLys: 0.433 ± 0.013	1.672AsnLeu: 1.672 ± 0.027	0.307AsnMet: 0.307 ± 0.011	0.453AsnAsn: 0.453 ± 0.015	1.37AsnPro: 1.37 ± 0.028	0.55AsnGln: 0.55 ± 0.016	1.292AsnArg: 1.292 ± 0.021	0.984AsnSer: 0.984 ± 0.019	1.149AsnThr: 1.149 ± 0.025	1.401AsnVal: 1.401 ± 0.023	0.317AsnTrp: 0.317 ± 0.011	0.427AsnTyr: 0.427 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.231ProAla: 8.231 ± 0.063	0.338ProCys: 0.338 ± 0.012	4.686ProAsp: 4.686 ± 0.046	4.428ProGlu: 4.428 ± 0.051	1.544ProPhe: 1.544 ± 0.023	6.321ProGly: 6.321 ± 0.062	1.423ProHis: 1.423 ± 0.027	1.297ProIle: 1.297 ± 0.023	1.263ProLys: 1.263 ± 0.029	5.458ProLeu: 5.458 ± 0.049	0.976ProMet: 0.976 ± 0.019	0.953ProAsn: 0.953 ± 0.02	3.502ProPro: 3.502 ± 0.06	1.848ProGln: 1.848 ± 0.036	3.915ProArg: 3.915 ± 0.041	3.261ProSer: 3.261 ± 0.039	3.458ProThr: 3.458 ± 0.047	5.439ProVal: 5.439 ± 0.046	0.919ProTrp: 0.919 ± 0.019	1.449ProTyr: 1.449 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.772GlnAla: 3.772 ± 0.047	0.187GlnCys: 0.187 ± 0.009	1.51GlnAsp: 1.51 ± 0.024	1.542GlnGlu: 1.542 ± 0.033	0.685GlnPhe: 0.685 ± 0.016	2.411GlnGly: 2.411 ± 0.03	0.69GlnHis: 0.69 ± 0.017	1.083GlnIle: 1.083 ± 0.02	0.632GlnLys: 0.632 ± 0.017	3.166GlnLeu: 3.166 ± 0.033	0.514GlnMet: 0.514 ± 0.013	0.527GlnAsn: 0.527 ± 0.014	1.747GlnPro: 1.747 ± 0.042	1.296GlnGln: 1.296 ± 0.034	2.44GlnArg: 2.44 ± 0.033	1.31GlnSer: 1.31 ± 0.023	1.424GlnThr: 1.424 ± 0.026	2.445GlnVal: 2.445 ± 0.032	0.504GlnTrp: 0.504 ± 0.014	0.646GlnTyr: 0.646 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.631ArgAla: 9.631 ± 0.065	0.579ArgCys: 0.579 ± 0.017	4.338ArgAsp: 4.338 ± 0.043	4.772ArgGlu: 4.772 ± 0.056	2.334ArgPhe: 2.334 ± 0.027	5.727ArgGly: 5.727 ± 0.049	2.158ArgHis: 2.158 ± 0.031	3.153ArgIle: 3.153 ± 0.035	1.686ArgLys: 1.686 ± 0.027	8.912ArgLeu: 8.912 ± 0.082	1.697ArgMet: 1.697 ± 0.024	1.323ArgAsn: 1.323 ± 0.022	4.906ArgPro: 4.906 ± 0.05	2.357ArgGln: 2.357 ± 0.037	7.531ArgArg: 7.531 ± 0.064	3.997ArgSer: 3.997 ± 0.04	5.384ArgThr: 5.384 ± 0.051	5.858ArgVal: 5.858 ± 0.051	1.358ArgTrp: 1.358 ± 0.022	1.819ArgTyr: 1.819 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.788SerAla: 6.788 ± 0.057	0.418SerCys: 0.418 ± 0.013	2.857SerAsp: 2.857 ± 0.03	2.532SerGlu: 2.532 ± 0.038	1.508SerPhe: 1.508 ± 0.023	5.936SerGly: 5.936 ± 0.054	1.005SerHis: 1.005 ± 0.021	1.407SerIle: 1.407 ± 0.023	1.094SerLys: 1.094 ± 0.022	4.848SerLeu: 4.848 ± 0.04	1.048SerMet: 1.048 ± 0.021	0.9SerAsn: 0.9 ± 0.02	3.274SerPro: 3.274 ± 0.039	1.304SerGln: 1.304 ± 0.025	3.649SerArg: 3.649 ± 0.039	2.872SerSer: 2.872 ± 0.042	3.15SerThr: 3.15 ± 0.038	4.321SerVal: 4.321 ± 0.046	0.916SerTrp: 0.916 ± 0.02	1.277SerTyr: 1.277 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.999ThrAla: 8.999 ± 0.068	0.466ThrCys: 0.466 ± 0.014	3.772ThrAsp: 3.772 ± 0.037	3.353ThrGlu: 3.353 ± 0.037	1.628ThrPhe: 1.628 ± 0.026	6.688ThrGly: 6.688 ± 0.05	1.266ThrHis: 1.266 ± 0.02	1.715ThrIle: 1.715 ± 0.028	1.244ThrLys: 1.244 ± 0.022	5.769ThrLeu: 5.769 ± 0.049	0.921ThrMet: 0.921 ± 0.016	1.036ThrAsn: 1.036 ± 0.02	4.313ThrPro: 4.313 ± 0.046	1.382ThrGln: 1.382 ± 0.022	3.976ThrArg: 3.976 ± 0.033	3.325ThrSer: 3.325 ± 0.041	3.98ThrThr: 3.98 ± 0.045	6.075ThrVal: 6.075 ± 0.057	0.946ThrTrp: 0.946 ± 0.019	1.462ThrTyr: 1.462 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.523ValAla: 10.523 ± 0.071	0.775ValCys: 0.775 ± 0.017	5.025ValAsp: 5.025 ± 0.047	4.826ValGlu: 4.826 ± 0.038	2.397ValPhe: 2.397 ± 0.034	6.507ValGly: 6.507 ± 0.055	1.97ValHis: 1.97 ± 0.027	2.88ValIle: 2.88 ± 0.036	1.756ValLys: 1.756 ± 0.031	9.289ValLeu: 9.289 ± 0.077	1.376ValMet: 1.376 ± 0.022	1.706ValAsn: 1.706 ± 0.032	5.266ValPro: 5.266 ± 0.05	2.124ValGln: 2.124 ± 0.029	7.265ValArg: 7.265 ± 0.053	4.31ValSer: 4.31 ± 0.035	5.767ValThr: 5.767 ± 0.054	8.008ValVal: 8.008 ± 0.071	1.209ValTrp: 1.209 ± 0.021	1.635ValTyr: 1.635 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.703TrpAla: 1.703 ± 0.025	0.149TrpCys: 0.149 ± 0.008	0.899TrpAsp: 0.899 ± 0.019	0.771TrpGlu: 0.771 ± 0.017	0.504TrpPhe: 0.504 ± 0.015	1.075TrpGly: 1.075 ± 0.021	0.392TrpHis: 0.392 ± 0.013	0.573TrpIle: 0.573 ± 0.015	0.394TrpLys: 0.394 ± 0.012	1.834TrpLeu: 1.834 ± 0.03	0.305TrpMet: 0.305 ± 0.011	0.445TrpAsn: 0.445 ± 0.013	0.766TrpPro: 0.766 ± 0.017	0.692TrpGln: 0.692 ± 0.017	1.366TrpArg: 1.366 ± 0.024	0.986TrpSer: 0.986 ± 0.02	1.091TrpThr: 1.091 ± 0.021	0.986TrpVal: 0.986 ± 0.021	0.347TrpTrp: 0.347 ± 0.012	0.394TrpTyr: 0.394 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.82TyrAla: 2.82 ± 0.03	0.182TyrCys: 0.182 ± 0.009	1.661TyrAsp: 1.661 ± 0.031	1.341TyrGlu: 1.341 ± 0.021	0.666TyrPhe: 0.666 ± 0.015	2.386TyrGly: 2.386 ± 0.034	0.409TyrHis: 0.409 ± 0.014	0.493TyrIle: 0.493 ± 0.012	0.441TyrLys: 0.441 ± 0.014	2.132TyrLeu: 2.132 ± 0.029	0.254TyrMet: 0.254 ± 0.01	0.44TyrAsn: 0.44 ± 0.013	1.057TyrPro: 1.057 ± 0.023	0.619TyrGln: 0.619 ± 0.014	1.867TyrArg: 1.867 ± 0.028	1.004TyrSer: 1.004 ± 0.02	1.207TyrThr: 1.207 ± 0.019	1.782TyrVal: 1.782 ± 0.029	0.379TyrTrp: 0.379 ± 0.012	0.487TyrTyr: 0.487 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8422 proteins (2849544 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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