Amino acid dipepetide frequency for Streptomyces dioscori

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.345AlaAla: 20.345 ± 0.136	1.036AlaCys: 1.036 ± 0.021	8.361AlaAsp: 8.361 ± 0.068	8.513AlaGlu: 8.513 ± 0.067	3.422AlaPhe: 3.422 ± 0.041	13.046AlaGly: 13.046 ± 0.083	2.829AlaHis: 2.829 ± 0.039	3.295AlaIle: 3.295 ± 0.038	2.78AlaLys: 2.78 ± 0.043	14.205AlaLeu: 14.205 ± 0.113	2.337AlaMet: 2.337 ± 0.032	1.938AlaAsn: 1.938 ± 0.028	6.891AlaPro: 6.891 ± 0.073	3.769AlaGln: 3.769 ± 0.043	10.001AlaArg: 10.001 ± 0.071	6.211AlaSer: 6.211 ± 0.048	7.096AlaThr: 7.096 ± 0.052	12.173AlaVal: 12.173 ± 0.085	1.859AlaTrp: 1.859 ± 0.025	2.8AlaTyr: 2.8 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.035CysAla: 1.035 ± 0.02	0.092CysCys: 0.092 ± 0.007	0.462CysAsp: 0.462 ± 0.013	0.387CysGlu: 0.387 ± 0.011	0.208CysPhe: 0.208 ± 0.009	0.912CysGly: 0.912 ± 0.018	0.181CysHis: 0.181 ± 0.008	0.148CysIle: 0.148 ± 0.007	0.104CysLys: 0.104 ± 0.007	0.727CysLeu: 0.727 ± 0.015	0.115CysMet: 0.115 ± 0.006	0.125CysAsn: 0.125 ± 0.007	0.444CysPro: 0.444 ± 0.014	0.157CysGln: 0.157 ± 0.007	0.571CysArg: 0.571 ± 0.015	0.421CysSer: 0.421 ± 0.014	0.509CysThr: 0.509 ± 0.013	0.647CysVal: 0.647 ± 0.015	0.122CysTrp: 0.122 ± 0.006	0.146CysTyr: 0.146 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.598AspAla: 7.598 ± 0.05	0.407AspCys: 0.407 ± 0.012	3.772AspAsp: 3.772 ± 0.043	3.927AspGlu: 3.927 ± 0.04	1.691AspPhe: 1.691 ± 0.026	6.653AspGly: 6.653 ± 0.06	1.447AspHis: 1.447 ± 0.02	1.98AspIle: 1.98 ± 0.027	1.283AspLys: 1.283 ± 0.027	6.236AspLeu: 6.236 ± 0.055	0.833AspMet: 0.833 ± 0.016	1.017AspAsn: 1.017 ± 0.022	4.48AspPro: 4.48 ± 0.046	1.552AspGln: 1.552 ± 0.025	4.92AspArg: 4.92 ± 0.043	2.854AspSer: 2.854 ± 0.033	3.442AspThr: 3.442 ± 0.04	4.824AspVal: 4.824 ± 0.046	1.053AspTrp: 1.053 ± 0.022	1.128AspTyr: 1.128 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	7.241GluAla: 7.241 ± 0.064	0.356GluCys: 0.356 ± 0.011	2.814GluAsp: 2.814 ± 0.034	3.425GluGlu: 3.425 ± 0.047	1.455GluPhe: 1.455 ± 0.025	4.431GluGly: 4.431 ± 0.038	1.487GluHis: 1.487 ± 0.025	2.198GluIle: 2.198 ± 0.029	1.496GluLys: 1.496 ± 0.025	6.774GluLeu: 6.774 ± 0.057	0.861GluMet: 0.861 ± 0.019	1.101GluAsn: 1.101 ± 0.021	3.417GluPro: 3.417 ± 0.041	2.21GluGln: 2.21 ± 0.035	5.308GluArg: 5.308 ± 0.05	2.746GluSer: 2.746 ± 0.029	2.943GluThr: 2.943 ± 0.03	4.367GluVal: 4.367 ± 0.048	0.751GluTrp: 0.751 ± 0.018	1.157GluTyr: 1.157 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.609PheAla: 3.609 ± 0.038	0.248PheCys: 0.248 ± 0.009	1.984PheAsp: 1.984 ± 0.027	1.481PheGlu: 1.481 ± 0.024	0.878PhePhe: 0.878 ± 0.02	3.031PheGly: 3.031 ± 0.039	0.609PheHis: 0.609 ± 0.014	0.711PheIle: 0.711 ± 0.015	0.526PheLys: 0.526 ± 0.014	2.639PheLeu: 2.639 ± 0.035	0.419PheMet: 0.419 ± 0.013	0.559PheAsn: 0.559 ± 0.016	1.4PhePro: 1.4 ± 0.022	0.673PheGln: 0.673 ± 0.013	1.83PheArg: 1.83 ± 0.026	1.504PheSer: 1.504 ± 0.023	2.052PheThr: 2.052 ± 0.026	2.282PheVal: 2.282 ± 0.032	0.414PheTrp: 0.414 ± 0.012	0.572PheTyr: 0.572 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	11.236GlyAla: 11.236 ± 0.062	0.788GlyCys: 0.788 ± 0.016	5.353GlyAsp: 5.353 ± 0.047	5.069GlyGlu: 5.069 ± 0.044	2.917GlyPhe: 2.917 ± 0.034	9.182GlyGly: 9.182 ± 0.091	2.283GlyHis: 2.283 ± 0.032	3.455GlyIle: 3.455 ± 0.035	2.47GlyLys: 2.47 ± 0.036	9.449GlyLeu: 9.449 ± 0.067	1.921GlyMet: 1.921 ± 0.027	1.848GlyAsn: 1.848 ± 0.032	5.287GlyPro: 5.287 ± 0.061	2.753GlyGln: 2.753 ± 0.033	7.743GlyArg: 7.743 ± 0.059	5.873GlySer: 5.873 ± 0.063	6.759GlyThr: 6.759 ± 0.05	7.644GlyVal: 7.644 ± 0.065	1.638GlyTrp: 1.638 ± 0.027	2.233GlyTyr: 2.233 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.599HisAla: 2.599 ± 0.032	0.216HisCys: 0.216 ± 0.009	1.352HisAsp: 1.352 ± 0.024	1.249HisGlu: 1.249 ± 0.02	0.659HisPhe: 0.659 ± 0.015	2.385HisGly: 2.385 ± 0.032	0.698HisHis: 0.698 ± 0.017	0.696HisIle: 0.696 ± 0.016	0.352HisLys: 0.352 ± 0.01	2.423HisLeu: 2.423 ± 0.034	0.333HisMet: 0.333 ± 0.01	0.368HisAsn: 0.368 ± 0.012	1.77HisPro: 1.77 ± 0.031	0.634HisGln: 0.634 ± 0.017	2.06HisArg: 2.06 ± 0.027	1.051HisSer: 1.051 ± 0.021	1.373HisThr: 1.373 ± 0.023	1.705HisVal: 1.705 ± 0.03	0.372HisTrp: 0.372 ± 0.011	0.478HisTyr: 0.478 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.622IleAla: 4.622 ± 0.047	0.27IleCys: 0.27 ± 0.009	2.217IleAsp: 2.217 ± 0.03	1.923IleGlu: 1.923 ± 0.029	0.702IlePhe: 0.702 ± 0.017	3.529IleGly: 3.529 ± 0.04	0.632IleHis: 0.632 ± 0.014	0.833IleIle: 0.833 ± 0.021	0.733IleLys: 0.733 ± 0.017	2.378IleLeu: 2.378 ± 0.032	0.44IleMet: 0.44 ± 0.015	0.669IleAsn: 0.669 ± 0.016	1.765IlePro: 1.765 ± 0.024	0.713IleGln: 0.713 ± 0.016	2.21IleArg: 2.21 ± 0.027	1.702IleSer: 1.702 ± 0.025	2.194IleThr: 2.194 ± 0.028	2.641IleVal: 2.641 ± 0.035	0.383IleTrp: 0.383 ± 0.012	0.518IleTyr: 0.518 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.943LysAla: 2.943 ± 0.045	0.115LysCys: 0.115 ± 0.007	1.426LysAsp: 1.426 ± 0.031	1.251LysGlu: 1.251 ± 0.026	0.486LysPhe: 0.486 ± 0.015	1.916LysGly: 1.916 ± 0.033	0.43LysHis: 0.43 ± 0.012	0.836LysIle: 0.836 ± 0.02	0.952LysLys: 0.952 ± 0.025	2.035LysLeu: 2.035 ± 0.029	0.372LysMet: 0.372 ± 0.013	0.542LysAsn: 0.542 ± 0.016	1.331LysPro: 1.331 ± 0.024	0.705LysGln: 0.705 ± 0.015	1.416LysArg: 1.416 ± 0.026	1.283LysSer: 1.283 ± 0.028	1.312LysThr: 1.312 ± 0.028	1.925LysVal: 1.925 ± 0.032	0.299LysTrp: 0.299 ± 0.012	0.488LysTyr: 0.488 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.645LeuAla: 14.645 ± 0.104	0.812LeuCys: 0.812 ± 0.017	6.798LeuAsp: 6.798 ± 0.049	4.469LeuGlu: 4.469 ± 0.04	2.689LeuPhe: 2.689 ± 0.034	9.182LeuGly: 9.182 ± 0.072	2.256LeuHis: 2.256 ± 0.029	3.272LeuIle: 3.272 ± 0.044	2.092LeuLys: 2.092 ± 0.036	11.123LeuLeu: 11.123 ± 0.087	1.683LeuMet: 1.683 ± 0.024	1.732LeuAsn: 1.732 ± 0.026	6.428LeuPro: 6.428 ± 0.056	2.168LeuGln: 2.168 ± 0.025	8.63LeuArg: 8.63 ± 0.065	5.537LeuSer: 5.537 ± 0.051	7.027LeuThr: 7.027 ± 0.061	8.747LeuVal: 8.747 ± 0.066	1.283LeuTrp: 1.283 ± 0.023	1.9LeuTyr: 1.9 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.138MetAla: 2.138 ± 0.031	0.127MetCys: 0.127 ± 0.007	0.88MetAsp: 0.88 ± 0.022	0.74MetGlu: 0.74 ± 0.02	0.452MetPhe: 0.452 ± 0.015	1.332MetGly: 1.332 ± 0.026	0.344MetHis: 0.344 ± 0.01	0.614MetIle: 0.614 ± 0.015	0.418MetLys: 0.418 ± 0.013	1.643MetLeu: 1.643 ± 0.022	0.29MetMet: 0.29 ± 0.01	0.463MetAsn: 0.463 ± 0.012	1.066MetPro: 1.066 ± 0.019	0.429MetGln: 0.429 ± 0.013	1.425MetArg: 1.425 ± 0.025	1.301MetSer: 1.301 ± 0.022	1.502MetThr: 1.502 ± 0.022	1.237MetVal: 1.237 ± 0.019	0.222MetTrp: 0.222 ± 0.009	0.337MetTyr: 0.337 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.198AsnAla: 2.198 ± 0.03	0.167AsnCys: 0.167 ± 0.009	1.004AsnAsp: 1.004 ± 0.019	0.856AsnGlu: 0.856 ± 0.017	0.515AsnPhe: 0.515 ± 0.013	1.987AsnGly: 1.987 ± 0.031	0.41AsnHis: 0.41 ± 0.012	0.672AsnIle: 0.672 ± 0.015	0.427AsnLys: 0.427 ± 0.013	1.668AsnLeu: 1.668 ± 0.024	0.298AsnMet: 0.298 ± 0.011	0.451AsnAsn: 0.451 ± 0.015	1.346AsnPro: 1.346 ± 0.024	0.538AsnGln: 0.538 ± 0.015	1.259AsnArg: 1.259 ± 0.023	1.055AsnSer: 1.055 ± 0.024	1.192AsnThr: 1.192 ± 0.025	1.389AsnVal: 1.389 ± 0.023	0.305AsnTrp: 0.305 ± 0.011	0.436AsnTyr: 0.436 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.407ProAla: 8.407 ± 0.064	0.32ProCys: 0.32 ± 0.01	4.558ProAsp: 4.558 ± 0.043	4.22ProGlu: 4.22 ± 0.035	1.549ProPhe: 1.549 ± 0.024	6.571ProGly: 6.571 ± 0.066	1.374ProHis: 1.374 ± 0.029	1.211ProIle: 1.211 ± 0.022	1.216ProLys: 1.216 ± 0.023	5.375ProLeu: 5.375 ± 0.057	0.988ProMet: 0.988 ± 0.019	0.924ProAsn: 0.924 ± 0.019	3.5ProPro: 3.5 ± 0.053	1.764ProGln: 1.764 ± 0.034	3.963ProArg: 3.963 ± 0.051	3.301ProSer: 3.301 ± 0.039	3.291ProThr: 3.291 ± 0.035	5.523ProVal: 5.523 ± 0.044	0.891ProTrp: 0.891 ± 0.019	1.407ProTyr: 1.407 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.604GlnAla: 3.604 ± 0.044	0.16GlnCys: 0.16 ± 0.009	1.488GlnAsp: 1.488 ± 0.021	1.525GlnGlu: 1.525 ± 0.024	0.706GlnPhe: 0.706 ± 0.014	2.369GlnGly: 2.369 ± 0.035	0.657GlnHis: 0.657 ± 0.018	1.058GlnIle: 1.058 ± 0.02	0.643GlnLys: 0.643 ± 0.018	3.053GlnLeu: 3.053 ± 0.036	0.467GlnMet: 0.467 ± 0.012	0.532GlnAsn: 0.532 ± 0.016	1.668GlnPro: 1.668 ± 0.036	1.273GlnGln: 1.273 ± 0.035	2.338GlnArg: 2.338 ± 0.035	1.356GlnSer: 1.356 ± 0.024	1.349GlnThr: 1.349 ± 0.023	2.38GlnVal: 2.38 ± 0.031	0.434GlnTrp: 0.434 ± 0.013	0.613GlnTyr: 0.613 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.699ArgAla: 9.699 ± 0.068	0.542ArgCys: 0.542 ± 0.015	4.275ArgAsp: 4.275 ± 0.042	4.627ArgGlu: 4.627 ± 0.045	2.304ArgPhe: 2.304 ± 0.033	5.896ArgGly: 5.896 ± 0.047	2.104ArgHis: 2.104 ± 0.03	3.189ArgIle: 3.189 ± 0.032	1.604ArgLys: 1.604 ± 0.028	8.616ArgLeu: 8.616 ± 0.073	1.654ArgMet: 1.654 ± 0.022	1.367ArgAsn: 1.367 ± 0.024	4.95ArgPro: 4.95 ± 0.055	2.247ArgGln: 2.247 ± 0.03	7.488ArgArg: 7.488 ± 0.06	4.185ArgSer: 4.185 ± 0.04	5.73ArgThr: 5.73 ± 0.052	5.83ArgVal: 5.83 ± 0.049	1.305ArgTrp: 1.305 ± 0.024	1.773ArgTyr: 1.773 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	7.174SerAla: 7.174 ± 0.055	0.418SerCys: 0.418 ± 0.013	2.965SerAsp: 2.965 ± 0.037	2.597SerGlu: 2.597 ± 0.036	1.593SerPhe: 1.593 ± 0.026	6.459SerGly: 6.459 ± 0.064	1.082SerHis: 1.082 ± 0.019	1.442SerIle: 1.442 ± 0.026	1.148SerLys: 1.148 ± 0.026	4.957SerLeu: 4.957 ± 0.048	1.099SerMet: 1.099 ± 0.018	0.959SerAsn: 0.959 ± 0.02	3.308SerPro: 3.308 ± 0.032	1.307SerGln: 1.307 ± 0.022	3.839SerArg: 3.839 ± 0.044	3.135SerSer: 3.135 ± 0.039	3.254SerThr: 3.254 ± 0.036	4.495SerVal: 4.495 ± 0.04	0.955SerTrp: 0.955 ± 0.02	1.3SerTyr: 1.3 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.97ThrAla: 8.97 ± 0.064	0.404ThrCys: 0.404 ± 0.012	3.909ThrAsp: 3.909 ± 0.046	3.404ThrGlu: 3.404 ± 0.034	1.657ThrPhe: 1.657 ± 0.028	7.018ThrGly: 7.018 ± 0.059	1.239ThrHis: 1.239 ± 0.022	1.657ThrIle: 1.657 ± 0.025	1.247ThrLys: 1.247 ± 0.025	5.868ThrLeu: 5.868 ± 0.05	0.946ThrMet: 0.946 ± 0.021	1.043ThrAsn: 1.043 ± 0.023	4.254ThrPro: 4.254 ± 0.047	1.411ThrGln: 1.411 ± 0.025	3.986ThrArg: 3.986 ± 0.041	3.421ThrSer: 3.421 ± 0.036	3.996ThrThr: 3.996 ± 0.049	6.302ThrVal: 6.302 ± 0.055	0.925ThrTrp: 0.925 ± 0.02	1.453ThrTyr: 1.453 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.471ValAla: 10.471 ± 0.08	0.728ValCys: 0.728 ± 0.017	5.067ValAsp: 5.067 ± 0.042	4.782ValGlu: 4.782 ± 0.044	2.386ValPhe: 2.386 ± 0.03	6.611ValGly: 6.611 ± 0.055	1.972ValHis: 1.972 ± 0.027	2.733ValIle: 2.733 ± 0.038	1.754ValLys: 1.754 ± 0.027	9.526ValLeu: 9.526 ± 0.073	1.373ValMet: 1.373 ± 0.024	1.671ValAsn: 1.671 ± 0.022	5.205ValPro: 5.205 ± 0.049	2.147ValGln: 2.147 ± 0.026	7.318ValArg: 7.318 ± 0.054	4.537ValSer: 4.537 ± 0.041	5.781ValThr: 5.781 ± 0.047	8.038ValVal: 8.038 ± 0.065	1.19ValTrp: 1.19 ± 0.019	1.555ValTyr: 1.555 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.615TrpAla: 1.615 ± 0.029	0.136TrpCys: 0.136 ± 0.007	0.861TrpAsp: 0.861 ± 0.02	0.736TrpGlu: 0.736 ± 0.016	0.496TrpPhe: 0.496 ± 0.015	1.057TrpGly: 1.057 ± 0.021	0.366TrpHis: 0.366 ± 0.011	0.564TrpIle: 0.564 ± 0.013	0.381TrpLys: 0.381 ± 0.012	1.726TrpLeu: 1.726 ± 0.024	0.28TrpMet: 0.28 ± 0.011	0.44TrpAsn: 0.44 ± 0.013	0.788TrpPro: 0.788 ± 0.018	0.646TrpGln: 0.646 ± 0.016	1.273TrpArg: 1.273 ± 0.021	0.99TrpSer: 0.99 ± 0.021	1.077TrpThr: 1.077 ± 0.02	0.966TrpVal: 0.966 ± 0.021	0.331TrpTrp: 0.331 ± 0.011	0.375TrpTyr: 0.375 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.756TyrAla: 2.756 ± 0.032	0.171TyrCys: 0.171 ± 0.008	1.553TyrAsp: 1.553 ± 0.03	1.354TyrGlu: 1.354 ± 0.022	0.659TyrPhe: 0.659 ± 0.016	2.333TyrGly: 2.333 ± 0.036	0.373TyrHis: 0.373 ± 0.012	0.508TyrIle: 0.508 ± 0.014	0.437TyrLys: 0.437 ± 0.013	2.054TyrLeu: 2.054 ± 0.024	0.251TyrMet: 0.251 ± 0.011	0.423TyrAsn: 0.423 ± 0.012	1.054TyrPro: 1.054 ± 0.02	0.578TyrGln: 0.578 ± 0.015	1.806TyrArg: 1.806 ± 0.028	1.02TyrSer: 1.02 ± 0.019	1.23TyrThr: 1.23 ± 0.024	1.733TyrVal: 1.733 ± 0.026	0.374TyrTrp: 0.374 ± 0.013	0.482TyrTyr: 0.482 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8299 proteins (2876625 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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