Amino acid dipepetide frequency for Koribacter versatilis (strain Ellin345)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.176AlaAla: 12.176 ± 0.11	0.947AlaCys: 0.947 ± 0.031	5.249AlaAsp: 5.249 ± 0.056	6.211AlaGlu: 6.211 ± 0.079	3.833AlaPhe: 3.833 ± 0.055	8.152AlaGly: 8.152 ± 0.072	2.16AlaHis: 2.16 ± 0.037	5.864AlaIle: 5.864 ± 0.065	4.987AlaLys: 4.987 ± 0.066	9.965AlaLeu: 9.965 ± 0.089	2.78AlaMet: 2.78 ± 0.042	3.612AlaAsn: 3.612 ± 0.048	4.681AlaPro: 4.681 ± 0.07	4.302AlaGln: 4.302 ± 0.058	5.744AlaArg: 5.744 ± 0.077	6.355AlaSer: 6.355 ± 0.066	6.211AlaThr: 6.211 ± 0.079	7.864AlaVal: 7.864 ± 0.074	1.25AlaTrp: 1.25 ± 0.026	2.594AlaTyr: 2.594 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.95CysAla: 0.95 ± 0.026	0.151CysCys: 0.151 ± 0.01	0.506CysAsp: 0.506 ± 0.017	0.525CysGlu: 0.525 ± 0.018	0.373CysPhe: 0.373 ± 0.016	0.948CysGly: 0.948 ± 0.029	0.312CysHis: 0.312 ± 0.031	0.419CysIle: 0.419 ± 0.018	0.308CysLys: 0.308 ± 0.016	0.724CysLeu: 0.724 ± 0.021	0.165CysMet: 0.165 ± 0.009	0.296CysAsn: 0.296 ± 0.013	0.437CysPro: 0.437 ± 0.019	0.213CysGln: 0.213 ± 0.011	0.46CysArg: 0.46 ± 0.017	0.638CysSer: 0.638 ± 0.021	0.532CysThr: 0.532 ± 0.02	0.698CysVal: 0.698 ± 0.024	0.126CysTrp: 0.126 ± 0.009	0.249CysTyr: 0.249 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	5.623AspAla: 5.623 ± 0.056	0.448AspCys: 0.448 ± 0.021	2.662AspAsp: 2.662 ± 0.035	3.22AspGlu: 3.22 ± 0.043	2.289AspPhe: 2.289 ± 0.038	4.55AspGly: 4.55 ± 0.07	1.176AspHis: 1.176 ± 0.028	2.636AspIle: 2.636 ± 0.042	2.084AspLys: 2.084 ± 0.04	5.146AspLeu: 5.146 ± 0.055	1.072AspMet: 1.072 ± 0.026	1.563AspAsn: 1.563 ± 0.03	3.347AspPro: 3.347 ± 0.055	1.723AspGln: 1.723 ± 0.035	3.167AspArg: 3.167 ± 0.041	2.861AspSer: 2.861 ± 0.04	2.472AspThr: 2.472 ± 0.046	4.072AspVal: 4.072 ± 0.054	0.851AspTrp: 0.851 ± 0.02	1.611AspTyr: 1.611 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	5.642GluAla: 5.642 ± 0.074	0.447GluCys: 0.447 ± 0.018	2.571GluAsp: 2.571 ± 0.043	3.348GluGlu: 3.348 ± 0.062	2.41GluPhe: 2.41 ± 0.039	3.647GluGly: 3.647 ± 0.053	1.527GluHis: 1.527 ± 0.034	3.606GluIle: 3.606 ± 0.049	3.197GluLys: 3.197 ± 0.054	5.7GluLeu: 5.7 ± 0.063	1.654GluMet: 1.654 ± 0.036	1.965GluAsn: 1.965 ± 0.037	2.322GluPro: 2.322 ± 0.038	2.565GluGln: 2.565 ± 0.041	4.056GluArg: 4.056 ± 0.056	3.116GluSer: 3.116 ± 0.045	2.955GluThr: 2.955 ± 0.047	4.084GluVal: 4.084 ± 0.059	0.768GluTrp: 0.768 ± 0.022	1.549GluTyr: 1.549 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.421PheAla: 4.421 ± 0.055	0.446PheCys: 0.446 ± 0.018	2.56PheAsp: 2.56 ± 0.038	2.283PheGlu: 2.283 ± 0.041	1.725PhePhe: 1.725 ± 0.045	3.645PheGly: 3.645 ± 0.049	0.95PheHis: 0.95 ± 0.024	1.63PheIle: 1.63 ± 0.038	1.343PheLys: 1.343 ± 0.03	3.661PheLeu: 3.661 ± 0.053	0.76PheMet: 0.76 ± 0.022	1.444PheAsn: 1.444 ± 0.04	1.808PhePro: 1.808 ± 0.033	1.32PheGln: 1.32 ± 0.026	2.394PheArg: 2.394 ± 0.04	2.715PheSer: 2.715 ± 0.045	2.525PheThr: 2.525 ± 0.044	3.085PheVal: 3.085 ± 0.046	0.569PheTrp: 0.569 ± 0.021	1.245PheTyr: 1.245 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.451GlyAla: 7.451 ± 0.075	0.798GlyCys: 0.798 ± 0.022	4.11GlyAsp: 4.11 ± 0.065	4.182GlyGlu: 4.182 ± 0.053	3.403GlyPhe: 3.403 ± 0.05	6.67GlyGly: 6.67 ± 0.105	1.816GlyHis: 1.816 ± 0.033	4.463GlyIle: 4.463 ± 0.05	4.202GlyLys: 4.202 ± 0.048	6.616GlyLeu: 6.616 ± 0.067	2.0GlyMet: 2.0 ± 0.042	2.941GlyAsn: 2.941 ± 0.06	2.881GlyPro: 2.881 ± 0.042	2.64GlyGln: 2.64 ± 0.049	4.317GlyArg: 4.317 ± 0.056	5.223GlySer: 5.223 ± 0.074	5.372GlyThr: 5.372 ± 0.092	6.041GlyVal: 6.041 ± 0.072	1.242GlyTrp: 1.242 ± 0.034	2.582GlyTyr: 2.582 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.149HisAla: 2.149 ± 0.039	0.244HisCys: 0.244 ± 0.013	1.272HisAsp: 1.272 ± 0.028	1.356HisGlu: 1.356 ± 0.032	1.031HisPhe: 1.031 ± 0.025	1.987HisGly: 1.987 ± 0.034	0.61HisHis: 0.61 ± 0.021	1.089HisIle: 1.089 ± 0.03	0.771HisLys: 0.771 ± 0.022	2.06HisLeu: 2.06 ± 0.036	0.513HisMet: 0.513 ± 0.018	0.711HisAsn: 0.711 ± 0.018	1.413HisPro: 1.413 ± 0.026	0.696HisGln: 0.696 ± 0.023	1.377HisArg: 1.377 ± 0.024	1.311HisSer: 1.311 ± 0.028	1.15HisThr: 1.15 ± 0.028	1.594HisVal: 1.594 ± 0.032	0.379HisTrp: 0.379 ± 0.017	0.705HisTyr: 0.705 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.478IleAla: 6.478 ± 0.062	0.537IleCys: 0.537 ± 0.017	2.949IleAsp: 2.949 ± 0.048	3.305IleGlu: 3.305 ± 0.05	2.113IlePhe: 2.113 ± 0.034	4.546IleGly: 4.546 ± 0.065	1.174IleHis: 1.174 ± 0.026	2.139IleIle: 2.139 ± 0.034	1.731IleLys: 1.731 ± 0.029	4.313IleLeu: 4.313 ± 0.056	0.813IleMet: 0.813 ± 0.024	1.672IleAsn: 1.672 ± 0.032	2.719IlePro: 2.719 ± 0.045	1.67IleGln: 1.67 ± 0.032	3.061IleArg: 3.061 ± 0.04	3.398IleSer: 3.398 ± 0.05	3.243IleThr: 3.243 ± 0.043	4.14IleVal: 4.14 ± 0.057	0.568IleTrp: 0.568 ± 0.02	1.484IleTyr: 1.484 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.477LysAla: 4.477 ± 0.063	0.311LysCys: 0.311 ± 0.016	2.313LysAsp: 2.313 ± 0.039	2.395LysGlu: 2.395 ± 0.048	1.673LysPhe: 1.673 ± 0.035	2.841LysGly: 2.841 ± 0.043	1.002LysHis: 1.002 ± 0.026	2.481LysIle: 2.481 ± 0.045	2.612LysLys: 2.612 ± 0.055	4.41LysLeu: 4.41 ± 0.049	1.27LysMet: 1.27 ± 0.032	1.675LysAsn: 1.675 ± 0.031	2.512LysPro: 2.512 ± 0.04	1.891LysGln: 1.891 ± 0.036	2.698LysArg: 2.698 ± 0.043	2.611LysSer: 2.611 ± 0.046	2.618LysThr: 2.618 ± 0.046	3.141LysVal: 3.141 ± 0.056	0.516LysTrp: 0.516 ± 0.018	1.28LysTyr: 1.28 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	10.266LeuAla: 10.266 ± 0.108	0.923LeuCys: 0.923 ± 0.025	5.036LeuAsp: 5.036 ± 0.061	5.074LeuGlu: 5.074 ± 0.062	3.581LeuPhe: 3.581 ± 0.054	7.03LeuGly: 7.03 ± 0.067	2.086LeuHis: 2.086 ± 0.036	4.469LeuIle: 4.469 ± 0.057	4.271LeuLys: 4.271 ± 0.056	9.351LeuLeu: 9.351 ± 0.099	2.01LeuMet: 2.01 ± 0.038	3.227LeuAsn: 3.227 ± 0.052	4.874LeuPro: 4.874 ± 0.051	3.446LeuGln: 3.446 ± 0.05	6.334LeuArg: 6.334 ± 0.064	5.937LeuSer: 5.937 ± 0.075	5.351LeuThr: 5.351 ± 0.051	6.648LeuVal: 6.648 ± 0.071	1.214LeuTrp: 1.214 ± 0.032	2.397LeuTyr: 2.397 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.488MetAla: 2.488 ± 0.043	0.168MetCys: 0.168 ± 0.011	1.061MetAsp: 1.061 ± 0.028	1.184MetGlu: 1.184 ± 0.028	0.786MetPhe: 0.786 ± 0.023	1.685MetGly: 1.685 ± 0.033	0.528MetHis: 0.528 ± 0.018	1.156MetIle: 1.156 ± 0.025	1.373MetLys: 1.373 ± 0.03	2.267MetLeu: 2.267 ± 0.036	0.599MetMet: 0.599 ± 0.019	0.895MetAsn: 0.895 ± 0.024	1.359MetPro: 1.359 ± 0.029	0.984MetGln: 0.984 ± 0.024	1.601MetArg: 1.601 ± 0.032	1.585MetSer: 1.585 ± 0.032	1.424MetThr: 1.424 ± 0.032	1.54MetVal: 1.54 ± 0.035	0.235MetTrp: 0.235 ± 0.013	0.495MetTyr: 0.495 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.655AsnAla: 3.655 ± 0.048	0.375AsnCys: 0.375 ± 0.017	1.822AsnAsp: 1.822 ± 0.034	1.718AsnGlu: 1.718 ± 0.037	1.564AsnPhe: 1.564 ± 0.033	3.296AsnGly: 3.296 ± 0.064	0.743AsnHis: 0.743 ± 0.023	1.737AsnIle: 1.737 ± 0.035	1.156AsnLys: 1.156 ± 0.026	3.216AsnLeu: 3.216 ± 0.045	0.68AsnMet: 0.68 ± 0.02	1.348AsnAsn: 1.348 ± 0.038	2.339AsnPro: 2.339 ± 0.046	1.198AsnGln: 1.198 ± 0.028	1.889AsnArg: 1.889 ± 0.037	2.228AsnSer: 2.228 ± 0.043	2.026AsnThr: 2.026 ± 0.042	2.779AsnVal: 2.779 ± 0.045	0.544AsnTrp: 0.544 ± 0.021	1.106AsnTyr: 1.106 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.381ProAla: 5.381 ± 0.065	0.353ProCys: 0.353 ± 0.015	3.091ProAsp: 3.091 ± 0.042	3.603ProGlu: 3.603 ± 0.055	1.904ProPhe: 1.904 ± 0.033	4.009ProGly: 4.009 ± 0.054	1.032ProHis: 1.032 ± 0.025	2.407ProIle: 2.407 ± 0.037	2.382ProLys: 2.382 ± 0.044	4.108ProLeu: 4.108 ± 0.051	1.123ProMet: 1.123 ± 0.029	1.981ProAsn: 1.981 ± 0.038	2.48ProPro: 2.48 ± 0.059	2.032ProGln: 2.032 ± 0.036	2.391ProArg: 2.391 ± 0.039	3.079ProSer: 3.079 ± 0.048	2.959ProThr: 2.959 ± 0.051	3.835ProVal: 3.835 ± 0.045	0.67ProTrp: 0.67 ± 0.02	1.346ProTyr: 1.346 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.65GlnAla: 3.65 ± 0.057	0.247GlnCys: 0.247 ± 0.012	1.553GlnAsp: 1.553 ± 0.03	1.897GlnGlu: 1.897 ± 0.037	1.519GlnPhe: 1.519 ± 0.032	2.326GlnGly: 2.326 ± 0.041	0.899GlnHis: 0.899 ± 0.025	2.153GlnIle: 2.153 ± 0.035	1.858GlnLys: 1.858 ± 0.035	3.505GlnLeu: 3.505 ± 0.046	1.092GlnMet: 1.092 ± 0.026	1.387GlnAsn: 1.387 ± 0.03	1.991GlnPro: 1.991 ± 0.042	2.038GlnGln: 2.038 ± 0.047	2.545GlnArg: 2.545 ± 0.038	2.357GlnSer: 2.357 ± 0.039	2.091GlnThr: 2.091 ± 0.038	2.663GlnVal: 2.663 ± 0.039	0.522GlnTrp: 0.522 ± 0.019	1.056GlnTyr: 1.056 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	5.596ArgAla: 5.596 ± 0.074	0.473ArgCys: 0.473 ± 0.016	3.343ArgAsp: 3.343 ± 0.041	4.177ArgGlu: 4.177 ± 0.066	2.518ArgPhe: 2.518 ± 0.034	3.994ArgGly: 3.994 ± 0.057	1.294ArgHis: 1.294 ± 0.029	3.481ArgIle: 3.481 ± 0.046	2.777ArgLys: 2.777 ± 0.046	5.495ArgLeu: 5.495 ± 0.061	1.691ArgMet: 1.691 ± 0.035	2.114ArgAsn: 2.114 ± 0.034	2.564ArgPro: 2.564 ± 0.051	2.232ArgGln: 2.232 ± 0.039	3.975ArgArg: 3.975 ± 0.064	3.461ArgSer: 3.461 ± 0.048	3.191ArgThr: 3.191 ± 0.045	4.537ArgVal: 4.537 ± 0.048	0.95ArgTrp: 0.95 ± 0.027	1.827ArgTyr: 1.827 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.624SerAla: 6.624 ± 0.075	0.554SerCys: 0.554 ± 0.021	3.276SerAsp: 3.276 ± 0.046	3.232SerGlu: 3.232 ± 0.05	2.589SerPhe: 2.589 ± 0.038	5.952SerGly: 5.952 ± 0.092	1.312SerHis: 1.312 ± 0.028	3.077SerIle: 3.077 ± 0.047	2.535SerLys: 2.535 ± 0.034	5.773SerLeu: 5.773 ± 0.065	1.337SerMet: 1.337 ± 0.03	2.235SerAsn: 2.235 ± 0.046	3.129SerPro: 3.129 ± 0.049	2.191SerGln: 2.191 ± 0.039	3.326SerArg: 3.326 ± 0.046	4.378SerSer: 4.378 ± 0.067	3.786SerThr: 3.786 ± 0.063	4.663SerVal: 4.663 ± 0.057	0.778SerTrp: 0.778 ± 0.022	1.77SerTyr: 1.77 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.224ThrAla: 6.224 ± 0.075	0.482ThrCys: 0.482 ± 0.018	2.951ThrAsp: 2.951 ± 0.047	2.841ThrGlu: 2.841 ± 0.04	2.423ThrPhe: 2.423 ± 0.041	5.039ThrGly: 5.039 ± 0.073	1.171ThrHis: 1.171 ± 0.029	3.235ThrIle: 3.235 ± 0.048	2.257ThrLys: 2.257 ± 0.038	5.702ThrLeu: 5.702 ± 0.064	1.231ThrMet: 1.231 ± 0.027	2.073ThrAsn: 2.073 ± 0.052	3.526ThrPro: 3.526 ± 0.057	1.946ThrGln: 1.946 ± 0.035	2.951ThrArg: 2.951 ± 0.039	3.771ThrSer: 3.771 ± 0.061	3.767ThrThr: 3.767 ± 0.072	4.759ThrVal: 4.759 ± 0.068	0.81ThrTrp: 0.81 ± 0.028	1.556ThrTyr: 1.556 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.907ValAla: 7.907 ± 0.078	0.73ValCys: 0.73 ± 0.021	3.867ValAsp: 3.867 ± 0.057	4.379ValGlu: 4.379 ± 0.055	2.872ValPhe: 2.872 ± 0.04	5.367ValGly: 5.367 ± 0.061	1.618ValHis: 1.618 ± 0.035	3.976ValIle: 3.976 ± 0.051	3.182ValLys: 3.182 ± 0.047	7.581ValLeu: 7.581 ± 0.075	1.661ValMet: 1.661 ± 0.034	2.632ValAsn: 2.632 ± 0.042	3.887ValPro: 3.887 ± 0.055	2.668ValGln: 2.668 ± 0.04	4.58ValArg: 4.58 ± 0.058	4.755ValSer: 4.755 ± 0.055	4.642ValThr: 4.642 ± 0.067	6.125ValVal: 6.125 ± 0.079	0.869ValTrp: 0.869 ± 0.026	1.899ValTyr: 1.899 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.121TrpAla: 1.121 ± 0.028	0.126TrpCys: 0.126 ± 0.008	0.643TrpAsp: 0.643 ± 0.022	0.612TrpGlu: 0.612 ± 0.023	0.584TrpPhe: 0.584 ± 0.019	0.904TrpGly: 0.904 ± 0.025	0.354TrpHis: 0.354 ± 0.015	0.805TrpIle: 0.805 ± 0.024	0.711TrpLys: 0.711 ± 0.021	1.381TrpLeu: 1.381 ± 0.035	0.429TrpMet: 0.429 ± 0.017	0.605TrpAsn: 0.605 ± 0.02	0.551TrpPro: 0.551 ± 0.019	0.593TrpGln: 0.593 ± 0.02	0.917TrpArg: 0.917 ± 0.029	0.872TrpSer: 0.872 ± 0.027	0.867TrpThr: 0.867 ± 0.024	0.861TrpVal: 0.861 ± 0.024	0.27TrpTrp: 0.27 ± 0.014	0.38TrpTyr: 0.38 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.658TyrAla: 2.658 ± 0.043	0.272TyrCys: 0.272 ± 0.013	1.737TyrAsp: 1.737 ± 0.039	1.585TyrGlu: 1.585 ± 0.033	1.338TyrPhe: 1.338 ± 0.028	2.363TyrGly: 2.363 ± 0.041	0.655TyrHis: 0.655 ± 0.019	1.23TyrIle: 1.23 ± 0.029	0.989TyrLys: 0.989 ± 0.027	2.554TyrLeu: 2.554 ± 0.042	0.534TyrMet: 0.534 ± 0.02	1.044TyrAsn: 1.044 ± 0.032	1.344TyrPro: 1.344 ± 0.034	1.0TyrGln: 1.0 ± 0.025	1.908TyrArg: 1.908 ± 0.032	1.868TyrSer: 1.868 ± 0.038	1.535TyrThr: 1.535 ± 0.034	2.064TyrVal: 2.064 ± 0.045	0.455TyrTrp: 0.455 ± 0.019	0.947TyrTyr: 0.947 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4771 proteins (1677413 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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