Amino acid dipepetide frequency for Mesoflavibacter sabulilitoris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.625AlaAla: 3.625 ± 0.076	0.551AlaCys: 0.551 ± 0.031	3.218AlaAsp: 3.218 ± 0.078	3.864AlaGlu: 3.864 ± 0.066	3.333AlaPhe: 3.333 ± 0.059	3.708AlaGly: 3.708 ± 0.082	0.995AlaHis: 0.995 ± 0.036	5.41AlaIle: 5.41 ± 0.089	4.841AlaLys: 4.841 ± 0.079	6.135AlaLeu: 6.135 ± 0.094	1.399AlaMet: 1.399 ± 0.044	3.831AlaAsn: 3.831 ± 0.075	1.76AlaPro: 1.76 ± 0.05	2.326AlaGln: 2.326 ± 0.055	1.709AlaArg: 1.709 ± 0.046	3.957AlaSer: 3.957 ± 0.07	3.865AlaThr: 3.865 ± 0.075	3.791AlaVal: 3.791 ± 0.067	0.539AlaTrp: 0.539 ± 0.024	2.417AlaTyr: 2.417 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.425CysAla: 0.425 ± 0.027	0.101CysCys: 0.101 ± 0.012	0.523CysAsp: 0.523 ± 0.037	0.43CysGlu: 0.43 ± 0.024	0.398CysPhe: 0.398 ± 0.02	0.638CysGly: 0.638 ± 0.04	0.159CysHis: 0.159 ± 0.015	0.533CysIle: 0.533 ± 0.025	0.537CysLys: 0.537 ± 0.027	0.616CysLeu: 0.616 ± 0.029	0.14CysMet: 0.14 ± 0.014	0.473CysAsn: 0.473 ± 0.026	0.342CysPro: 0.342 ± 0.027	0.239CysGln: 0.239 ± 0.017	0.163CysArg: 0.163 ± 0.013	0.527CysSer: 0.527 ± 0.03	0.396CysThr: 0.396 ± 0.02	0.45CysVal: 0.45 ± 0.023	0.056CysTrp: 0.056 ± 0.008	0.291CysTyr: 0.291 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.908AspAla: 3.908 ± 0.082	0.491AspCys: 0.491 ± 0.029	3.152AspAsp: 3.152 ± 0.074	3.612AspGlu: 3.612 ± 0.067	3.714AspPhe: 3.714 ± 0.07	3.66AspGly: 3.66 ± 0.093	0.9AspHis: 0.9 ± 0.03	4.747AspIle: 4.747 ± 0.065	4.535AspLys: 4.535 ± 0.094	5.533AspLeu: 5.533 ± 0.089	1.062AspMet: 1.062 ± 0.033	4.054AspAsn: 4.054 ± 0.079	1.559AspPro: 1.559 ± 0.058	2.003AspGln: 2.003 ± 0.049	1.697AspArg: 1.697 ± 0.042	3.141AspSer: 3.141 ± 0.06	3.182AspThr: 3.182 ± 0.062	4.123AspVal: 4.123 ± 0.077	0.685AspTrp: 0.685 ± 0.027	3.123AspTyr: 3.123 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	4.572GluAla: 4.572 ± 0.084	0.31GluCys: 0.31 ± 0.021	4.384GluAsp: 4.384 ± 0.078	4.957GluGlu: 4.957 ± 0.103	2.978GluPhe: 2.978 ± 0.059	3.522GluGly: 3.522 ± 0.066	1.104GluHis: 1.104 ± 0.035	5.222GluIle: 5.222 ± 0.073	5.467GluLys: 5.467 ± 0.086	5.602GluLeu: 5.602 ± 0.083	1.297GluMet: 1.297 ± 0.043	4.739GluAsn: 4.739 ± 0.077	1.393GluPro: 1.393 ± 0.039	2.469GluGln: 2.469 ± 0.047	2.175GluArg: 2.175 ± 0.056	3.182GluSer: 3.182 ± 0.059	4.03GluThr: 4.03 ± 0.075	4.317GluVal: 4.317 ± 0.08	0.489GluTrp: 0.489 ± 0.022	2.259GluTyr: 2.259 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	2.807PheAla: 2.807 ± 0.058	0.421PheCys: 0.421 ± 0.023	3.455PheAsp: 3.455 ± 0.067	3.475PheGlu: 3.475 ± 0.052	2.765PhePhe: 2.765 ± 0.069	3.589PheGly: 3.589 ± 0.076	0.747PheHis: 0.747 ± 0.028	4.115PheIle: 4.115 ± 0.083	4.487PheLys: 4.487 ± 0.088	4.567PheLeu: 4.567 ± 0.083	1.068PheMet: 1.068 ± 0.031	3.953PheAsn: 3.953 ± 0.071	1.565PhePro: 1.565 ± 0.044	1.415PheGln: 1.415 ± 0.035	1.406PheArg: 1.406 ± 0.044	3.916PheSer: 3.916 ± 0.07	3.358PheThr: 3.358 ± 0.077	3.033PheVal: 3.033 ± 0.058	0.547PheTrp: 0.547 ± 0.028	2.268PheTyr: 2.268 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	3.844GlyAla: 3.844 ± 0.077	0.571GlyCys: 0.571 ± 0.034	3.384GlyAsp: 3.384 ± 0.077	3.327GlyGlu: 3.327 ± 0.058	3.584GlyPhe: 3.584 ± 0.074	3.957GlyGly: 3.957 ± 0.098	1.031GlyHis: 1.031 ± 0.032	4.867GlyIle: 4.867 ± 0.085	4.51GlyLys: 4.51 ± 0.069	5.492GlyLeu: 5.492 ± 0.079	1.368GlyMet: 1.368 ± 0.043	3.746GlyAsn: 3.746 ± 0.09	1.264GlyPro: 1.264 ± 0.04	1.942GlyGln: 1.942 ± 0.055	1.822GlyArg: 1.822 ± 0.044	3.638GlySer: 3.638 ± 0.071	3.935GlyThr: 3.935 ± 0.109	4.069GlyVal: 4.069 ± 0.071	0.693GlyTrp: 0.693 ± 0.029	2.655GlyTyr: 2.655 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.876HisAla: 0.876 ± 0.027	0.168HisCys: 0.168 ± 0.013	0.827HisAsp: 0.827 ± 0.035	0.829HisGlu: 0.829 ± 0.029	1.112HisPhe: 1.112 ± 0.037	0.925HisGly: 0.925 ± 0.03	0.443HisHis: 0.443 ± 0.025	1.4HisIle: 1.4 ± 0.037	1.314HisLys: 1.314 ± 0.037	1.773HisLeu: 1.773 ± 0.053	0.319HisMet: 0.319 ± 0.016	1.038HisAsn: 1.038 ± 0.033	0.801HisPro: 0.801 ± 0.029	0.696HisGln: 0.696 ± 0.029	0.554HisArg: 0.554 ± 0.025	0.975HisSer: 0.975 ± 0.031	0.849HisThr: 0.849 ± 0.032	0.91HisVal: 0.91 ± 0.032	0.209HisTrp: 0.209 ± 0.016	0.842HisTyr: 0.842 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.38IleAla: 5.38 ± 0.086	0.591IleCys: 0.591 ± 0.028	5.147IleAsp: 5.147 ± 0.065	5.794IleGlu: 5.794 ± 0.088	3.73IlePhe: 3.73 ± 0.07	4.839IleGly: 4.839 ± 0.087	1.23IleHis: 1.23 ± 0.037	6.452IleIle: 6.452 ± 0.102	6.565IleLys: 6.565 ± 0.093	6.946IleLeu: 6.946 ± 0.1	1.321IleMet: 1.321 ± 0.047	5.555IleAsn: 5.555 ± 0.097	3.087IlePro: 3.087 ± 0.057	2.488IleGln: 2.488 ± 0.056	2.101IleArg: 2.101 ± 0.052	5.712IleSer: 5.712 ± 0.084	5.075IleThr: 5.075 ± 0.078	4.923IleVal: 4.923 ± 0.076	0.644IleTrp: 0.644 ± 0.03	2.914IleTyr: 2.914 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	5.172LysAla: 5.172 ± 0.084	0.337LysCys: 0.337 ± 0.018	5.246LysAsp: 5.246 ± 0.098	6.132LysGlu: 6.132 ± 0.109	3.031LysPhe: 3.031 ± 0.058	4.296LysGly: 4.296 ± 0.069	1.697LysHis: 1.697 ± 0.05	6.147LysIle: 6.147 ± 0.1	6.97LysLys: 6.97 ± 0.124	7.067LysLeu: 7.067 ± 0.1	1.869LysMet: 1.869 ± 0.044	5.604LysAsn: 5.604 ± 0.089	2.576LysPro: 2.576 ± 0.058	3.494LysGln: 3.494 ± 0.078	2.919LysArg: 2.919 ± 0.06	4.683LysSer: 4.683 ± 0.084	5.297LysThr: 5.297 ± 0.088	4.816LysVal: 4.816 ± 0.077	0.729LysTrp: 0.729 ± 0.029	3.118LysTyr: 3.118 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	5.405LeuAla: 5.405 ± 0.087	0.636LeuCys: 0.636 ± 0.027	5.672LeuAsp: 5.672 ± 0.084	6.07LeuGlu: 6.07 ± 0.08	4.78LeuPhe: 4.78 ± 0.092	5.356LeuGly: 5.356 ± 0.09	1.465LeuHis: 1.465 ± 0.041	7.327LeuIle: 7.327 ± 0.125	8.422LeuLys: 8.422 ± 0.119	8.343LeuLeu: 8.343 ± 0.116	1.912LeuMet: 1.912 ± 0.045	6.276LeuAsn: 6.276 ± 0.095	3.494LeuPro: 3.494 ± 0.053	3.329LeuGln: 3.329 ± 0.065	2.895LeuArg: 2.895 ± 0.053	6.497LeuSer: 6.497 ± 0.096	5.297LeuThr: 5.297 ± 0.083	5.194LeuVal: 5.194 ± 0.085	0.711LeuTrp: 0.711 ± 0.029	3.093LeuTyr: 3.093 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.356MetAla: 1.356 ± 0.045	0.129MetCys: 0.129 ± 0.011	0.993MetAsp: 0.993 ± 0.033	1.118MetGlu: 1.118 ± 0.037	0.894MetPhe: 0.894 ± 0.033	1.056MetGly: 1.056 ± 0.037	0.356MetHis: 0.356 ± 0.02	1.408MetIle: 1.408 ± 0.043	2.053MetLys: 2.053 ± 0.048	1.846MetLeu: 1.846 ± 0.049	0.516MetMet: 0.516 ± 0.028	1.074MetAsn: 1.074 ± 0.032	0.817MetPro: 0.817 ± 0.03	0.876MetGln: 0.876 ± 0.034	0.715MetArg: 0.715 ± 0.027	1.484MetSer: 1.484 ± 0.043	1.122MetThr: 1.122 ± 0.037	1.23MetVal: 1.23 ± 0.039	0.136MetTrp: 0.136 ± 0.012	0.737MetTyr: 0.737 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	4.111AsnAla: 4.111 ± 0.067	0.553AsnCys: 0.553 ± 0.031	3.6AsnAsp: 3.6 ± 0.065	3.849AsnGlu: 3.849 ± 0.067	3.473AsnPhe: 3.473 ± 0.081	4.289AsnGly: 4.289 ± 0.106	1.11AsnHis: 1.11 ± 0.036	5.44AsnIle: 5.44 ± 0.088	5.173AsnLys: 5.173 ± 0.092	5.938AsnLeu: 5.938 ± 0.096	1.232AsnMet: 1.232 ± 0.036	5.273AsnAsn: 5.273 ± 0.127	2.978AsnPro: 2.978 ± 0.067	2.769AsnGln: 2.769 ± 0.065	2.068AsnArg: 2.068 ± 0.049	4.081AsnSer: 4.081 ± 0.081	4.501AsnThr: 4.501 ± 0.088	3.878AsnVal: 3.878 ± 0.064	0.784AsnTrp: 0.784 ± 0.03	3.325AsnTyr: 3.325 ± 0.072	0.0AsnXaa: 0.0 ± 0.0
Pro	1.695ProAla: 1.695 ± 0.055	0.215ProCys: 0.215 ± 0.015	1.964ProAsp: 1.964 ± 0.049	2.755ProGlu: 2.755 ± 0.055	1.795ProPhe: 1.795 ± 0.041	1.591ProGly: 1.591 ± 0.052	0.536ProHis: 0.536 ± 0.028	2.727ProIle: 2.727 ± 0.052	2.768ProLys: 2.768 ± 0.05	2.859ProLeu: 2.859 ± 0.057	0.67ProMet: 0.67 ± 0.028	2.436ProAsn: 2.436 ± 0.056	0.698ProPro: 0.698 ± 0.034	1.095ProGln: 1.095 ± 0.033	0.785ProArg: 0.785 ± 0.032	1.988ProSer: 1.988 ± 0.054	2.141ProThr: 2.141 ± 0.055	2.01ProVal: 2.01 ± 0.051	0.278ProTrp: 0.278 ± 0.017	1.376ProTyr: 1.376 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.08GlnAla: 2.08 ± 0.048	0.19GlnCys: 0.19 ± 0.016	2.013GlnAsp: 2.013 ± 0.054	2.105GlnGlu: 2.105 ± 0.049	2.026GlnPhe: 2.026 ± 0.047	1.674GlnGly: 1.674 ± 0.047	0.691GlnHis: 0.691 ± 0.028	2.924GlnIle: 2.924 ± 0.061	2.762GlnLys: 2.762 ± 0.066	4.07GlnLeu: 4.07 ± 0.072	0.766GlnMet: 0.766 ± 0.028	2.442GlnAsn: 2.442 ± 0.064	1.236GlnPro: 1.236 ± 0.034	1.607GlnGln: 1.607 ± 0.055	1.229GlnArg: 1.229 ± 0.04	1.975GlnSer: 1.975 ± 0.051	2.329GlnThr: 2.329 ± 0.062	2.055GlnVal: 2.055 ± 0.047	0.329GlnTrp: 0.329 ± 0.018	1.391GlnTyr: 1.391 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	1.921ArgAla: 1.921 ± 0.046	0.161ArgCys: 0.161 ± 0.013	1.649ArgAsp: 1.649 ± 0.048	1.947ArgGlu: 1.947 ± 0.049	1.747ArgPhe: 1.747 ± 0.044	1.695ArgGly: 1.695 ± 0.053	0.585ArgHis: 0.585 ± 0.027	2.48ArgIle: 2.48 ± 0.062	2.384ArgLys: 2.384 ± 0.058	3.1ArgLeu: 3.1 ± 0.057	0.707ArgMet: 0.707 ± 0.025	1.784ArgAsn: 1.784 ± 0.043	0.957ArgPro: 0.957 ± 0.034	1.177ArgGln: 1.177 ± 0.036	1.18ArgArg: 1.18 ± 0.042	1.608ArgSer: 1.608 ± 0.047	1.606ArgThr: 1.606 ± 0.045	1.943ArgVal: 1.943 ± 0.052	0.313ArgTrp: 0.313 ± 0.018	1.458ArgTyr: 1.458 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.636SerAla: 3.636 ± 0.071	0.618SerCys: 0.618 ± 0.03	3.356SerAsp: 3.356 ± 0.067	3.749SerGlu: 3.749 ± 0.068	3.733SerPhe: 3.733 ± 0.069	4.25SerGly: 4.25 ± 0.091	1.021SerHis: 1.021 ± 0.035	5.29SerIle: 5.29 ± 0.08	5.2SerLys: 5.2 ± 0.085	5.632SerLeu: 5.632 ± 0.075	1.129SerMet: 1.129 ± 0.04	4.316SerAsn: 4.316 ± 0.088	1.859SerPro: 1.859 ± 0.047	2.208SerGln: 2.208 ± 0.048	1.811SerArg: 1.811 ± 0.047	4.073SerSer: 4.073 ± 0.093	3.853SerThr: 3.853 ± 0.073	3.879SerVal: 3.879 ± 0.062	0.597SerTrp: 0.597 ± 0.027	2.676SerTyr: 2.676 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	3.677ThrAla: 3.677 ± 0.076	0.465ThrCys: 0.465 ± 0.027	3.586ThrAsp: 3.586 ± 0.093	3.786ThrGlu: 3.786 ± 0.07	3.314ThrPhe: 3.314 ± 0.06	3.88ThrGly: 3.88 ± 0.098	0.922ThrHis: 0.922 ± 0.028	5.49ThrIle: 5.49 ± 0.087	4.363ThrLys: 4.363 ± 0.076	5.825ThrLeu: 5.825 ± 0.088	0.95ThrMet: 0.95 ± 0.032	4.059ThrAsn: 4.059 ± 0.084	2.469ThrPro: 2.469 ± 0.064	2.046ThrGln: 2.046 ± 0.058	1.53ThrArg: 1.53 ± 0.047	4.127ThrSer: 4.127 ± 0.076	4.129ThrThr: 4.129 ± 0.115	4.174ThrVal: 4.174 ± 0.081	0.606ThrTrp: 0.606 ± 0.03	2.624ThrTyr: 2.624 ± 0.064	0.0ThrXaa: 0.0 ± 0.0
Val	3.908ValAla: 3.908 ± 0.074	0.508ValCys: 0.508 ± 0.025	3.751ValAsp: 3.751 ± 0.063	4.066ValGlu: 4.066 ± 0.072	3.494ValPhe: 3.494 ± 0.064	3.766ValGly: 3.766 ± 0.066	0.858ValHis: 0.858 ± 0.035	4.957ValIle: 4.957 ± 0.08	4.688ValLys: 4.688 ± 0.079	5.912ValLeu: 5.912 ± 0.083	1.233ValMet: 1.233 ± 0.039	3.929ValAsn: 3.929 ± 0.073	1.943ValPro: 1.943 ± 0.048	1.618ValGln: 1.618 ± 0.044	1.852ValArg: 1.852 ± 0.048	4.212ValSer: 4.212 ± 0.075	3.944ValThr: 3.944 ± 0.089	4.118ValVal: 4.118 ± 0.087	0.524ValTrp: 0.524 ± 0.027	2.454ValTyr: 2.454 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.494TrpAla: 0.494 ± 0.027	0.085TrpCys: 0.085 ± 0.009	0.568TrpAsp: 0.568 ± 0.027	0.541TrpGlu: 0.541 ± 0.025	0.583TrpPhe: 0.583 ± 0.028	0.458TrpGly: 0.458 ± 0.024	0.198TrpHis: 0.198 ± 0.015	0.691TrpIle: 0.691 ± 0.028	0.719TrpLys: 0.719 ± 0.028	0.96TrpLeu: 0.96 ± 0.033	0.28TrpMet: 0.28 ± 0.019	0.674TrpAsn: 0.674 ± 0.028	0.18TrpPro: 0.18 ± 0.015	0.438TrpGln: 0.438 ± 0.023	0.351TrpArg: 0.351 ± 0.019	0.611TrpSer: 0.611 ± 0.029	0.549TrpThr: 0.549 ± 0.029	0.527TrpVal: 0.527 ± 0.026	0.147TrpTrp: 0.147 ± 0.014	0.441TrpTyr: 0.441 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.382TyrAla: 2.382 ± 0.058	0.337TyrCys: 0.337 ± 0.02	2.392TyrAsp: 2.392 ± 0.05	2.064TyrGlu: 2.064 ± 0.05	2.471TyrPhe: 2.471 ± 0.052	2.554TyrGly: 2.554 ± 0.055	0.812TyrHis: 0.812 ± 0.032	2.87TyrIle: 2.87 ± 0.051	3.442TyrLys: 3.442 ± 0.07	3.958TyrLeu: 3.958 ± 0.072	0.675TyrMet: 0.675 ± 0.027	3.17TyrAsn: 3.17 ± 0.067	1.405TyrPro: 1.405 ± 0.044	1.656TyrGln: 1.656 ± 0.046	1.438TyrArg: 1.438 ± 0.038	2.5TyrSer: 2.5 ± 0.056	2.564TyrThr: 2.564 ± 0.066	2.296TyrVal: 2.296 ± 0.05	0.48TyrTrp: 0.48 ± 0.023	1.937TyrTyr: 1.937 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2809 proteins (940475 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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