Amino acid dipepetide frequency for Klebsiella indica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.434AlaAla: 10.434 ± 0.127	1.242AlaCys: 1.242 ± 0.03	5.073AlaAsp: 5.073 ± 0.066	5.748AlaGlu: 5.748 ± 0.07	3.758AlaPhe: 3.758 ± 0.053	7.706AlaGly: 7.706 ± 0.082	1.989AlaHis: 1.989 ± 0.041	6.414AlaIle: 6.414 ± 0.073	3.592AlaLys: 3.592 ± 0.051	12.451AlaLeu: 12.451 ± 0.131	3.08AlaMet: 3.08 ± 0.052	2.958AlaAsn: 2.958 ± 0.051	3.685AlaPro: 3.685 ± 0.055	4.463AlaGln: 4.463 ± 0.058	6.097AlaArg: 6.097 ± 0.079	5.654AlaSer: 5.654 ± 0.072	4.822AlaThr: 4.822 ± 0.06	6.858AlaVal: 6.858 ± 0.074	1.717AlaTrp: 1.717 ± 0.037	1.998AlaTyr: 1.998 ± 0.04	0.001AlaXaa: 0.001 ± 0.001
Cys	1.126CysAla: 1.126 ± 0.028	0.222CysCys: 0.222 ± 0.012	0.6CysAsp: 0.6 ± 0.021	0.601CysGlu: 0.601 ± 0.018	0.458CysPhe: 0.458 ± 0.015	1.164CysGly: 1.164 ± 0.033	0.34CysHis: 0.34 ± 0.015	0.578CysIle: 0.578 ± 0.022	0.318CysLys: 0.318 ± 0.016	1.095CysLeu: 1.095 ± 0.029	0.261CysMet: 0.261 ± 0.014	0.336CysAsn: 0.336 ± 0.014	0.536CysPro: 0.536 ± 0.021	0.497CysGln: 0.497 ± 0.022	0.716CysArg: 0.716 ± 0.02	0.69CysSer: 0.69 ± 0.021	0.508CysThr: 0.508 ± 0.02	0.805CysVal: 0.805 ± 0.023	0.201CysTrp: 0.201 ± 0.01	0.34CysTyr: 0.34 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.175AspAla: 5.175 ± 0.071	0.541AspCys: 0.541 ± 0.022	2.958AspAsp: 2.958 ± 0.054	3.438AspGlu: 3.438 ± 0.05	2.075AspPhe: 2.075 ± 0.041	3.689AspGly: 3.689 ± 0.054	0.996AspHis: 0.996 ± 0.025	3.565AspIle: 3.565 ± 0.053	2.425AspLys: 2.425 ± 0.048	4.592AspLeu: 4.592 ± 0.056	1.331AspMet: 1.331 ± 0.031	2.177AspAsn: 2.177 ± 0.044	2.263AspPro: 2.263 ± 0.044	1.424AspGln: 1.424 ± 0.033	2.681AspArg: 2.681 ± 0.039	2.764AspSer: 2.764 ± 0.043	2.455AspThr: 2.455 ± 0.04	3.738AspVal: 3.738 ± 0.049	0.79AspTrp: 0.79 ± 0.022	1.793AspTyr: 1.793 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.165GluAla: 5.165 ± 0.06	0.471GluCys: 0.471 ± 0.019	2.203GluAsp: 2.203 ± 0.038	3.247GluGlu: 3.247 ± 0.052	1.714GluPhe: 1.714 ± 0.034	3.476GluGly: 3.476 ± 0.054	1.376GluHis: 1.376 ± 0.032	3.336GluIle: 3.336 ± 0.05	3.161GluLys: 3.161 ± 0.047	5.695GluLeu: 5.695 ± 0.073	1.793GluMet: 1.793 ± 0.037	2.292GluAsn: 2.292 ± 0.042	2.006GluPro: 2.006 ± 0.043	3.205GluGln: 3.205 ± 0.052	3.614GluArg: 3.614 ± 0.057	2.876GluSer: 2.876 ± 0.047	2.792GluThr: 2.792 ± 0.049	3.579GluVal: 3.579 ± 0.058	0.761GluTrp: 0.761 ± 0.023	1.378GluTyr: 1.378 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.875PheAla: 3.875 ± 0.062	0.586PheCys: 0.586 ± 0.021	2.292PheAsp: 2.292 ± 0.042	1.59PheGlu: 1.59 ± 0.038	1.732PhePhe: 1.732 ± 0.044	3.244PheGly: 3.244 ± 0.051	0.831PheHis: 0.831 ± 0.024	2.683PheIle: 2.683 ± 0.04	1.155PheLys: 1.155 ± 0.03	3.395PheLeu: 3.395 ± 0.057	0.976PheMet: 0.976 ± 0.025	1.736PheAsn: 1.736 ± 0.031	1.642PhePro: 1.642 ± 0.034	1.114PheGln: 1.114 ± 0.028	1.962PheArg: 1.962 ± 0.036	3.227PheSer: 3.227 ± 0.05	2.381PheThr: 2.381 ± 0.04	2.558PheVal: 2.558 ± 0.045	0.651PheTrp: 0.651 ± 0.024	1.178PheTyr: 1.178 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	6.388GlyAla: 6.388 ± 0.077	1.092GlyCys: 1.092 ± 0.035	3.615GlyAsp: 3.615 ± 0.06	4.544GlyGlu: 4.544 ± 0.056	3.353GlyPhe: 3.353 ± 0.057	5.658GlyGly: 5.658 ± 0.08	1.719GlyHis: 1.719 ± 0.035	5.398GlyIle: 5.398 ± 0.066	3.928GlyLys: 3.928 ± 0.054	7.808GlyLeu: 7.808 ± 0.079	2.505GlyMet: 2.505 ± 0.045	2.603GlyAsn: 2.603 ± 0.046	2.198GlyPro: 2.198 ± 0.038	2.924GlyGln: 2.924 ± 0.043	3.925GlyArg: 3.925 ± 0.055	4.247GlySer: 4.247 ± 0.06	3.694GlyThr: 3.694 ± 0.058	5.813GlyVal: 5.813 ± 0.068	1.314GlyTrp: 1.314 ± 0.035	2.643GlyTyr: 2.643 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.043HisAla: 2.043 ± 0.037	0.344HisCys: 0.344 ± 0.014	1.225HisAsp: 1.225 ± 0.029	1.09HisGlu: 1.09 ± 0.03	1.045HisPhe: 1.045 ± 0.027	1.857HisGly: 1.857 ± 0.039	0.803HisHis: 0.803 ± 0.027	1.415HisIle: 1.415 ± 0.031	0.791HisLys: 0.791 ± 0.025	2.322HisLeu: 2.322 ± 0.045	0.569HisMet: 0.569 ± 0.017	0.869HisAsn: 0.869 ± 0.021	1.393HisPro: 1.393 ± 0.029	1.185HisGln: 1.185 ± 0.031	1.334HisArg: 1.334 ± 0.028	1.305HisSer: 1.305 ± 0.026	1.076HisThr: 1.076 ± 0.028	1.286HisVal: 1.286 ± 0.029	0.402HisTrp: 0.402 ± 0.017	0.904HisTyr: 0.904 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.978IleAla: 6.978 ± 0.077	0.753IleCys: 0.753 ± 0.022	3.634IleAsp: 3.634 ± 0.053	3.184IleGlu: 3.184 ± 0.057	2.216IlePhe: 2.216 ± 0.042	4.977IleGly: 4.977 ± 0.074	1.269IleHis: 1.269 ± 0.029	3.684IleIle: 3.684 ± 0.062	2.292IleLys: 2.292 ± 0.046	5.216IleLeu: 5.216 ± 0.068	1.347IleMet: 1.347 ± 0.03	2.702IleAsn: 2.702 ± 0.041	2.946IlePro: 2.946 ± 0.044	1.851IleGln: 1.851 ± 0.034	3.081IleArg: 3.081 ± 0.049	4.019IleSer: 4.019 ± 0.049	3.424IleThr: 3.424 ± 0.044	4.17IleVal: 4.17 ± 0.064	0.753IleTrp: 0.753 ± 0.024	1.561IleTyr: 1.561 ± 0.03	0.001IleXaa: 0.001 ± 0.001
Lys	4.108LysAla: 4.108 ± 0.059	0.29LysCys: 0.29 ± 0.016	1.87LysAsp: 1.87 ± 0.043	2.3LysGlu: 2.3 ± 0.045	1.062LysPhe: 1.062 ± 0.027	2.838LysGly: 2.838 ± 0.045	0.838LysHis: 0.838 ± 0.023	2.372LysIle: 2.372 ± 0.042	2.174LysLys: 2.174 ± 0.039	4.041LysLeu: 4.041 ± 0.054	1.23LysMet: 1.23 ± 0.03	1.646LysAsn: 1.646 ± 0.034	1.944LysPro: 1.944 ± 0.037	1.822LysGln: 1.822 ± 0.034	2.431LysArg: 2.431 ± 0.044	2.269LysSer: 2.269 ± 0.044	2.423LysThr: 2.423 ± 0.04	2.806LysVal: 2.806 ± 0.049	0.453LysTrp: 0.453 ± 0.017	1.097LysTyr: 1.097 ± 0.027	0.001LysXaa: 0.001 ± 0.001
Leu	12.219LeuAla: 12.219 ± 0.115	1.331LeuCys: 1.331 ± 0.033	5.36LeuAsp: 5.36 ± 0.059	5.307LeuGlu: 5.307 ± 0.07	4.391LeuPhe: 4.391 ± 0.062	7.392LeuGly: 7.392 ± 0.087	2.349LeuHis: 2.349 ± 0.042	6.069LeuIle: 6.069 ± 0.076	4.303LeuLys: 4.303 ± 0.057	12.615LeuLeu: 12.615 ± 0.147	2.958LeuMet: 2.958 ± 0.043	4.29LeuAsn: 4.29 ± 0.059	5.842LeuPro: 5.842 ± 0.07	4.273LeuGln: 4.273 ± 0.059	6.409LeuArg: 6.409 ± 0.08	7.412LeuSer: 7.412 ± 0.076	6.361LeuThr: 6.361 ± 0.062	7.208LeuVal: 7.208 ± 0.076	1.515LeuTrp: 1.515 ± 0.036	2.557LeuTyr: 2.557 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.979MetAla: 2.979 ± 0.046	0.216MetCys: 0.216 ± 0.012	1.143MetAsp: 1.143 ± 0.027	1.2MetGlu: 1.2 ± 0.027	0.872MetPhe: 0.872 ± 0.025	1.942MetGly: 1.942 ± 0.037	0.553MetHis: 0.553 ± 0.019	1.595MetIle: 1.595 ± 0.036	1.366MetLys: 1.366 ± 0.025	3.302MetLeu: 3.302 ± 0.053	0.927MetMet: 0.927 ± 0.03	1.104MetAsn: 1.104 ± 0.024	1.4MetPro: 1.4 ± 0.032	1.18MetGln: 1.18 ± 0.026	1.55MetArg: 1.55 ± 0.034	1.88MetSer: 1.88 ± 0.037	1.806MetThr: 1.806 ± 0.033	2.007MetVal: 2.007 ± 0.041	0.256MetTrp: 0.256 ± 0.014	0.53MetTyr: 0.53 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.574AsnAla: 3.574 ± 0.047	0.322AsnCys: 0.322 ± 0.015	1.982AsnAsp: 1.982 ± 0.04	1.869AsnGlu: 1.869 ± 0.033	1.303AsnPhe: 1.303 ± 0.032	2.964AsnGly: 2.964 ± 0.043	0.894AsnHis: 0.894 ± 0.027	2.331AsnIle: 2.331 ± 0.039	1.487AsnLys: 1.487 ± 0.036	3.472AsnLeu: 3.472 ± 0.055	0.935AsnMet: 0.935 ± 0.023	1.526AsnAsn: 1.526 ± 0.04	2.125AsnPro: 2.125 ± 0.039	1.555AsnGln: 1.555 ± 0.03	2.02AsnArg: 2.02 ± 0.039	1.863AsnSer: 1.863 ± 0.039	1.89AsnThr: 1.89 ± 0.038	2.522AsnVal: 2.522 ± 0.041	0.575AsnTrp: 0.575 ± 0.02	1.127AsnTyr: 1.127 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.624ProAla: 4.624 ± 0.062	0.42ProCys: 0.42 ± 0.018	2.737ProAsp: 2.737 ± 0.054	3.211ProGlu: 3.211 ± 0.049	1.897ProPhe: 1.897 ± 0.04	3.764ProGly: 3.764 ± 0.053	1.132ProHis: 1.132 ± 0.024	1.867ProIle: 1.867 ± 0.036	1.368ProLys: 1.368 ± 0.029	5.392ProLeu: 5.392 ± 0.071	1.125ProMet: 1.125 ± 0.029	1.235ProAsn: 1.235 ± 0.029	1.729ProPro: 1.729 ± 0.039	2.49ProGln: 2.49 ± 0.041	2.142ProArg: 2.142 ± 0.042	2.139ProSer: 2.139 ± 0.04	2.103ProThr: 2.103 ± 0.042	3.902ProVal: 3.902 ± 0.052	0.81ProTrp: 0.81 ± 0.027	1.193ProTyr: 1.193 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.628GlnAla: 4.628 ± 0.065	0.385GlnCys: 0.385 ± 0.016	1.745GlnAsp: 1.745 ± 0.035	2.106GlnGlu: 2.106 ± 0.044	1.465GlnPhe: 1.465 ± 0.031	3.034GlnGly: 3.034 ± 0.051	1.241GlnHis: 1.241 ± 0.03	2.359GlnIle: 2.359 ± 0.043	1.75GlnLys: 1.75 ± 0.032	5.012GlnLeu: 5.012 ± 0.065	1.239GlnMet: 1.239 ± 0.028	1.451GlnAsn: 1.451 ± 0.032	2.184GlnPro: 2.184 ± 0.047	3.282GlnGln: 3.282 ± 0.064	3.169GlnArg: 3.169 ± 0.053	2.298GlnSer: 2.298 ± 0.04	2.147GlnThr: 2.147 ± 0.037	2.881GlnVal: 2.881 ± 0.042	0.685GlnTrp: 0.685 ± 0.023	1.165GlnTyr: 1.165 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.767ArgAla: 4.767 ± 0.064	0.653ArgCys: 0.653 ± 0.02	3.089ArgAsp: 3.089 ± 0.048	3.79ArgGlu: 3.79 ± 0.057	2.691ArgPhe: 2.691 ± 0.045	3.595ArgGly: 3.595 ± 0.053	1.72ArgHis: 1.72 ± 0.037	3.522ArgIle: 3.522 ± 0.052	2.301ArgLys: 2.301 ± 0.043	6.743ArgLeu: 6.743 ± 0.093	1.571ArgMet: 1.571 ± 0.033	1.999ArgAsn: 1.999 ± 0.035	2.345ArgPro: 2.345 ± 0.046	3.426ArgGln: 3.426 ± 0.051	3.798ArgArg: 3.798 ± 0.057	2.807ArgSer: 2.807 ± 0.05	2.502ArgThr: 2.502 ± 0.045	3.886ArgVal: 3.886 ± 0.046	1.054ArgTrp: 1.054 ± 0.032	2.247ArgTyr: 2.247 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.942SerAla: 5.942 ± 0.069	0.606SerCys: 0.606 ± 0.022	3.065SerAsp: 3.065 ± 0.05	3.038SerGlu: 3.038 ± 0.051	2.226SerPhe: 2.226 ± 0.043	5.545SerGly: 5.545 ± 0.071	1.456SerHis: 1.456 ± 0.031	3.014SerIle: 3.014 ± 0.052	1.897SerLys: 1.897 ± 0.036	6.833SerLeu: 6.833 ± 0.081	1.479SerMet: 1.479 ± 0.029	1.806SerAsn: 1.806 ± 0.04	2.688SerPro: 2.688 ± 0.044	2.494SerGln: 2.494 ± 0.041	3.663SerArg: 3.663 ± 0.047	3.47SerSer: 3.47 ± 0.061	2.903SerThr: 2.903 ± 0.053	4.21SerVal: 4.21 ± 0.051	0.994SerTrp: 0.994 ± 0.027	1.623SerTyr: 1.623 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	4.966ThrAla: 4.966 ± 0.063	0.532ThrCys: 0.532 ± 0.018	2.47ThrAsp: 2.47 ± 0.044	2.418ThrGlu: 2.418 ± 0.04	2.066ThrPhe: 2.066 ± 0.037	4.46ThrGly: 4.46 ± 0.06	1.244ThrHis: 1.244 ± 0.029	2.979ThrIle: 2.979 ± 0.045	1.368ThrLys: 1.368 ± 0.027	7.405ThrLeu: 7.405 ± 0.069	1.163ThrMet: 1.163 ± 0.028	1.422ThrAsn: 1.422 ± 0.033	3.189ThrPro: 3.189 ± 0.042	1.979ThrGln: 1.979 ± 0.035	3.131ThrArg: 3.131 ± 0.051	2.876ThrSer: 2.876 ± 0.049	2.775ThrThr: 2.775 ± 0.051	3.808ThrVal: 3.808 ± 0.052	0.821ThrTrp: 0.821 ± 0.024	1.084ThrTyr: 1.084 ± 0.031	0.001ThrXaa: 0.001 ± 0.001
Val	7.246ValAla: 7.246 ± 0.069	0.816ValCys: 0.816 ± 0.024	3.68ValAsp: 3.68 ± 0.055	3.802ValGlu: 3.802 ± 0.057	2.601ValPhe: 2.601 ± 0.046	4.885ValGly: 4.885 ± 0.065	1.277ValHis: 1.277 ± 0.03	4.659ValIle: 4.659 ± 0.068	2.932ValLys: 2.932 ± 0.044	7.301ValLeu: 7.301 ± 0.063	2.287ValMet: 2.287 ± 0.039	2.713ValAsn: 2.713 ± 0.051	3.042ValPro: 3.042 ± 0.043	2.288ValGln: 2.288 ± 0.04	3.727ValArg: 3.727 ± 0.049	4.627ValSer: 4.627 ± 0.058	4.107ValThr: 4.107 ± 0.056	5.504ValVal: 5.504 ± 0.073	0.944ValTrp: 0.944 ± 0.027	1.68ValTyr: 1.68 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.03TrpAla: 1.03 ± 0.025	0.193TrpCys: 0.193 ± 0.012	0.632TrpAsp: 0.632 ± 0.023	0.545TrpGlu: 0.545 ± 0.019	0.744TrpPhe: 0.744 ± 0.023	0.964TrpGly: 0.964 ± 0.032	0.493TrpHis: 0.493 ± 0.019	0.761TrpIle: 0.761 ± 0.024	0.502TrpLys: 0.502 ± 0.02	2.472TrpLeu: 2.472 ± 0.055	0.434TrpMet: 0.434 ± 0.018	0.496TrpAsn: 0.496 ± 0.022	0.713TrpPro: 0.713 ± 0.022	1.193TrpGln: 1.193 ± 0.028	1.204TrpArg: 1.204 ± 0.03	0.835TrpSer: 0.835 ± 0.025	0.579TrpThr: 0.579 ± 0.02	0.928TrpVal: 0.928 ± 0.029	0.233TrpTrp: 0.233 ± 0.014	0.424TrpTyr: 0.424 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.468TyrAla: 2.468 ± 0.043	0.377TyrCys: 0.377 ± 0.013	1.496TyrAsp: 1.496 ± 0.033	1.115TyrGlu: 1.115 ± 0.03	1.139TyrPhe: 1.139 ± 0.029	2.212TyrGly: 2.212 ± 0.041	0.739TyrHis: 0.739 ± 0.021	1.458TyrIle: 1.458 ± 0.035	0.906TyrLys: 0.906 ± 0.028	3.0TyrLeu: 3.0 ± 0.053	0.598TyrMet: 0.598 ± 0.021	0.976TyrAsn: 0.976 ± 0.029	1.411TyrPro: 1.411 ± 0.027	1.581TyrGln: 1.581 ± 0.036	1.852TyrArg: 1.852 ± 0.041	1.693TyrSer: 1.693 ± 0.039	1.409TyrThr: 1.409 ± 0.039	1.647TyrVal: 1.647 ± 0.035	0.446TyrTrp: 0.446 ± 0.018	0.902TyrTyr: 0.902 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4627 proteins (1489319 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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