Amino acid dipepetide frequency for Candidatus Aquirickettsiella gammari

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.464AlaAla: 7.464 ± 0.161
1.155AlaCys: 1.155 ± 0.052
3.575AlaAsp: 3.575 ± 0.111
4.645AlaGlu: 4.645 ± 0.12
3.044AlaPhe: 3.044 ± 0.084
5.16AlaGly: 5.16 ± 0.145
1.797AlaHis: 1.797 ± 0.052
6.505AlaIle: 6.505 ± 0.133
5.485AlaLys: 5.485 ± 0.127
10.442AlaLeu: 10.442 ± 0.176
1.857AlaMet: 1.857 ± 0.073
3.6AlaAsn: 3.6 ± 0.093
2.731AlaPro: 2.731 ± 0.108
3.728AlaGln: 3.728 ± 0.1
3.861AlaArg: 3.861 ± 0.112
5.129AlaSer: 5.129 ± 0.099
4.14AlaThr: 4.14 ± 0.117
4.721AlaVal: 4.721 ± 0.106
1.076AlaTrp: 1.076 ± 0.048
2.817AlaTyr: 2.817 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.858CysAla: 0.858 ± 0.043
0.182CysCys: 0.182 ± 0.021
0.495CysAsp: 0.495 ± 0.035
0.563CysGlu: 0.563 ± 0.037
0.682CysPhe: 0.682 ± 0.043
0.815CysGly: 0.815 ± 0.047
0.344CysHis: 0.344 ± 0.028
0.86CysIle: 0.86 ± 0.05
0.525CysLys: 0.525 ± 0.038
1.569CysLeu: 1.569 ± 0.068
0.191CysMet: 0.191 ± 0.021
0.369CysAsn: 0.369 ± 0.03
0.563CysPro: 0.563 ± 0.04
0.576CysGln: 0.576 ± 0.035
0.525CysArg: 0.525 ± 0.037
0.671CysSer: 0.671 ± 0.041
0.468CysThr: 0.468 ± 0.038
0.75CysVal: 0.75 ± 0.042
0.146CysTrp: 0.146 ± 0.018
0.446CysTyr: 0.446 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
3.244AspAla: 3.244 ± 0.092
0.448AspCys: 0.448 ± 0.032
1.709AspAsp: 1.709 ± 0.074
2.751AspGlu: 2.751 ± 0.08
2.308AspPhe: 2.308 ± 0.076
2.103AspGly: 2.103 ± 0.078
0.892AspHis: 0.892 ± 0.048
3.517AspIle: 3.517 ± 0.09
3.253AspLys: 3.253 ± 0.106
5.428AspLeu: 5.428 ± 0.118
0.853AspMet: 0.853 ± 0.052
1.923AspAsn: 1.923 ± 0.083
2.112AspPro: 2.112 ± 0.077
1.709AspGln: 1.709 ± 0.067
2.17AspArg: 2.17 ± 0.071
2.722AspSer: 2.722 ± 0.089
1.999AspThr: 1.999 ± 0.069
2.441AspVal: 2.441 ± 0.072
0.617AspTrp: 0.617 ± 0.032
2.049AspTyr: 2.049 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
4.42GluAla: 4.42 ± 0.117
0.518GluCys: 0.518 ± 0.038
2.168GluAsp: 2.168 ± 0.073
3.427GluGlu: 3.427 ± 0.112
2.069GluPhe: 2.069 ± 0.069
2.706GluGly: 2.706 ± 0.084
1.078GluHis: 1.078 ± 0.058
4.37GluIle: 4.37 ± 0.107
5.003GluLys: 5.003 ± 0.126
6.025GluLeu: 6.025 ± 0.136
1.241GluMet: 1.241 ± 0.058
2.873GluAsn: 2.873 ± 0.089
1.556GluPro: 1.556 ± 0.066
3.33GluGln: 3.33 ± 0.117
2.961GluArg: 2.961 ± 0.092
2.772GluSer: 2.772 ± 0.09
2.711GluThr: 2.711 ± 0.078
3.247GluVal: 3.247 ± 0.086
0.518GluTrp: 0.518 ± 0.032
1.502GluTyr: 1.502 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.141PheAla: 3.141 ± 0.081
0.552PheCys: 0.552 ± 0.033
2.035PheAsp: 2.035 ± 0.071
1.869PheGlu: 1.869 ± 0.063
2.438PhePhe: 2.438 ± 0.102
2.357PheGly: 2.357 ± 0.086
0.966PheHis: 0.966 ± 0.052
3.71PheIle: 3.71 ± 0.116
2.501PheLys: 2.501 ± 0.071
5.041PheLeu: 5.041 ± 0.155
0.831PheMet: 0.831 ± 0.042
2.38PheAsn: 2.38 ± 0.069
1.792PhePro: 1.792 ± 0.062
1.576PheGln: 1.576 ± 0.062
1.7PheArg: 1.7 ± 0.067
3.895PheSer: 3.895 ± 0.122
2.468PheThr: 2.468 ± 0.099
2.206PheVal: 2.206 ± 0.075
0.516PheTrp: 0.516 ± 0.043
1.767PheTyr: 1.767 ± 0.069
0.0PheXaa: 0.0 ± 0.0
Gly
4.345GlyAla: 4.345 ± 0.115
0.795GlyCys: 0.795 ± 0.05
2.587GlyAsp: 2.587 ± 0.081
3.067GlyGlu: 3.067 ± 0.092
3.078GlyPhe: 3.078 ± 0.101
4.149GlyGly: 4.149 ± 0.178
1.529GlyHis: 1.529 ± 0.072
4.901GlyIle: 4.901 ± 0.13
3.681GlyLys: 3.681 ± 0.101
7.403GlyLeu: 7.403 ± 0.158
1.414GlyMet: 1.414 ± 0.054
2.258GlyAsn: 2.258 ± 0.129
1.939GlyPro: 1.939 ± 0.099
2.488GlyGln: 2.488 ± 0.083
2.9GlyArg: 2.9 ± 0.093
3.611GlySer: 3.611 ± 0.119
2.796GlyThr: 2.796 ± 0.114
3.834GlyVal: 3.834 ± 0.111
0.72GlyTrp: 0.72 ± 0.033
2.148GlyTyr: 2.148 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.722HisAla: 1.722 ± 0.068
0.403HisCys: 0.403 ± 0.028
0.896HisAsp: 0.896 ± 0.048
1.011HisGlu: 1.011 ± 0.043
1.238HisPhe: 1.238 ± 0.048
1.286HisGly: 1.286 ± 0.064
0.802HisHis: 0.802 ± 0.048
1.605HisIle: 1.605 ± 0.064
1.069HisLys: 1.069 ± 0.053
3.094HisLeu: 3.094 ± 0.096
0.41HisMet: 0.41 ± 0.032
0.862HisAsn: 0.862 ± 0.039
1.369HisPro: 1.369 ± 0.062
1.171HisGln: 1.171 ± 0.052
1.254HisArg: 1.254 ± 0.057
1.394HisSer: 1.394 ± 0.055
1.042HisThr: 1.042 ± 0.05
1.096HisVal: 1.096 ± 0.045
0.374HisTrp: 0.374 ± 0.032
1.234HisTyr: 1.234 ± 0.054
0.0HisXaa: 0.0 ± 0.0
Ile
6.944IleAla: 6.944 ± 0.149
0.876IleCys: 0.876 ± 0.05
4.059IleAsp: 4.059 ± 0.112
4.431IleGlu: 4.431 ± 0.111
3.175IlePhe: 3.175 ± 0.12
4.607IleGly: 4.607 ± 0.118
1.637IleHis: 1.637 ± 0.07
5.516IleIle: 5.516 ± 0.119
4.798IleLys: 4.798 ± 0.124
7.975IleLeu: 7.975 ± 0.165
1.259IleMet: 1.259 ± 0.054
4.044IleAsn: 4.044 ± 0.117
3.569IlePro: 3.569 ± 0.078
3.152IleGln: 3.152 ± 0.088
3.303IleArg: 3.303 ± 0.08
5.183IleSer: 5.183 ± 0.108
3.956IleThr: 3.956 ± 0.133
4.152IleVal: 4.152 ± 0.098
0.709IleTrp: 0.709 ± 0.044
2.418IleTyr: 2.418 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
4.622LysAla: 4.622 ± 0.108
0.471LysCys: 0.471 ± 0.034
2.627LysAsp: 2.627 ± 0.095
3.956LysGlu: 3.956 ± 0.111
1.923LysPhe: 1.923 ± 0.077
3.028LysGly: 3.028 ± 0.1
1.326LysHis: 1.326 ± 0.045
5.109LysIle: 5.109 ± 0.141
5.849LysLys: 5.849 ± 0.14
6.93LysLeu: 6.93 ± 0.155
1.265LysMet: 1.265 ± 0.05
3.771LysAsn: 3.771 ± 0.112
2.609LysPro: 2.609 ± 0.078
3.56LysGln: 3.56 ± 0.097
3.118LysArg: 3.118 ± 0.09
3.616LysSer: 3.616 ± 0.117
3.762LysThr: 3.762 ± 0.09
3.22LysVal: 3.22 ± 0.085
0.513LysTrp: 0.513 ± 0.038
1.653LysTyr: 1.653 ± 0.076
0.0LysXaa: 0.0 ± 0.0
Leu
11.796LeuAla: 11.796 ± 0.214
1.315LeuCys: 1.315 ± 0.06
5.354LeuAsp: 5.354 ± 0.118
6.385LeuGlu: 6.385 ± 0.138
5.347LeuPhe: 5.347 ± 0.144
7.441LeuGly: 7.441 ± 0.151
2.495LeuHis: 2.495 ± 0.082
9.096LeuIle: 9.096 ± 0.174
7.707LeuLys: 7.707 ± 0.144
14.558LeuLeu: 14.558 ± 0.302
2.355LeuMet: 2.355 ± 0.083
6.079LeuAsn: 6.079 ± 0.138
5.228LeuPro: 5.228 ± 0.118
5.28LeuGln: 5.28 ± 0.127
5.455LeuArg: 5.455 ± 0.114
9.118LeuSer: 9.118 ± 0.149
6.065LeuThr: 6.065 ± 0.127
6.423LeuVal: 6.423 ± 0.127
1.175LeuTrp: 1.175 ± 0.053
3.094LeuTyr: 3.094 ± 0.1
0.0LeuXaa: 0.0 ± 0.0
Met
1.999MetAla: 1.999 ± 0.069
0.176MetCys: 0.176 ± 0.019
0.883MetAsp: 0.883 ± 0.04
1.006MetGlu: 1.006 ± 0.05
0.57MetPhe: 0.57 ± 0.043
1.466MetGly: 1.466 ± 0.063
0.423MetHis: 0.423 ± 0.03
1.202MetIle: 1.202 ± 0.054
1.164MetLys: 1.164 ± 0.049
2.236MetLeu: 2.236 ± 0.074
0.536MetMet: 0.536 ± 0.039
0.885MetAsn: 0.885 ± 0.043
1.031MetPro: 1.031 ± 0.058
1.085MetGln: 1.085 ± 0.052
1.164MetArg: 1.164 ± 0.058
1.43MetSer: 1.43 ± 0.061
1.103MetThr: 1.103 ± 0.05
1.063MetVal: 1.063 ± 0.048
0.131MetTrp: 0.131 ± 0.016
0.356MetTyr: 0.356 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.429AsnAla: 3.429 ± 0.079
0.527AsnCys: 0.527 ± 0.035
1.772AsnAsp: 1.772 ± 0.065
2.215AsnGlu: 2.215 ± 0.073
2.076AsnPhe: 2.076 ± 0.08
2.168AsnGly: 2.168 ± 0.098
1.063AsnHis: 1.063 ± 0.053
3.47AsnIle: 3.47 ± 0.091
3.337AsnLys: 3.337 ± 0.098
5.3AsnLeu: 5.3 ± 0.131
0.871AsnMet: 0.871 ± 0.046
2.522AsnAsn: 2.522 ± 0.101
2.657AsnPro: 2.657 ± 0.08
2.288AsnGln: 2.288 ± 0.078
2.105AsnArg: 2.105 ± 0.07
2.895AsnSer: 2.895 ± 0.096
2.603AsnThr: 2.603 ± 0.084
2.096AsnVal: 2.096 ± 0.079
0.572AsnTrp: 0.572 ± 0.043
1.806AsnTyr: 1.806 ± 0.075
0.0AsnXaa: 0.0 ± 0.0
Pro
3.055ProAla: 3.055 ± 0.09
0.471ProCys: 0.471 ± 0.036
2.06ProAsp: 2.06 ± 0.073
2.549ProGlu: 2.549 ± 0.08
1.898ProPhe: 1.898 ± 0.068
2.625ProGly: 2.625 ± 0.102
1.009ProHis: 1.009 ± 0.048
3.233ProIle: 3.233 ± 0.072
2.168ProLys: 2.168 ± 0.074
5.19ProLeu: 5.19 ± 0.121
0.797ProMet: 0.797 ± 0.039
1.869ProAsn: 1.869 ± 0.078
1.499ProPro: 1.499 ± 0.065
1.686ProGln: 1.686 ± 0.063
1.617ProArg: 1.617 ± 0.057
2.839ProSer: 2.839 ± 0.084
2.017ProThr: 2.017 ± 0.061
2.758ProVal: 2.758 ± 0.122
0.489ProTrp: 0.489 ± 0.037
1.517ProTyr: 1.517 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
4.739GlnAla: 4.739 ± 0.122
0.513GlnCys: 0.513 ± 0.033
1.812GlnAsp: 1.812 ± 0.068
2.652GlnGlu: 2.652 ± 0.08
1.882GlnPhe: 1.882 ± 0.075
3.184GlnGly: 3.184 ± 0.085
1.304GlnHis: 1.304 ± 0.059
3.395GlnIle: 3.395 ± 0.107
2.632GlnLys: 2.632 ± 0.075
6.268GlnLeu: 6.268 ± 0.142
0.831GlnMet: 0.831 ± 0.049
1.743GlnAsn: 1.743 ± 0.063
1.241GlnPro: 1.241 ± 0.055
3.501GlnGln: 3.501 ± 0.13
2.731GlnArg: 2.731 ± 0.096
2.682GlnSer: 2.682 ± 0.08
2.479GlnThr: 2.479 ± 0.086
2.866GlnVal: 2.866 ± 0.084
0.507GlnTrp: 0.507 ± 0.035
1.297GlnTyr: 1.297 ± 0.061
0.0GlnXaa: 0.0 ± 0.0
Arg
3.517ArgAla: 3.517 ± 0.098
0.619ArgCys: 0.619 ± 0.036
2.119ArgAsp: 2.119 ± 0.072
2.817ArgGlu: 2.817 ± 0.089
2.425ArgPhe: 2.425 ± 0.078
2.594ArgGly: 2.594 ± 0.083
1.268ArgHis: 1.268 ± 0.061
3.542ArgIle: 3.542 ± 0.087
2.569ArgLys: 2.569 ± 0.086
6.412ArgLeu: 6.412 ± 0.141
0.883ArgMet: 0.883 ± 0.05
1.848ArgAsn: 1.848 ± 0.069
1.722ArgPro: 1.722 ± 0.064
2.459ArgGln: 2.459 ± 0.087
2.682ArgArg: 2.682 ± 0.089
2.661ArgSer: 2.661 ± 0.072
1.97ArgThr: 1.97 ± 0.078
2.841ArgVal: 2.841 ± 0.091
0.639ArgTrp: 0.639 ± 0.041
2.047ArgTyr: 2.047 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
5.228SerAla: 5.228 ± 0.118
0.775SerCys: 0.775 ± 0.041
3.087SerAsp: 3.087 ± 0.093
3.301SerGlu: 3.301 ± 0.098
2.994SerPhe: 2.994 ± 0.092
4.262SerGly: 4.262 ± 0.125
1.554SerHis: 1.554 ± 0.057
4.694SerIle: 4.694 ± 0.124
3.415SerLys: 3.415 ± 0.1
8.652SerLeu: 8.652 ± 0.19
1.286SerMet: 1.286 ± 0.056
2.693SerAsn: 2.693 ± 0.074
2.582SerPro: 2.582 ± 0.082
3.053SerGln: 3.053 ± 0.087
2.745SerArg: 2.745 ± 0.081
4.46SerSer: 4.46 ± 0.129
3.188SerThr: 3.188 ± 0.097
3.839SerVal: 3.839 ± 0.092
0.675SerTrp: 0.675 ± 0.041
2.141SerTyr: 2.141 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.3ThrAla: 4.3 ± 0.123
0.491ThrCys: 0.491 ± 0.035
2.26ThrAsp: 2.26 ± 0.068
2.859ThrGlu: 2.859 ± 0.091
1.765ThrPhe: 1.765 ± 0.072
3.488ThrGly: 3.488 ± 0.1
1.45ThrHis: 1.45 ± 0.059
3.596ThrIle: 3.596 ± 0.099
2.396ThrLys: 2.396 ± 0.079
6.59ThrLeu: 6.59 ± 0.119
0.892ThrMet: 0.892 ± 0.043
1.776ThrAsn: 1.776 ± 0.059
2.83ThrPro: 2.83 ± 0.102
2.546ThrGln: 2.546 ± 0.086
2.355ThrArg: 2.355 ± 0.076
3.166ThrSer: 3.166 ± 0.087
2.873ThrThr: 2.873 ± 0.115
3.343ThrVal: 3.343 ± 0.148
0.549ThrTrp: 0.549 ± 0.033
1.486ThrTyr: 1.486 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
4.908ValAla: 4.908 ± 0.112
0.673ValCys: 0.673 ± 0.038
2.949ValAsp: 2.949 ± 0.093
3.035ValGlu: 3.035 ± 0.082
2.54ValPhe: 2.54 ± 0.088
3.614ValGly: 3.614 ± 0.093
1.123ValHis: 1.123 ± 0.049
4.625ValIle: 4.625 ± 0.103
3.454ValLys: 3.454 ± 0.103
6.48ValLeu: 6.48 ± 0.137
1.358ValMet: 1.358 ± 0.057
2.736ValAsn: 2.736 ± 0.081
2.263ValPro: 2.263 ± 0.102
1.923ValGln: 1.923 ± 0.067
2.348ValArg: 2.348 ± 0.08
3.643ValSer: 3.643 ± 0.094
3.204ValThr: 3.204 ± 0.15
3.616ValVal: 3.616 ± 0.112
0.592ValTrp: 0.592 ± 0.041
1.704ValTyr: 1.704 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.691TrpAla: 0.691 ± 0.042
0.137TrpCys: 0.137 ± 0.015
0.509TrpAsp: 0.509 ± 0.031
0.495TrpGlu: 0.495 ± 0.039
0.491TrpPhe: 0.491 ± 0.034
0.599TrpGly: 0.599 ± 0.034
0.317TrpHis: 0.317 ± 0.027
0.93TrpIle: 0.93 ± 0.059
0.462TrpLys: 0.462 ± 0.035
1.531TrpLeu: 1.531 ± 0.074
0.25TrpMet: 0.25 ± 0.027
0.439TrpAsn: 0.439 ± 0.031
0.518TrpPro: 0.518 ± 0.039
0.871TrpGln: 0.871 ± 0.049
0.691TrpArg: 0.691 ± 0.039
0.624TrpSer: 0.624 ± 0.04
0.453TrpThr: 0.453 ± 0.032
0.693TrpVal: 0.693 ± 0.04
0.173TrpTrp: 0.173 ± 0.025
0.304TrpTyr: 0.304 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.51TyrAla: 2.51 ± 0.084
0.504TyrCys: 0.504 ± 0.036
1.29TyrAsp: 1.29 ± 0.057
1.459TyrGlu: 1.459 ± 0.055
1.799TyrPhe: 1.799 ± 0.079
1.995TyrGly: 1.995 ± 0.074
0.957TyrHis: 0.957 ± 0.05
1.884TyrIle: 1.884 ± 0.062
1.461TyrLys: 1.461 ± 0.059
4.643TyrLeu: 4.643 ± 0.126
0.527TyrMet: 0.527 ± 0.041
1.101TyrAsn: 1.101 ± 0.049
1.536TyrPro: 1.536 ± 0.061
2.276TyrGln: 2.276 ± 0.071
1.948TyrArg: 1.948 ± 0.07
2.114TyrSer: 2.114 ± 0.078
1.713TyrThr: 1.713 ± 0.083
1.581TyrVal: 1.581 ± 0.053
0.486TyrTrp: 0.486 ± 0.035
1.252TyrTyr: 1.252 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1375 proteins (444153 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski