Amino acid dipepetide frequency for Hungateiclostridium clariflavum (strain DSM 19732 / NBRC 101661 / EBR45) (Clostridium clariflavum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.696AlaAla: 4.696 ± 0.081	0.727AlaCys: 0.727 ± 0.029	3.332AlaAsp: 3.332 ± 0.056	4.321AlaGlu: 4.321 ± 0.058	2.676AlaPhe: 2.676 ± 0.046	4.12AlaGly: 4.12 ± 0.074	0.834AlaHis: 0.834 ± 0.027	5.354AlaIle: 5.354 ± 0.073	4.975AlaLys: 4.975 ± 0.071	5.873AlaLeu: 5.873 ± 0.082	1.568AlaMet: 1.568 ± 0.042	2.841AlaAsn: 2.841 ± 0.051	1.484AlaPro: 1.484 ± 0.038	1.717AlaGln: 1.717 ± 0.039	2.465AlaArg: 2.465 ± 0.046	3.384AlaSer: 3.384 ± 0.058	2.822AlaThr: 2.822 ± 0.065	4.888AlaVal: 4.888 ± 0.069	0.526AlaTrp: 0.526 ± 0.023	2.486AlaTyr: 2.486 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.669CysAla: 0.669 ± 0.026	0.216CysCys: 0.216 ± 0.014	0.699CysAsp: 0.699 ± 0.023	0.866CysGlu: 0.866 ± 0.028	0.556CysPhe: 0.556 ± 0.024	1.024CysGly: 1.024 ± 0.031	0.218CysHis: 0.218 ± 0.016	1.035CysIle: 1.035 ± 0.028	0.853CysLys: 0.853 ± 0.03	0.946CysLeu: 0.946 ± 0.029	0.295CysMet: 0.295 ± 0.016	0.648CysAsn: 0.648 ± 0.025	0.507CysPro: 0.507 ± 0.023	0.297CysGln: 0.297 ± 0.016	0.516CysArg: 0.516 ± 0.018	0.853CysSer: 0.853 ± 0.028	0.563CysThr: 0.563 ± 0.023	0.7CysVal: 0.7 ± 0.024	0.115CysTrp: 0.115 ± 0.01	0.457CysTyr: 0.457 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.092AspAla: 3.092 ± 0.058	0.66AspCys: 0.66 ± 0.024	3.01AspAsp: 3.01 ± 0.057	4.67AspGlu: 4.67 ± 0.057	2.885AspPhe: 2.885 ± 0.055	4.0AspGly: 4.0 ± 0.074	0.596AspHis: 0.596 ± 0.023	5.984AspIle: 5.984 ± 0.069	4.71AspLys: 4.71 ± 0.069	4.832AspLeu: 4.832 ± 0.058	1.5AspMet: 1.5 ± 0.032	3.134AspAsn: 3.134 ± 0.053	1.72AspPro: 1.72 ± 0.043	0.973AspGln: 0.973 ± 0.027	2.35AspArg: 2.35 ± 0.047	3.461AspSer: 3.461 ± 0.056	2.668AspThr: 2.668 ± 0.048	3.831AspVal: 3.831 ± 0.065	0.586AspTrp: 0.586 ± 0.025	2.942AspTyr: 2.942 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	4.624GluAla: 4.624 ± 0.066	0.727GluCys: 0.727 ± 0.025	4.007GluAsp: 4.007 ± 0.052	6.39GluGlu: 6.39 ± 0.083	3.126GluPhe: 3.126 ± 0.049	4.086GluGly: 4.086 ± 0.061	1.04GluHis: 1.04 ± 0.029	7.097GluIle: 7.097 ± 0.074	7.256GluLys: 7.256 ± 0.091	6.761GluLeu: 6.761 ± 0.081	1.941GluMet: 1.941 ± 0.044	4.887GluAsn: 4.887 ± 0.062	1.843GluPro: 1.843 ± 0.045	2.17GluGln: 2.17 ± 0.043	3.093GluArg: 3.093 ± 0.056	3.71GluSer: 3.71 ± 0.054	3.031GluThr: 3.031 ± 0.057	4.884GluVal: 4.884 ± 0.07	0.658GluTrp: 0.658 ± 0.023	3.366GluTyr: 3.366 ± 0.07	0.0GluXaa: 0.0 ± 0.0
Phe	2.709PheAla: 2.709 ± 0.053	0.658PheCys: 0.658 ± 0.027	2.815PheAsp: 2.815 ± 0.047	3.219PheGlu: 3.219 ± 0.05	1.957PhePhe: 1.957 ± 0.05	2.972PheGly: 2.972 ± 0.055	0.525PheHis: 0.525 ± 0.021	4.082PheIle: 4.082 ± 0.066	3.184PheLys: 3.184 ± 0.059	3.696PheLeu: 3.696 ± 0.077	1.074PheMet: 1.074 ± 0.032	2.382PheAsn: 2.382 ± 0.04	1.352PhePro: 1.352 ± 0.039	0.964PheGln: 0.964 ± 0.031	1.64PheArg: 1.64 ± 0.04	3.236PheSer: 3.236 ± 0.06	2.345PheThr: 2.345 ± 0.046	2.904PheVal: 2.904 ± 0.057	0.399PheTrp: 0.399 ± 0.018	1.847PheTyr: 1.847 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	3.663GlyAla: 3.663 ± 0.069	0.893GlyCys: 0.893 ± 0.03	3.583GlyAsp: 3.583 ± 0.07	4.263GlyGlu: 4.263 ± 0.058	3.086GlyPhe: 3.086 ± 0.048	4.092GlyGly: 4.092 ± 0.089	0.962GlyHis: 0.962 ± 0.031	6.405GlyIle: 6.405 ± 0.081	5.476GlyLys: 5.476 ± 0.077	5.35GlyLeu: 5.35 ± 0.078	1.843GlyMet: 1.843 ± 0.049	3.464GlyAsn: 3.464 ± 0.08	1.337GlyPro: 1.337 ± 0.041	1.61GlyGln: 1.61 ± 0.041	2.659GlyArg: 2.659 ± 0.055	3.699GlySer: 3.699 ± 0.07	3.601GlyThr: 3.601 ± 0.072	4.329GlyVal: 4.329 ± 0.071	0.639GlyTrp: 0.639 ± 0.025	3.142GlyTyr: 3.142 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	0.756HisAla: 0.756 ± 0.024	0.223HisCys: 0.223 ± 0.014	0.705HisAsp: 0.705 ± 0.021	0.829HisGlu: 0.829 ± 0.026	0.63HisPhe: 0.63 ± 0.024	0.952HisGly: 0.952 ± 0.032	0.288HisHis: 0.288 ± 0.017	1.29HisIle: 1.29 ± 0.034	0.947HisLys: 0.947 ± 0.03	1.144HisLeu: 1.144 ± 0.032	0.322HisMet: 0.322 ± 0.016	0.772HisAsn: 0.772 ± 0.026	0.682HisPro: 0.682 ± 0.025	0.391HisGln: 0.391 ± 0.019	0.635HisArg: 0.635 ± 0.024	0.831HisSer: 0.831 ± 0.026	0.688HisThr: 0.688 ± 0.026	0.767HisVal: 0.767 ± 0.026	0.172HisTrp: 0.172 ± 0.012	0.636HisTyr: 0.636 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.776IleAla: 5.776 ± 0.083	1.119IleCys: 1.119 ± 0.029	5.875IleAsp: 5.875 ± 0.069	6.907IleGlu: 6.907 ± 0.088	3.656IlePhe: 3.656 ± 0.068	5.34IleGly: 5.34 ± 0.075	1.163IleHis: 1.163 ± 0.036	7.612IleIle: 7.612 ± 0.1	7.684IleLys: 7.684 ± 0.084	7.773IleLeu: 7.773 ± 0.107	2.042IleMet: 2.042 ± 0.047	5.358IleAsn: 5.358 ± 0.081	3.432IlePro: 3.432 ± 0.057	2.136IleGln: 2.136 ± 0.05	3.481IleArg: 3.481 ± 0.057	6.544IleSer: 6.544 ± 0.088	4.618IleThr: 4.618 ± 0.079	5.818IleVal: 5.818 ± 0.077	0.614IleTrp: 0.614 ± 0.023	3.493IleTyr: 3.493 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	5.23LysAla: 5.23 ± 0.074	0.859LysCys: 0.859 ± 0.029	5.102LysAsp: 5.102 ± 0.081	7.143LysGlu: 7.143 ± 0.08	2.864LysPhe: 2.864 ± 0.054	4.885LysGly: 4.885 ± 0.072	1.168LysHis: 1.168 ± 0.03	7.278LysIle: 7.278 ± 0.086	7.019LysLys: 7.019 ± 0.099	7.127LysLeu: 7.127 ± 0.071	2.012LysMet: 2.012 ± 0.043	5.114LysAsn: 5.114 ± 0.08	2.511LysPro: 2.511 ± 0.061	2.253LysGln: 2.253 ± 0.047	3.377LysArg: 3.377 ± 0.058	4.8LysSer: 4.8 ± 0.065	4.169LysThr: 4.169 ± 0.063	5.707LysVal: 5.707 ± 0.078	0.712LysTrp: 0.712 ± 0.023	3.874LysTyr: 3.874 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	5.45LeuAla: 5.45 ± 0.078	1.13LeuCys: 1.13 ± 0.029	4.893LeuAsp: 4.893 ± 0.066	6.486LeuGlu: 6.486 ± 0.077	3.877LeuPhe: 3.877 ± 0.077	5.643LeuGly: 5.643 ± 0.087	1.144LeuHis: 1.144 ± 0.031	7.213LeuIle: 7.213 ± 0.105	8.028LeuLys: 8.028 ± 0.08	7.849LeuLeu: 7.849 ± 0.103	2.183LeuMet: 2.183 ± 0.044	5.035LeuAsn: 5.035 ± 0.065	3.134LeuPro: 3.134 ± 0.063	2.094LeuGln: 2.094 ± 0.041	3.443LeuArg: 3.443 ± 0.059	6.21LeuSer: 6.21 ± 0.081	4.349LeuThr: 4.349 ± 0.057	5.38LeuVal: 5.38 ± 0.06	0.703LeuTrp: 0.703 ± 0.027	3.423LeuTyr: 3.423 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.768MetAla: 1.768 ± 0.041	0.245MetCys: 0.245 ± 0.015	1.473MetAsp: 1.473 ± 0.035	1.864MetGlu: 1.864 ± 0.038	0.936MetPhe: 0.936 ± 0.031	1.649MetGly: 1.649 ± 0.044	0.335MetHis: 0.335 ± 0.018	1.853MetIle: 1.853 ± 0.034	2.286MetLys: 2.286 ± 0.052	2.28MetLeu: 2.28 ± 0.042	0.603MetMet: 0.603 ± 0.021	1.344MetAsn: 1.344 ± 0.032	0.997MetPro: 0.997 ± 0.031	0.738MetGln: 0.738 ± 0.027	0.983MetArg: 0.983 ± 0.03	1.522MetSer: 1.522 ± 0.036	1.143MetThr: 1.143 ± 0.029	1.601MetVal: 1.601 ± 0.034	0.163MetTrp: 0.163 ± 0.013	0.87MetTyr: 0.87 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.2AsnAla: 3.2 ± 0.06	0.689AsnCys: 0.689 ± 0.026	2.841AsnAsp: 2.841 ± 0.05	3.84AsnGlu: 3.84 ± 0.062	2.362AsnPhe: 2.362 ± 0.05	3.891AsnGly: 3.891 ± 0.088	0.685AsnHis: 0.685 ± 0.022	5.788AsnIle: 5.788 ± 0.074	4.353AsnLys: 4.353 ± 0.06	4.89AsnLeu: 4.89 ± 0.077	1.391AsnMet: 1.391 ± 0.032	3.482AsnAsn: 3.482 ± 0.07	2.316AsnPro: 2.316 ± 0.049	1.398AsnGln: 1.398 ± 0.038	2.289AsnArg: 2.289 ± 0.047	3.849AsnSer: 3.849 ± 0.069	2.908AsnThr: 2.908 ± 0.048	3.443AsnVal: 3.443 ± 0.054	0.553AsnTrp: 0.553 ± 0.023	2.478AsnTyr: 2.478 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	1.891ProAla: 1.891 ± 0.038	0.316ProCys: 0.316 ± 0.015	2.187ProAsp: 2.187 ± 0.043	2.985ProGlu: 2.985 ± 0.064	1.572ProPhe: 1.572 ± 0.04	2.174ProGly: 2.174 ± 0.049	0.517ProHis: 0.517 ± 0.023	2.536ProIle: 2.536 ± 0.052	2.336ProLys: 2.336 ± 0.051	2.649ProLeu: 2.649 ± 0.053	0.669ProMet: 0.669 ± 0.022	1.5ProAsn: 1.5 ± 0.04	0.911ProPro: 0.911 ± 0.031	0.968ProGln: 0.968 ± 0.028	0.922ProArg: 0.922 ± 0.03	2.014ProSer: 2.014 ± 0.048	2.068ProThr: 2.068 ± 0.144	2.716ProVal: 2.716 ± 0.051	0.301ProTrp: 0.301 ± 0.021	1.383ProTyr: 1.383 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.62GlnAla: 1.62 ± 0.045	0.247GlnCys: 0.247 ± 0.016	1.244GlnAsp: 1.244 ± 0.032	1.793GlnGlu: 1.793 ± 0.039	1.094GlnPhe: 1.094 ± 0.027	1.398GlnGly: 1.398 ± 0.036	0.334GlnHis: 0.334 ± 0.016	2.308GlnIle: 2.308 ± 0.046	2.378GlnLys: 2.378 ± 0.051	2.317GlnLeu: 2.317 ± 0.047	0.713GlnMet: 0.713 ± 0.024	1.608GlnAsn: 1.608 ± 0.035	0.749GlnPro: 0.749 ± 0.032	0.906GlnGln: 0.906 ± 0.034	1.182GlnArg: 1.182 ± 0.034	1.537GlnSer: 1.537 ± 0.038	1.192GlnThr: 1.192 ± 0.031	1.674GlnVal: 1.674 ± 0.037	0.258GlnTrp: 0.258 ± 0.013	1.227GlnTyr: 1.227 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.229ArgAla: 2.229 ± 0.042	0.449ArgCys: 0.449 ± 0.018	2.123ArgAsp: 2.123 ± 0.045	3.224ArgGlu: 3.224 ± 0.058	1.732ArgPhe: 1.732 ± 0.037	2.123ArgGly: 2.123 ± 0.042	0.59ArgHis: 0.59 ± 0.022	3.921ArgIle: 3.921 ± 0.052	3.64ArgLys: 3.64 ± 0.065	3.673ArgLeu: 3.673 ± 0.06	1.051ArgMet: 1.051 ± 0.027	2.258ArgAsn: 2.258 ± 0.042	1.167ArgPro: 1.167 ± 0.028	1.237ArgGln: 1.237 ± 0.034	1.759ArgArg: 1.759 ± 0.042	1.877ArgSer: 1.877 ± 0.037	1.818ArgThr: 1.818 ± 0.044	2.563ArgVal: 2.563 ± 0.044	0.359ArgTrp: 0.359 ± 0.018	1.824ArgTyr: 1.824 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.55SerAla: 3.55 ± 0.058	0.74SerCys: 0.74 ± 0.027	3.545SerAsp: 3.545 ± 0.058	4.308SerGlu: 4.308 ± 0.056	3.056SerPhe: 3.056 ± 0.055	4.681SerGly: 4.681 ± 0.072	0.847SerHis: 0.847 ± 0.028	5.869SerIle: 5.869 ± 0.079	5.198SerLys: 5.198 ± 0.066	5.427SerLeu: 5.427 ± 0.076	1.572SerMet: 1.572 ± 0.033	3.537SerAsn: 3.537 ± 0.063	1.928SerPro: 1.928 ± 0.043	1.695SerGln: 1.695 ± 0.035	2.285SerArg: 2.285 ± 0.044	4.107SerSer: 4.107 ± 0.075	3.062SerThr: 3.062 ± 0.051	4.204SerVal: 4.204 ± 0.06	0.568SerTrp: 0.568 ± 0.027	2.517SerTyr: 2.517 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	3.374ThrAla: 3.374 ± 0.057	0.515ThrCys: 0.515 ± 0.02	2.909ThrAsp: 2.909 ± 0.055	3.271ThrGlu: 3.271 ± 0.06	2.178ThrPhe: 2.178 ± 0.046	3.919ThrGly: 3.919 ± 0.068	0.752ThrHis: 0.752 ± 0.024	4.247ThrIle: 4.247 ± 0.067	3.233ThrLys: 3.233 ± 0.06	4.276ThrLeu: 4.276 ± 0.062	1.054ThrMet: 1.054 ± 0.031	2.274ThrAsn: 2.274 ± 0.052	2.52ThrPro: 2.52 ± 0.138	1.244ThrGln: 1.244 ± 0.033	1.775ThrArg: 1.775 ± 0.036	3.119ThrSer: 3.119 ± 0.06	2.619ThrThr: 2.619 ± 0.079	4.145ThrVal: 4.145 ± 0.086	0.399ThrTrp: 0.399 ± 0.02	2.151ThrTyr: 2.151 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	3.933ValAla: 3.933 ± 0.061	0.897ValCys: 0.897 ± 0.028	3.952ValAsp: 3.952 ± 0.05	4.772ValGlu: 4.772 ± 0.065	3.187ValPhe: 3.187 ± 0.053	3.821ValGly: 3.821 ± 0.057	0.896ValHis: 0.896 ± 0.024	5.925ValIle: 5.925 ± 0.067	5.499ValLys: 5.499 ± 0.078	6.324ValLeu: 6.324 ± 0.084	1.553ValMet: 1.553 ± 0.035	3.767ValAsn: 3.767 ± 0.06	2.393ValPro: 2.393 ± 0.051	1.647ValGln: 1.647 ± 0.032	2.51ValArg: 2.51 ± 0.051	4.522ValSer: 4.522 ± 0.063	3.611ValThr: 3.611 ± 0.083	4.656ValVal: 4.656 ± 0.082	0.567ValTrp: 0.567 ± 0.027	2.818ValTyr: 2.818 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.529TrpAla: 0.529 ± 0.02	0.108TrpCys: 0.108 ± 0.01	0.584TrpAsp: 0.584 ± 0.024	0.623TrpGlu: 0.623 ± 0.022	0.426TrpPhe: 0.426 ± 0.021	0.586TrpGly: 0.586 ± 0.025	0.168TrpHis: 0.168 ± 0.012	0.733TrpIle: 0.733 ± 0.026	0.679TrpLys: 0.679 ± 0.026	0.811TrpLeu: 0.811 ± 0.027	0.239TrpMet: 0.239 ± 0.013	0.535TrpAsn: 0.535 ± 0.022	0.21TrpPro: 0.21 ± 0.015	0.284TrpGln: 0.284 ± 0.016	0.338TrpArg: 0.338 ± 0.018	0.508TrpSer: 0.508 ± 0.024	0.431TrpThr: 0.431 ± 0.018	0.511TrpVal: 0.511 ± 0.021	0.114TrpTrp: 0.114 ± 0.011	0.395TrpTyr: 0.395 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.329TyrAla: 2.329 ± 0.053	0.616TyrCys: 0.616 ± 0.023	2.725TyrAsp: 2.725 ± 0.098	2.923TyrGlu: 2.923 ± 0.051	2.105TyrPhe: 2.105 ± 0.05	2.739TyrGly: 2.739 ± 0.055	0.601TyrHis: 0.601 ± 0.022	3.911TyrIle: 3.911 ± 0.059	3.474TyrLys: 3.474 ± 0.057	3.67TyrLeu: 3.67 ± 0.056	1.022TyrMet: 1.022 ± 0.028	2.704TyrAsn: 2.704 ± 0.066	1.422TyrPro: 1.422 ± 0.034	1.055TyrGln: 1.055 ± 0.032	1.915TyrArg: 1.915 ± 0.038	2.916TyrSer: 2.916 ± 0.055	2.266TyrThr: 2.266 ± 0.057	2.529TyrVal: 2.529 ± 0.049	0.407TyrTrp: 0.407 ± 0.023	2.177TyrTyr: 2.177 ± 0.064	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3774 proteins (1259243 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---