Amino acid dipepetide frequency for Bathymodiolus platifrons methanotrophic gill symbiont

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.42AlaAla: 6.42 ± 0.108	0.954AlaCys: 0.954 ± 0.034	4.375AlaAsp: 4.375 ± 0.077	5.507AlaGlu: 5.507 ± 0.088	2.991AlaPhe: 2.991 ± 0.062	5.662AlaGly: 5.662 ± 0.092	1.695AlaHis: 1.695 ± 0.041	5.976AlaIle: 5.976 ± 0.081	4.914AlaLys: 4.914 ± 0.072	8.458AlaLeu: 8.458 ± 0.117	2.178AlaMet: 2.178 ± 0.052	3.303AlaAsn: 3.303 ± 0.062	2.435AlaPro: 2.435 ± 0.06	3.386AlaGln: 3.386 ± 0.061	3.498AlaArg: 3.498 ± 0.062	4.589AlaSer: 4.589 ± 0.073	4.009AlaThr: 4.009 ± 0.073	5.226AlaVal: 5.226 ± 0.081	0.941AlaTrp: 0.941 ± 0.03	2.345AlaTyr: 2.345 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.815CysAla: 0.815 ± 0.027	0.172CysCys: 0.172 ± 0.014	0.644CysAsp: 0.644 ± 0.027	0.604CysGlu: 0.604 ± 0.026	0.508CysPhe: 0.508 ± 0.022	0.777CysGly: 0.777 ± 0.032	0.346CysHis: 0.346 ± 0.022	0.71CysIle: 0.71 ± 0.027	0.547CysLys: 0.547 ± 0.022	1.058CysLeu: 1.058 ± 0.037	0.227CysMet: 0.227 ± 0.017	0.368CysAsn: 0.368 ± 0.021	0.52CysPro: 0.52 ± 0.025	0.448CysGln: 0.448 ± 0.024	0.44CysArg: 0.44 ± 0.022	0.72CysSer: 0.72 ± 0.027	0.534CysThr: 0.534 ± 0.027	0.664CysVal: 0.664 ± 0.025	0.111CysTrp: 0.111 ± 0.014	0.367CysTyr: 0.367 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.181AspAla: 4.181 ± 0.076	0.596AspCys: 0.596 ± 0.024	3.029AspAsp: 3.029 ± 0.061	3.847AspGlu: 3.847 ± 0.075	2.888AspPhe: 2.888 ± 0.063	3.486AspGly: 3.486 ± 0.076	1.05AspHis: 1.05 ± 0.035	4.564AspIle: 4.564 ± 0.068	3.962AspLys: 3.962 ± 0.073	5.594AspLeu: 5.594 ± 0.071	1.27AspMet: 1.27 ± 0.041	2.63AspAsn: 2.63 ± 0.058	2.025AspPro: 2.025 ± 0.047	1.903AspGln: 1.903 ± 0.048	2.245AspArg: 2.245 ± 0.049	3.481AspSer: 3.481 ± 0.069	2.833AspThr: 2.833 ± 0.057	3.476AspVal: 3.476 ± 0.066	0.898AspTrp: 0.898 ± 0.029	2.211AspTyr: 2.211 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.623GluAla: 4.623 ± 0.08	0.549GluCys: 0.549 ± 0.026	3.093GluAsp: 3.093 ± 0.064	4.12GluGlu: 4.12 ± 0.084	2.529GluPhe: 2.529 ± 0.051	3.561GluGly: 3.561 ± 0.066	1.641GluHis: 1.641 ± 0.049	4.91GluIle: 4.91 ± 0.07	4.619GluLys: 4.619 ± 0.087	6.924GluLeu: 6.924 ± 0.096	1.643GluMet: 1.643 ± 0.041	3.114GluAsn: 3.114 ± 0.063	1.855GluPro: 1.855 ± 0.045	4.036GluGln: 4.036 ± 0.08	3.086GluArg: 3.086 ± 0.065	3.783GluSer: 3.783 ± 0.07	3.4GluThr: 3.4 ± 0.06	4.136GluVal: 4.136 ± 0.083	0.707GluTrp: 0.707 ± 0.027	2.049GluTyr: 2.049 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.997PheAla: 2.997 ± 0.066	0.55PheCys: 0.55 ± 0.024	2.621PheAsp: 2.621 ± 0.05	2.308PheGlu: 2.308 ± 0.057	2.03PhePhe: 2.03 ± 0.059	2.587PheGly: 2.587 ± 0.069	0.84PheHis: 0.84 ± 0.03	3.271PheIle: 3.271 ± 0.068	2.609PheLys: 2.609 ± 0.059	3.781PheLeu: 3.781 ± 0.08	1.062PheMet: 1.062 ± 0.041	2.229PheAsn: 2.229 ± 0.047	1.667PhePro: 1.667 ± 0.041	1.437PheGln: 1.437 ± 0.044	1.629PheArg: 1.629 ± 0.045	3.583PheSer: 3.583 ± 0.062	2.274PheThr: 2.274 ± 0.05	2.505PheVal: 2.505 ± 0.053	0.546PheTrp: 0.546 ± 0.026	1.473PheTyr: 1.473 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.623GlyAla: 4.623 ± 0.086	0.883GlyCys: 0.883 ± 0.033	3.545GlyAsp: 3.545 ± 0.078	3.981GlyGlu: 3.981 ± 0.066	3.098GlyPhe: 3.098 ± 0.059	4.626GlyGly: 4.626 ± 0.099	1.47GlyHis: 1.47 ± 0.042	4.781GlyIle: 4.781 ± 0.082	4.535GlyLys: 4.535 ± 0.078	6.58GlyLeu: 6.58 ± 0.091	1.847GlyMet: 1.847 ± 0.053	2.743GlyAsn: 2.743 ± 0.064	1.387GlyPro: 1.387 ± 0.043	2.388GlyGln: 2.388 ± 0.053	3.166GlyArg: 3.166 ± 0.07	4.025GlySer: 4.025 ± 0.072	3.235GlyThr: 3.235 ± 0.071	4.6GlyVal: 4.6 ± 0.081	0.893GlyTrp: 0.893 ± 0.034	2.378GlyTyr: 2.378 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.681HisAla: 1.681 ± 0.043	0.335HisCys: 0.335 ± 0.022	1.23HisAsp: 1.23 ± 0.036	1.177HisGlu: 1.177 ± 0.038	1.093HisPhe: 1.093 ± 0.038	1.538HisGly: 1.538 ± 0.041	0.567HisHis: 0.567 ± 0.025	1.571HisIle: 1.571 ± 0.04	1.37HisLys: 1.37 ± 0.042	2.279HisLeu: 2.279 ± 0.052	0.466HisMet: 0.466 ± 0.021	0.977HisAsn: 0.977 ± 0.035	1.117HisPro: 1.117 ± 0.037	0.999HisGln: 0.999 ± 0.032	1.068HisArg: 1.068 ± 0.035	1.431HisSer: 1.431 ± 0.039	1.097HisThr: 1.097 ± 0.036	1.279HisVal: 1.279 ± 0.039	0.354HisTrp: 0.354 ± 0.019	0.959HisTyr: 0.959 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.321IleAla: 6.321 ± 0.085	0.673IleCys: 0.673 ± 0.026	4.752IleAsp: 4.752 ± 0.073	5.18IleGlu: 5.18 ± 0.084	2.731IlePhe: 2.731 ± 0.064	4.39IleGly: 4.39 ± 0.076	1.475IleHis: 1.475 ± 0.041	5.065IleIle: 5.065 ± 0.081	4.839IleLys: 4.839 ± 0.083	6.254IleLeu: 6.254 ± 0.086	1.428IleMet: 1.428 ± 0.041	3.815IleAsn: 3.815 ± 0.078	3.131IlePro: 3.131 ± 0.057	2.707IleGln: 2.707 ± 0.058	3.095IleArg: 3.095 ± 0.053	5.284IleSer: 5.284 ± 0.075	3.925IleThr: 3.925 ± 0.067	4.256IleVal: 4.256 ± 0.062	0.648IleTrp: 0.648 ± 0.029	2.236IleTyr: 2.236 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.931LysAla: 4.931 ± 0.084	0.452LysCys: 0.452 ± 0.025	3.402LysAsp: 3.402 ± 0.065	4.133LysGlu: 4.133 ± 0.074	1.919LysPhe: 1.919 ± 0.049	3.908LysGly: 3.908 ± 0.079	1.557LysHis: 1.557 ± 0.037	4.654LysIle: 4.654 ± 0.075	4.755LysLys: 4.755 ± 0.102	5.939LysLeu: 5.939 ± 0.089	1.557LysMet: 1.557 ± 0.045	3.435LysAsn: 3.435 ± 0.067	2.494LysPro: 2.494 ± 0.058	3.633LysGln: 3.633 ± 0.065	3.016LysArg: 3.016 ± 0.055	4.033LysSer: 4.033 ± 0.072	3.782LysThr: 3.782 ± 0.07	3.936LysVal: 3.936 ± 0.062	0.576LysTrp: 0.576 ± 0.028	2.003LysTyr: 2.003 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	8.799LeuAla: 8.799 ± 0.108	1.107LeuCys: 1.107 ± 0.041	5.657LeuAsp: 5.657 ± 0.082	6.215LeuGlu: 6.215 ± 0.105	4.253LeuPhe: 4.253 ± 0.075	6.375LeuGly: 6.375 ± 0.098	2.133LeuHis: 2.133 ± 0.05	6.88LeuIle: 6.88 ± 0.086	6.454LeuLys: 6.454 ± 0.085	10.377LeuLeu: 10.377 ± 0.154	2.446LeuMet: 2.446 ± 0.058	4.877LeuAsn: 4.877 ± 0.082	4.454LeuPro: 4.454 ± 0.081	4.194LeuGln: 4.194 ± 0.079	4.303LeuArg: 4.303 ± 0.064	7.478LeuSer: 7.478 ± 0.109	5.438LeuThr: 5.438 ± 0.082	6.011LeuVal: 6.011 ± 0.084	1.07LeuTrp: 1.07 ± 0.037	2.815LeuTyr: 2.815 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.199MetAla: 2.199 ± 0.053	0.196MetCys: 0.196 ± 0.013	1.216MetAsp: 1.216 ± 0.036	1.323MetGlu: 1.323 ± 0.038	0.755MetPhe: 0.755 ± 0.028	1.586MetGly: 1.586 ± 0.051	0.544MetHis: 0.544 ± 0.025	1.582MetIle: 1.582 ± 0.037	1.435MetLys: 1.435 ± 0.046	2.507MetLeu: 2.507 ± 0.053	0.659MetMet: 0.659 ± 0.029	1.106MetAsn: 1.106 ± 0.034	1.173MetPro: 1.173 ± 0.037	1.337MetGln: 1.337 ± 0.043	1.156MetArg: 1.156 ± 0.04	1.661MetSer: 1.661 ± 0.045	1.445MetThr: 1.445 ± 0.036	1.42MetVal: 1.42 ± 0.041	0.174MetTrp: 0.174 ± 0.012	0.55MetTyr: 0.55 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.378AsnAla: 3.378 ± 0.065	0.459AsnCys: 0.459 ± 0.021	2.401AsnAsp: 2.401 ± 0.056	2.841AsnGlu: 2.841 ± 0.058	1.817AsnPhe: 1.817 ± 0.047	2.895AsnGly: 2.895 ± 0.062	1.045AsnHis: 1.045 ± 0.04	3.708AsnIle: 3.708 ± 0.066	3.293AsnLys: 3.293 ± 0.062	4.136AsnLeu: 4.136 ± 0.071	1.037AsnMet: 1.037 ± 0.03	2.512AsnAsn: 2.512 ± 0.061	2.246AsnPro: 2.246 ± 0.047	2.022AsnGln: 2.022 ± 0.055	1.992AsnArg: 1.992 ± 0.059	3.135AsnSer: 3.135 ± 0.065	2.626AsnThr: 2.626 ± 0.068	2.475AsnVal: 2.475 ± 0.052	0.569AsnTrp: 0.569 ± 0.024	1.597AsnTyr: 1.597 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	2.992ProAla: 2.992 ± 0.055	0.358ProCys: 0.358 ± 0.019	2.606ProAsp: 2.606 ± 0.055	3.482ProGlu: 3.482 ± 0.072	1.624ProPhe: 1.624 ± 0.038	2.392ProGly: 2.392 ± 0.056	0.783ProHis: 0.783 ± 0.029	2.565ProIle: 2.565 ± 0.054	2.264ProLys: 2.264 ± 0.06	3.65ProLeu: 3.65 ± 0.066	0.818ProMet: 0.818 ± 0.029	1.475ProAsn: 1.475 ± 0.043	1.242ProPro: 1.242 ± 0.041	1.279ProGln: 1.279 ± 0.04	1.376ProArg: 1.376 ± 0.043	2.236ProSer: 2.236 ± 0.056	1.78ProThr: 1.78 ± 0.046	3.031ProVal: 3.031 ± 0.053	0.43ProTrp: 0.43 ± 0.026	1.271ProTyr: 1.271 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.14GlnAla: 4.14 ± 0.078	0.433GlnCys: 0.433 ± 0.021	2.236GlnAsp: 2.236 ± 0.047	2.745GlnGlu: 2.745 ± 0.069	1.661GlnPhe: 1.661 ± 0.046	2.799GlnGly: 2.799 ± 0.059	1.215GlnHis: 1.215 ± 0.036	2.78GlnIle: 2.78 ± 0.058	2.605GlnLys: 2.605 ± 0.061	4.801GlnLeu: 4.801 ± 0.095	1.056GlnMet: 1.056 ± 0.035	1.703GlnAsn: 1.703 ± 0.043	1.424GlnPro: 1.424 ± 0.036	2.948GlnGln: 2.948 ± 0.079	2.21GlnArg: 2.21 ± 0.049	2.496GlnSer: 2.496 ± 0.054	2.247GlnThr: 2.247 ± 0.054	2.868GlnVal: 2.868 ± 0.065	0.646GlnTrp: 0.646 ± 0.027	1.408GlnTyr: 1.408 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	3.157ArgAla: 3.157 ± 0.069	0.492ArgCys: 0.492 ± 0.023	2.306ArgAsp: 2.306 ± 0.047	2.885ArgGlu: 2.885 ± 0.056	2.096ArgPhe: 2.096 ± 0.047	2.581ArgGly: 2.581 ± 0.055	1.124ArgHis: 1.124 ± 0.04	3.213ArgIle: 3.213 ± 0.055	2.973ArgLys: 2.973 ± 0.058	4.78ArgLeu: 4.78 ± 0.078	1.102ArgMet: 1.102 ± 0.039	2.095ArgAsn: 2.095 ± 0.048	1.491ArgPro: 1.491 ± 0.043	2.087ArgGln: 2.087 ± 0.059	2.151ArgArg: 2.151 ± 0.051	2.542ArgSer: 2.542 ± 0.058	2.04ArgThr: 2.04 ± 0.048	2.912ArgVal: 2.912 ± 0.057	0.678ArgTrp: 0.678 ± 0.029	1.82ArgTyr: 1.82 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.118SerAla: 5.118 ± 0.073	0.707SerCys: 0.707 ± 0.031	3.721SerAsp: 3.721 ± 0.068	4.022SerGlu: 4.022 ± 0.07	2.986SerPhe: 2.986 ± 0.06	5.028SerGly: 5.028 ± 0.079	1.432SerHis: 1.432 ± 0.04	4.735SerIle: 4.735 ± 0.071	3.611SerLys: 3.611 ± 0.075	6.949SerLeu: 6.949 ± 0.089	1.616SerMet: 1.616 ± 0.043	2.881SerAsn: 2.881 ± 0.061	2.463SerPro: 2.463 ± 0.05	2.466SerGln: 2.466 ± 0.054	2.875SerArg: 2.875 ± 0.052	4.607SerSer: 4.607 ± 0.078	3.26SerThr: 3.26 ± 0.059	4.194SerVal: 4.194 ± 0.068	0.835SerTrp: 0.835 ± 0.03	2.168SerTyr: 2.168 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	4.231ThrAla: 4.231 ± 0.071	0.419ThrCys: 0.419 ± 0.022	3.03ThrAsp: 3.03 ± 0.06	3.595ThrGlu: 3.595 ± 0.065	2.024ThrPhe: 2.024 ± 0.046	4.069ThrGly: 4.069 ± 0.063	1.252ThrHis: 1.252 ± 0.038	3.566ThrIle: 3.566 ± 0.062	2.878ThrLys: 2.878 ± 0.052	5.861ThrLeu: 5.861 ± 0.088	1.014ThrMet: 1.014 ± 0.033	2.128ThrAsn: 2.128 ± 0.055	2.437ThrPro: 2.437 ± 0.057	2.257ThrGln: 2.257 ± 0.053	2.236ThrArg: 2.236 ± 0.048	3.1ThrSer: 3.1 ± 0.067	2.775ThrThr: 2.775 ± 0.06	3.581ThrVal: 3.581 ± 0.062	0.565ThrTrp: 0.565 ± 0.024	1.515ThrTyr: 1.515 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	5.059ValAla: 5.059 ± 0.089	0.732ValCys: 0.732 ± 0.029	3.8ValAsp: 3.8 ± 0.07	4.011ValGlu: 4.011 ± 0.076	2.85ValPhe: 2.85 ± 0.057	3.791ValGly: 3.791 ± 0.07	1.261ValHis: 1.261 ± 0.038	4.857ValIle: 4.857 ± 0.078	3.867ValLys: 3.867 ± 0.065	6.393ValLeu: 6.393 ± 0.102	1.631ValMet: 1.631 ± 0.043	2.917ValAsn: 2.917 ± 0.059	2.277ValPro: 2.277 ± 0.046	2.307ValGln: 2.307 ± 0.055	2.66ValArg: 2.66 ± 0.063	4.558ValSer: 4.558 ± 0.073	3.586ValThr: 3.586 ± 0.071	4.2ValVal: 4.2 ± 0.082	0.73ValTrp: 0.73 ± 0.031	1.88ValTyr: 1.88 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.788TrpAla: 0.788 ± 0.031	0.128TrpCys: 0.128 ± 0.011	0.651TrpAsp: 0.651 ± 0.03	0.658TrpGlu: 0.658 ± 0.027	0.516TrpPhe: 0.516 ± 0.025	0.762TrpGly: 0.762 ± 0.031	0.341TrpHis: 0.341 ± 0.02	0.74TrpIle: 0.74 ± 0.028	0.603TrpLys: 0.603 ± 0.031	1.51TrpLeu: 1.51 ± 0.045	0.317TrpMet: 0.317 ± 0.018	0.528TrpAsn: 0.528 ± 0.025	0.366TrpPro: 0.366 ± 0.018	0.766TrpGln: 0.766 ± 0.032	0.629TrpArg: 0.629 ± 0.025	0.776TrpSer: 0.776 ± 0.032	0.508TrpThr: 0.508 ± 0.028	0.867TrpVal: 0.867 ± 0.033	0.184TrpTrp: 0.184 ± 0.017	0.405TrpTyr: 0.405 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.411TyrAla: 2.411 ± 0.053	0.383TyrCys: 0.383 ± 0.018	1.855TyrAsp: 1.855 ± 0.062	1.744TyrGlu: 1.744 ± 0.05	1.633TyrPhe: 1.633 ± 0.043	1.97TyrGly: 1.97 ± 0.043	0.82TyrHis: 0.82 ± 0.027	2.076TyrIle: 2.076 ± 0.046	1.98TyrLys: 1.98 ± 0.055	3.506TyrLeu: 3.506 ± 0.062	0.65TyrMet: 0.65 ± 0.025	1.348TyrAsn: 1.348 ± 0.039	1.448TyrPro: 1.448 ± 0.046	1.819TyrGln: 1.819 ± 0.05	1.695TyrArg: 1.695 ± 0.048	2.155TyrSer: 2.155 ± 0.056	1.739TyrThr: 1.739 ± 0.054	1.729TyrVal: 1.729 ± 0.043	0.49TyrTrp: 0.49 ± 0.023	1.094TyrTyr: 1.094 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3127 proteins (912154 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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